CN106581422A - Medicine composition for lipomyoma surgery anesthesia and preparation method thereof - Google Patents
Medicine composition for lipomyoma surgery anesthesia and preparation method thereof Download PDFInfo
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- CN106581422A CN106581422A CN201611272310.4A CN201611272310A CN106581422A CN 106581422 A CN106581422 A CN 106581422A CN 201611272310 A CN201611272310 A CN 201611272310A CN 106581422 A CN106581422 A CN 106581422A
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a medicine composition for lipomyoma surgery anesthesia and a preparation method thereof. The medicine composition is prepared from the following medicines in parts by weight: elecampane, radix sophorae subprostratae, adenophora tetraphylla, pokeberry roots, semen torreya, mistletoes, saururus chinensis, sargentgloryvine stems, radix polygonati officinalis, radix paeoniae alba, common hogfenneI roots and semen lepidii. The medicine composition is prepared through an aqueous extracting process. By measuring the normal pressure hypoxia tolerance time and load swimming time of mice, the clinical observation result of lipomyoma surgery anesthesia shows that the total effective rate reaches an average of 95.3% in 450 patients, thereby indicating that the effect of the medicine composition in lipomyoma surgery anesthesia is obvious. The medicine composition is a new medicine worthy of being popularized.
Description
Technical field
The present invention relates to field of medicine invention, and in particular to a kind of pharmaceutical composition for lipoma surgery anesthesia and its
Preparation method.
Background technology
Anaesthetic can make central nervous system be inhibited, and show as mind and disappear, ache and feel that forfeiture, forgetting, reflection press down
System and skeletal muscle relaxation, the degree that Central nervous system suppresses are relevant with drug level in blood, and can control and adjust
Section, this suppression is completely reversibility, and when medicine is metabolized or after discharging in vivo, the mind of patient and various reflections are gradually extensive
It is multiple.At present, known lipoma operation adopts Western medicine anesthesia injection method, many lipomatous patients, because fearing injection
And the untoward reaction for causing such as pale complexion, nervous, uncomfortable in chest, nauseous etc., serious can also there is shock, and have it is postoperative
Situations such as haemophilia, infection, occurs, also anaphylaxiss etc. in addition.These all fearness psychology and reaction happen occasionally, to fat
The work of tumor operative doctor brings many troubles, makes patient feel pain deeply.Therefore research and develop it is a kind of have easy to use, effect it is strong,
The Chinese medicine composition of the advantages of instant effect, lasting medicine is necessary.
The present inventor have developed a kind of new drug to solve the above problems.
The content of the invention
It is an object of the invention to provide a kind of pharmaceutical composition for surgery anesthesia.
It is a further object of the present invention to provide a kind of preparation method of the pharmaceutical composition for surgery anesthesia.
The present invention provides a kind of pharmaceutical composition for surgery anesthesia, medicine of the pharmaceutical composition by following weight portion
Make：Radix Inulae 50-95 parts, Radix Sophorae Tonkinensiss 30-60 parts, Radix Adenophorae 100-200 parts, Radix Phytolaccae 25-55 parts, Semen Torreyae 28-70 parts, Mongolian oak are posted
Raw 30-60 parts, Rhizoma Saururi (Herba Saururi) 20-45 parts, Caulis Sargentodoxae 10-50 parts, Rhizoma Polygonati Odorati 20-70 parts, Radix Paeoniae Alba 100-160 parts, Radix Peucedani 10-50 parts,
Semen Lepidii (Semen Descurainiae) 30-80 parts.
Preferably, pharmaceutical composition of the present invention is made up of the medicine of following weight portion：Radix Inulae 55-90 parts, mountain
Radix Sophorae Tonkinensis 35-55 parts, Radix Adenophorae 110-190 parts, Radix Phytolaccae 30-50 parts, Semen Torreyae 35-65 parts, Herba Visci 35-55 parts, Rhizoma Saururi (Herba Saururi) 23-42
Part, Caulis Sargentodoxae 15-45 parts, Rhizoma Polygonati Odorati 30-60 parts, Radix Paeoniae Alba 110-150 parts, Radix Peucedani 15-45 parts, Semen Lepidii (Semen Descurainiae) 35-75 parts.
It is further preferred that pharmaceutical composition of the present invention is made up of the medicine of following weight portion：Radix Inulae 60-85
Part, Radix Sophorae Tonkinensiss 38-52 parts, Radix Adenophorae 130-170 parts, Radix Phytolaccae 35-45 parts, Semen Torreyae 40-60 parts, Herba Visci 40-50 parts, Rhizoma Saururi (Herba Saururi)
28-37 parts, Caulis Sargentodoxae 20-40 parts, Rhizoma Polygonati Odorati 35-55 parts, Radix Paeoniae Alba 115-145 parts, Radix Peucedani 20-40 parts, Semen Lepidii (Semen Descurainiae) 40-70 parts.
Still more preferably, pharmaceutical composition of the present invention is made up of the medicine of following weight portion：Radix Inulae 65-
80 parts, it is Radix Sophorae Tonkinensiss 40-50 parts, Radix Adenophorae 140-160 parts, Radix Phytolaccae 38-42 parts, Semen Torreyae 45-55 parts, Herba Visci 42-48 parts, three white
Careless 30-35 parts, Caulis Sargentodoxae 25-35 parts, Rhizoma Polygonati Odorati 40-50 parts, Radix Paeoniae Alba 120-140 parts, Radix Peucedani 25-35 parts, Semen Lepidii (Semen Descurainiae) 50-60 parts.
Still more preferably, pharmaceutical composition of the present invention is made up of the medicine of following weight portion：Radix Inulae 72
Part, 45 parts of Radix Sophorae Tonkinensiss, 150 parts of Radix Adenophorae, 40 parts of Radix Phytolaccae, 50 parts of Semen Torreyae, 45 parts of Herba Visci, 32 parts of Rhizoma Saururi (Herba Saururi), 30 parts of Caulis Sargentodoxae,
45 parts of Rhizoma Polygonati Odorati, 130 parts of the Radix Paeoniae Alba, 30 parts of Radix Peucedani, 55 parts of Semen Lepidii (Semen Descurainiae).
Pharmaceutical composition of the present invention also contains pharmaceutically acceptable carrier or diluent.
Pharmaceutical composition of the present invention is solid preparation or liquid preparation, the solid preparation be tablet, capsule,
Granule or pill；The liquid preparation is oral liquid, spray.
The preparation method of pharmaceutical composition of the present invention is comprised the following steps：By Radix Inulae, Radix Sophorae Tonkinensiss, Radix Adenophorae, business
Land, Semen Torreyae, Herba Visci, Rhizoma Saururi (Herba Saururi), Caulis Sargentodoxae, Rhizoma Polygonati Odorati, the Radix Paeoniae Alba, Radix Peucedani, Semen Lepidii (Semen Descurainiae) pulverize and sieve, with pharmaceutically acceptable load
Body or diluent mix homogeneously, are prepared into preparation.The preparation method of pharmaceutical composition of the present invention is comprised the following steps：
1) add 10-15 times to measure soaking in Chinese liquor 3-5 days Radix Phytolaccae, Semen Torreyae, Herba Visci, Rhizoma Saururi (Herba Saururi), Caulis Sargentodoxae, filter, filtrate
Concentrate drying, is ground into fine powder, standby；
2) Radix Sophorae Tonkinensiss are fried 20 minutes with slow fire, is ground into fine powder, it is standby；
3) add 2-5 times to measure decocting Radix Inulae, the Radix Paeoniae Alba, Radix Peucedani, Semen Lepidii (Semen Descurainiae) to boil 2-4 time, each 0.5-1 hours, filter, close
And filtrate, filtrate concentrate drying, it is ground into fine powder standby；
4) Rhizoma Polygonati Odorati, 2-4 times of Nansha participation are measured decocting and is boiled 2-4 time, each 0.5-1.5 hours are filtered, merging filtrate, filter
Liquid concentrate drying, is ground into fine powder standby；
5) by step 1) 2) 3) 4) standby fine powder mix homogeneously, add pharmaceutically acceptable carrier or diluent mixing
Uniformly, make preparation.
Preferably, the preparation method of pharmaceutical composition of the present invention is comprised the following steps：
1) Radix Phytolaccae, Semen Torreyae, Herba Visci, Rhizoma Saururi (Herba Saururi), Caulis Sargentodoxae are added into 12 times of amount soaking in Chinese liquor 4 days, is filtered, filtrate concentration is dry
It is dry, fine powder is ground into, it is standby；
2) Radix Sophorae Tonkinensiss are fried 20 minutes with slow fire, is ground into fine powder, it is standby；
3) add 3 times of amount decoctings to boil 3 times Radix Inulae, the Radix Paeoniae Alba, Radix Peucedani, Semen Lepidii (Semen Descurainiae), 0.8 hour every time, filter, merge filter
Liquid, filtrate concentrate drying, is ground into fine powder standby；
4) Rhizoma Polygonati Odorati, Nansha are participated in 3 times of amount decoctings to boil 3 times, 0.8 hour every time, filters, merging filtrate, filtrate concentration is dry
It is dry, it is ground into fine powder standby；
5) by step 1) 2) 3) 4) standby fine powder mix homogeneously, add pharmaceutically acceptable carrier or diluent mixing
Uniformly, make preparation.
The parts by weight can be unit of weight known to the field of medicaments such as μ g, mg, g, kg.
The implication of amount refers to the weight ratio of medical material again.
The pharmaceutically acceptable carrier or diluent refer to the conventional pharmaceutical carrier of pharmaceutical field, selected from filler,
One or more in binding agent, disintegrating agent, lubricant, surfactant or correctivess.
Wherein described filler is selected from starch, sucrose, Lactose, Mannitol, Sorbitol, xylitol, Microcrystalline Cellulose or Portugal
Grape sugar etc.；
Described adhesive is selected from cellulose derivative, alginate, gelatin or polyvinylpyrrolidone etc.；
The disintegrating agent is selected from Microcrystalline Cellulose, carboxymethyl starch sodium, polyvinylpyrrolidone, low substituted hydroxy-propyl fiber
Element or Croscarmellose Sodium；
The lubricant is selected from stearic acid, Polyethylene Glycol, Calcium Carbonate, sodium bicarbonate, silicon dioxide, Pulvis Talci or stearic acid
Magnesium；
The surfactant is selected from dodecylbenzene sodium sulfonate, stearic acid, Pluronic F68, fat
Pyrusussuriensiss are smooth or Polysorbate (tween) etc. for fat acid；
The correctivess are selected from aspartame, Sucralose or saccharin sodium.
The invention has the advantages that：
Shown by lipoma Clinical observation of anaesthesia in operation for herniated result, in 450 patients, total effective rate averagely reaches
95.3%, present invention effect is significant in lipoma surgery anesthesia is illustrated, is a kind of new drug being worthy to be popularized.
Specific embodiment
Following examples are used to illustrate the present invention, but are not limited to the scope of the present invention.
Embodiment 1
Prescription：Radix Inulae 50g, Radix Sophorae Tonkinensiss 30g, Radix Adenophorae 100g, Radix Phytolaccae 25g, Semen Torreyae 28g, Herba Visci 30g, Rhizoma Saururi (Herba Saururi)
20g, Caulis Sargentodoxae 10g, Rhizoma Polygonati Odorati 20g, Radix Paeoniae Alba 100g, Radix Peucedani 10g, Semen Lepidii (Semen Descurainiae) 30g.
Preparation method：
1) Radix Phytolaccae, Semen Torreyae, Herba Visci, Rhizoma Saururi (Herba Saururi), Caulis Sargentodoxae are added into 10 times of amount soaking in Chinese liquor 3 days, is filtered, filtrate concentration is dry
It is dry, fine powder is ground into, it is standby；
2) Radix Sophorae Tonkinensiss are fried 20 minutes with slow fire, is ground into fine powder, it is standby；
3) add 2 times of amount decoctings to boil 2 times Radix Inulae, the Radix Paeoniae Alba, Radix Peucedani, Semen Lepidii (Semen Descurainiae), 0.5 hour every time, filter, merge filter
Liquid, filtrate concentrate drying, is ground into fine powder standby；
4) Rhizoma Polygonati Odorati, Nansha are participated in 2 times of amount decoctings to boil 2 times, 0.5 hour every time, filters, merging filtrate, filtrate concentration is dry
It is dry, it is ground into fine powder standby；
5) by step 1) 2) 3) 4) standby fine powder mix homogeneously, add 2 times of 40% ethanol of amount to soak 6 hours, filter, filter
Liquid loads in spray bottle, obtains final product spray.
Embodiment 2
Prescription：Radix Inulae 95g, Radix Sophorae Tonkinensiss 60g, Radix Adenophorae 200g, Radix Phytolaccae 55g, Semen Torreyae 70g, Herba Visci 60g, Rhizoma Saururi (Herba Saururi)
45g, Caulis Sargentodoxae 50g, Rhizoma Polygonati Odorati 70g, Radix Paeoniae Alba 160g, Radix Peucedani 50g, Semen Lepidii (Semen Descurainiae) 80g.
Preparation method：
1) Radix Phytolaccae, Semen Torreyae, Herba Visci, Rhizoma Saururi (Herba Saururi), Caulis Sargentodoxae are added into 15 times of amount soaking in Chinese liquor 5 days, is filtered, filtrate concentration is dry
It is dry, fine powder is ground into, it is standby；
2) Radix Sophorae Tonkinensiss are fried 20 minutes with slow fire, is ground into fine powder, it is standby；
3) add 5 times of amount decoctings to boil 4 times Radix Inulae, the Radix Paeoniae Alba, Radix Peucedani, Semen Lepidii (Semen Descurainiae), 1 hour every time, filter, merging filtrate,
Filtrate concentrate drying, is ground into fine powder standby；
4) Rhizoma Polygonati Odorati, Nansha are participated in 4 times of amount decoctings to boil 4 times, 1.5 hours every time, filters, merging filtrate, filtrate concentration is dry
It is dry, it is ground into fine powder standby；
5) by step 1) 2) 3) 4) standby fine powder mix homogeneously, add 5 times of 40% ethanol of amount to soak 6 hours, filter, filter
Liquid loads in spray bottle, obtains final product spray.
Embodiment 3
Prescription：Radix Inulae 55g, Radix Sophorae Tonkinensiss 35g, Radix Adenophorae 110g, Radix Phytolaccae 30g, Semen Torreyae 35g, Herba Visci 35g, Rhizoma Saururi (Herba Saururi)
23g, Caulis Sargentodoxae 15g, Rhizoma Polygonati Odorati 30g, Radix Paeoniae Alba 110g, Radix Peucedani 15g, Semen Lepidii (Semen Descurainiae) 35g.
Preparation method：
1) Radix Phytolaccae, Semen Torreyae, Herba Visci, Rhizoma Saururi (Herba Saururi), Caulis Sargentodoxae are added into 12 times of amount soaking in Chinese liquor 4 days, is filtered, filtrate concentration is dry
It is dry, fine powder is ground into, it is standby；
2) Radix Sophorae Tonkinensiss are fried 20 minutes with slow fire, is ground into fine powder, it is standby；
3) add 3 times of amount decoctings to boil 3 times Radix Inulae, the Radix Paeoniae Alba, Radix Peucedani, Semen Lepidii (Semen Descurainiae), 0.6 hour every time, filter, merge filter
Liquid, filtrate concentrate drying, is ground into fine powder standby；
4) Rhizoma Polygonati Odorati, Nansha are participated in 3 times of amount decoctings to boil 3 times, 0.8 hour every time, filters, merging filtrate, filtrate concentration is dry
It is dry, it is ground into fine powder standby；
5) by step 1) 2) 3) 4) standby fine powder mix homogeneously, add 3 times of 40% ethanol of amount to soak 6 hours, filter, filter
Liquid loads in spray bottle, obtains final product spray.
Embodiment 4
Prescription：Radix Inulae 90g, Radix Sophorae Tonkinensiss 55g, Radix Adenophorae 190g, Radix Phytolaccae 50g, Semen Torreyae 65g, Herba Visci 55g, Rhizoma Saururi (Herba Saururi)
42g, Caulis Sargentodoxae 45g, Rhizoma Polygonati Odorati 60g, Radix Paeoniae Alba 150g, Radix Peucedani 45g, Semen Lepidii (Semen Descurainiae) 75g.
Preparation method：
1) Radix Phytolaccae, Semen Torreyae, Herba Visci, Rhizoma Saururi (Herba Saururi), Caulis Sargentodoxae are added into 14 times of amount soaking in Chinese liquor 4 days, is filtered, filtrate concentration is dry
It is dry, fine powder is ground into, it is standby；
2) Radix Sophorae Tonkinensiss are fried 20 minutes with slow fire, is ground into fine powder, it is standby；
3) 4 times of amount decoctings are added to boil 3 times Radix Inulae, the Radix Paeoniae Alba, Radix Peucedani, Semen Lepidii (Semen Descurainiae), each 0.5-1 hours are filtered, and merge filter
Liquid, filtrate concentrate drying, is ground into fine powder standby；
4) Rhizoma Polygonati Odorati, Nansha are participated in 3 times of amount decoctings to boil 3 times, 1 hour every time, filter, merging filtrate, filtrate concentrate drying,
It is ground into fine powder standby；
5) by step 1) 2) 3) 4) standby fine powder mix homogeneously, add 4 times of 40% ethanol of amount to soak 6 hours, filter, filter
Liquid loads in spray bottle, obtains final product spray.
Embodiment 5
Prescription：Radix Inulae 60g, Radix Sophorae Tonkinensiss 38g, Radix Adenophorae 130g, Radix Phytolaccae 35g, Semen Torreyae 40g, Herba Visci 40g, Rhizoma Saururi (Herba Saururi)
28g, Caulis Sargentodoxae 20g, Rhizoma Polygonati Odorati 35g, Radix Paeoniae Alba 115g, Radix Peucedani 20g, Semen Lepidii (Semen Descurainiae) 40g.
Preparation method：
1) Radix Phytolaccae, Semen Torreyae, Herba Visci, Rhizoma Saururi (Herba Saururi), Caulis Sargentodoxae are added into 12 times of amount soaking in Chinese liquor 4 days, is filtered, filtrate concentration is dry
It is dry, fine powder is ground into, it is standby；
2) Radix Sophorae Tonkinensiss are fried 20 minutes with slow fire, is ground into fine powder, it is standby；
3) add 3 times of amount decoctings to boil 3 times Radix Inulae, the Radix Paeoniae Alba, Radix Peucedani, Semen Lepidii (Semen Descurainiae), 0.8 hour every time, filter, merge filter
Liquid, filtrate concentrate drying, is ground into fine powder standby；
4) Rhizoma Polygonati Odorati, Nansha are participated in 3 times of amount decoctings to boil 3 times, 0.8 hour every time, filters, merging filtrate, filtrate concentration is dry
It is dry, it is ground into fine powder standby；
5) by step 1) 2) 3) 4) standby fine powder mix homogeneously, add 4 times of 40% ethanol of amount to soak 6 hours, filter, filter
Liquid loads in spray bottle, obtains final product spray.
Embodiment 6
Prescription：Radix Inulae 85g, Radix Sophorae Tonkinensiss 52g, Radix Adenophorae 170g, Radix Phytolaccae 45g, Semen Torreyae 60g, Herba Visci 50g, Rhizoma Saururi (Herba Saururi)
37g, Caulis Sargentodoxae 40g, Rhizoma Polygonati Odorati 55g, Radix Paeoniae Alba 145g, Radix Peucedani 40g, Semen Lepidii (Semen Descurainiae) 70g.
Preparation method：
1) Radix Phytolaccae, Semen Torreyae, Herba Visci, Rhizoma Saururi (Herba Saururi), Caulis Sargentodoxae are added into 12 times of amount soaking in Chinese liquor 4 days, is filtered, filtrate concentration is dry
It is dry, fine powder is ground into, it is standby；
2) Radix Sophorae Tonkinensiss are fried 20 minutes with slow fire, is ground into fine powder, it is standby；
3) add 3 times of amount decoctings to boil 3 times Radix Inulae, the Radix Paeoniae Alba, Radix Peucedani, Semen Lepidii (Semen Descurainiae), 0.8 hour every time, filter, merge filter
Liquid, filtrate concentrate drying, is ground into fine powder standby；
4) Rhizoma Polygonati Odorati, Nansha are participated in 3 times of amount decoctings to boil 3 times, 0.8 hour every time, filters, merging filtrate, filtrate concentration is dry
It is dry, it is ground into fine powder standby；
5) by step 1) 2) 3) 4) standby fine powder mix homogeneously, add 4 times of 40% ethanol of amount to soak 6 hours, filter, filter
Liquid loads in spray bottle, obtains final product spray.
Embodiment 7
Prescription：Radix Inulae 65g, Radix Sophorae Tonkinensiss 40g, Radix Adenophorae 140g, Radix Phytolaccae 38g, Semen Torreyae 45g, Herba Visci 42g, Rhizoma Saururi (Herba Saururi)
30g, Caulis Sargentodoxae 25g, Rhizoma Polygonati Odorati 40g, Radix Paeoniae Alba 120g, Radix Peucedani 25g, Semen Lepidii (Semen Descurainiae) 50g.
Preparation method：
1) Radix Phytolaccae, Semen Torreyae, Herba Visci, Rhizoma Saururi (Herba Saururi), Caulis Sargentodoxae are added into 12 times of amount soaking in Chinese liquor 4 days, is filtered, filtrate concentration is dry
It is dry, fine powder is ground into, it is standby；
2) Radix Sophorae Tonkinensiss are fried 20 minutes with slow fire, is ground into fine powder, it is standby；
3) add 3 times of amount decoctings to boil 3 times Radix Inulae, the Radix Paeoniae Alba, Radix Peucedani, Semen Lepidii (Semen Descurainiae), 0.8 hour every time, filter, merge filter
Liquid, filtrate concentrate drying, is ground into fine powder standby；
4) Rhizoma Polygonati Odorati, Nansha are participated in 3 times of amount decoctings to boil 3 times, 0.8 hour every time, filters, merging filtrate, filtrate concentration is dry
It is dry, it is ground into fine powder standby；
5) by step 1) 2) 3) 4) standby fine powder mix homogeneously, add 4 times of 40% ethanol of amount to soak 6 hours, filter, filter
Liquid loads in spray bottle, obtains final product spray.
Embodiment 8
Prescription：Radix Inulae 80g, Radix Sophorae Tonkinensiss 50g, Radix Adenophorae 160g, Radix Phytolaccae 42g, Semen Torreyae 55g, Herba Visci 48g, Rhizoma Saururi (Herba Saururi)
35g, Caulis Sargentodoxae 35g, Rhizoma Polygonati Odorati 50g, Radix Paeoniae Alba 140g, Radix Peucedani 35g, Semen Lepidii (Semen Descurainiae) 60g.
Preparation method：
1) Radix Phytolaccae, Semen Torreyae, Herba Visci, Rhizoma Saururi (Herba Saururi), Caulis Sargentodoxae are added into 12 times of amount soaking in Chinese liquor 4 days, is filtered, filtrate concentration is dry
It is dry, fine powder is ground into, it is standby；
2) Radix Sophorae Tonkinensiss are fried 20 minutes with slow fire, is ground into fine powder, it is standby；
3) add 3 times of amount decoctings to boil 3 times Radix Inulae, the Radix Paeoniae Alba, Radix Peucedani, Semen Lepidii (Semen Descurainiae), 0.8 hour every time, filter, merge filter
Liquid, filtrate concentrate drying, is ground into fine powder standby；
4) Rhizoma Polygonati Odorati, Nansha are participated in 3 times of amount decoctings to boil 3 times, 0.8 hour every time, filters, merging filtrate, filtrate concentration is dry
It is dry, it is ground into fine powder standby；
5) by step 1) 2) 3) 4) standby fine powder mix homogeneously, add 4 times of 40% ethanol of amount to soak 6 hours, filter, filter
Liquid loads in spray bottle, obtains final product spray.
Embodiment 9
Prescription：Radix Inulae 72g, Radix Sophorae Tonkinensiss 45g, Radix Adenophorae 150g, Radix Phytolaccae 40g, Semen Torreyae 50g, Herba Visci 45g, Rhizoma Saururi (Herba Saururi)
32g, Caulis Sargentodoxae 30g, Rhizoma Polygonati Odorati 45g, Radix Paeoniae Alba 130g, Radix Peucedani 30g, Semen Lepidii (Semen Descurainiae) 55g.
Preparation method：
1) Radix Phytolaccae, Semen Torreyae, Herba Visci, Rhizoma Saururi (Herba Saururi), Caulis Sargentodoxae are added into 12 times of amount soaking in Chinese liquor 4 days, is filtered, filtrate concentration is dry
It is dry, fine powder is ground into, it is standby；
2) Radix Sophorae Tonkinensiss are fried 20 minutes with slow fire, is ground into fine powder, it is standby；
3) add 3 times of amount decoctings to boil 3 times Radix Inulae, the Radix Paeoniae Alba, Radix Peucedani, Semen Lepidii (Semen Descurainiae), 0.8 hour every time, filter, merge filter
Liquid, filtrate concentrate drying, is ground into fine powder standby；
4) Rhizoma Polygonati Odorati, Nansha are participated in 3 times of amount decoctings to boil 3 times, 0.8 hour every time, filters, merging filtrate, filtrate concentration is dry
It is dry, it is ground into fine powder standby；
5) by step 1) 2) 3) 4) standby fine powder mix homogeneously, add 4 times of 40% ethanol of amount to soak 6 hours, filter, filter
Liquid loads in spray bottle, obtains final product spray.
In order to further sketch beneficial effects of the present invention, inventor has done clinical research, specific as follows：
1st, case selection：
450 clinical observations of patient for selecting lipoma operation anaesthetize, 21～65 years old age, 35 years old mean age.
2nd, medicament selection：
Experimental group patient uses anaesthetic of the present invention, preoperative to be uniformly sprayed on operative site.
3rd, efficacy determination：
(1) effectively：It is painless in operation process, have no adverse reaction, it is postoperative to have no side effect.
(2) it is invalid：There is pain in operation process, or have untoward reaction, or postoperative have side effect.
4th, result see the table below：
Clinical observation result shows that, in 450 patients, total effective rate averagely reaches 95.3%, illustrates the present invention in fat
Effect is significant in tumor surgery anesthesia, is a kind of new drug being worthy to be popularized.
Model case is illustrated：
1st, Xiao's ××, man, 27 years old, suffers from lipoma 6 months, is paid attention to, and unbearably, urgent need carries out operation to Short-term Pain
Remove.Anaesthetized using 1 pharmaceutical composition of the embodiment of the present invention, performed the operation after 5 minutes, it is painless in operation, without anesthesia
Side effect, lipoma are released.
2nd, Zhao's ××, female 39 years old, suffer from lipoma 2 months, and Short-term Pain unbearably, need to carry out operation removal.Using the present invention
2 pharmaceutical composition of embodiment is anaesthetized, and is performed the operation after 5 minutes, painless in operation, without anesthetis side effect, lipoma
Release.
3rd, woods ××, female 39 years old, suffer from lipoma 3 months, and Short-term Pain unbearably, need to carry out operation removal.Using the present invention
3 pharmaceutical composition of embodiment is anaesthetized, and is performed the operation after 5 minutes, painless in operation, without anesthetis side effect, lipoma
Release.
4th, Korea Spro's ××, man, 55 years old, suffers from lipoma 1 month, and Short-term Pain unbearably, need to carry out operation removal.Using the present invention
4 pharmaceutical composition of embodiment is anaesthetized, and is performed the operation after 7 clocks, painless in operation, without anesthetis side effect, lipoma solution
Remove.
5th, white ××, man, 49 years old.Suffer from lipoma 1.5 months, Short-term Pain unbearably, need to carry out operation removal.Using this
5 pharmaceutical composition of bright embodiment is anaesthetized, and is performed the operation after 6 clocks, painless in operation, without anesthetis side effect, lipoma
Release.
6th, white ××, man, 42 years old.Suffer from lipoma 10 months, Short-term Pain unbearably, need to carry out operation removal.Using this
6 pharmaceutical composition of bright embodiment is anaesthetized, and is performed the operation after 10 clocks, painless in operation, without anesthetis side effect, lipoma
Release.
7th, white ××, man, 37 years old.Suffer from lipoma 8 months, Short-term Pain unbearably, need to carry out operation removal.Using the present invention
7 pharmaceutical composition of embodiment is anaesthetized, and is performed the operation after 8 clocks, painless in operation, without anesthetis side effect, lipoma solution
Remove.
8th, grandson's ××, female, 33 years old.Suffer from lipoma 6 months, Short-term Pain unbearably, need to carry out operation removal.Using the present invention
8 pharmaceutical composition of embodiment is anaesthetized, and is performed the operation after 10 clocks, painless in operation, without anesthetis side effect, lipoma solution
Remove.
9th, Guo's ××, female, 36 years old.Suffer from lipoma 12 months, Short-term Pain unbearably, need to carry out operation removal.Using this
9 pharmaceutical composition of bright embodiment is anaesthetized, and is performed the operation after 8 clocks, painless in operation, without anesthetis side effect, lipoma
Release.
Although above having used general explanation, specific embodiment and test, the present invention having been made to retouch in detail
State, but on the basis of the present invention, some modifications can be made to it or be improved, this is aobvious and easy to those skilled in the art
See.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to claimed
Scope.
Claims (10)
1. a kind of pharmaceutical composition for lipoma surgery anesthesia, it is characterised in that the pharmaceutical composition is by following weight portion
Medicine is made：Radix Inulae 50-95 parts, Radix Sophorae Tonkinensiss 30-60 parts, Radix Adenophorae 100-200 parts, Radix Phytolaccae 25-55 parts, Semen Torreyae 28-70 parts,
Herba Visci 30-60 parts, Rhizoma Saururi (Herba Saururi) 20-45 parts, Caulis Sargentodoxae 10-50 parts, Rhizoma Polygonati Odorati 20-70 parts, Radix Paeoniae Alba 100-160 parts, Radix Peucedani 10-50
Part, Semen Lepidii (Semen Descurainiae) 30-80 parts.
2. pharmaceutical composition according to claim 1, it is characterised in that medicine of the pharmaceutical composition by following weight portion
Make：Radix Inulae 55-90 parts, Radix Sophorae Tonkinensiss 35-55 parts, Radix Adenophorae 110-190 parts, Radix Phytolaccae 30-50 parts, Semen Torreyae 35-65 parts, Mongolian oak are posted
Raw 35-55 parts, Rhizoma Saururi (Herba Saururi) 23-42 parts, Caulis Sargentodoxae 15-45 parts, Rhizoma Polygonati Odorati 30-60 parts, Radix Paeoniae Alba 110-150 parts, Radix Peucedani 15-45 parts,
Semen Lepidii (Semen Descurainiae) 35-75 parts.
3. pharmaceutical composition according to claim 2, it is characterised in that medicine of the pharmaceutical composition by following weight portion
Make：Radix Inulae 60-85 parts, Radix Sophorae Tonkinensiss 38-52 parts, Radix Adenophorae 130-170 parts, Radix Phytolaccae 35-45 parts, Semen Torreyae 40-60 parts, Mongolian oak are posted
Raw 40-50 parts, Rhizoma Saururi (Herba Saururi) 28-37 parts, Caulis Sargentodoxae 20-40 parts, Rhizoma Polygonati Odorati 35-55 parts, Radix Paeoniae Alba 115-145 parts, Radix Peucedani 20-40 parts,
Semen Lepidii (Semen Descurainiae) 40-70 parts.
4. pharmaceutical composition according to claim 3, it is characterised in that medicine of the pharmaceutical composition by following weight portion
Make：Radix Inulae 65-80 parts, Radix Sophorae Tonkinensiss 40-50 parts, Radix Adenophorae 140-160 parts, Radix Phytolaccae 38-42 parts, Semen Torreyae 45-55 parts, Mongolian oak are posted
Raw 42-48 parts, Rhizoma Saururi (Herba Saururi) 30-35 parts, Caulis Sargentodoxae 25-35 parts, Rhizoma Polygonati Odorati 40-50 parts, Radix Paeoniae Alba 120-140 parts, Radix Peucedani 25-35 parts,
Semen Lepidii (Semen Descurainiae) 50-60 parts.
5. pharmaceutical composition according to claim 4, it is characterised in that medicine of the pharmaceutical composition by following weight portion
Make：72 parts of Radix Inulae, 45 parts of Radix Sophorae Tonkinensiss, 150 parts of Radix Adenophorae, 40 parts of Radix Phytolaccae, 50 parts of Semen Torreyae, 45 parts of Herba Visci, Rhizoma Saururi (Herba Saururi) 32
Part, 30 parts of Caulis Sargentodoxae, 45 parts of Rhizoma Polygonati Odorati, 130 parts of the Radix Paeoniae Alba, 30 parts of Radix Peucedani, 55 parts of Semen Lepidii (Semen Descurainiae).
6. the pharmaceutical composition according to any one of claim 1-5, it is characterised in that the pharmaceutical composition also contains pharmacy
Upper acceptable carrier or diluent.
7. pharmaceutical composition according to claim 6, it is characterised in that described pharmaceutical composition is solid preparation or liquid
Preparation, the solid preparation are tablet, capsule, granule or pill；The liquid preparation is oral liquid, spray.
8. a kind of method for preparing the pharmaceutical composition described in any one of claim 1-5, it is characterised in that the method include with
Lower step：By Radix Inulae, Radix Sophorae Tonkinensiss, Radix Adenophorae, Radix Phytolaccae, Semen Torreyae, Herba Visci, Rhizoma Saururi (Herba Saururi), Caulis Sargentodoxae, Rhizoma Polygonati Odorati, the Radix Paeoniae Alba, Radix Peucedani,
Semen Lepidii (Semen Descurainiae) pulverizes and sieves, and mixs homogeneously with pharmaceutically acceptable carrier or diluent, is prepared into preparation.
9. a kind of method for preparing claim 1-5 any one described pharmaceutical composition, it is characterised in that the method includes following
Step：
1) add 10-15 times to measure soaking in Chinese liquor 3-5 days Radix Phytolaccae, Semen Torreyae, Herba Visci, Rhizoma Saururi (Herba Saururi), Caulis Sargentodoxae, filter, filtrate concentration
Fine powder is dry, pulverize into, it is standby；
2) Radix Sophorae Tonkinensiss are fried 20 minutes with slow fire, is ground into fine powder, it is standby；
3) add 2-5 times to measure decocting Radix Inulae, the Radix Paeoniae Alba, Radix Peucedani, Semen Lepidii (Semen Descurainiae) to boil 2-4 time, each 0.5-1 hours, filter, merge filter
Liquid, filtrate concentrate drying, is ground into fine powder standby；
4) Rhizoma Polygonati Odorati, 2-4 times of Nansha participation are measured decocting and is boiled 2-4 time, each 0.5-1.5 hours are filtered, and merging filtrate, filtrate are dense
It is standby that contracting dry, pulverize into fine powder；
5) by step 1) 2) 3) 4) standby fine powder mix homogeneously, add pharmaceutically acceptable carrier or diluent mixing equal
It is even, make preparation.
10. the preparation method of pharmaceutical composition according to claim 9, it is characterised in that the method is comprised the following steps：
1) Radix Phytolaccae, Semen Torreyae, Herba Visci, Rhizoma Saururi (Herba Saururi), Caulis Sargentodoxae are added into 12 times of amount soaking in Chinese liquor 4 days, are filtered, filtrate concentrate drying,
Fine powder is ground into, it is standby；
2) Radix Sophorae Tonkinensiss are fried 20 minutes with slow fire, is ground into fine powder, it is standby；
3) add 3 times of amount decoctings to boil 3 times Radix Inulae, the Radix Paeoniae Alba, Radix Peucedani, Semen Lepidii (Semen Descurainiae), 0.8 hour every time, filter, merging filtrate, filter
Liquid concentrate drying, is ground into fine powder standby；
4) Rhizoma Polygonati Odorati, Nansha are participated in 3 times of amount decoctings to boil 3 times, 0.8 hour every time, filters, merging filtrate, filtrate concentrate drying, powder
It is broken into fine powder standby；
5) by step 1) 2) 3) 4) standby fine powder mix homogeneously, add pharmaceutically acceptable carrier or diluent mixing equal
It is even, make preparation.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611272310.4A CN106581422A (en) | 2016-12-30 | 2016-12-30 | Medicine composition for lipomyoma surgery anesthesia and preparation method thereof |
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| CN201611272310.4A CN106581422A (en) | 2016-12-30 | 2016-12-30 | Medicine composition for lipomyoma surgery anesthesia and preparation method thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105030930A (en) * | 2015-09-15 | 2015-11-11 | 陈红 | Medicine composition for treating lumbago and back pains generated after epidural anesthesia and application thereof |
| CN105079420A (en) * | 2015-09-30 | 2015-11-25 | 柳波 | Anesthesia ointment for wound surface and preparation method of anesthesia ointment |
| CN105168650A (en) * | 2015-09-06 | 2015-12-23 | 江淑芬 | Traditional Chinese medicinal composition for anesthesia and analgesia for operations of general surgery |
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2016
- 2016-12-30 CN CN201611272310.4A patent/CN106581422A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105168650A (en) * | 2015-09-06 | 2015-12-23 | 江淑芬 | Traditional Chinese medicinal composition for anesthesia and analgesia for operations of general surgery |
| CN105030930A (en) * | 2015-09-15 | 2015-11-11 | 陈红 | Medicine composition for treating lumbago and back pains generated after epidural anesthesia and application thereof |
| CN105079420A (en) * | 2015-09-30 | 2015-11-25 | 柳波 | Anesthesia ointment for wound surface and preparation method of anesthesia ointment |
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