CN1066041C

CN1066041C - Anti-inflammatory, antipruritic and prickly-heat-expelling skin liquid

Info

Publication number: CN1066041C
Application number: CN97104392A
Authority: CN
Inventors: 朱珊引
Original assignee: Individual
Current assignee: Individual
Priority date: 1997-05-26
Filing date: 1997-05-26
Publication date: 2001-05-23
Anticipated expiration: 2017-05-26
Also published as: CN1175403A

Abstract

The present invention relates to antiphlogistic antipruritic and prickly heat expelling skin protection liquid comprising borneol, menthol, vitamin B6, arginine, chloramphenicol, triamcinolone, propanediol and deionized water. The skin protection and health care liquid can prevent skin inflammation, and can also have efficient, rapid, safe and toxic therapeutic functions of inflammatory skin. The skin protection liquid particularly has obvious therapeutic effects to the skin inflammation of dermatitis, prickly heat, ringworm, acne (whelks), flat warts, etc. The skin protection liquid has the advantages of prickly heat expelling, itch relieving, inflammation relieving, muscle promotion, and ideal efficacy of antibiotic skin protection, indeed has unique position, and is very ideal.

Description

Anti-inflammatory, antipruritic, remove Rush help care cream

The present invention relates to a protection of the skin and treatment of skin exposed liquid, in particular an anti-inflammatory, only Health remove Rush itch lotion liquid.

In everyday life, we often found that: born in various parts of the face and body dermatitis, prickly heat, Psoriasis and acne (also known as acne), warts and other skin inflammation, both cause pain to the patient, but also affect the U.S. Concept.

Now remove Rush ShangXi liquid, commonly used ingredients containing calamine and borneol liniment, as well as names Variety of liquid and remove Rush Rush cured powder, it is just a temporary skin inflammation antipruritic effect, while others simply No effect. Can essentially be treated. There are some ointment on the market for sale, Cream Products, due to lack of technology, combined with ointment, cream type products easily blocked pores, contaminated clothing, And the extent of drug release is slow, so, in effect, reflect the poor, slow phenomenon, not receive expected The purpose of achieving the desired results.

The object of the present invention has two, one of: to provide a both prevent skin inflammation, but also on the Already inflamed skin play a fast and efficient, safe and non-toxic therapeutic effect, become a real security Health care help reveal fluid. Second: To care lotion liquid into millions of households, individuals become essential, Beauty Necessary, the travel essential, essential household care to share, truly prevention correct.

Product of the invention is achieved by the following technical solutions.

Anti-inflammatory anti-itch lotion remove Rush health, mainly by borneol, menthol, vitamin B6, arginine Acid, chloramphenicol, triamcinolone, propylene glycol, ethanol and deionized water formed.

The weight ratio of:

Borneol 1-2%, 1-2% menthol, vitamin B60.5-1%, 0.2% arginine, chloramphenicol Su 1-2%, 0.025% triamcinolone, 50-60% propylene glycol, 5% ethanol, the rest is non-ionic Water.

Example 1:

Its preparation method as follows: the above-mentioned materials were quantitatively stand. A predetermined amount of Of propylene glycol and deionized water are mixed and heated to 90 ℃ ~ 100 ℃, for 10 minutes. As a basic solution, start stirring, cooling, temperature control at 90 ℃ begin feeding. Adding a predetermined amount of chloramphenicol before and after the temperature cooled to 70 ℃, adding a predetermined amount Indeed Triamcinolone, until the temperature cooled to 60 ℃, adding arginine, vitamin B6, cooled to 50 ℃, adding menthol, cooled to 40 ℃, adding borneol, at 40 ℃, Victoria Held 30-50 minutes, with the 500CC cylinder sampling to observe whether there yet Dissolved solids, - cut normal sieve with 300 yards, to be finished. ...

Cold Addition: Feeding with 100kg total:

Weigh 60kg propylene glycol, into a mixing container, in 1 minute 12 0 rpm stirring speed, the tasteless chloramphenicol gradually into the container, over 20 '~ 30' Around the time observation, propylene glycol liquid is transparent. Achieve full transparency, then prove that all Portion is dissolved.

Next, the borneol, menthol and vitamin B6 each dissolved in ethanol, the total amount of 5 kg ethanol. Some articles that have been dissolved solids remaining leave some quality, availability deionized water to dilute Dissolution, except that the non-ionic water, including the amount of water inside. Into the above solution containing A propylene glycol solution of chloramphenicol tasteless while determining triamcinolone, arginine is input. When all of the drug material cast exhausted, and then make up the non-ionic water, stirring maintained at 120 rev / min speed Degrees. This method is named cold addition, mainly to save energy, while also reducing the menthol, So borneol volatile active ingredients. However, this method is feeding little longer, the container should be sterilized Special attention. After feeding all of the above, to maintain stirring for 60 minutes, the middle 500CC cylinder sampling to observe whether the quality has not been dissolved solids, if everything is normal, to 1 hour with a 300 mesh sieve, the material. To be finished. ...

Note: Cold addition operation should note the following:

1, the use of deionized water must be approved by ultraviolet disinfection;

2, the container must be pre-production with 75% alcohol disinfection, including a Cut appliances.

3, the PH value of the finished product must be controlled at about 5.5 to 6.5 range;

4, prior to use tasteless chloramphenicol glycol beaten pulp, and feeding, the aim of Control dust Yang, accelerated dissolution, easy to agglomerate.

5, triamcinolone equally diluted with propylene glycol feeding.

6, the formula used to dissolve the ethanol borneol, menthol, vitamin B6. After three 00 mesh sieve the material, get the finished product: Anti-class itching remove Rush care lotion.

Skin Care Lotion present invention fluid from the treatment, nutrition, myogenic purpose of starting, three one Body, to achieve different desired results. This lotion was easy to use, the effect is significant, Only a drop, a few hours to see the results. For example: baby prickly heat in 45 minutes effective, In 3 to 5 hours eliminate adult prickly effective in three hours, in a 12 to 2 4 hours can be all the more. Truly reflect the efficient, rapidly the characteristics, non-toxic and safe. Even if Child accidentally strayed into the mouth, and no dangerous, non-irritating. No side effects.

Here, want to emphasize that the present invention has the following five characteristics:

One, synergies:

After fourteen years of conscientiously sum up experiences, constantly refining and in clinical practice To find effects, and finally summed up a more complete recipe program. All raw materials are among the An anti-inflammatory, anti-inflammatory, antipruritic and other properties. Combined with better results. In particular with 60% Propylene glycol to dissolve the chloramphenicol and other materials odorless, has a good penetration enhancer effect. Specially designed for ideal results.

Second, the rapid myogenic:

In the invention, human cells are essential amino acids and vitamins B6, fat has been observed Now: it timely recovery organization and function of human cells. In the course of medication, better body Emerged advance effective, accelerate healing features.

Third, the liquid dosage forms:

Liquid on the skin epidermis good permeability, can effectively prevent clogged pores, control inflammation Development is to improve the efficacy of the key.

Fourth, natural dissemination:

Borneol, menthol is a natural source of dissemination of materials, with strong penetration, guide drug effects, can Particularly to improve efficacy. Of which there are propylene glycol, can effectively dissolve drugs, play permeation enhancer Into effect. These two together, effectively combine its role peculiar.

Five, safe non-toxic:

The selection of raw materials of the present invention, can be administered orally, high safety factor. The aim: rapid Security, a multi-effect products, widely adaptable, the effect is particularly evident clinically so Use, welcomed by patients. Second:

The present invention aims: that contribute to society, to the patient a little more help to make patients Were obtained in the absence of pain healing, relieve pain, take heart, to participate in the socialist Economic construction.

Comparison:

Example (a):

Adult sites in the lower extremities of patients with dermatitis and eczema are more corticosteroids alone oil Cream or cream medications, subject to two days time before they can see the results. Some severely ill patient is unable to Effective. The reason is: the sites of inflammation, without good ventilation conditions, plus oil Cream substances applied to the skin surface in the summer, easy to impede permeability, are more likely to increase inflammation, The disease is more serious, and because of scratching, which leads to more serious cross-infection.

The anti-inflammatory effects with this product itching remove Rush care lotion that is usually in 3-5 hours Can be effective, itching, effective control of the disease. 12 to 24 hours, can redness Inflammation subsided significantly, until all the more. If re-treatment once or twice, the effect is more ideal. Truly reflect the "rapid and safe" function.

Cases (two):

Difficult to treat infants susceptible to prickly heat. The reason is the baby sleep in a long time can not swaddle Stand, poor ventilation, and sometimes adults holding closely aligns the body, the two sides of the heat can not be distributed, Under these conditions, easy to get prickly heat, caused by objective conditions, and very difficult to better. Special use of this product Remove Rush effective anti-inflammatory anti-itch lotion care, baby bear fruit in 45 minutes, the naked eye can see the baby Children have prickly parts, after coated with lotion, gradually eliminate red, about 3 hours, you can Into the original skin color. The use of other drugs, two or three days failed to achieve the desired The effect. Infants itching to crying, but increase the heat, and the results are predictable. So the product of the invention can be quickly ruled out the baby painful for parents to bring peace, good Social benefits. Present, there is a product with 45 minutes to 3 hours to see into the inner Good results, and the present invention is comparable official cartoon health care, but also to achieve safe and nontoxic. ...

Baby milk ringworm is quite common in the clinical data seen in all current treatments do France, its effect is not very satisfactory, but also, sometimes to relapse, time better slow effect. Anti-inflammatory effects of using this product, itching, remove Rush care lotion liquid, slightly diluted two to three Times, after coating or within 12 hours of being able to eliminate inflammation, in one step.

Cases (four):

Paronychia patients using a commercially available drugs, two to three days is still better off because of paronychia Nails with meat paste is very tight, ointments and creams drugs difficult to enter into snapping inflammation of meat Position, so the effect is also quite slow.

Anti-inflammatory effects of applying the product itching remove Rush care lotion liquid, the liquid flow Can be good, plus the product has a strong penetrant, penetration enhancers drugs, therefore, have direct contact with Myogenic inflammatory skin quickly achieve good results in the 24 hours that can relieve pain better Rpm. In a city famous podiatry clinics, have adopted this product as a treatment for foot disease Drugs.

Example (V):

Stubborn psoriasis (psoriasis), because of its morbid intractable, generally taking Tu Rub other drugs, with little success. The present invention care lotion liquid, after patient use, With little peculiar. According to the letter reflects the user, the patient suffering from psoriasis for many years, painful, When the disease need to use a razor blade peeling, itching, until bled before stop. Once used Various types of multiple drugs is not ideal, but it was introduced after using this product, then in just two, Three days, which makes the once troubled, tortured years of psoriasis disease to be controlled better, not Re itching, the patient's mood is increasingly better, and worry about their work. Praise our health care Lotion products, is a major contribution to patients with psoriasis. ...

Effect of similar products comparison chart

Prescription No.	Prescription	Baby prickly heat 6 months	Adult prickly heat 20 to 45 years of age	Mosquito bites Itching situation	Scope of use Use of results
Prescription No.	Prescription	Baby prickly heat 6 months	Adult prickly heat 20 to 45 years of age	Mosquito bites Itching situation	Scope of use Use of results	1	Glycerol, ethanol, Turtle bone fluid	A certain amount of Ethanol for babies Not too much stimulation Suitable applications.	Anti Department cooling, to prickly heat, insect repellent, insect
2	Musk, pearls, Bringing cakes, waist yellow, Bezoar, borneol				Remove Rush itching, anti-inflammatory, detoxifying mention cool God	1	Glycerol, ethanol, Turtle bone fluid
2	Musk, pearls, Bringing cakes, waist yellow, Bezoar, borneol					3	Montmorillonite, boiling Stone, meerschaum		Prevention dermatitis, psoriasis, eczema, prickly heat
4	Citrus, astragalus, HUANG Ling, Cork, Sophora, Dan, Honeysuckle				Prayer for the treatment of sore wonders for acne, Aphthous boils, insect bites, Jiao bite, prickly heat, Burns are effective	3	Montmorillonite, boiling Stone, meerschaum		Prevention dermatitis, psoriasis, eczema, prickly heat
4						5	Borneol, menthol Brain, vitamins B6, amino acids, Triamcinolone		Itching of the skin, acne, paint over Min, dermatitis and eczema have a certain effect (This recipe is not the main drug, the proportion of prescriptions Inaccurate, both theoretical and practical work There are many problems)
6	Borneol, musk, Yin-hua, Huang Jing, Bitters			For 1 to 2 minutes Itch	Sweat stain, heat rash dermatitis markedly. General Skin itching, painted the products 1 to 2 minutes May relieve itching.	5

7	Triamcinolone, Chlorpheniramine, brain, Paraben B, Chloromycetin	Contact dermatitis, neurodermatitis, over Sensitization dermatitis, eczema, clinical efficiency 100% cure rate 91.42%
7			8	Aconitum, high winds Son, yellow alum, wolves Poison, camphor, snake Bile powder, alcohol-based Ginger, sandalwood				Soaked in hot water to use, can prevent seat Sores, scabies, eczema, prickly heat, acne, Atopic dermatitis, the man outside urethritis, Woman outside vaginitis, Yin Daoqi smell, etc., Effective rate of 90% or more, but need long Using.
9	Talc, ice Tablets, zinc chloride, Boric acid, where Lee Snow, sublimed sulfur	Rush to high efficiency, quick	8
9		Rush to high efficiency, quick	10	Borneol, menthol Brain, vitamins B6, arginine, Tasteless chloramphenicol Su, Yan Shu indeed Pine, propylene glycol, Ethanol, without leave Deionized water (effective Standard square) Description: This side Experienced fourteen Year of not Summary Improvement broken Improved, well- Test. The Department The first in the country side An application, By the Chinese People's Liability insurance company Any insured, Projects. ...	Borneol, menthol Brain, vitamins B6, arginine, Tasteless chloramphenicol Su, Yan Shu indeed Pine, propylene glycol, Ethanol, without leave Deionized water (effective Standard square) Description: This side Experienced fourteen Year of not Summary Improvement broken Improved, well- Test. The Department The first in the country side An application, By the Chinese People's Liability insurance company Any insured, Projects. ...	12 hours up to The more water to the full Flat, rapidly, Ann Full, no stimulation Sex	30 seconds for details	(1) 4-5 Vincent acne more (2) 15 to 30 day fully heal warts (3) an effective athlete's foot (4) Baby Milk Ringworm diluted two to three times, once effective All the more, (5) atopic dermatitis, 12 small When more (6) drops a Yin Daoqing washed Times itching (7) FDA face, To remove facial small pigment, (8) Yan Heavy pruritus patients once effective (9) VD external support antipruritics time I saw Effect (10) paronychia patients in the three Hours, anti-inflammatory analgesic (11) Leather Drops markedly in patients with psoriasis, itching, repeatedly Use can make skin smooth (12) Wet Rash, dermatitis ending within 30 seconds Itching, 12 hours to control inflammation, medication a Times effective. On the risk of bed sores, acne, hot Injury, old rotten feet, triangular hazardous areas Unknown swelling, acne, external pressure ulcers, Ulcer patients, etc. The products are The good feature to promote wound healing. In addition, there is also a treatment of frostbite Given effect. ...

Claims

(1) 4-5 Vincent acne more (2) 15 to 30 day fully heal warts (3) an effective athlete's foot (4) Baby Milk Ringworm diluted two to three times, once effective All the more, (5) atopic dermatitis, 12 small When more (6) drops a Yin Daoqing washed Times itching (7) FDA face, To remove facial small pigment, (8) Yan Heavy pruritus patients once effective (9) VD external support antipruritics time I saw Effect (10) paronychia patients in the three Hours, anti-inflammatory analgesic (11) Leather Drops markedly in patients with psoriasis, itching, repeatedly Use can make skin smooth (12) Wet Rash, dermatitis ending within 30 seconds Itching, 12 hours to control inflammation, medication a Times effective. On the risk of bed sores, acne, hot Injury, old rotten feet, triangular hazardous areas Unknown swelling, acne, external pressure ulcers, Ulcer patients, etc. The products are The good feature to promote wound healing. In addition, there is also a treatment of frostbite Given effect. ...

Borneol 1-2%, 1-2% menthol, vitamin B60.5-1%, 0.2% arginine, Chloramphenicol 1-2%, 0.025% triamcinolone, propylene glycol 50-60%, 5% ethanol, The rest is deionized water.