CN106619583A - Ointment for preventing and treating mosquito bite and preparation method of ointment - Google Patents
Ointment for preventing and treating mosquito bite and preparation method of ointment Download PDFInfo
- Publication number
- CN106619583A CN106619583A CN201611056885.2A CN201611056885A CN106619583A CN 106619583 A CN106619583 A CN 106619583A CN 201611056885 A CN201611056885 A CN 201611056885A CN 106619583 A CN106619583 A CN 106619583A
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- CN
- China
- Prior art keywords
- parts
- ointment
- borneol
- menthol
- glycerine
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Abstract
The invention provides ointment for preventing and treating mosquito bite, can solve the technical problems that a product for preventing mosquito bite in the prior art is poor in swelling subduing effect and is not suitable for people with allergic constitution, and further provides a preparation method of the ointment. The ointment consists of the following raw materials in parts by weight: 192-196 parts of water, 5-10 parts of glycerine, 1-5 parts of sodium lauryl sulfate, 0.8-1.6 parts of menthol, 0.6-1.2 parts of borneol, 10-18 parts of mineral oil, 20-30 parts of stearyl alcohol, 0.2-0.4 part of methyl hydroxybenzoate, 0.2-0.4 part of propyl hydroxybenzoate, and 0.2-0.6 part of glyceryl stearate.
Description
Technical field
The present invention relates to field of medicaments, and in particular to a kind of ointment bitten for mosquito control and preparation method thereof.
Background technology
Summer temperature is raised, and mosquito grows, unavoidably by bite by mosquitos.After bite by mosquitos, it may appear that it is red and swollen, itch, pain etc.
Symptom, if too scratch grabbed, is also susceptible to infection.Prevent the product category of bite by mosquitos various currently on the market, for example, pass
The cooling ointment of system, essential wind oil, this kind of product has cooling feeling using after, there is certain antipruritic effect, but its detumescence effect on driving birds is not good,
Simultaneously because there is alcoholic content, the people for being not suitable for allergic constitution uses；And although mosquito does not sting and with the addition of Metadelphene, can be effective
Bite by mosquitos, but effect of not subsiding a swelling are prevented, and are also not suitable for the people of allergic constitution to use.
The content of the invention
For the problems referred to above, the invention provides a kind of ointment bitten for mosquito control, it can solve prior art
In prevent the detumescence of bite by mosquitos product effect on driving birds is not good and to be not suitable for the technical problem that the people of allergic constitution uses；The present invention
Additionally provide the preparation method of the ointment.
Its technical scheme is such, and it is made up of the raw material of following weight portion：192 parts ~ 196 parts of water, glycerine 5 parts ~ 10
Part, 1 part ~ 5 parts of laruyl alcohol sodium sulfovinate, 0.8 part ~ 1.6 parts of menthol, 0.6 part ~ 1.2 parts of borneol, 10 parts ~ 18 parts of Dormant oils is stearic
20 parts ~ 30 parts of alcohol, 0.2 part ~ 0.4 part of methyl hydroxybenzoate, 0.2 part ~ 0.4 part of Nipasol, 0.2 part ~ 0.6 part of stearine.
Further, above-mentioned ointment is made up of the raw material of following weight portion：194 parts of water, 10 parts of glycerine, bay alcohol sulfuric ester
3 parts of sodium, 1.5 parts of menthol, 1 part of borneol, 15 parts of Dormant oils, 25 parts of stearyl alcohol, 0.25 part of methyl hydroxybenzoate, 0.25 part of Nipasol,
0.2 part of stearine.
The preparation method of above-mentioned ointment, it is comprised the following steps：
In step one, the water by above-mentioned raw materials, glycerine, laruyl alcohol sodium sulfovinate, menthol and borneol input water phase pot, heating
To 90 DEG C, constant temperature is stirred 10 minutes；
Step 2, the Dormant oils by above-mentioned raw materials, stearyl alcohol, methyl hydroxybenzoate, Nipasol and stearine input oil phase
Pot, is heated to 90 DEG C, and constant temperature is stirred 10 minutes；
Step 3, step one and step 2 are processed after raw mixture be evacuated in retort, homogeneous 2 minutes stirs 30 points
Clock；
Step 4, step 3 is processed after raw mixture be cooled to 55 DEG C, constant temperature is stirred 15 minutes；
Step 5, step 4 is processed after raw mixture be cooled to 38 DEG C of dischargings.
Above-mentioned each raw material：
Menthol, taste is pungent is cool in nature；There is dispelling wind, heat-clearing.Cure mainly anemopyretic cold, headache, hot eyes, abscess of throat, tooth
Bitterly, the symptom such as pruitus.
Borneol, main scattered stagnated fire, can deep heat, control frightened epilepsy, phlegm fan, larynx numbness, tongue is swollen, toothache, deafness, breath, hot eyes float screen,
Acne poison caves in, desinsection, hemorrhoid, expedite the emergence of, and property is walked and do not kept, also can myogenic pain relieving.
Glycerine, with moisture-keeping function.
Laruyl alcohol sodium sulfovinate, stearine, with excellent emulsibility.
Dormant oils, not only with excellent infiltration facilitation effect, can help each active component more easily to penetrate into skin, and
And the effect with emulsifying agent.
Nipasol, the effect with sterilization and anticorrosion.
It is verified by experiments, after bite by mosquitos, smears the ointment bitten for mosquito control of the present invention, can disappears within 2 ~ 3 days
It is swollen, and the people of allergic constitution, using rear without allergic reaction, applicability is good；Additionally, the ointment also has good mosquito-proof effect.
Specific embodiment
Embodiment 1
A kind of ointment bitten for mosquito control, it is made up of the raw material of following weight portion：192 parts of water, 7.5 parts of glycerine, the moon
3 parts of cinnamic alcohol sodium sulfovinate, 0.8 part of menthol, 0.6 part of borneol, 14 parts of Dormant oils, 20 parts of stearyl alcohol, 0.3 part of methyl hydroxybenzoate, oxybenzene
0.2 part of propyl ester, 0.6 part of stearine.
The preparation method of above-mentioned ointment, it is comprised the following steps：
In step one, the water by above-mentioned raw materials, glycerine, laruyl alcohol sodium sulfovinate, menthol and borneol input water phase pot, heating
To 90 DEG C, constant temperature is stirred 10 minutes；
Step 2, the Dormant oils by above-mentioned raw materials, stearyl alcohol, methyl hydroxybenzoate, Nipasol and stearine input oil phase
Pot, is heated to 90 DEG C, and constant temperature is stirred 10 minutes；
Step 3, step one and step 2 are processed after raw mixture be evacuated in retort, homogeneous 2 minutes stirs 30 points
Clock；Wherein the motor rotary speed of homogeneous is 2000 revs/min ~ 3000 revs/min, the motor rotary speed of stirring is 800 revs/min ~
1200 revs/min；
Step 4, step 3 is processed after raw mixture be cooled to 55 DEG C, constant temperature is stirred 15 minutes；
Step 5, step 4 is processed after raw mixture be cooled to 38 DEG C of dischargings；
Wherein, Dormant oils is purchased from Hangzhou Fuda goods and materials petrochemical industry Co., Ltd, and stearyl alcohol is purchased from Nanjing Yi Shengchang Science and Technology Ltd.s.
Embodiment 2
A kind of ointment bitten for mosquito control, it is made up of the raw material of following weight portion：194 parts of water, 5 parts of glycerine, bay
1 part of alcohol sulfuric ester sodium, 1.6 parts of menthol, 1.2 parts of borneol, 18 parts of Dormant oils, 30 parts of stearyl alcohol, 0.4 part of methyl hydroxybenzoate, oxybenzene third
0.3 part of ester, 0.2 part of stearine.
The preparation method of the ointment is identical with the preparation method of the ointment in embodiment 1, and it the difference is that only component
Content it is different.
Embodiment 3
A kind of ointment bitten for mosquito control, it is made up of the raw material of following weight portion：196 parts of water, 10 parts of glycerine, bay
5 parts of alcohol sulfuric ester sodium, 2.4 parts of menthol, 0.9 part of borneol, 10 parts of Dormant oils, 25 parts of stearyl alcohol, 0.2 part of methyl hydroxybenzoate, oxybenzene third
0.4 part of ester, 0.4 part of stearine.
The preparation method of the ointment is identical with the preparation method of the ointment in embodiment 1, and it the difference is that only component
Content it is different.
Embodiment 4
A kind of ointment bitten for mosquito control, it is made up of the raw material of following weight portion：194 parts of water, 10 parts of glycerine, bay
3 parts of alcohol sulfuric ester sodium, 1.5 parts of menthol, 1 part of borneol, 15 parts of Dormant oils, 25 parts of stearyl alcohol, 0.25 part of methyl hydroxybenzoate, Nipasol
0.25 part, 0.2 part of stearine.
The preparation method of the ointment is identical with the preparation method of the ointment in embodiment 1, and it the difference is that only component
Content it is different.
Experimental example 1
Bite by mosquitos patient 90 is chosen, red and swollen, pruritis, the wherein male sex 45 occur after biting, women 45, at random
Three groups are assigned as, per group of 30 people, respectively experimental group, control group 1 and control group 2.
Medicining condition：
Experimental group, the ointment bitten for mosquito control prepared using embodiment 4, is applied in and bites place, two times a day；
Control group 1, using essential wind oil, is applied in and bites place, two times a day；
Control group 2, is not stung using mosquito, is applied in and is bitten place, two times a day.
Three groups of clinical drug effects compare：
Experimental group, subsides a swelling for 2 ~ 3 days, cures 30；
Control group 1, cures 29, and 1 is invalid, wherein, 26, subside a swelling within 4 ~ 5 days, 3, subside a swelling within 7 ~ 8 days；
Control group is red and swollen after 2,7 days gradually to disappear.
Should be it is experimentally confirmed that the ointment of the present invention not be stung compared to essential wind oil or mosquito, with detumescence effect well.
Experimental example 2
The bite by mosquitos patient 10 with allergic constitution is successively chosen, red and swollen symptom, the wherein male sex 5 occurs after biting,
Women 5.The ointment bitten for mosquito control prepared using embodiment 4, is applied in and bites place, two times a day, using rear 2 ~
Detumescence in 3 days, healing, and occur without allergic phenomena during medication.
Should it is experimentally confirmed that the present invention ointment be applied to allergic constitution people use, applicability is good.
Claims (3)
1. a kind of ointment bitten for mosquito control, it is made up of the raw material of following weight portion：192 parts ~ 196 parts of water, glycerine 5
Part ~ 10 parts, 1 part ~ 5 parts of laruyl alcohol sodium sulfovinate, 0.8 part ~ 1.6 parts of menthol, 0.6 part ~ 1.2 parts of borneol, Dormant oils 10 parts ~ 18
Part, 20 parts ~ 30 parts of stearyl alcohol, 0.2 part ~ 0.4 part of methyl hydroxybenzoate, 0.2 part ~ 0.4 part of Nipasol, 0.2 part of stearine ~
0.6 part.
2. a kind of ointment bitten for mosquito control according to claim 1, it is characterised in that：Above-mentioned ointment is by following
The raw material composition of weight portion：194 parts of water, 10 parts of glycerine, 3 parts of laruyl alcohol sodium sulfovinate, 1.5 parts of menthol, 1 part of borneol, Dormant oils
15 parts, 25 parts of stearyl alcohol, 0.25 part of methyl hydroxybenzoate, 0.25 part of Nipasol, 0.2 part of stearine.
3. the preparation method of the ointment bitten for mosquito control as claimed in claim 1 or 2, it is comprised the following steps：
In step one, the water by above-mentioned raw materials, glycerine, laruyl alcohol sodium sulfovinate, menthol and borneol input water phase pot, heating
To 90 DEG C, constant temperature is stirred 10 minutes；
Step 2, the Dormant oils by above-mentioned raw materials, stearyl alcohol, methyl hydroxybenzoate, Nipasol and stearine input oil phase
Pot, is heated to 90 DEG C, and constant temperature is stirred 10 minutes；
Step 3, step one and step 2 are processed after raw mixture be evacuated in retort, homogeneous 2 minutes stirs 30 points
Clock；
Step 4, step 3 is processed after raw mixture be cooled to 55 DEG C, constant temperature is stirred 15 minutes；
Step 5, step 4 is processed after raw mixture be cooled to 38 DEG C of dischargings.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611056885.2A CN106619583A (en) | 2016-11-26 | 2016-11-26 | Ointment for preventing and treating mosquito bite and preparation method of ointment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611056885.2A CN106619583A (en) | 2016-11-26 | 2016-11-26 | Ointment for preventing and treating mosquito bite and preparation method of ointment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106619583A true CN106619583A (en) | 2017-05-10 |
Family
ID=58811492
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611056885.2A Pending CN106619583A (en) | 2016-11-26 | 2016-11-26 | Ointment for preventing and treating mosquito bite and preparation method of ointment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106619583A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102258441A (en) * | 2011-07-07 | 2011-11-30 | 何家庆 | Snakegourd fruit frost crack prevention skin care product and preparation method thereof |
-
2016
- 2016-11-26 CN CN201611056885.2A patent/CN106619583A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102258441A (en) * | 2011-07-07 | 2011-11-30 | 何家庆 | Snakegourd fruit frost crack prevention skin care product and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 王嘉德等: "肤乐灵霜的研制与临床应用", 《药学实践杂志》 * |
| 罗明生等: "《中国药用辅料》", 30 April 2006, 化学工业出版社 * |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170510 |