CN106581534A - Medicine composition used for toothache surgery anesthesia and preparation method of medicine composition - Google Patents
Medicine composition used for toothache surgery anesthesia and preparation method of medicine composition Download PDFInfo
- Publication number
- CN106581534A CN106581534A CN201611272382.9A CN201611272382A CN106581534A CN 106581534 A CN106581534 A CN 106581534A CN 201611272382 A CN201611272382 A CN 201611272382A CN 106581534 A CN106581534 A CN 106581534A
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Classifications
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/236—Ligusticum (licorice-root)
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a medicine composition used for toothache surgery anesthesia and a preparation method of the medicine composition. The medicine composition is prepared from the following medicines, by weight, tatarian aster roots, uniflower swisscentaury roots, allium macrostemon, perilla leaves, cortex phellodendri, myrrh, poria cocos peels, pericarpium arecae, rhizoma sparganii, liquoric roots, ligusticum wallichii and spikenard, and is prepared through water extraction and alcohol extraction processes, a toothache surgery anesthesia clinically-observed result shows that in 360 cases of patients, the total effective rate averagely reaches 93.9%, and it shows that the medicine composition is remarkable in effect in toothache surgery anesthesia and is a new medicine worthy of popularization.
Description
Technical field
The present invention relates to field of medicine invention, and in particular to a kind of pharmaceutical composition and its system for surgery anesthesia of having a toothache
Preparation Method.
Background technology
Anesthesia original meaning refers to the forfeiture of sensation or consciousness, then refer to thereafter can make patient undergo surgery or during invasive operation not
Feel the state of pain and discomfort.It is generally believed that anesthesia is a kind of nervus centraliss and surrounding produced by medicine or additive method
The characteristics of reversibility function inhibitio of nervous system, this suppression, mainly feels the forfeiture for being particularly the pain sensation.
Anaesthetic can make central nervous system be inhibited, and show as mind and disappear, ache and feel that forfeiture, forgetting, reflection press down
System and skeletal muscle relaxation, the degree that Central nervous system suppresses are relevant with drug level in blood, and can control and adjust
Section, this suppression is completely reversibility, and when medicine is metabolized or after discharging in vivo, the mind of patient and various reflections are gradually extensive
It is multiple.At present, known dentistry exodontia adopts Western medicine anesthesia injection method, and many deciduous teeth change tooth, wisdom tooth, cacodontia into needs what is pulled out
Patient, the untoward reaction caused because fearing injection such as pale complexion, nervous, uncomfortable in chest, nauseous etc., serious can also go out
Now suffer a shock, and the postoperative hemorrhage having is more than, occur situations such as infection, also anaphylaxiss etc. in addition.These are all be afraid of psychology and
Reaction happens occasionally, and brings many troubles to the work of odontologist, makes dental patient feel pain deeply.Therefore research and development one kind has
The Chinese medicine composition of the advantages of easy to use, effect strong, instant effect, lasting medicine is necessary.
The present inventor have developed a kind of new drug to solve the above problems.
The content of the invention
It is an object of the invention to provide a kind of pharmaceutical composition for surgery anesthesia of having a toothache.
It is a further object of the present invention to provide a kind of preparation method of the pharmaceutical composition for surgery anesthesia of having a toothache.
The present invention provides a kind of pharmaceutical composition for surgery anesthesia of having a toothache, and the pharmaceutical composition is by following weight portion
Medicine is made：Radix Asteriss 10-50 parts, Radix Rhapontici 15-65 parts, Bulbus Allii Macrostemonis 10-60 parts, Folium Perillae 20-70 parts, Cortex Phellodendri 65-100 parts, Myrrha
35-78 parts, Cortex Sclerotii Poriae 20-60 parts, Pericarpium Arecae 15-68 parts, Rhizoma Sparganii 20-70 parts, Radix Glycyrrhizae 10-40 parts, Rhizoma Chuanxiong 20-60 parts, Radix Et Rhizoma Nardostachyos
20-70 parts.
Preferably, pharmaceutical composition of the present invention is made up of the medicine of following weight portion：Radix Asteriss 15-45 parts, Radix Rhapontici
20-60 parts, Bulbus Allii Macrostemonis 15-55 parts, Folium Perillae 30-60 parts, Cortex Phellodendri 80-95 parts, Myrrha 40-73 parts, Cortex Sclerotii Poriae 25-55 parts, big abdomen
Skin 20-63 parts, Rhizoma Sparganii 25-55 parts, Radix Glycyrrhizae 15-35 parts, Rhizoma Chuanxiong 25-55 parts, Radix Et Rhizoma Nardostachyos 25-65 parts.
It is further preferred that pharmaceutical composition of the present invention is made up of the medicine of following weight portion：Radix Asteriss 20-40
Part, Radix Rhapontici 25-55 parts, Bulbus Allii Macrostemonis 20-50 parts, Folium Perillae 35-55 parts, Cortex Phellodendri 83-92 parts, Myrrha 45-70 parts, Cortex Sclerotii Poriae 30-50
Part, Pericarpium Arecae 25-58 parts, Rhizoma Sparganii 30-50 parts, Radix Glycyrrhizae 20-30 parts, Rhizoma Chuanxiong 30-50 parts, Radix Et Rhizoma Nardostachyos 30-60 parts.
Still more preferably, pharmaceutical composition of the present invention is made up of the medicine of following weight portion：Radix Asteriss 25-35
Part, Radix Rhapontici 30-50 parts, Bulbus Allii Macrostemonis 25-45 parts, Folium Perillae 40-50 parts, Cortex Phellodendri 85-90 parts, Myrrha 52-62 parts, Cortex Sclerotii Poriae 35-45
Part, Pericarpium Arecae 30-50 parts, Rhizoma Sparganii 35-45 parts, Radix Glycyrrhizae 22-28 parts, Rhizoma Chuanxiong 35-45 parts, Radix Et Rhizoma Nardostachyos 35-55 parts.
Still more preferably, pharmaceutical composition of the present invention is made up of the medicine of following weight portion：30 parts of Radix Asteriss,
35 parts of Radix Rhapontici, 32 parts of Bulbus Allii Macrostemonis, 45 parts of Folium Perillae, 88 parts of Cortex Phellodendri, 58 parts of Myrrha, 40 parts of Cortex Sclerotii Poriae, 35 parts of Pericarpium Arecae, Rhizoma Sparganii 40
Part, 25 parts of Radix Glycyrrhizae, 40 parts of Rhizoma Chuanxiong, 45 parts of Radix Et Rhizoma Nardostachyos.
Pharmaceutical composition of the present invention also contains pharmaceutically acceptable carrier or diluent.
Pharmaceutical composition of the present invention is solid preparation or liquid preparation, the solid preparation be tablet, capsule,
Granule or pill；The liquid preparation is oral liquid, spray.
The preparation method of pharmaceutical composition of the present invention is comprised the following steps：By Radix Asteriss, Radix Rhapontici, Bulbus Allii Macrostemonis, Folium Perillae, Huang
Cypress, Myrrha, Cortex Sclerotii Poriae, Pericarpium Arecae, Rhizoma Sparganii, Radix Glycyrrhizae, Rhizoma Chuanxiong, Radix Et Rhizoma Nardostachyos pulverize and sieve, with pharmaceutically acceptable carrier or dilution
Agent mix homogeneously, is prepared into preparation.
The preparation method of pharmaceutical composition of the present invention is comprised the following steps：
1) Myrrha is ground into into fine powder, plus 20-40 times is measured water and soaked 3-6 days, is filtered, filtrate is standby；
2) add 2-5 times to measure decocting Radix Asteriss, Radix Rhapontici, Bulbus Allii Macrostemonis, Folium Perillae, Cortex Phellodendri to boil 1-2 time, each 0.5-1 hours, mistake
Filter, merging filtrate, filtrate concentrate drying are ground into fine powder standby；
3) Cortex Sclerotii Poriae, Pericarpium Arecae, Rhizoma Sparganii, Radix Glycyrrhizae, Rhizoma Chuanxiong, Radix Et Rhizoma Nardostachyos are added into the 3-5 times of ethanol decoction for measuring 75% 2-4 time, often
Secondary 2-4 hours, filter, and merging filtrate, filtrate concentrate drying are ground into fine powder standby；Filtering residue adds step 1) filtrate immersion 10-
12 hours, filtration, filtrate concentration, drying were ground into fine powder standby；
4) by step 2) 3) standby fine powder mix homogeneously, add pharmaceutically acceptable carrier or diluent mixing equal
It is even, make preparation.
Preferably, the preparation method of pharmaceutical composition of the present invention is comprised the following steps：
1) Myrrha is ground into into fine powder, plus 30 times of amount water soaks 5 days, filter, filtrate is standby；
2) add 3 times of amount decoctings to boil 1 time Radix Asteriss, Radix Rhapontici, Bulbus Allii Macrostemonis, Folium Perillae, Cortex Phellodendri, 0.5 hour every time, filter, merge
Filtrate, filtrate concentrate drying, is ground into fine powder standby；
3) ethanol of 4 times of amounts 75% is added to decoct 3 times Cortex Sclerotii Poriae, Pericarpium Arecae, Rhizoma Sparganii, Radix Glycyrrhizae, Rhizoma Chuanxiong, Radix Et Rhizoma Nardostachyos, 3 is little every time
When, filtering, merging filtrate, filtrate concentrate drying are ground into fine powder standby；Filtering residue adds step 1) filtrate soak 11 hours, filter
Cross, filtrate concentration, drying are ground into fine powder standby；
4) by step 2) 3) standby fine powder mix homogeneously, add pharmaceutically acceptable carrier or diluent mixing equal
It is even, make preparation.
The parts by weight can be unit of weight known to the field of medicaments such as μ g, mg, g, kg.
The implication of amount refers to the weight ratio of medical material again.
The pharmaceutically acceptable carrier or diluent refer to the conventional pharmaceutical carrier of pharmaceutical field, selected from filler,
One or more in binding agent, disintegrating agent, lubricant, surfactant or correctivess.
Wherein described filler is selected from starch, sucrose, Lactose, Mannitol, Sorbitol, xylitol, Microcrystalline Cellulose or Portugal
Grape sugar etc.；
Described adhesive is selected from cellulose derivative, alginate, gelatin or polyvinylpyrrolidone etc.；
The disintegrating agent is selected from Microcrystalline Cellulose, carboxymethyl starch sodium, polyvinylpyrrolidone, low substituted hydroxy-propyl fiber
Element or Croscarmellose Sodium；
The lubricant is selected from stearic acid, Polyethylene Glycol, Calcium Carbonate, sodium bicarbonate, silicon dioxide, Pulvis Talci or stearic acid
Magnesium；
The surfactant is selected from dodecylbenzene sodium sulfonate, stearic acid, Pluronic F68, fat
Pyrusussuriensiss are smooth or Polysorbate (tween) etc. for fat acid；
The correctivess are selected from aspartame, Sucralose or saccharin sodium.
The invention has the advantages that：
By having a toothache, Clinical observation of anaesthesia in operation for herniated result shows that, in 360 patients, total effective rate averagely reaches 93.9%,
Present invention effect is significant in toothache surgery anesthesia is illustrated, is a kind of new drug being worthy to be popularized.
Specific embodiment
Following examples are used to illustrate the present invention, but are not limited to the scope of the present invention.
Embodiment 1
Prescription：Radix Asteriss 10g, Radix Rhapontici 15g, Bulbus Allii Macrostemonis 10g, Folium Perillae 20g, Cortex Phellodendri 65g, Myrrha 35g, Cortex Sclerotii Poriae 20g, big abdomen
Skin 15g, Rhizoma Sparganii 20g, Radix Glycyrrhizae 10g, Rhizoma Chuanxiong 20g, Radix Et Rhizoma Nardostachyos 20g.
Preparation method：
1) Myrrha is ground into into fine powder, plus 20 times of amount water soaks 3 days, filter, filtrate is standby；
2) 2 times of amount decoctings are added to boil 1 time Radix Asteriss, Radix Rhapontici, Bulbus Allii Macrostemonis, Folium Perillae, Cortex Phellodendri, each 0.5-1 hours are filtered, filter
Liquid concentrate drying, is ground into fine powder standby；
3) ethanol of 3 times of amounts 75% is added to decoct 2 times Cortex Sclerotii Poriae, Pericarpium Arecae, Rhizoma Sparganii, Radix Glycyrrhizae, Rhizoma Chuanxiong, Radix Et Rhizoma Nardostachyos, 2 is little every time
When, filtering, merging filtrate, filtrate concentrate drying are ground into fine powder standby；Filtering residue adds step 1) filtrate soak 10 hours, filter
Cross, filtrate concentration, drying are ground into fine powder standby；
4) by step 2) 3) standby fine powder mix homogeneously, add 6 times of 45% ethanol of amount to soak 5 hours, filter, filtrate dress
Enter in spray bottle, obtain final product spray.
Embodiment 2
Prescription：It is Radix Asteriss 50g, Radix Rhapontici 65g, Bulbus Allii Macrostemonis 60g, Folium Perillae 70g, Cortex Phellodendri 100g, Myrrha 78g, Cortex Sclerotii Poriae 60g, big
Pericarpium Arecae 68g, Rhizoma Sparganii 70g, Radix Glycyrrhizae 40g, Rhizoma Chuanxiong 60g, Radix Et Rhizoma Nardostachyos 70g.
Preparation method：
1) Myrrha is ground into into fine powder, plus 40 times of amount water soaks 6 days, filter, filtrate is standby；
2) 5 times of amount decoctings are added to boil 2 times Radix Asteriss, Radix Rhapontici, Bulbus Allii Macrostemonis, Folium Perillae, Cortex Phellodendri, each 0.5-1 hours are filtered, and are closed
And filtrate, filtrate concentrate drying, it is ground into fine powder standby；
3) ethanol of 5 times of amounts 75% is added to decoct 4 times Cortex Sclerotii Poriae, Pericarpium Arecae, Rhizoma Sparganii, Radix Glycyrrhizae, Rhizoma Chuanxiong, Radix Et Rhizoma Nardostachyos, 4 is little every time
When, filtering, merging filtrate, filtrate concentrate drying are ground into fine powder standby；Filtering residue adds step 1) filtrate soak 12 hours, filter
Cross, filtrate concentration, drying are ground into fine powder standby；
4) by step 2) 3) standby fine powder mix homogeneously, add 6 times of 45% ethanol of amount to soak 5 hours, filter, filtrate dress
Enter in spray bottle, obtain final product spray.
Embodiment 3
Prescription：Radix Asteriss 15g, Radix Rhapontici 20g, Bulbus Allii Macrostemonis 15g, Folium Perillae 30g, Cortex Phellodendri 80g, Myrrha 40g, Cortex Sclerotii Poriae 25g, big abdomen
Skin 20g, Rhizoma Sparganii 25g, Radix Glycyrrhizae 15g, Rhizoma Chuanxiong 25g, Radix Et Rhizoma Nardostachyos 25g.
Preparation method：
1) Myrrha is ground into into fine powder, plus 25 times of amount water soaks 4 days, filter, filtrate is standby；
2) add 3 times of amount decoctings to boil 2 times Radix Asteriss, Radix Rhapontici, Bulbus Allii Macrostemonis, Folium Perillae, Cortex Phellodendri, 1 hour every time, filter, merge filter
Liquid, filtrate concentrate drying, is ground into fine powder standby；
3) ethanol of 4 times of amounts 75% is added to decoct 3 times Cortex Sclerotii Poriae, Pericarpium Arecae, Rhizoma Sparganii, Radix Glycyrrhizae, Rhizoma Chuanxiong, Radix Et Rhizoma Nardostachyos, 3 is little every time
When, filtering, merging filtrate, filtrate concentrate drying are ground into fine powder standby；Filtering residue adds step 1) filtrate soak 11 hours, filter
Cross, filtrate concentration, drying are ground into fine powder standby；
4) by step 2) 3) standby fine powder mix homogeneously, add 6 times of 45% ethanol of amount to soak 5 hours, filter, filtrate dress
Enter in spray bottle, obtain final product spray.
Embodiment 4
Prescription：Radix Asteriss 45g, Radix Rhapontici 60g, Bulbus Allii Macrostemonis 55g, Folium Perillae 60g, Cortex Phellodendri 95g, Myrrha 73g, Cortex Sclerotii Poriae 55g, big abdomen
Skin 63g, Rhizoma Sparganii 55g, Radix Glycyrrhizae 35g, Rhizoma Chuanxiong 55g, Radix Et Rhizoma Nardostachyos 65g.
Preparation method：
1) Myrrha is ground into into fine powder, plus 35 times of amount water soaks 5 days, filter, filtrate is standby；
2) add 4 times of amount decoctings to boil 2 times Radix Asteriss, Radix Rhapontici, Bulbus Allii Macrostemonis, Folium Perillae, Cortex Phellodendri, 1 hour every time, filter, merge filter
Liquid, filtrate concentrate drying, is ground into fine powder standby；
3) the 3-5 times of ethanol for measuring 75% is added to decoct 3 times Cortex Sclerotii Poriae, Pericarpium Arecae, Rhizoma Sparganii, Radix Glycyrrhizae, Rhizoma Chuanxiong, Radix Et Rhizoma Nardostachyos, every time 3
Hour, filtering, merging filtrate, filtrate concentrate drying are ground into fine powder standby；Filtering residue adds step 1) filtrate soak 11 hours,
Filtration, filtrate concentration, drying are ground into fine powder standby；
4) by step 2) 3) standby fine powder mix homogeneously, add 6 times of 45% ethanol of amount to soak 5 hours, filter, filtrate dress
Enter in spray bottle, obtain final product spray.
Embodiment 5
Prescription：Radix Asteriss 20g, Radix Rhapontici 25g, Bulbus Allii Macrostemonis 20g, Folium Perillae 35g, Cortex Phellodendri 83g, Myrrha 45g, Cortex Sclerotii Poriae 30g, big abdomen
Skin 25g, Rhizoma Sparganii 30g, Radix Glycyrrhizae 20g, Rhizoma Chuanxiong 30g, Radix Et Rhizoma Nardostachyos 30g.
Preparation method：
1) Myrrha is ground into into fine powder, plus 30 times of amount water soaks 5 days, filter, filtrate is standby；
2) add 3 times of amount decoctings to boil 1 time Radix Asteriss, Radix Rhapontici, Bulbus Allii Macrostemonis, Folium Perillae, Cortex Phellodendri, 0.5 hour every time, filter, merge
Filtrate, filtrate concentrate drying, is ground into fine powder standby；
3) ethanol of 4 times of amounts 75% is added to decoct 3 times Cortex Sclerotii Poriae, Pericarpium Arecae, Rhizoma Sparganii, Radix Glycyrrhizae, Rhizoma Chuanxiong, Radix Et Rhizoma Nardostachyos, 3 is little every time
When, filtering, merging filtrate, filtrate concentrate drying are ground into fine powder standby；Filtering residue adds step 1) filtrate soak 11 hours, filter
Cross, filtrate concentration, drying are ground into fine powder standby；
4) by step 2) 3) standby fine powder mix homogeneously, add 6 times of 45% ethanol of amount to soak 5 hours, filter, filtrate dress
Enter in spray bottle, obtain final product spray.
Embodiment 6
Prescription：Radix Asteriss 40g, Radix Rhapontici 55g, Bulbus Allii Macrostemonis 50g, Folium Perillae 55g, Cortex Phellodendri 92g, Myrrha 70g, Cortex Sclerotii Poriae 50g, big abdomen
Skin 58g, Rhizoma Sparganii 50g, Radix Glycyrrhizae 30g, Rhizoma Chuanxiong 50g, Radix Et Rhizoma Nardostachyos 60g.
Preparation method：
1) Myrrha is ground into into fine powder, plus 30 times of amount water soaks 5 days, filter, filtrate is standby；
2) add 3 times of amount decoctings to boil 1 time Radix Asteriss, Radix Rhapontici, Bulbus Allii Macrostemonis, Folium Perillae, Cortex Phellodendri, 0.5 hour every time, filter, merge
Filtrate, filtrate concentrate drying, is ground into fine powder standby；
3) ethanol of 4 times of amounts 75% is added to decoct 3 times Cortex Sclerotii Poriae, Pericarpium Arecae, Rhizoma Sparganii, Radix Glycyrrhizae, Rhizoma Chuanxiong, Radix Et Rhizoma Nardostachyos, 3 is little every time
When, filtering, merging filtrate, filtrate concentrate drying are ground into fine powder standby；Filtering residue adds step 1) filtrate soak 11 hours, filter
Cross, filtrate concentration, drying are ground into fine powder standby；
4) by step 2) 3) standby fine powder mix homogeneously, add 6 times of 45% ethanol of amount to soak 5 hours, filter, filtrate dress
Enter in spray bottle, obtain final product spray.
Embodiment 7
Prescription：Radix Asteriss 25g, Radix Rhapontici 30g, Bulbus Allii Macrostemonis 25g, Folium Perillae 40g, Cortex Phellodendri 85g, Myrrha 52g, Cortex Sclerotii Poriae 35g, big abdomen
Skin 30g, Rhizoma Sparganii 35g, Radix Glycyrrhizae 22g, Rhizoma Chuanxiong 35g, Radix Et Rhizoma Nardostachyos 35g.
Preparation method：
1) Myrrha is ground into into fine powder, plus 30 times of amount water soaks 5 days, filter, filtrate is standby；
2) add 3 times of amount decoctings to boil 1 time Radix Asteriss, Radix Rhapontici, Bulbus Allii Macrostemonis, Folium Perillae, Cortex Phellodendri, 0.5 hour every time, filter, merge
Filtrate, filtrate concentrate drying, is ground into fine powder standby；
3) ethanol of 4 times of amounts 75% is added to decoct 3 times Cortex Sclerotii Poriae, Pericarpium Arecae, Rhizoma Sparganii, Radix Glycyrrhizae, Rhizoma Chuanxiong, Radix Et Rhizoma Nardostachyos, 3 is little every time
When, filtering, merging filtrate, filtrate concentrate drying are ground into fine powder standby；Filtering residue adds step 1) filtrate soak 11 hours, filter
Cross, filtrate concentration, drying are ground into fine powder standby；
4) by step 2) 3) standby fine powder mix homogeneously, add 6 times of 45% ethanol of amount to soak 5 hours, filter, filtrate dress
Enter in spray bottle, obtain final product spray.
Embodiment 8
Prescription：Radix Asteriss 35g, Radix Rhapontici 50g, Bulbus Allii Macrostemonis 45g, Folium Perillae 50g, Cortex Phellodendri 90g, Myrrha 62g, Cortex Sclerotii Poriae 45g, big abdomen
Skin 50g, Rhizoma Sparganii 45g, Radix Glycyrrhizae 28g, Rhizoma Chuanxiong 45g, Radix Et Rhizoma Nardostachyos 55g.
Preparation method：
1) Myrrha is ground into into fine powder, plus 30 times of amount water soaks 5 days, filter, filtrate is standby；
2) add 3 times of amount decoctings to boil 1 time Radix Asteriss, Radix Rhapontici, Bulbus Allii Macrostemonis, Folium Perillae, Cortex Phellodendri, 0.5 hour every time, filter, merge
Filtrate, filtrate concentrate drying, is ground into fine powder standby；
3) ethanol of 4 times of amounts 75% is added to decoct 3 times Cortex Sclerotii Poriae, Pericarpium Arecae, Rhizoma Sparganii, Radix Glycyrrhizae, Rhizoma Chuanxiong, Radix Et Rhizoma Nardostachyos, 3 is little every time
When, filtering, merging filtrate, filtrate concentrate drying are ground into fine powder standby；Filtering residue adds step 1) filtrate soak 11 hours, filter
Cross, filtrate concentration, drying are ground into fine powder standby；
4) by step 2) 3) standby fine powder mix homogeneously, add 6 times of 45% ethanol of amount to soak 5 hours, filter, filtrate dress
Enter in spray bottle, obtain final product spray.
Embodiment 9
Prescription：Radix Asteriss 30g, Radix Rhapontici 35g, Bulbus Allii Macrostemonis 32g, Folium Perillae 45g, Cortex Phellodendri 88g, Myrrha 58g, Cortex Sclerotii Poriae 40g, big abdomen
Skin 35g, Rhizoma Sparganii 40g, Radix Glycyrrhizae 25g, Rhizoma Chuanxiong 40g, Radix Et Rhizoma Nardostachyos 45g.
Preparation method：
1) Myrrha is ground into into fine powder, plus 30 times of amount water soaks 5 days, filter, filtrate is standby；
2) add 3 times of amount decoctings to boil 1 time Radix Asteriss, Radix Rhapontici, Bulbus Allii Macrostemonis, Folium Perillae, Cortex Phellodendri, 0.5 hour every time, filter, merge
Filtrate, filtrate concentrate drying, is ground into fine powder standby；
3) ethanol of 4 times of amounts 75% is added to decoct 3 times Cortex Sclerotii Poriae, Pericarpium Arecae, Rhizoma Sparganii, Radix Glycyrrhizae, Rhizoma Chuanxiong, Radix Et Rhizoma Nardostachyos, 3 is little every time
When, filtering, merging filtrate, filtrate concentrate drying are ground into fine powder standby；Filtering residue adds step 1) filtrate soak 11 hours, filter
Cross, filtrate concentration, drying are ground into fine powder standby；
4) by step 2) 3) standby fine powder mix homogeneously, add 6 times of 45% ethanol of amount to soak 5 hours, filter, filtrate dress
Enter in spray bottle, obtain final product spray.
In order to further sketch beneficial effects of the present invention, inventor has done clinical research, specific as follows：
1st, case selection：
Selection need to do 360 clinical observations of patient of toothache anesthesia surgery, 15～70 years old age, 43 years old mean age.
2nd, medicament selection：
Experimental group patient uses anaesthetic of the present invention, preoperative to be uniformly sprayed on operative site.
3rd, efficacy determination：
(1) effectively：It is painless in operation process, have no adverse reaction, it is postoperative to have no side effect.
(2) it is invalid：There is pain in operation process, or have untoward reaction, or postoperative have side effect.
4th, result see the table below：
Clinical observation result shows that, in 360 patients, total effective rate averagely reaches 93.9%, illustrates the present invention in toothache
Effect is significant in surgery anesthesia, is a kind of new drug being worthy to be popularized.
Model case is illustrated：
1st, Guo's ××, female, 18 years old, student, patient had a toothache one week, are paid attention to, and recent periodontal is red and swollen, hurt like hell,
Urgent need carries out extraction.Anaesthetized using 1 pharmaceutical composition of the embodiment of the present invention, performed the operation after 10 minutes, nothing in operation
Pain, without anesthetis side effect, toothache is released.
2nd, Lee's ××, female, 32 years old, office worker.Patient teeth draws and has a pain 10 days, does not heal always, and morbidity is serious in the recent period, need to enter
The cleaning operation of row tooth foreign body.Anaesthetized using 2 pharmaceutical composition of the embodiment of the present invention, performed the operation after 6 minutes, nothing in operation
Pain, without anesthetis side effect.
3rd, Du's ××, female, 62 years old, retirement.Patient suffers from gingivitiss, needs tooth pulling surgery, using 3 medicine of the embodiment of the present invention
Compositions are anaesthetized, and are performed the operation after 5 minutes, painless in art, are had no adverse reaction.
4th, Lee's ××, female, 58 years old.Patient teeth loosens, and needs tooth pulling surgery, using 4 drug regimen of the embodiment of the present invention
Thing is anaesthetized, and is performed the operation after 8 minutes, painless in art, is had no adverse reaction.
5th, Jiang's ××, man, 56 years old.Patient needs tooth pulling surgery because of tooth of growing permanent teeth, using 5 drug regimen of the embodiment of the present invention
Thing is anaesthetized, and is performed the operation after 9 minutes, painless in art, is had no adverse reaction.
6th, field ××, female, 63 years old.Patient needs tooth pulling surgery because of dental inflammation, hurt like hell, using present invention enforcement
6 pharmaceutical composition of example is anaesthetized, and is performed the operation after 7 minutes, painless in art, is had no adverse reaction.
7th, woods ××, man, 66 years old.Patient is rotted because of root of the tooth, hurt like hell, needs cleaning, using 7 medicine of the embodiment of the present invention
Compositions are anaesthetized, and are performed the operation after 6 minutes, painless in art, are had no adverse reaction.
8th, Zhao's ××, female, 67 years old.Patient needs cleaning, using 8 medicine of the embodiment of the present invention because of odontoseisiies, hurt like hell
Compositions are anaesthetized, and are performed the operation after 7 minutes, painless in art, are had no adverse reaction.
9th, Lee's ××, female, 55 years old.Patient unbearably, needs exodontia, using 9 medicine group of the embodiment of the present invention because of dental pain
Compound is anaesthetized, and is performed the operation after 5 minutes, painless in art, is had no adverse reaction.
Although above having used general explanation, specific embodiment and test, the present invention having been made to retouch in detail
State, but on the basis of the present invention, some modifications can be made to it or be improved, this is aobvious and easy to those skilled in the art
See.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to claimed
Scope.
Claims (10)
1. a kind of pharmaceutical composition for surgery anesthesia of having a toothache, it is characterised in that medicine of the pharmaceutical composition by following weight portion
Thing is made：Radix Asteriss 10-50 parts, Radix Rhapontici 15-65 parts, Bulbus Allii Macrostemonis 10-60 parts, Folium Perillae 20-70 parts, Cortex Phellodendri 65-100 parts, Myrrha 35-
78 parts, Cortex Sclerotii Poriae 20-60 parts, Pericarpium Arecae 15-68 parts, Rhizoma Sparganii 20-70 parts, Radix Glycyrrhizae 10-40 parts, Rhizoma Chuanxiong 20-60 parts, Radix Et Rhizoma Nardostachyos 20-
70 parts.
2. pharmaceutical composition according to claim 1, it is characterised in that medicine of the pharmaceutical composition by following weight portion
Make：Radix Asteriss 15-45 parts, Radix Rhapontici 20-60 parts, Bulbus Allii Macrostemonis 15-55 parts, Folium Perillae 30-60 parts, Cortex Phellodendri 80-95 parts, Myrrha 40-73
Part, Cortex Sclerotii Poriae 25-55 parts, Pericarpium Arecae 20-63 parts, Rhizoma Sparganii 25-55 parts, Radix Glycyrrhizae 15-35 parts, Rhizoma Chuanxiong 25-55 parts, Radix Et Rhizoma Nardostachyos 25-65
Part.
3. pharmaceutical composition according to claim 2, it is characterised in that medicine of the pharmaceutical composition by following weight portion
Make：Radix Asteriss 20-40 parts, Radix Rhapontici 25-55 parts, Bulbus Allii Macrostemonis 20-50 parts, Folium Perillae 35-55 parts, Cortex Phellodendri 83-92 parts, Myrrha 45-70
Part, Cortex Sclerotii Poriae 30-50 parts, Pericarpium Arecae 25-58 parts, Rhizoma Sparganii 30-50 parts, Radix Glycyrrhizae 20-30 parts, Rhizoma Chuanxiong 30-50 parts, Radix Et Rhizoma Nardostachyos 30-60
Part.
4. pharmaceutical composition according to claim 3, it is characterised in that medicine of the pharmaceutical composition by following weight portion
Make：Radix Asteriss 25-35 parts, Radix Rhapontici 30-50 parts, Bulbus Allii Macrostemonis 25-45 parts, Folium Perillae 40-50 parts, Cortex Phellodendri 85-90 parts, Myrrha 52-62
Part, Cortex Sclerotii Poriae 35-45 parts, Pericarpium Arecae 30-50 parts, Rhizoma Sparganii 35-45 parts, Radix Glycyrrhizae 22-28 parts, Rhizoma Chuanxiong 35-45 parts, Radix Et Rhizoma Nardostachyos 35-55
Part.
5. pharmaceutical composition according to claim 4, it is characterised in that medicine of the pharmaceutical composition by following weight portion
Make：30 parts of Radix Asteriss, 35 parts of Radix Rhapontici, 32 parts of Bulbus Allii Macrostemonis, 45 parts of Folium Perillae, 88 parts of Cortex Phellodendri, 58 parts of Myrrha, 40 parts of Cortex Sclerotii Poriae, big abdomen
35 parts of skin, 40 parts of Rhizoma Sparganii, 25 parts of Radix Glycyrrhizae, 40 parts of Rhizoma Chuanxiong, 45 parts of Radix Et Rhizoma Nardostachyos.
6. the pharmaceutical composition according to any one of claim 1-5, it is characterised in that the pharmaceutical composition also contains pharmacy
Upper acceptable carrier or diluent.
7. pharmaceutical composition according to claim 6, it is characterised in that described pharmaceutical composition is solid preparation or liquid
Preparation, the solid preparation are tablet, capsule, granule or pill；The liquid preparation is oral liquid, spray.
8. a kind of method for preparing the pharmaceutical composition described in any one of claim 1-5, it is characterised in that the method include with
Lower step：By Radix Asteriss, Radix Rhapontici, Bulbus Allii Macrostemonis, Folium Perillae, Cortex Phellodendri, Myrrha, Cortex Sclerotii Poriae, Pericarpium Arecae, Rhizoma Sparganii, Radix Glycyrrhizae, Rhizoma Chuanxiong, Radix Et Rhizoma Nardostachyos powder
It is broken to sieve, mix homogeneously with pharmaceutically acceptable carrier or diluent, be prepared into preparation.
9. a kind of method for preparing claim 1-5 any one described pharmaceutical composition, it is characterised in that the method includes following
Step：
1) Myrrha is ground into into fine powder, plus 20-40 times is measured water and soaked 3-6 days, is filtered, filtrate is standby；
2) add 2-5 times to measure decocting Radix Asteriss, Radix Rhapontici, Bulbus Allii Macrostemonis, Folium Perillae, Cortex Phellodendri to boil 1-2 time, each 0.5-1 hours, filter, close
And filtrate, filtrate concentrate drying, it is ground into fine powder standby；
3) the 3-5 times of ethanol for measuring 75% is added to decoct 2-4 time Cortex Sclerotii Poriae, Pericarpium Arecae, Rhizoma Sparganii, Radix Glycyrrhizae, Rhizoma Chuanxiong, Radix Et Rhizoma Nardostachyos, each 2-4
Hour, filtering, merging filtrate, filtrate concentrate drying are ground into fine powder standby；Filtering residue adds step 1) filtrate immersion 10-12 it is little
When, filtration, filtrate concentration, drying are ground into fine powder standby；
4) by step 2) 3) standby fine powder mix homogeneously, add pharmaceutically acceptable carrier or diluent mix homogeneously, system
Into preparation.
10. the preparation method of pharmaceutical composition according to claim 9, it is characterised in that the method is comprised the following steps：
1) Myrrha is ground into into fine powder, plus 30 times of amount water soaks 5 days, filter, filtrate is standby；
2) add 3 times of amount decoctings to boil 1 time Radix Asteriss, Radix Rhapontici, Bulbus Allii Macrostemonis, Folium Perillae, Cortex Phellodendri, 0.5 hour every time, filter, merging filtrate,
Filtrate concentrate drying, is ground into fine powder standby；
3) by Cortex Sclerotii Poriae, Pericarpium Arecae, Rhizoma Sparganii, Radix Glycyrrhizae, Rhizoma Chuanxiong, Radix Et Rhizoma Nardostachyos add 4 times amount 75% ethanol decoct 3 times, 3 hours every time,
Filter, merging filtrate, filtrate concentrate drying are ground into fine powder standby；Filtering residue adds step 1) filtrate soak 11 hours, filtration,
Filtrate concentrates, drying, is ground into fine powder standby；
4) by step 2) 3) standby fine powder mix homogeneously, add pharmaceutically acceptable carrier or diluent mix homogeneously, system
Into preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611272382.9A CN106581534A (en) | 2016-12-30 | 2016-12-30 | Medicine composition used for toothache surgery anesthesia and preparation method of medicine composition |
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|---|---|---|---|
| CN201611272382.9A CN106581534A (en) | 2016-12-30 | 2016-12-30 | Medicine composition used for toothache surgery anesthesia and preparation method of medicine composition |
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| Application Number | Title | Priority Date | Filing Date |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104491166A (en) * | 2014-12-30 | 2015-04-08 | 青岛市肿瘤医院 | Traditional Chinese medicine composition with auxiliary anesthetic effect |
| CN105853987A (en) * | 2016-06-08 | 2016-08-17 | 雷知雅 | Traditional Chinese medicine composition for treating peripheral nerve injury caused by anesthesia and preparing method thereof |
-
2016
- 2016-12-30 CN CN201611272382.9A patent/CN106581534A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104491166A (en) * | 2014-12-30 | 2015-04-08 | 青岛市肿瘤医院 | Traditional Chinese medicine composition with auxiliary anesthetic effect |
| CN105853987A (en) * | 2016-06-08 | 2016-08-17 | 雷知雅 | Traditional Chinese medicine composition for treating peripheral nerve injury caused by anesthesia and preparing method thereof |
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Application publication date: 20170426 |