CN106581091A - Extraction method of erythropalum scandens and application as medicine treating gout - Google Patents
Extraction method of erythropalum scandens and application as medicine treating gout Download PDFInfo
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- CN106581091A CN106581091A CN201611049241.0A CN201611049241A CN106581091A CN 106581091 A CN106581091 A CN 106581091A CN 201611049241 A CN201611049241 A CN 201611049241A CN 106581091 A CN106581091 A CN 106581091A
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- erythropalum scandens
- scandens blume
- erythropalum
- blume
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Abstract
The invention discloses an extraction method of erythropalum scandens. The extraction method comprises the steps of 1, washing erythropalum scandens rhizomes, drying, smashing to 100 mesh or below, adding 2-3 fold water according to the weight of erythropalum scandens powder, adding mixed enzyme, and conducting enzymolysis; 2, separating medicine residues after enzymolysis to obtain erythropalum scandens enzymatic hydrolysate; 3, adding the medicine residues into one fold water by weight, soaking for 10-30 minutes to squeeze medicine liquor, mixing the medicine liquor with the erythropalum scandens enzymatic hydrolysate, wherein the medicine residues are adopted as additive or fertilizer; 4, conducting low-temperature vacuum concentration, and mixing the mixed erythropalum scandens enzymatic hydrolysate in the step 3 into paste to obtain erythropalum scandens zymolyte. The invention further discloses application of erythropalum scandens extract as a medicine treating gout.
Description
Technical field
The present invention relates to the medical field for the treatment of by Chinese herbs difficult and complicated cases, specifically a kind of Erythropalum Scandens Blume extracting method and extract
As the purposes for the treatment of gout medicine.
Background technology
Erythropalum Scandens Blume（Classification system：Erythropalum scandens Bl. ）Another name, the ears of an ox or cow rattan, the rattan that withers (Hainan Island),
China, side amaranth (Guangxi), thin green rattan (Yunnan) are hooked, is Olacaceae（Olacaceae）Erythropalum Scandens Blume belongs to（Erythropalum）For many years
The evergreen large-scale bejuco of life.Erythropalum Scandens Blume has higher edible, medicinal and afforestation ornamental value, and main product is in cloud
The ground such as south, Guizhou, Guangxi, Guangdong；China Guangdong, Guangxi are grown in that height above sea level 280-550m is regional, and Yunnan, Guizhou are grown in height above sea level
1000 ~ 1500m is regional, in being more common in the border of low mountain and knob or mountain area small stream side, mountain valley, thick forest or sparse woods or shrubbery.
Foreign countries' distribution：India, Nepal, Burma, Vietnam, Laos, Malaysia, Indonesia, Philippine.
Erythropalum Scandens Blume is the precious medicinal plant grown in overhanging cliff crack of stone.Erythropalum Scandens Blume is evergreen large-scale woody climber, grows 5
~ 15m, branch is dense and extends to the periphery, its well developed root system, strong adaptability, easily breeding.Flower lines up the forked cyme of armpit life
There is the wavy carnassial tooth for harboring on sequence, corolla white, calyx cylinder top, and reddish tan when ripe is yellowish-brown after doing.Leaf papery is to thickness
Papery, it is avette, above leaf green, the back side powder green, form sagging fruit, bluish violet when ripe, be very excellent sight leaf,
See fruit landscape seeds, great ornamental value.Erythropalum Scandens Blume can also make garden ornamental tree species, hedgerow and make domatic vertical greening tree
Kind, it is also possible to plant by courtyard, flower stand, allow it to climb nature Cheng Jing.
Document report, treatment of the Erythropalum Scandens Blume to diseases such as high lithemia, gout, kidney stone, frequent micturition, urgent urination, odynurias extremely has
Effect.Erythropalum Scandens Blume tea --- kidney toxin expelling is washed, deacidification controls gout, Erythropalum Scandens Blume【Cure mainly】：For liver and gallbladder damp-heat, stomachache, diarrhoea,【Work(
Effect】To rheumatoid arthritis, gout, jaundice, liver and gallbladder damp-heat, row stone diuresis, lithangiuria, expelling wind and activating blood flow, chronic nephritis,
The illnesss such as cystitis, kidney stone are effective in cure.【Active ingredient】Sexual element containing phenol in Erythropalum Scandens Blume, resin and triterpene, resin it is main
Composition is sumaresinolic acid, coniferyl cinnamate.【Meridian distribution of property and flavor】：Hardship, puts down.Enter liver, kidney two warp.
Erythropalum Scandens Blume is numerous in variety, and several Erythropalum Scandens Blumes can be simultaneously grown in same ecological environment, is divided into green bud and red bud
Erythropalum Scandens Blume, effect is identical.Erythropalum Scandens Blume is the edible edible wild herbs of the torrid zone and subtropical zone distribution, is also a kind of natural nuisance-free
Untapped wild plant resource.The tender sharp leaf edible of Erythropalum Scandens Blume, can be used to eat raw, stir-fries and eats, cooks filling, cooks soup, cooks congee, floods stain
Deng, delicious flavour, delicate fragrance Yi Kou, and unique flavor, it is among the people with collection tender shoots in south of Yunnan and Guangxi, Guangdong, Hainan etc.
Edible custom.
Huang Yuanhe, Huang Yineng, Pan Qiaodan, Han Jiadi were once studied《Erythropalum Scandens Blume alcohol extract is to hyperuricemia mouse
Affect》, its method is：
1st, the g of Erythropalum Scandens Blume stem powder 100 is taken, after petroleum ether degreasing 2 times, 75% ethanol for adding 8 times of medicinal material amounts is heated to reflux 3
Secondary, every time 2 h, concentrates after 3 backflow gained filtrate mixing, and concentrate is put into oven for drying and obtains medicinal extract.Medicinal extract and distilled water are taken,
It is configured to the experimental group of the corresponding crude drug amount of Erythropalum Scandens Blume alcohol extract, i.e. low dose group（5 g·kg-1）, middle dosage（10 g·kg-
1）, high dose group（15g·kg-1）.
2nd, mouse is randomly divided into into 6 groups, 10 per group.That is blank group, hyperuricemia model group, Erythropalum Scandens Blume alcohol extract（5
g·kg-1、10g·kg-1、15g·kg-1）And positive control drug allopurinol（10 mgkg-1) group.Positive control is not fast
Purine alcohol group and each dosage group difference ig administrations of Erythropalum Scandens Blume alcohol extract, administration volume is 15 mlkg-1, Normal group and height
Uricacidemia model group ig gives normal saline, the d of successive administration 7.
3 compare with blank group, and model group serum uric acid is significantly raised（P ＜ 0.01）.Compare with model group, Erythropalum Scandens Blume alcohol
Extract（5 g·kg-1、10g·kg-1、15g·kg-1）Group and allopurinol can significantly reduce serum uric acid level（P ＜
0.01）, Erythropalum Scandens Blume alcohol extract anti-trioxypurine effect enhanced trend with dosage increase.Allopurinol group and Erythropalum Scandens Blume alcohol extract
（10g·kg-1、15g·kg-1）Hyperuricemia mice serum uric acid level can be reduced below normal value.
4th, Erythropalum Scandens Blume alcohol extract can significantly reduce the serum uric acid level of hyperuricemia mouse, and show a certain amount
Effect relation.Serum creatinine level is to evaluate the important indicator of renal function.Compared with model group, the Erythropalum Scandens Blume alcohol extract of various dose
Creatine concentration in hyperuricemia mouse body can be reduced, this shows that Erythropalum Scandens Blume alcohol extract can suppress hyperuricemia to Mouse Kidney
The dirty damage for causing, with security.
But there are no the open source literature for extracting Erythropalum Scandens Blume using enzymatic isolation method to report.
The content of the invention
It is an object of the invention to provide a kind of extracting method of Erythropalum Scandens Blume, be using mixed enzyme extract Erythropalum Scandens Blume it is effective into
Point, then extract is made into pharmaceutically acceptable oral formulations, for treating hyperuricemia（Gout）Illness.
Medicine Erythropalum Scandens Blume of the present invention（Erythropalum scandens Bl.）It is Olacaceae
（Olacaceae）Erythropalum Scandens Blume belongs to（Erythropalum）The large-scale bejuco of perennial evergreen.
1st, the extracting method of Erythropalum Scandens Blume, comprises the following steps：
（1）Erythropalum Scandens Blume rhizome cleaning, drying are crushed to below 100 mesh, by Erythropalum Scandens Blume grain weight amount 2-3 times of water is added, added
Mixed enzyme, is digested, and the time is 5-10 hours, and temperature is 25-40 DEG C；
（2）The dregs of a decoction after enzymolysis are separated；Obtain Erythropalum Scandens Blume enzymolysis liquid；
（3）The dregs of a decoction add the water of 1 times of weight, and after immersion 10-30 minutes taking liquid is squeezed, and merge with Erythropalum Scandens Blume enzymolysis liquid, medicine
Slag is used as feed addictive or fertilizer；
（4）Cryogenic vacuum is concentrated, by the（3）The merging Erythropalum Scandens Blume enzymolysis liquid concentration of step is paste, obtains Erythropalum Scandens Blume zymolyte.
Above-described mixed enzyme be cellulase, AMS, wood sugar alcoholase and pectase, each component in mixed enzyme
Weight ratio preferably 1:1:1:1.It is 1-2% that mixed enzyme adds the weight of Erythropalum Scandens Blume powder.Several enzymes can be purchased from microorganism center
Buy.
Described Erythropalum Scandens Blume zymolyte adds the auxiliary material medically permitted, makes oral formulations, such as oral liquid, particle
Agent, tablet, capsule, pill etc..
Purposes of the described Erythropalum Scandens Blume enzymolysis composition oral preparation as treatment gout medicine.
Inventors believe that Erythropalum Scandens Blume is as the mechanism for the treatment of gout medicine：
Document is introduced, Erythropalum Scandens Blume【Effect】：Reducing fever and causing diuresis.【Cure mainly】：For diseases such as liver and gallbladder damp-heat, stomachache, diarrhoea.【Nature and flavor
Return through】：Hardship, flat, enter liver, kidney two warp.【Effect】Rheumatoid arthritis, gout, jaundice, liver and gallbladder damp-heat, row's stone diuresis are had
Therapeutic action.
So the present invention using Erythropalum Scandens Blume as treatment gout medication medication, gout (gout) is due to purine substance metabolism
Disorder, produce uric acid it is excessive and（Or）Underexcretion, serum Uric Acid Concentration persistently increases causes urate crystal to deposit soft group
One group of caused metabolic disease is knitted, and hyperuricemia is the most important biochemical basis of gout.Treatment is clinically commonly used at present
Substantially, such as colchicum and allopurinol, bad reaction is more, common nausea,vomiting,diarrhea, mistake for the chemicals effect of gout
Quick reaction, hepatorenal damage etc., therefore the inhibiting hyperuricemia medicine found safely, effectively, economic is particularly important.Perhaps Erythropalum Scandens Blume
Enzyme extract remain phenol sexual element, resin and Triterpenoid, role of correcting can be played to purine substance metabolic disorder,
Hyperuricemia mice serum uric acid level can be reduced in normal value.
Utstanding substantial characteristics and significant improvement of the present invention：
1st, Erythropalum Scandens Blume is carried out mixed enzyme and is extracted by the present invention, and extraction conditions are gentle, do not destroy general flavone, the phenol of Erythropalum Scandens Blume
Composition, resin and triterpene, retain to greatest extent effective medicinal ingredient of Erythropalum Scandens Blume.Propose the enzymolysis and extraction of Erythropalum Scandens Blume first
Technique, the extract efficacy obtained than alcohol extracting method is improved, and opens new field.
2nd, extraction time is short, low cost, is adapted to the production equipment of existing Chinese medicine factory.
3rd, the bad reaction of past western medicine gout is more, common nausea,vomiting,diarrhea, allergic reaction, hepatorenal damage
Deng, present invention enzymolysis Erythropalum Scandens Blume method safely, effectively, it is economical, obtain inhibiting hyperuricemia medicine.
4th, after taking Erythropalum Scandens Blume enzymatic preparations of the present invention, the higher people's focus of uric acid level has pain, redness, two days later
Detumescence, pain disappears.Take afterwards and there will be no pain.Kidney toxin is cleaned, urine cacosmia, night urine time
Number is reduced or not had.
Description of the drawings
Fig. 1 is the picture of Erythropalum Scandens Blume shoot.
Fig. 2 is the picture that Erythropalum Scandens Blume grows fruit.
Specific embodiment
Erythropalum Scandens Blume medicine preparation embodiment：
Embodiment 1
Preparation process is as follows：（1）Erythropalum Scandens Blume rhizome cleaning, drying are crushed to below 100 mesh, are added by Erythropalum Scandens Blume grain weight amount
2-3 times of water, adds mixed enzyme, is digested, and the time is 5-7 hours, and temperature is 30-40 DEG C；Described mixed enzyme is fiber
Plain enzyme, AMS, wood sugar alcoholase and pectase, the weight ratio preferably 1 of each component in mixed enzyme:1:1:1.Mixed enzyme adds
The weight for entering Erythropalum Scandens Blume powder is 1%.（2）The dregs of a decoction after enzymolysis are separated；Obtain Erythropalum Scandens Blume enzymolysis liquid；（3）The dregs of a decoction add 1 times of weight
The water of amount, after immersion 10-30 minutes taking liquid is squeezed, and is merged with Erythropalum Scandens Blume enzymolysis liquid, and the dregs of a decoction are used as feed addictive or fertilizer
Material；（4）Cryogenic vacuum is concentrated, by the（3）The merging Erythropalum Scandens Blume enzymolysis liquid concentration of step is paste, obtains Erythropalum Scandens Blume zymolyte.Plus
Enter the suitable amount of sucrose aqueous solution, make oral liquid.
Embodiment 2
The wild Erythropalum Scandens Blume of collection, removes yellow leaf and impurity, cleans, and complete stool is dried, then with microwave drying to water content 8%
Within, preparation process is as follows：（1）Erythropalum Scandens Blume rhizome cleaning, drying are crushed to below 100 mesh, are added by Erythropalum Scandens Blume grain weight amount
2-3 times of water, adds mixed enzyme, is digested, and the time is 7-10 hours, and temperature is 25-35 DEG C；Described mixed enzyme is fiber
Plain enzyme, AMS, wood sugar alcoholase and pectase, the weight ratio preferably 1 of each component in mixed enzyme:1:1:1.Mixed enzyme adds
The weight for entering Erythropalum Scandens Blume powder is 1.5%.（2）The dregs of a decoction after enzymolysis are separated；Obtain Erythropalum Scandens Blume enzymolysis liquid；（3）The dregs of a decoction add 1 times
The water of weight, after immersion 10-30 minutes taking liquid is squeezed, and is merged with Erythropalum Scandens Blume enzymolysis liquid, the dregs of a decoction as feed addictive or
Fertilizer；（4）Cryogenic vacuum is concentrated, by the（3）The merging Erythropalum Scandens Blume enzymolysis liquid concentration of step is paste, obtains Erythropalum Scandens Blume zymolyte.
Appropriate amount of auxiliary materials is added, tablet is made.
Embodiment 3
Preparation process such as embodiment 1, after obtaining Erythropalum Scandens Blume zymolyte, adds appropriate amount of auxiliary materials, makes capsule.
Embodiment 4
Preparation process such as embodiment 2, after obtaining Erythropalum Scandens Blume zymolyte, adds suitable amount of sucrose and starch, makes granule.
The present invention extracts Erythropalum Scandens Blume and extracts the comparison of Erythropalum Scandens Blume with alcohol extracting method using enzymatic isolation method
| General flavone（Account for total extract content） | Phenol sexual element | Triterpene | Paste-forming rate | |
| Embodiment 1 | General flavone 80% can be extracted | 78% can be extracted | 72% can be extracted | 25% |
| Embodiment 2 | General flavone 82% can be extracted | 76% can be extracted | 75% can be extracted | 25% |
| Alcohol extracting method | General flavone 75% can be extracted | 65% can be extracted | 68% can be extracted | 18 |
| Common water extraction | General flavone 60% can be extracted | 40% can be extracted | 50% can be extracted | 15 |
Situation of the Erythropalum Scandens Blume zymolyte of the present invention as treatment gout medicine：
Started from 2014, the present inventor, as treatment gout, is introduced using Erythropalum Scandens Blume zymolyte by hospital or friend,
There is the gouty patient of 30 multidigits（Volunteer）Treatment test is carried out, the present inventor understands first the medical history of patient, arrives first hospital
Check, it is that the patient of the gout that uric acid height causes carries out Erythropalum Scandens Blume zymolyte drug treatment to make a definite diagnosis, and is entered with Erythropalum Scandens Blume alcohol extract
Row compares 2014-2016, and patient takes the product of the Erythropalum Scandens Blume zymolyte of embodiment 1 and 2, daily 2 times, each 1-2 gram, 30 people
In, the patient for having 25 people's gouts has positive effect for 3 days, and Erythropalum Scandens Blume alcohol extract needs 6 days；
Case 1：
Liu, man, 36 years old, certain unit product sales promotion person drank because Jing is often treated with courtesy, misses potter and drinks a lot beer, 2015 years 3
Month, find there is gout situation, uriesthesis pain, frequent micturition, hospital diagnosis are 756.9 μm of ol/L of uric acid level, later using the present invention
The product of the Erythropalum Scandens Blume zymolyte of embodiment 1, daily 2 times, 1 gram every time, using 2 days, focus had pain, redness, two days later
Detumescence, pain disappears, and gout symptom has improvement after taking 10 days, disappears, and takes there will be no pain afterwards.Take one
Determine 432.1 μm of ol/L of uric acid level within individual month.
Case 2：
Chen, 43 years old, certain millworker was not careful in one's diet at ordinary times, and Jing often gobbles big drink, and in June, 2015, discovery has uriesthesis
Bitterly, frequent micturition, hospital diagnosis are that uric acid is high, through the Erythropalum Scandens Blume granule with the embodiment of the present invention 2, once a day, 1 gram every time, are made
Start to reduce with uriesthesis pain, the situation of frequent micturition after 5 days, slowly fully recover later within 30 days, illustrate that Erythropalum Scandens Blume of the present invention can be controlled
Treat gout.
Case 3：
Lee, man, 45 years old, certain business event person, Jing often drink by dinner party, and in April, 2015, discovery has urodynia, frequent micturition, to hospital
With western medicine, symptom takes a turn for the better, but does not note, is also on the drink, and causes gout situation repeatedly, later using present invention enforcement
The tablet of the Erythropalum Scandens Blume of example 2, daily 2 times, 1 gram every time, using 15 days, situation had improvement.
Claims (4)
1. the extracting method of Erythropalum Scandens Blume, comprises the following steps：
（1）Erythropalum Scandens Blume rhizome cleaning, drying are crushed to below 100 mesh, by Erythropalum Scandens Blume grain weight amount 2-3 times of water is added, added
Mixed enzyme, is digested, and the time is 5-10 hours, and temperature is 25-40 DEG C；
（2）The dregs of a decoction after enzymolysis are separated；Obtain Erythropalum Scandens Blume enzymolysis liquid；
（3）The dregs of a decoction add the water of 1 times of weight, and after immersion 10-30 minutes taking liquid is squeezed, and merge with Erythropalum Scandens Blume enzymolysis liquid, medicine
Slag is used as feed addictive or fertilizer；
（4）Cryogenic vacuum is concentrated, by the（3）The Erythropalum Scandens Blume enzymolysis liquid concentration of step is paste, obtains Erythropalum Scandens Blume zymolyte.
2. the extracting method of Erythropalum Scandens Blume according to claim 1, described mixed enzyme is cellulase, AMS, wood
Sugar alcohol enzyme and pectase, the weight ratio preferably 1 of each component in mixed enzyme:1:1:1；Mixed enzyme adds the weight of Erythropalum Scandens Blume powder
For 1-2%.
3. the extracting method of Erythropalum Scandens Blume according to claim 1, it is characterised in that：Described Erythropalum Scandens Blume zymolyte adds doctor
The auxiliary material permitted on, makes oral formulations.
4. the extracting method of Erythropalum Scandens Blume according to claim 3, it is characterised in that：Described Erythropalum Scandens Blume zymolyte is orally made
Purposes of the agent as treatment gout medicine.
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106929353A (en) * | 2017-02-14 | 2017-07-07 | 广西肽王生物科技有限公司 | A kind of antidepressant Moringa peptide method for preparing medicated wine |
| CN107494817A (en) * | 2017-08-25 | 2017-12-22 | 广西中医药大学 | A kind of hypoglycemic tea |
| CN107951922A (en) * | 2017-12-08 | 2018-04-24 | 杨英珠 | Erythropalum Scandens Blume deacidification tea and preparation method thereof |
| CN108743634A (en) * | 2018-06-26 | 2018-11-06 | 广西医科大学 | A kind of preparation method of granules of civil medicine-food two-purpose Erythropalum Scandens Blume |
| CN109045081A (en) * | 2018-09-05 | 2018-12-21 | 广西中医药大学 | The extracting method and diuresis of Erythropalum Scandens Blume |
| CN109122879A (en) * | 2018-08-27 | 2019-01-04 | 广西南亚热带农业科学研究所 | A kind of Queensland nut fruit milk drink and preparation method thereof |
| CN113274478A (en) * | 2021-07-12 | 2021-08-20 | 林雪玉 | Traditional Chinese medicine fermentation preparation for treating gout and preparation method thereof |
| CN113303472A (en) * | 2021-06-08 | 2021-08-27 | 广西壮族自治区农业科学院 | Functional beverage produced by using litsea cubeba and preparation process thereof |
| CN114195908A (en) * | 2021-12-20 | 2022-03-18 | 右江民族医学院 | Enzyme extraction and purification process of polysaccharide from leaves of litsea cubeba |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106929353A (en) * | 2017-02-14 | 2017-07-07 | 广西肽王生物科技有限公司 | A kind of antidepressant Moringa peptide method for preparing medicated wine |
| CN107494817A (en) * | 2017-08-25 | 2017-12-22 | 广西中医药大学 | A kind of hypoglycemic tea |
| CN107951922A (en) * | 2017-12-08 | 2018-04-24 | 杨英珠 | Erythropalum Scandens Blume deacidification tea and preparation method thereof |
| CN108743634A (en) * | 2018-06-26 | 2018-11-06 | 广西医科大学 | A kind of preparation method of granules of civil medicine-food two-purpose Erythropalum Scandens Blume |
| CN109122879A (en) * | 2018-08-27 | 2019-01-04 | 广西南亚热带农业科学研究所 | A kind of Queensland nut fruit milk drink and preparation method thereof |
| CN109045081A (en) * | 2018-09-05 | 2018-12-21 | 广西中医药大学 | The extracting method and diuresis of Erythropalum Scandens Blume |
| CN113303472A (en) * | 2021-06-08 | 2021-08-27 | 广西壮族自治区农业科学院 | Functional beverage produced by using litsea cubeba and preparation process thereof |
| CN113274478A (en) * | 2021-07-12 | 2021-08-20 | 林雪玉 | Traditional Chinese medicine fermentation preparation for treating gout and preparation method thereof |
| CN113274478B (en) * | 2021-07-12 | 2022-04-29 | 林雪玉 | Traditional Chinese medicine fermentation preparation for treating gout and preparation method thereof |
| CN114195908A (en) * | 2021-12-20 | 2022-03-18 | 右江民族医学院 | Enzyme extraction and purification process of polysaccharide from leaves of litsea cubeba |
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Application publication date: 20170426 |