CN106577721A - Bactericidal composition containing benzisothiazolinone and moroxydine hydrochloride - Google Patents
Bactericidal composition containing benzisothiazolinone and moroxydine hydrochloride Download PDFInfo
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- CN106577721A CN106577721A CN201610993692.3A CN201610993692A CN106577721A CN 106577721 A CN106577721 A CN 106577721A CN 201610993692 A CN201610993692 A CN 201610993692A CN 106577721 A CN106577721 A CN 106577721A
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- moroxydine hydrochloride
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
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- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
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- General Health & Medical Sciences (AREA)
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Abstract
The invention provides a bactericidal composition containing two effective components A and B. The active component A is a compound having a structure represented by the formula (I). The active component B is moroxydine hydrochloride. The weight ratio of the component A to the component B is 1:0.1-30. The invention also provides a preparation method and applications of the composition. The test results show that the provided bactericidal composition has a prominent synergistic effect; more importantly, the using amount is reduced, and thus the using cost is reduced. The bactericidal composition can effectively control crop diseases caused by special bacteria or fungi. The bactericides with different action mechanisms and action modes are compounded to enlarge the bactericidal spectrum, retard the drug resistance of fungi and bacteria, and improve the control effect.
Description
Technical field
The invention belongs to agriculture plant protection field, more particularly to a kind of bactericidal composition with improvement performance, tool
Say it is to be related to a kind of bactericidal composition comprising BIT class and moroxydine hydrochloride body.
Background technology
BIT class compound is a kind of new, wide-spectrum bactericide, is mainly used in preventing and treating and treating Cereal
The various bacterias such as crop, veterinary antibiotics, fungal disease.Its bactericidal action mechanism, it is main to include destruction pathogenic bacteria nucleus knot
Structure so as to lose the metabolism of cardia and exhaustion death and interference pathogenic bacteria cell so as to physiologic derangement, ultimately results in dead
Die two aspects.Disease early period of origination using can effective protection plant do not infected by pathogen, disease increases as one sees fit after occurring
Dosage can substantially control spreading for pathogenic bacteria, so as to the dual function for reaching protection and root out.
Moroxydine hydrochloride (Moroxydine hydrochloride) is a kind of wide spectrum, hypovirus control agent.After dilution
Medicinal liquid spray application to after plant leaf surface, medicament can be entered in plant body by aqueous vapor hole, suppress or destroy nucleic acid and lipoprotein
Formed, prevent the reproduction process of virus, play the effect of preventing and treating virus.Not only to Virus Diseases of Rice, banded sclerotial blight, full rot, red
The fungoids pathological changes of mildew, rice blast and other field crops and bacillary have potent anti-with virosiss cross infection disease
Control and go out malicious effect, while also having preventing and treating well to the virosiss of the gourd, fruit and vegetable class such as Fructus Lycopersici esculenti, Fructus Capsici, Fructus Cucumidis sativi, Brassica campestris L, Chinese cabbage
And therapeutic effect.
Actual pesticide experience have shown that, repeats and single-minded applies a kind of reactive compound to prevent and treat harmful fungoid very
To cause the fast selective of fungal bacterial strain in the case of many, be that reduction refractory fungal bacterial strain is selectively dangerous, at present generally
Harmful fungoid is prevented and treated using the mixture of different activities compound.By the way that the reactive compound with the different mechanisms of action is entered
Row combination, can delaying drug resistance produce, reduce amount of application, reduce cost accounting.
The content of the invention
The purpose of the present invention is to be directed to antibacterial resistance and pedo relict problem in actual applications, filters out difference and kills
The antibacterial of bacterium principle is compounded, and obtains a kind of new microbicide compositions, to improve bactericidal agent for preventing and treating effect, delaying drug resistance
Produce, reduce amount of application, reduce cost accounting.
It is a further object to provide preventing and treating in agriculture field comprising two kinds of effective constituents As and B bactericidal compositions
Application in corps diseases.
The purpose of the present invention can be reached by following measures：
A kind of microbicide compositions with potentiation, said composition includes two kinds of active components of A and B, wherein activity
Component A is the structural compounds with formula I, and active component B is moroxydine hydrochloride.
In formula I, R is selected from H or C1～C8Alkyl.
C in the present invention1～C8Alkyl refers to the straight or branched alkyl containing 1 to 8 carbon atom, and it includes C1Alkyl
(such as methyl), C2Alkyl (such as ethyl), C3Alkyl (such as n-pro-pyl, isopropyl), C4Alkyl (as normal-butyl, isobutyl group, the tert-butyl group,
Sec-butyl), C5Alkyl (such as n-pentyl), C6Alkyl, C7Alkyl, C8Alkyl.It includes but is not limited to C1～C6Alkyl, C1～C5
Alkyl, C1～C4Alkyl etc..
In a kind of preferred version, R is selected from H or C1～C4Alkyl.
In a kind of preferred scheme, R is selected from H ,-CH3Or-C4H9。
In formula I, when R is H, A is BIT (abbreviation BIT in description).
In formula I, when R is CH3When, A be 2- methyl isophthalic acids, 2- benzisothiazole-3-ketones (abbreviation MBIT in description).
In formula I, when R is C4H9When, A is 2- butyl-BIT, and " butyl " in the formula is preferably
Normal-butyl (abbreviation BBIT in description).
Inventor is found by experiment that the compositionss of the present invention are used to prevent and treat crops antibacterial or fungal disease, prevent and treat
Potentiation is obvious, it is often more important that amount of application is reduced, and reduces use cost.Compound structure type containing component A and component B is not
Together, mechanism of action is different, and both can expand fungicidal spectrum at compounding, and can to a certain extent delay the product of pathogen resistance
No interactions resistance between raw and development speed, and component A and component B.
Weight ratio between two components in microbicide compositions of the present invention is 1:0.1～30.To make the medicine between two components
Effect potentiation is more notable, and the weight ratio between component A and the component of component B two can further be optimized to 1：1～20.
In a kind of preferred scheme, the weight ratio between A and the components of B two arbitrarily can enter in the range of following proportionings
Row adjustment 10:1、9:1、8:1、7:1、6:1、5:1、4:1、3:1、2:1、1:1、1:2、1:3、1:4、1:5、1:6、1:7、1:8、1:
9、1:10、1:11、1:12、1:13、1:14、1:15、1:16、1:17、1:18、1:19、1:20、1:21、1:22、1:23、1:24、
1:25、1:26、1:27、1:28、1:29、1:30, it is also possible to selected in the range of two proportionings of any of the above are constituted,
These ratios can be understood as weight ratio, it is also possible to including mol ratio.
The compositionss of the present invention can be made up the dosage form allowed on pesticide of active component and insecticides adjuvant or adjuvant.Enter one
Step, said composition is made up of the active component of 2～80% weight portions and the insecticides adjuvant of 98～20% weight portions and permit on pesticide
Perhaps dosage form.
The invention provides the bactericidal composition comprising component A and component B is in terms of agriculture field preventing and treating corps diseases
Purposes, particularly prevent and treat some crops funguses or bacterial disease in terms of purposes.
Above-mentioned composition specifically can be comprising insecticides adjuvant or adjuvant, such as carrier, solvent, dispersant, wetting agent, gluing
One or more in agent, thickening agent, binding agent, surfactant or fertilizer etc..Can mix during administration conventional
Auxiliary agent.
Suitable auxiliary agent or adjuvant can be solid or liquid, and they are typically the material commonly used during formulation,
For example natural or regeneration mineral, solvent, dispersant, wetting agent, adhesive, thickening agent, binding agent.
The application process of the present composition includes the compositionss of the present invention are used for the aerial partss of plant growing, especially
It is leaf portion or blade face.Can select to soak seed or be applied in controlling object surface.The frequency and amount of application of administration depends on pathogen
Biology and weather conditions of existence.Can be by the growth place of plant, such as rice field is soaked with the liquid preparation of compositionss, or
Person is in solid form applied to compositionss in soil, and such as in granular form (soil application), compositionss can be planted by soil Jing
Thing root is entered in plant body (systemic action).
The compositionss of the present invention can be prepared into acceptable various dosage forms on pesticide, including but not limited to cream, suspension
Agent, wettable powder, water dispersible granules, powder, granule, water preparation, aqueous emulsion, microemulsion, poison bait, mother solution, female powder etc., in one kind
In preferred version, the dosage form of the present invention adopts wettable powder, suspending agent, water dispersible granules, aqueous emulsion or microemulsion.According to this
The property of a little compositionss and apply purpose and the ambient conditions that compositionss to be reached, can select by compositionss to spray,
Atomizing, dust, broadcast sowing or sprinkle the method poured or the like and apply.
Can with known method can by the present invention compositionss be prepared into various dosage forms, can by effective ingredient with help
Agent, such as solvent, solid carrier, can uniformly mix together with surfactant when needing, grind, and be prepared into required agent
Type.
Above-mentioned solvent may be selected from aromatic hydrocarbon, preferably containing 8-12 carbon atom, such as xylene mixture or substituted benzene, and phthalein
Esters of gallic acid, such as Dibutyl phthalate or phthalandione two is sad, fat hydrocarbon, such as thiacyclohexane or paraffin, alcohol and ethylene glycol and their ether
And ester, such as ethanol, ethylene glycol, ethylene glycol monomethyl；Ketone, such as cyclohexanone, such as highly polar solvent, N- methyl -2- pyrrolidines
Ketone, dimethyl sulfoxide or dimethylformamide, and vegetable oil or vegetable oil, such as soybean oil.
Above-mentioned solid carrier, is such as used for powder and dispersibles the typically natural mineral fillers of agent, such as Talcum, kaolinite
Soil, montmorillonite or active hargil.In order to manage the physical property of compositionss, it is also possible to add polymolecularity silicic acid or polymolecularity
Adsorpting polymerization thing carrier, such as granulated adsorptive carriers or non-adsorbed carrier, suitable granulated adsorptive carriers are porous types, such as floating
Stone, Bentonite or bentonite；Suitable non-adsorbed carrier such as calcite or sand.Further, it is possible to use substantial amounts of inorganic in nature or having
The prefabricated material for granulating of machine property is used as carrier, particularly dolomite.
According to the chemical property of effective ingredient in the present composition, suitable surfactant is lignin sulfonic acid, naphthalene
Sulfonic acid, phenolsulfonic acid, alkali salt or amine salt, alkylaryl sulfonatess, alkyl sulfate, alkylsulfonate, fatty alcohol sulfur
The condensation substance of hydrochlorate, fatty acid and sulphated fatty alcohol glycol ether, also sulfonated naphthalene and naphthalene derivativeses and formaldehyde, naphthalene or naphthalene sulphur
Acid and phenol and the condensation substance of formaldehyde, NONIN HS 240, ethoxylated isooctyl-phenol, octyl phenol, nonyl phenol, alkyl
Aryl polyglycol ether, tributyl benzene polyglycol ether, three stearyl phenyl polyglycol ethers, alkyl aryl polyether alcohol, ethoxy
Base Oleum Ricini, polyoxyethylene alkyl ether, ethylene oxide condensation substance, ethoxylation polyoxypropylene, the contracting of lauric acid polyglycol ether
Aldehyde, sorbitol ester, lignin sulfite waste liquor and methylcellulose.
When liquid or solid dosage formss is prepared, first active component A can be dissolved in into some specific alkaline matters, form benzene
And isothiazoline slaine, suitable alkaline matter includes：Alkali carbonate, alkali metal hydroxide are (such as sodium hydroxide, hydrogen
Potassium oxide), alkali metal alkoxyl carbonate, alkali metal alcoholates or Bis(methoxy)magnesium.
Two kinds of effective ingredient show as synergistic effect in the compositionss of the present invention, and the activity of said composition is than using individualized
The expected summation of activity of compound, and the independent activity of single compound is more notable.Synergistic effect shows as allowing amount of application
Reduce, broader antifungal control spectrum, instant effect, more longlasting prevention effect, by only once or minority is applied several times more
Good control plant pest funguses and broaden the possible administration interval time.These characteristics are plant epiphyte control practices
During especially need.
The microbicide compositions of the present invention can be applicable to agriculture field preventing and treating corps diseases aspect, targeted concrete disease
Disease includes but is not limited to wheat diseases (such as：Wheat scab, wheat powdery mildew, wheat rust etc.), rice disease (such as：Oryza sativa L.
Banded sclerotial blight, rice green smut, rice blast, paddy bacterial streak etc.), maize diseases (such as：Smut of maize, Semen Maydiss are big
Pinta, corn southern leaf blight), cucumber disease (such as：The bacillary angle speckle of cucumber downy mildew, powdery mildew of cucumber, cucumber anthracnose, Fructus Cucumidis sativi
Disease etc.), tomato disease (such as：Anthracnose of tomato, graw mold of tomato, tomato bacterial angular leaf spot etc.), grape disease (such as：Fructus Vitis viniferae
Downy mildew, grape grey mould, uncinula necator), apple disease (such as ring rot of apple, apple anthracnose), citrus disease (Citrus chachiensis Hort.
Fructus Citri tangerinae Peptic Ulcerss, Citrus scab simultaneously, citrus anthracnose), tobacco diseases (wildfire) etc..
Other features for showing of the bactericidal composition of the present invention are mainly shown as：1st, compositionss mixture of the invention tool
There is obvious potentiation；2nd, because two single dose chemical constitutions of this compositions are widely different, the mechanism of action is entirely different, no
There is cross resistance, can delay two single doses that produced resistance problem is used alone；3rd, compositionss of the invention to crop safety,
Preventive effect is good.Tests prove that, microbicide compositions stable chemical nature of the present invention, potentiation significantly, shows bright to controlling object
Aobvious potentiation and complementary action.
Specific embodiment
In order that the objects, technical solutions and advantages of the present invention become more apparent, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that specific embodiment described herein is not used to limit only to explain the present invention
The fixed present invention, all any modification, equivalent and improvement made within the spirit and principles in the present invention etc., should be included in
Within protection scope of the present invention.
Percentage ratio is weight percentage in all formula of following examples.The processing work of the various preparations of the present composition
Skill is prior art, can be varied from according to different situations.
First, dosage form prepares embodiment
(1) processing of water dispersible granules and embodiment
By active components A and moroxydine hydrochloride, mix homogeneously in the ratio of formula with auxiliary agent and filler, Jing comminution by gas stream into
Wettable powder, adds a certain amount of water mixing extruder grain, and water dispersible granules product is obtained after drying screening.
(1) active component A (BIT) prepares water dispersible granules with moroxydine hydrochloride
Embodiment 1：18%BIT moroxydine hydrochloride water dispersible granules
BIT 3%, moroxydine hydrochloride 15%, sulfonate sodium 6%, ammonium sulfate 5%, sodium lauryl sulphate 6%, magnesium silicate
Aluminum 5%, Kaolin complements to 100%.
Embodiment 2：63%BIT moroxydine hydrochloride water dispersible granules
BIT 3%, moroxydine hydrochloride 60%, Nekal BX 10%, carbamide 6%, fatty alcohol-polyoxyethylene ether 5%, hydroxyl
Cellulose 4%, kieselguhr complements to 100%.
(2) active component A (MBIT) prepares water dispersible granules with moroxydine hydrochloride
Embodiment 3：18%MBIT moroxydine hydrochloride water dispersible granules
MBIT 3%, moroxydine hydrochloride 15%, remaining component is prepared according to the method for embodiment 1.
Embodiment 4：63%MBIT moroxydine hydrochloride water dispersible granules
MBIT 3%, moroxydine hydrochloride 60%, remaining component is prepared according to the method for embodiment 2.
(3) active component A (BBIT) prepares aqueous emulsion with moroxydine hydrochloride
Embodiment 5：18%BBIT moroxydine hydrochloride water dispersible granules
BBIT 3%, moroxydine hydrochloride 15%, remaining component is prepared according to the method for embodiment 1.
Embodiment 6：63%BBIT moroxydine hydrochloride water dispersible granules
BBIT 3%, moroxydine hydrochloride 60%, remaining component is prepared according to the method for embodiment 2.
(2) processing of suspending agent and embodiment
By active component activity packet A and active component B, with each component such as dispersant, wetting agent, thickening agent and water by matching somebody with somebody
The ratio mix homogeneously of side, Jing after sand milling and/or high speed shear, obtains semi-finished product, mends after analysis and is mixed with water filtration i.e.
Obtain finished product.
(1) active component A (BIT) prepares suspending agent with moroxydine hydrochloride
Embodiment 7：22%BIT moroxydine hydrochloride suspending agents
BIT 2%, moroxydine hydrochloride 20%, sodium lauryl sulphate 6%, xanthan gum 4%, ethylene glycol 5%, silicone oil
0.01%, water complements to 100%.
Embodiment 8：48%BIT moroxydine hydrochloride suspending agents
BIT 3%, moroxydine hydrochloride 45%, polyacrylamide 11%, xanthan gum 5%, Propylene Glycol 10%, poly dimethyl silicon
Oxygen alkane 0.03%, water complements to 100%.
(2) active component A (MBIT) prepares suspending agent with moroxydine hydrochloride
Embodiment 9：22%MBIT moroxydine hydrochloride suspending agents
MBIT 2%, moroxydine hydrochloride 20%, remaining component is prepared according to the method for embodiment 7.
Embodiment 10：48%MBIT moroxydine hydrochloride suspending agents
MBIT 3%, moroxydine hydrochloride 45%, remaining component is prepared according to the method for embodiment 8.
(3) active component A (BBIT) prepares suspending agent with moroxydine hydrochloride
Embodiment 11：22%BBIT moroxydine hydrochloride suspending agents
BBIT 2%, moroxydine hydrochloride 20%, remaining component is prepared according to the method for embodiment 7.
Embodiment 12：48%BBIT moroxydine hydrochloride suspending agents
BBIT 3%, moroxydine hydrochloride 45%, remaining component is prepared according to the method for embodiment 8.
(3) processing of wettable powder and embodiment
Active components A and B activity composition and various auxiliary agents and filler etc. are sufficiently mixed in proportion, Jing ultrafine crusher powder
Prepared wettable powder after broken.
(1) active component A (BIT) prepares wettable powder with moroxydine hydrochloride
Embodiment 13:5.5%BIT moroxydine hydrochloride wettable powders
BIT 5%, moroxydine hydrochloride 0.5%, sodium lauryl sulphate 2%, benzene sulfonic acid sodium salt 2%, bentonite 3% is concavo-convex
Rod soil complements to 100%.
Embodiment 14:10%BIT moroxydine hydrochloride wettable powders
BIT 5%, moroxydine hydrochloride 5%, methyl anyl alcohol 2%, sodium alklyarylsulfonate 2%, sodium bicarbonate 3%, Linesless charcoal
It is black to complement to 100%.
Embodiment 15:46.5%BIT moroxydine hydrochloride wettable powders
BIT 1.5%, moroxydine hydrochloride 45%, spaonin powder 10%, lignin sulfonic acid sodium salt 12%, ammonium sulfate 8%, kaolinite
Soil complements to 100%.
(2) active component A (MBIT) prepares wettable powder with moroxydine hydrochloride
Embodiment 16：5.5%MBIT moroxydine hydrochloride wettable powders
MBIT 5%, moroxydine hydrochloride 0.5%, remaining component is prepared according to the method for embodiment 13.
Embodiment 17：10%MBIT moroxydine hydrochloride wettable powders
MBIT5%, moroxydine hydrochloride 5%, remaining component is prepared according to the method for embodiment 14.
Embodiment 18：46.5%MBIT moroxydine hydrochloride wettable powders
MBIT 1.5%, moroxydine hydrochloride 45%, remaining component is prepared according to the method for embodiment 15.
(3) active component A (BBIT) prepares wettable powder with moroxydine hydrochloride
Embodiment 19：5.5%BBIT moroxydine hydrochloride wettable powders
BBIT 5%, moroxydine hydrochloride 0.5%, remaining component is prepared according to the method for embodiment 13.
Embodiment 20：10%BBIT moroxydine hydrochloride wettable powders
BBIT 5%, moroxydine hydrochloride 5%, remaining component is prepared according to the method for embodiment 14.
Embodiment 21：46.5%BBIT moroxydine hydrochloride wettable powders
BBIT 1.5%, moroxydine hydrochloride 45%, remaining component is prepared according to the method for embodiment 15.
2nd, drug effect checking test
(1) Assays Example
The incidence of whole strain blade is investigated according to test grade scale, disease index and prevention effect is calculated.
Prevention effect is converted into into niqueMin (y), liquor strength (μ g/ml) is converted into logarithm value (x), with method of least square
Concentration EC50 in calculating virulence equation and suppressing, according to the abundant methods of Sun Yun the toxicity index and co-toxicity coefficient (CTC) of medicament are calculated.
Actual measurement toxicity index (ATI)=(standard agent EC50/ reagent agents EC50) * 100
Percentage composition+B medicament toxicity index * the mixtures of A in theoretical toxicity index (TTI)=A medicament toxicity index * mixtures
The percentage composition of middle B
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (ATI)/mixture theoretical toxicity index (TTI)] * 100
CTC≤80, compositionss show as antagonism, 80 ＜ CTC ＜ 120, and compositionss show as summation action, and CTC >=
120, compositionss show as potentiation.
1st, BIT and moroxydine hydrochloride compounding are tested Fructus Capsici sclerotiniose toxicity test
Table 1.BIT is compounded to Fructus Capsici sclerotiniose toxicity test interpretation of result with moroxydine hydrochloride
As a result (table 1) shows that BIT compounds the prevention effect to Fructus Capsici sclerotiniose and significantly improves with moroxydine hydrochloride, especially
In its proportioning 1：The virulence coefficient of 0.1-30 is more than 130.Illustrate that both compoundings have significant to the preventing and treating of Fructus Capsici sclerotiniose
Potentiation.
2nd, MBIT and moroxydine hydrochloride compounding are tested leaf muld of tomato toxicity test
Table 2.MBIT is compounded to leaf muld of tomato toxicity test interpretation of result with moroxydine hydrochloride
As a result (table 2) shows that BIT compounds the prevention effect to leaf muld of tomato and significantly improves with moroxydine hydrochloride, especially
In its proportioning 1：The virulence coefficient of 0.1-30 is more than 176.Illustrate that both compoundings have significant to leaf muld of tomato preventing and treating
Potentiation.
3rd, BBIT and moroxydine hydrochloride are tested watermelon anthrax toxicity test
Table 3.BBIT is compounded to watermelon anthrax toxicity test interpretation of result with moroxydine hydrochloride
As a result (table 3) shows that BBIT compounds the prevention effect to watermelon anthrax and significantly improves with moroxydine hydrochloride, explanation
The two compounding has significant potentiation to watermelon anthrax preventing and treating.
(2) field efficacy checking test
Test method：At the initial stage of a disease, first time spraying being carried out immediately, second dispenser being carried out after 7 days, each processes 4
Individual cell, each square meter of cell 20.11 days investigation statisticses incidences before medicine and after second medicine, 5 points of each cell is random
Sampling, 5 plants of crops of per investigation, investigates the lesion area in whole strain per blade and accounts for the percentage rate of blade area and be classified, and calculates
Disease index and prevention effect.
Expected preventive effect (%)=X+Y-XY/100 (wherein, X, Y are single dose preventive effect)
Grade scale：
0 grade：Disease-free spot；
1 grade：Leaf spot lesion is less than 5, and length is less than 1cm；
3 grades：Leaf spot lesion 6-10, part scab length is more than 1cm；
5 grades：Leaf spot lesion 11-25, part scab is linked to be piece, and lesion area accounts for the 10-25% of leaf area；
7 grades：Leaf spot lesion more than 26, scab is linked to be piece, and lesion area accounts for the 26-50% of leaf area；
9 grades：Scab is linked to be piece, and lesion area accounts for more than the 50% of leaf area or full leaf is withered.
1st, BIT and moroxydine hydrochloride compounding field efficacy experiment
The BIT of table 4 is with moroxydine hydrochloride mixture to stripe disease prevention effect
Measurement result (table 4) shows that BIT is significantly improved with the compounding of moroxydine hydrochloride to stripe disease preventive effect,
Illustrate that the two compounding has significant potentiation to stripe disease.
2nd, MBIT and moroxydine hydrochloride compounding field efficacy experiment
The MBIT of table 5 is with moroxydine hydrochloride mixture to tobacco virus prevention effect
Measurement result (table 5) shows that MBIT is significantly improved with moroxydine hydrochloride mixture to the preventive effect of tobacco virus, explanation
The two compounding has significant potentiation to tobacco virus.
3rd, BBIT and moroxydine hydrochloride compounding field efficacy experiment
The BBIT of table 6 is with moroxydine hydrochloride mixture to ring rot of apple prevention effect
Measurement result (table 6) shows that BBIT is significantly improved with moroxydine hydrochloride mixture to the preventive effect of ring rot of apple, explanation
The two compounding has significant potentiation to ring rot of apple.
Claims (8)
1. a kind of microbicide compositions, it is characterised in that described compositionss include two kinds of active components of A and B, wherein activearm
A is divided to be the structural compounds with formula I, active component B is moroxydine hydrochloride, and the weight ratio between two components is 1:0.1～
30
In formula I, R is selected from H or C1～C8Alkyl.
2. microbicide compositions according to claim 1, it is characterised in that in formula I, R is selected from H or C1～C4Alkyl.
3. microbicide compositions according to claim 1, it is characterised in that in formula I, R is preferably selected from H ,-CH3Or-
C4H9, corresponding active component A is respectively BIT, 2- methyl isophthalic acids, 2- benzisothiazole-3-ketones or
2- butyl -1,2- benzisothiazole-3-ketones.
4. microbicide compositions according to claim 1, it is characterised in that the weight ratio of active component A and active component B
For 1:1～20.
5. microbicide compositions according to any one in Claims 1 to 4, it is characterised in that said composition by activity into
Divide and the dosage form allowed on pesticide is made with insecticides adjuvant or adjuvant.
6. microbicide compositions according to claim 5, it is characterised in that described dosage form is wettable powder, suspends
Agent, water dispersible granules, aqueous emulsion or microemulsion.
7. microbicide compositions according to claim 5 or 6, it is characterised in that the insecticides adjuvant or adjuvant are selected from carrying
One or more in body, solvent, dispersant, wetting agent, adhesive, thickening agent, binding agent, surfactant or fertilizer.
8. the microbicide compositions in claim 1～7 described in any one are in terms of agriculture field preventing and treating corps diseases
Purposes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610993692.3A CN106577721A (en) | 2016-11-11 | 2016-11-11 | Bactericidal composition containing benzisothiazolinone and moroxydine hydrochloride |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610993692.3A CN106577721A (en) | 2016-11-11 | 2016-11-11 | Bactericidal composition containing benzisothiazolinone and moroxydine hydrochloride |
Publications (1)
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110037041A (en) * | 2019-04-30 | 2019-07-23 | 三河市霍夫曼化学品制造有限公司 | A kind of isothiazolinone built-up microemulsion type biocide mildewcide, preparation method and application |
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| CN103704234A (en) * | 2014-01-07 | 2014-04-09 | 中国农业科学院植物保护研究所 | Composite for preventing and controlling agricultural bacterial disease |
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| CN105685061A (en) * | 2016-02-29 | 2016-06-22 | 陕西西大华特科技实业有限公司 | Application of benziothiazolinone in preventing and treating potato seed-borne diseases and promoting rooting and germination |
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| CN110037041A (en) * | 2019-04-30 | 2019-07-23 | 三河市霍夫曼化学品制造有限公司 | A kind of isothiazolinone built-up microemulsion type biocide mildewcide, preparation method and application |
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