CN106614599A - Bactericidal composition containing quinoline copper and kasugamycin - Google Patents
Bactericidal composition containing quinoline copper and kasugamycin Download PDFInfo
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- CN106614599A CN106614599A CN201611255349.5A CN201611255349A CN106614599A CN 106614599 A CN106614599 A CN 106614599A CN 201611255349 A CN201611255349 A CN 201611255349A CN 106614599 A CN106614599 A CN 106614599A
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- kasugarnycin
- copper
- hydroxyquinolinate
- bactericidal composition
- active component
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
- A01N43/42—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings condensed with carbocyclic rings
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
- A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
Abstract
The invention discloses a bactericidal composition containing quinoline copper and kasugamycin. Effective components of the bactericidal composition comprise a first active component which is quinoline copper and a second active component which is kasugamycin; the weight ratio of the first active component to the second active component is (1 to 7)-(15 to 1); the sum of the content of the first active component and the second active component is 5-80% of the total weight of the composition. The composition can be prepared into preparations such as suspension agents, water dispersible granules and wettable powder and the like which are allowed to be used in agriculture. The composition is reasonable in compound and excellent in bactericidal effect; the activity and the bactericidal effect of the composition are not simple superposition of the activity of the components; compared with the existing signal preparation, the composition has obvious synergistic effect besides obvious bactericidal effect, is high in safety to crops, and has obvious effects of preventing and treating rice blast.
Description
Technical field
The invention belongs to technical field of compounded pesticide, is related to a kind of bactericidal composition, the bactericidal composition contains the first work
Property composition be copper 8-hydroxyquinolinate and the second active component kasugarnycin.The invention further relates to the preparation formulation of the bactericidal composition with
And its in application agriculturally.
Background technology
Copper agent is one of disinfectant use in agriculture type the most ancient, and with has a broad antifungal spectrum, to be not likely to produce the resistance to the action of a drug etc. excellent
Point.Based on the usage history of the inorganic copper agent of Kocide SD, copper sulphate etc. more than 200 years, but due to its be difficult to by
It is biodegradable, it is long-term a large amount of using accumulation of the copper in soil has been had resulted in, can be to the normal growth of plant and soil function
Have undesirable effect.At present, the exploitation of organic copper agent, it has also become the hot topic of disinfectant use in agriculture production, organic copper agent
To crop safety, nuisanceless.
Copper 8-hydroxyquinolinate is synthesized as a kind of new organic chelated copper by organic quinolines and mantoquita.Copper 8-hydroxyquinolinate belongs to quinoline
Quinoline class protective fungicide, with the double sterilization activity that organic quinolines and mantoquita have.Sterilization mechanism is studied and shown, copper 8-hydroxyquinolinate energy
Suppress the G- protein synthesis of early stage cell expression, suppress the metabolism of germ spore, control cell to divide again and break up, and
Have Multi-contact activity concurrently, the pathogen spore of sprouting absorbs the chelated copper, Spores are directly killed inside pathogen, from
And reach the effect of controlling disease.
Copper 8-hydroxyquinolinate has extremely strong adhesion strength and resistance of rainwater washing against ability.Additionally, copper 8-hydroxyquinolinate is also equipped with safe, sterilization
Spectrum is wide, the lasting period is long, the features such as low cost, has preferable effect to preventing and treating bacterial disease, the preventing and treating to fungal disease
Also preferable effect is shown, alternative conventional Inorganic Copper series bactericidal agent is various bacillary and true on fruit tree, vegetables for preventing and treating
Fungal disease, and the activity of various enzymes in plant body can be stimulated, grow, purify fruit face, increase with photosynthesis, promotion is improved
Plus the effect such as yield, improving quality.At present in production, copper 8-hydroxyquinolinate is mainly used in preventing and treating：The late blight of tomato, bacterial canker
Disease, the epidemic disease of capsicum, canker, shot hole, downy mildew, the downy mildew of cucumber, bacterial leaf spot, the downy mildew of watermelon, charcoal
Subcutaneous ulcer disease, Acidovorax Avenae Subsp. Citrulli, the downy mildew of muskmelon, phytophthora rot, Bacterial fruit blotch, late blight of potato etc..
Kasugarnycin, also known as kasugarnycin, kasumin, chemical name：(5- amino-2-methyl -6- (2,3,4,5,6- hydroxyls
Butylcyclohexyl oxo) tetrahydropyran -3-base) amino-α-IMDA.Kasugarnycin is a kind of selective sterilization antibiosis of strong interior suction
Element, permeability is strong, resistance of rainwater washing against；To person poultry safety, to crop without poisoning.Kasugarnycin has protection and therapeutic action, main
It is used to prevent and treat rice blast, it can also be used to prevent and treat the diseases such as watermelon bacterial angular leaf spot, peach gummosis, shot hole, shothole disease,
Anthracnose of sorghum.Its mechanism of action is interference esterase system, affects amino acid metabolism, so as to affect protein to synthesize, suppresses bacterium
Filament is developed.In agricultural production, the formulation of kasugarnycin mainly has wettable powder, pulvis, aqua.Kasugarnycin can with it is many
Combined use of pesticides is planted, generally should not be mixed with Basic pesticides.
However, during the produce reality of agricultural, controlling disease is easiest to problem appear to is that the product of disease drug resistance
It is raw.Different cultivars is compounded, and is to prevent and treat the very common method of resistance disease.Heterogeneity is compounded, according to practical application
Effect come judge complex composition and be plus and, synergy or antagonism.In most cases, the compounding effect of agricultural chemicals is all
Be additive effect, really have the compounding of synergistic effect less, especially synergistic effect clearly, the very high compounding of co-toxicity coefficient
With regard to less.Through inventor's research, find that for copper 8-hydroxyquinolinate and kasugarnycin compounding good synergistic effect can be produced.
The content of the invention
There is resistance risk after copper 8-hydroxyquinolinate, kasugarnycin listing.Actual pesticide test it has been shown that alone copper 8-hydroxyquinolinate,
Kasugarnycin prevents and treats rice blast, is unfavorable for reducing resistance risk.It is mould to copper 8-hydroxyquinolinate, spring thunder to reduce rice Pyricularia grisea
Element produces the danger of resistance, and the reactive compound that the different mechanisms of action are usually used at present is combined to be prevented and treated.
It is an object of the invention to provide a kind of bactericidal composition containing copper 8-hydroxyquinolinate and kasugarnycin, the first active component is
Copper 8-hydroxyquinolinate and the second active component kasugarnycin.It is found by experiment that, the different copper 8-hydroxyquinolinate of the mechanism of action, kasugarnycin is multiple
Match somebody with somebody, with obvious synergistic effect, the prevention effect to rice blast can be significantly improved, reduce dosage, reduction is prevented and treated into
This, it is high to crop safety.
Another object of the present invention is to provide the preparation formulation of the bactericidal composition containing copper 8-hydroxyquinolinate and kasugarnycin.
It is still another object of the present invention to provide application of the above-mentioned composition in preventing and treating rice blast.
In order to overcome the defect of existing unitary agent, in above-mentioned bactericidal composition, its active ingredient by the first activity into
The weight ratio for dividing copper 8-hydroxyquinolinate and the second active component kasugarnycin composition, the first active component and the second active component is 1:7～
15:1。
Preferably, in the bactericidal composition containing copper 8-hydroxyquinolinate and kasugarnycin, the copper 8-hydroxyquinolinate exists with kasugarnycin
Weight ratio in bactericidal composition is 1:5～10:1.
Preferably, in the bactericidal composition containing copper 8-hydroxyquinolinate and kasugarnycin, the copper 8-hydroxyquinolinate exists with kasugarnycin
Weight ratio in bactericidal composition is 1:5～8:1.
According to physicochemical property and practical application between component, the copper 8-hydroxyquinolinate is described with the content sum of kasugarnycin
The 10%～80% of bactericidal composition gross weight.
Technical solution of the present invention further includes, the formulation of the bactericidal composition be suspending agent, water dispersible granules, can
WP.
Used as one of preferred embodiment, the formulation of the bactericidal composition is suspending agent, by mass percentage, quinoline
Quinoline copper 10～40%, kasugarnycin 2～20%, emulsifying agent 1～4%, dispersant 2～12%, wetting agent 1～8%, viscosity is adjusted
Agent 0.5～2%, antifreezing agent 5～8%, defoamer 0.3～0.5%, surplus deionized water is supplied；The suspending agent is according to matching somebody with somebody
Expect, morcel in advance, sand mill crushing, mixing preparation, packaging flow process processing, wherein sand mill crush use four sand mills, it is many
Level series connection, using fine sand and coarse sand, First skin grinder all fills coarse sand, and second skin grinder fills 2/3 coarse sand and 1/3 fine sand,
3rd sand mill fills 1/3 coarse sand and 2/3 fine sand, and the 4th sand mill all fills fine sand.
Used as one of preferred embodiment, the formulation of the bactericidal composition is suspending agent, by mass percentage,
40% copper 8-hydroxyquinolinate, 10% kasugarnycin, 4% emulsifying agent Nongru-700 #, 5% dispersant TERSPERSE 2020,2% wetting agent
TERSPERSE 2500,1.5% viscosity modifier xanthans, 5% antifreeze glycol, 0.5% organic silicon defoamer is balance of
Deionized water.
Used as one of preferred embodiment, the formulation of the bactericidal composition is wettable powder, by mass percentage
Meter, 10% copper 8-hydroxyquinolinate, 10% kasugarnycin, 5%Ufoxane 3A, 3%Morwet D-425,1.5% lauryl sodium sulfate,
6% white carbon, kaolin is filled up to 100% weight portion.
Used as one of preferred embodiment, the formulation of the bactericidal composition is water dispersible granules, by mass percentage
Meter, 10% copper 8-hydroxyquinolinate, 5% kasugarnycin, 2%TERSPERSE 2700,3% sodium lignin sulfonate, 1% Nekal BX, 1%0
Sodium dialkyl sulfate, 2% polyvinylpyrrolidone, 6% ammonium sulfate, 0.5% white carbon, diatomite adds to 100% weight portion.
Bactericidal composition of the present invention, according to the preparation formulation that method known in those skilled in the art can be prepared
Can be suspending agent, water dispersible granules, wettable powder.When above-mentioned formulation is prepared, can select as needed using different
Pesticidal preparations auxiliary element (auxiliary agent).The auxiliary element be decentralized medium, dispersant, emulsifying agent, wetting agent, thickener,
One or more in defoamer, antifreezing agent, disintegrant, binding agent, filler etc..
To suspending agent, the auxiliary agent that can be used has：Dispersant such as polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate (expand
Powder NNO), one or more in TERSPERSE 2020 (Huntsman Corporation of the U.S. produce, alkyl naphthalene sulfonic acid salt)；Emulsifying agent
Such as Nongru-700 # (common names：Alkyl phenol formaldehyde resin polyoxyethylene ether), agriculture breast 2201, this disk -60# (common names：Sorbitan
Alcohol stearate), Tween-60 # (common names：Polyoxyethylene sorbitan stearate), agriculture breast 1601# (common name：Triphen
Ethyl -phenol polyoxyethylene polyoxypropylene block polymer), in TERSPERSE 4894 (Huntsman Corporation of U.S. product) one
Plant or various；Wetting agent for example alkylphenol-polyethenoxy base ether formaldehyde condensation products sulfate, alkylphenol-polyethenoxy base ether phosphate,
Phenethyl phenol polyoxyethylene groups ether phosphate, alkyl sulfate, alkylsulfonate, the naphthalene sulfonate, (U.S. of TERSPERSE 2500
Huntsman Corporation produce) in one or more；It is a kind of or many in thickener such as xanthans, polyvinyl alcohol, bentonite, aluminium-magnesium silicate
Kind；One or more in preservative such as formaldehyde, benzoic acid, Sodium Benzoate；Stabilizer such as epoxidized soybean oil, epoxychloropropane, phosphorus
One or more in triphenyl phosphate ester；Defoamer such as silicone defoamer；Antifreezing agent for example ethylene glycol, propane diols, glycerine, urea,
One or more in inorganic salts such as sodium chloride；Water is deionized water.
For water dispersible granules, those skilled in the art are very familiar with completing the present invention using corresponding auxiliary agent.Dispersion
It is a kind of or many in agent such as polycarboxylate (TERSPERSE 2700, T36, GY-D06), lignosulfonates, alkylnaphthalene sulfonate
Kind；One or more in wetting agent such as alkyl sulfate, alkylsulfonate, naphthalene sulfonate；Disintegrant for example ammonium sulfate, sodium sulphate,
One or more in polyvinylpyrrolidone, starch and its derivative, bentonite；Binding agent such as starch, glucose, polyethylene
One or more in alcohol, polyethylene glycol, sodium carboxymethylcellulose, sucrose；Filler such as diatomite, kaolin, white carbon, light
Calcium, talcum powder, attapulgite, one or more of potter's clay.
To wettable powder, the auxiliary agent that can be used has：Dispersant such as polycarboxylic acid salt (TERSPERSE 2700, T36, GY-
D06 etc.), lignin sulfonate (Ufoxane 3A, Borresperse NA, Borresperse CA-SA etc.), naphthalene and alkyl
Naphthalene formaldehyde condensate sulfonates class (NNO, MF, Morwet D-425, Tamol NN, TERSPERSE2020 etc.), Nekal BX
(nekal), EO-PO block polyether classes, alkylphenol-polyethenoxy base ether phosphate, alkylphenol-polyethenoxy base ether
Formaldehyde condensation products sulfate (SOPA), in one or more；Wetting agent such as Sulfates (K-12), Sulfonates (ABS-Na,
BX, Terwet 1004 etc.), one or more in compound wetting agent (Morwet EFW)；Filler such as diatomite, kaolin, light
Calcium, talcum powder, white carbon, attapulgite, potter's clay, ammonium sulfate, urea, sucrose, glucose, cornstarch, sodium sulphate, poly phosphorus
One or more of sour sodium etc..
Compared with single pesticide composition, bactericidal composition of the present invention at least has following beneficial effect or advantage：
The farm chemical ingredients of the different cultivars difference mechanism of action are compounded, and are the effective of preventing and treating corps diseases resistance generation
Approach, exploitation is efficient with research, the complex preparation of low toxicity, low-residual has the advantages that small investment, R＆D cycle are short, thus is subject to
The attention of research and development institution both at home and abroad.The present invention on the basis of test, the bactericidal composition for being given comprising two kinds of activity into
Point, the weight ratio of the first active component copper 8-hydroxyquinolinate and the second active component kasugarnycin is 1:7～15:1.Copper 8-hydroxyquinolinate, spring thunder are mould
Element compounding shows as synergistic effect, and the activity and bactericidal effect of said composition are not the simple superposition of each component activity, but are had
Significant synergistic effect.Additionally, the advantage of the bactericidal composition is also manifested by component rationally, treatment and protective effect are had concurrently,
Bactericidal effect is good, and drug cost is low, good to crop safety, meets the security requirement of pesticidal preparations.In terms of drug effect, the group
Compound has preferable prevention effect to rice blast.
Specific embodiment
In order that the objects, technical solutions and advantages of the present invention become more apparent, with reference to embodiments, to the present invention
It is further elaborated on.It should be appreciated that specific embodiment described herein is not used to limit only to explain the present invention
The fixed present invention, all any modification, equivalent and improvement made within the spirit and principles in the present invention etc., should be included in
Within protection scope of the present invention.
(1) preparation prepares part
The first active component copper 8-hydroxyquinolinate is illustrated with the second active component kasugarnycin complex preparation first.Need
Bright, the percentage in following embodiment all formulations formulas is weight percentage.The various preparations of the present composition
Processing technology be able to can be varied from according to the different conditions of production.
Example of formulations 1
Weigh 30% copper 8-hydroxyquinolinate, 15% kasugarnycin, 4% emulsifying agent Nongru-700 # (common names：Alkylphenol-formaldehyde resin gathers
Oxygen vinethene), 5% dispersant TERSPERSE 2020 (Huntsman Corporation of U.S. product), 2% wetting agent TERSPERSE2500
(Huntsman Corporation of U.S. product), 1.5% viscosity modifier xanthans, 5% antifreeze glycol, 0.5% organic silicon defoamer
(trade name：S-29 Nanjing "four news" (new ideas applied chemistry product company produces), balance of deionized water.
Above-mentioned raw materials are blended, morcel in advance, sand mill crushing, mixing preparation, the flow process processing of packaging.Morcel in advance and mix
Allocating technology can select different parameters equipment according to actual production.The sand mill disintegrating process of the present embodiment suspending agent, uses four
Platform sand mill, plural serial stage, using fine sand and coarse sand, First skin grinder all fills coarse sand, and second skin grinder fills 2/3 coarse sand
With 1/3 fine sand, the 3rd sand mill fill 1/3 coarse sand and 2/3 fine sand, the whole dress fine sand of the 4th sand mill.By this preparation side
Legal system obtains active ingredient for 45% copper 8-hydroxyquinolinate kasugarnycin suspending agent.
Example of formulations 2
Weigh 40% copper 8-hydroxyquinolinate, 10% kasugarnycin, 3%TERSPERSE 4894 (Huntsman Corporation of U.S. product), 2%
TERSPERSE 2500 (Huntsman Corporation of U.S. product), 4% dispersing agent NNO, 1.5% bentonite, 1% xanthans, 8% second two
Alcohol, 0.5% formaldehyde, 0.5% organic silicon defoamer (trade name：S-29 Nanjing "four news" (new ideas applied chemistry product company produce), deionization
Water adds to 100% weight portion.
Above-mentioned raw materials are blended, morcel in advance, sand mill crushing, mixing preparation, the flow process processing of packaging.Morcel in advance and mix
Allocating technology can select different parameters equipment according to actual production.The sand mill disintegrating process of the present embodiment suspending agent, uses four
Platform sand mill, plural serial stage, using fine sand and coarse sand, First skin grinder all fills coarse sand, and second skin grinder fills 2/3 coarse sand
With 1/3 fine sand, the 3rd sand mill fill 1/3 coarse sand and 2/3 fine sand, the whole dress fine sand of the 4th sand mill.By this preparation side
Legal system obtains active ingredient for 50% copper 8-hydroxyquinolinate kasugarnycin suspending agent.
Example of formulations 3
Weigh 25% copper 8-hydroxyquinolinate, 15% kasugarnycin, 3%TERSPERSE 2700 (polycarboxylate, Huntsman Corporation of the U.S.
Produce), 3% sodium lignin sulfonate, 1% Nekal BX (nekal), 1% lauryl sodium sulfate (K-12), 2%
PVA (molecular weight 2000), 2% polyvinylpyrrolidone, 0.5% white carbon, kaolin adds to 100% weight portion.Above-mentioned raw materials
Jing routinely produces that the method for water dispersible granules mixes, ultra micro air-flow crushing, mixing, granulation step produce active ingredient for 40%
Copper 8-hydroxyquinolinate kasugamycin water-dispersion granule.
Example of formulations 4
Weigh 10% copper 8-hydroxyquinolinate, 5% kasugarnycin, 2%TERSPERSE 2700,3% sodium lignin sulfonate, 1% pulls open
Powder BX, 1% lauryl sodium sulfate, 2% polyvinylpyrrolidone, 6% ammonium sulfate, 0.5% white carbon, diatomite is added to
100% weight portion.Above-mentioned raw materials Jing routinely produce the method for water dispersible granules mix, ultra micro air-flow crushing, mixing, granulation step
Suddenly active ingredient is produced for 15% copper 8-hydroxyquinolinate kasugamycin water-dispersion granule.
Example of formulations 5
Weigh 30% copper 8-hydroxyquinolinate, 5% kasugarnycin, 4% calcium lignosulfonate (Ufoxane 3A), 4% alkyl naphthalene sulfonic acid
Salt formaldehyde condensation products (Tamol NN), 1% lauryl sodium sulfate, 8% white carbon, kaolin is filled up to 100% weight portion.
Above-mentioned raw materials are blended, ultra micro air-flow crushing, hybrid technique step are prepared into active ingredient for 35% copper 8-hydroxyquinolinate kasugarnycin
Wettable powder.
Example of formulations 6
Weigh 10% copper 8-hydroxyquinolinate, 10% kasugarnycin, 5% calcium lignosulfonate, 3% alkylnaphthalene sulfonate formaldehyde condensation products
(Morwet D-425), 1.5% lauryl sodium sulfate, 6% white carbon, kaolin is filled up to 100% weight portion.Above-mentioned original
Expect that blended, ultra micro air-flow crushing, hybrid technique step are prepared into active ingredient for 20% copper 8-hydroxyquinolinate kasugarnycin wettable
Pulvis.
(2) Biometric portion
Biological Examples 1：Rice blast Toxicity Determination
In order to prevent and treat the rice blast of hazard rice in agricultural production, inventor is carried out with copper 8-hydroxyquinolinate, kasugarnycin
The mutually synergy of compounding is studied, and concrete grammar is：
Subjects are rice blast.The test medicine that active compound is configured to need, single dose and each Mixed Pharmacy are set
(on the basis of pilot study result, bacteriostasis rate presses geometric progression in the range of 5%～90% to put 5 variable concentrations gradients
Setting).If clear water is compareed, it is repeated 3 times.Test adopts mycelial growth rate method, by cultured pathogen, aseptically
With a diameter of 5mm card punch, bacteria cake is cut from colony edge, put down the culture medium that bacteria cake is connected to different agents concentration with transfer needle
On plate, 28 DEG C are put, cultivate in saturated humidity incubator；When control group bacterium colony is covered with, colony diameter is measured, calculate each chemicals treatment
Suppress the percentage of mycelial growth, by the linear regression analysis between the probit value of inhibiting rate and the logarithm value of series concentration,
Obtain the EC of each medicament50Value, with the abundant methods of Sun Yun the co-toxicity coefficient (CTC) of mixture is calculated, and reagent agent is evaluated to germ with this
Activity.
The co-toxicity coefficient (CTC) >=120 of complex preparation shows as synergistic effect；CTC≤80 show as antagonism；80 ＜
CTC ＜ 120 show as summation action.
Interpretation：Several groups of set copper 8-hydroxyquinolinates of experiment have with the mixture of kasugarnycin to Pathogen of Rice Blast Fungus
There is higher bactericidal activity, concrete data are shown in Table 1.
The copper 8-hydroxyquinolinate of table 1 combines the Toxicity Determination to rice Pyricularia grisea with kasugarnycin
| Chemicals treatment | Virulence regression equation | Coefficient correlation (r) | EC50(mg/L) | Co-toxicity coefficient (CTC) |
| Copper 8-hydroxyquinolinate (A) | Y=1.727x+2.7481 | 0.9992 | 20.13 | — |
| Kasugarnycin (B) | Y=1.4664x+5.4099 | 0.9941 | 0.52 | — |
| A:B=1:7 | Y=1.3919x+5.4519 | 0.9949 | 0.46 | 128.72 |
| A:B=1:5 | Y=1.3827x+5.4888 | 0.9948 | 0.43 | 144.37 |
| A:B=1:2.5 | Y=1.3087x+5.4388 | 0.9931 | 0.46 | 156.64 |
| A:B=1:1 | Y=1.7311x+5.3549 | 0.9903 | 0.62 | 163.52 |
| A:B=2.5:1 | Y=1.4277x+5.0113 | 0.9962 | 0.98 | 174.45 |
| A:B=5:1 | Y=1.4502x+4.6844 | 0.9932 | 1.65 | 167.46 |
| A:B=8:1 | Y=1.4882x+4.3550 | 0.9877 | 2.72 | 142.59 |
| A:B=10:1 | Y=1.3244x+4.3200 | 0.9907 | 3.26 | 139.44 |
| A:B=15:1 | Y=1.4024x+4.0619 | 0.9912 | 4.66 | 128.68 |
Can be seen that copper 8-hydroxyquinolinate with the proportioning of kasugarnycin by the data of table 1 is 1:7～15:1 uses with, to rice blast
Germ has preferable virulence, there is significant synergistic effect.
Biological Examples 2：Preventing and treating rice blast field test
Example of formulations 2 (50% copper 8-hydroxyquinolinate kasugarnycin suspending agent), system have been carried out in Shaanxi Province's Hanzhong City within 2016
(15% copper 8-hydroxyquinolinate kasugarnycin moisture dissipates for agent embodiment 1 (45% copper 8-hydroxyquinolinate kasugarnycin suspending agent), example of formulations 4
Granula), example of formulations 6 (20% copper 8-hydroxyquinolinate kasugarnycin wettable powder) preventing and treating rice blast field test, checking
This prevention effect of several medicaments to rice blast and the security to paddy rice.Trial crops are paddy rice, and controlling object is rice
Seasonal febrile diseases.Test is located at Hanzhong City Yang County, and test medicine and dosage refer to table 2.Comparison medicament and blank are separately set, 4 are often processed
Secondary repetition, per plot area 30 ㎡, totally 44 cells, random district's groups arrangement.Using conventional spray-on process, mu dispenser liquid 50kg,
Even sprinkling paddy rice complete stool.Altogether dispenser 2 times, in paddy rice booting latter stage and each dispenser of full heading time 1 time.
Investigation and statistical method：
Investigate within 14 days after 2nd dispenser, investigation method is the 5 points of samplings of every cell, and per is investigated 50 fringes, and grade scale is such as
Under：
0 grade：It is disease-free；
1 grade：Loss less than 5% (indivedual branch stalk morbidities) per fringe；
3 grades：Loss 6%-20% (the stalk morbidity of 1/3 or so branch) per fringe；
5 grades：Loss 21%-50% per fringe (fringe neck or main shaft are fallen ill, and grain half is flat)；
7 grades：Loss 51%-70% per fringe (fringe neck is fallen ill, most of shrivelled kernel)；
9 grades：Loss 71%-100% per fringe (fringe neck is fallen ill, and causes dead ears).
Calculating preventive effect is referred to according to disease.Each some days after the 1st day and medicine after spray, observe medicament and respectively process shadow to paddy rice
Ring.
Disease index=[Σ (sick spike numbers at different levels × relative value of series)/total spike number × 9 of investigation] × 100
Prevention effect (%)=[(control disease index-process disease index)/control disease index] × 100
Table 2 prevents and treats rice blast field test results
Table of field test results is bright：50% copper 8-hydroxyquinolinate kasugarnycin suspending agent, 45% copper 8-hydroxyquinolinate kasugarnycin suspend
Agent, 15% copper 8-hydroxyquinolinate kasugamycin water-dispersion granule, 20% copper 8-hydroxyquinolinate kasugarnycin wettable powder effective ingredient consumption
For 50 grams/ha, to rice blast after second medicine the preventive effect of 14 days be respectively 95.56%, 94.04%, 96.57%,
95.05%, hence it is evident that better than 40% copper 8-hydroxyquinolinate suspending agent effective ingredient consumption be 200 grams/ha, 6% kasugarnycin wettable powder
Agent effective ingredient consumption is 30 grams/ha of preventive effects to rice blast, and preventive effect difference reaches the pole level of signifiance (referring to table 2),
Illustrate that synergy is notable after compounding.
Security survey to paddy rice, observes for some days after the 1st day and medicine after spray, and each test process are to paddy rice without poisoning
Phenomenon occurs.Test also finds that three kinds of Mixed Pharmacies also have good preventive effect to rice sheath blight disease, black streaked dwarf virus of rice.
Result of the test shows after copper 8-hydroxyquinolinate and kasugarnycin mixture, hence it is evident that improve the prevention effect to rice blast,
Dosage and drug cost are reduced, is the favourable agents for preventing and treating rice blast to paddy growth safety.
In sum, composition of the invention is compounded using two kinds of active components, and its activity and bactericidal effect are not each
The simple superposition of composition activity, compared with existing unitary agent, in addition to significant bactericidal effect, and has significant increasing
Effect is acted on, good to crop safety, meets the security requirement of pesticidal preparations.
Claims (10)
1. a kind of bactericidal composition containing copper 8-hydroxyquinolinate and kasugarnycin, it is characterised in that active ingredient is by the first active component quinoline
Quinoline copper and the second active component kasugarnycin are constituted, and the weight ratio of the first active component and the second active component is 1:7～15:1.
2. the bactericidal composition containing copper 8-hydroxyquinolinate and kasugarnycin according to claim 1, it is characterised in that the copper 8-hydroxyquinolinate with
Weight ratio of the kasugarnycin in bactericidal composition is 1:5～10:1.
3. the bactericidal composition containing copper 8-hydroxyquinolinate and kasugarnycin according to claim 2, it is characterised in that the copper 8-hydroxyquinolinate with
Weight ratio of the kasugarnycin in bactericidal composition is 1:5～8:1.
4. the bactericidal composition containing copper 8-hydroxyquinolinate and kasugarnycin according to claim 1, it is characterised in that the copper 8-hydroxyquinolinate with
The content sum of kasugarnycin is the 10%～80% of the bactericidal composition gross weight.
5. the bactericidal composition of copper 8-hydroxyquinolinate and kasugarnycin is contained according to claim 1, and the formulation of the bactericidal composition is
Suspending agent, water dispersible granules, wettable powder.
6. the bactericidal composition of copper 8-hydroxyquinolinate and kasugarnycin is contained according to claim 1, and the formulation of the bactericidal composition is
Suspending agent, by mass percentage, copper 8-hydroxyquinolinate 10～40%, kasugarnycin 2～20%, emulsifying agent 1～4%, dispersant 2～
12%, wetting agent 1～8%, viscosity modifier 0.5～2%, antifreezing agent 5～8%, defoamer 0.3～0.5%, surplus spend from
Sub- water is supplied；
The suspending agent is morcelled according to dispensing, in advance, sand mill crushing, mixing preparation, the flow process processing of packaging, wherein sand mill powder
It is broken to use four sand mills, plural serial stage, using fine sand and coarse sand, First skin grinder whole dress coarse sand, second skin grinder
2/3 coarse sand and 1/3 fine sand are filled, the 3rd sand mill fills 1/3 coarse sand and 2/3 fine sand, and the 4th sand mill all fills fine sand.
7. the bactericidal composition of copper 8-hydroxyquinolinate and kasugarnycin is contained according to claim 6, and the formulation of the bactericidal composition is
Suspending agent, by mass percentage, 40% copper 8-hydroxyquinolinate, 10% kasugarnycin, 4% emulsifying agent Nongru-700 #, 5% dispersant
TERSPERSE 2020,2% wetting agent TERSPERSE 2500,1.5% viscosity modifier xanthans, 5% antifreeze glycol,
0.5% organic silicon defoamer, balance of deionized water.
8. the bactericidal composition of copper 8-hydroxyquinolinate and kasugarnycin is contained according to claim 6, and the formulation of the bactericidal composition is
Wettable powder, by mass percentage, 10% copper 8-hydroxyquinolinate, 10% kasugarnycin, 5%Ufoxane 3A, 3%Morwet D-
425,1.5% lauryl sodium sulfate, 6% white carbon, kaolin is filled up to 100% weight portion.
9. the bactericidal composition of copper 8-hydroxyquinolinate and kasugarnycin is contained according to claim 6, and the formulation of the bactericidal composition is
Water dispersible granules, by mass percentage, 10% copper 8-hydroxyquinolinate, 5% kasugarnycin, 2%TERSPERSE 2700,3% lignin
Sodium sulfonate, 1% Nekal BX, 1% lauryl sodium sulfate, 2% polyvinylpyrrolidone, 6% ammonium sulfate, 0.5% white carbon,
Diatomite adds to 100% weight portion.
10. the bactericidal composition containing copper 8-hydroxyquinolinate and kasugarnycin according to any one of claim 1 to 9 is in preventing and treating paddy rice rice
The application of seasonal febrile diseases.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201611255349.5A CN106614599A (en) | 2016-12-30 | 2016-12-30 | Bactericidal composition containing quinoline copper and kasugamycin |
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| CN201611255349.5A CN106614599A (en) | 2016-12-30 | 2016-12-30 | Bactericidal composition containing quinoline copper and kasugamycin |
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| CN106614599A true CN106614599A (en) | 2017-05-10 |
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| CN201611255349.5A Pending CN106614599A (en) | 2016-12-30 | 2016-12-30 | Bactericidal composition containing quinoline copper and kasugamycin |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106973907A (en) * | 2017-03-29 | 2017-07-25 | 兴农药业（中国）有限公司 | A kind of composition pesticide containing copper 8-hydroxyquinolinate and kasugarnycin and its application |
| CN107156127A (en) * | 2017-06-30 | 2017-09-15 | 浙江东风化工有限公司 | A kind of disinfectant use in agriculture and its application containing kasugarnycin and the gloomy copper of thiophene |
| CN109258656A (en) * | 2018-09-30 | 2019-01-25 | 浙江海正化工股份有限公司 | Composition pesticide and its preparation method and application containing Ningnanmycin and copper 8-hydroxyquinolinate |
| CN110537543A (en) * | 2019-06-04 | 2019-12-06 | 广西汇丰生物科技有限公司 | Pesticide composition containing kasugamycin and quinolinone and bactericide |
| CN113647393A (en) * | 2021-07-27 | 2021-11-16 | 惠州市银农科技股份有限公司 | Suspending agent containing kasugamycin and oxine-copper and preparation method thereof |
| WO2022175654A1 (en) * | 2021-02-17 | 2022-08-25 | UPL Corporation Limited | A synergistic agricultural composition |
| CN115067344A (en) * | 2021-03-12 | 2022-09-20 | 顺毅股份有限公司 | Oxine-copper and kasugamycin compounded pesticide suspending agent |
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| CN103392740A (en) * | 2013-07-26 | 2013-11-20 | 海南正业中农高科股份有限公司 | Kasugamycin-containing sterilization composition and application thereof |
| CN104542601A (en) * | 2013-10-11 | 2015-04-29 | 兴农药业（中国）有限公司 | Pesticide composition containing copper quinolate and kasugamycin and application of pesticide composition |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103392740A (en) * | 2013-07-26 | 2013-11-20 | 海南正业中农高科股份有限公司 | Kasugamycin-containing sterilization composition and application thereof |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106973907A (en) * | 2017-03-29 | 2017-07-25 | 兴农药业（中国）有限公司 | A kind of composition pesticide containing copper 8-hydroxyquinolinate and kasugarnycin and its application |
| CN107156127A (en) * | 2017-06-30 | 2017-09-15 | 浙江东风化工有限公司 | A kind of disinfectant use in agriculture and its application containing kasugarnycin and the gloomy copper of thiophene |
| CN107156127B (en) * | 2017-06-30 | 2019-08-06 | 浙江东风化工有限公司 | A kind of disinfectant use in agriculture and its application containing kasugarnycin and the gloomy copper of thiophene |
| CN109258656A (en) * | 2018-09-30 | 2019-01-25 | 浙江海正化工股份有限公司 | Composition pesticide and its preparation method and application containing Ningnanmycin and copper 8-hydroxyquinolinate |
| CN110537543A (en) * | 2019-06-04 | 2019-12-06 | 广西汇丰生物科技有限公司 | Pesticide composition containing kasugamycin and quinolinone and bactericide |
| WO2022175654A1 (en) * | 2021-02-17 | 2022-08-25 | UPL Corporation Limited | A synergistic agricultural composition |
| CN115067344A (en) * | 2021-03-12 | 2022-09-20 | 顺毅股份有限公司 | Oxine-copper and kasugamycin compounded pesticide suspending agent |
| CN115067344B (en) * | 2021-03-12 | 2024-03-12 | 顺毅股份有限公司 | Pesticide suspending agent compounded by copper quinolinate and kasugamycin |
| CN113647393A (en) * | 2021-07-27 | 2021-11-16 | 惠州市银农科技股份有限公司 | Suspending agent containing kasugamycin and oxine-copper and preparation method thereof |
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