CN106573935B - 6,7-二氢吡唑并[1,5-a]吡嗪-4(5H)-酮化合物和其作为MGLUR2受体的负性别构调节物的用途 - Google Patents

6,7-二氢吡唑并[1,5-a]吡嗪-4(5H)-酮化合物和其作为MGLUR2受体的负性别构调节物的用途 Download PDF

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CN106573935B
CN106573935B CN201580041306.4A CN201580041306A CN106573935B CN 106573935 B CN106573935 B CN 106573935B CN 201580041306 A CN201580041306 A CN 201580041306A CN 106573935 B CN106573935 B CN 106573935B
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CN106573935A (zh
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J.I.安德烈-吉
M.L.M.范戈尔
A.A.特拉班科-苏亚雷兹
A.I.德鲁卡斯奥里瓦雷斯
迪伊戈 S-A.阿龙索-德
O.德加多-冈扎勒兹
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Janssen Pharmaceutica NV
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201580041306.4A 2014-08-01 2015-07-30 6,7-二氢吡唑并[1,5-a]吡嗪-4(5H)-酮化合物和其作为MGLUR2受体的负性别构调节物的用途 Expired - Fee Related CN106573935B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14179599 2014-08-01
EP14179599.7 2014-08-01
PCT/EP2015/067533 WO2016016381A1 (en) 2014-08-01 2015-07-30 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5h)-one compounds and their use as negative allosteric modulators of mglur2 receptors

Publications (2)

Publication Number Publication Date
CN106573935A CN106573935A (zh) 2017-04-19
CN106573935B true CN106573935B (zh) 2020-01-17

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CN201580041306.4A Expired - Fee Related CN106573935B (zh) 2014-08-01 2015-07-30 6,7-二氢吡唑并[1,5-a]吡嗪-4(5H)-酮化合物和其作为MGLUR2受体的负性别构调节物的用途

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US (1) US10112949B2 (https=)
EP (1) EP3174880B1 (https=)
JP (1) JP6615864B2 (https=)
KR (1) KR102531693B1 (https=)
CN (1) CN106573935B (https=)
AR (1) AR101393A1 (https=)
AU (1) AU2015295299B2 (https=)
BR (1) BR112017001998A2 (https=)
CA (1) CA2954218C (https=)
EA (1) EA031038B1 (https=)
ES (1) ES2702192T3 (https=)
JO (1) JO3601B1 (https=)
MX (1) MX2017001453A (https=)
TW (1) TWI696625B (https=)
WO (1) WO2016016381A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20150177B1 (ar) 2014-08-01 2021-08-17 Janssen Pharmaceutica Nv مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2
JOP20150179B1 (ar) 2014-08-01 2021-08-17 Janssen Pharmaceutica Nv مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2
AU2015357167B2 (en) * 2014-12-03 2020-06-25 Janssen Pharmaceutica Nv 6,7-dihydropyrazolo(1,5-alpha)pyrazin-4(5H)-one compounds and their use as negative allosteric modulators of mGluR2 receptors
JP6861154B2 (ja) 2014-12-03 2021-04-21 ヤンセン ファーマシューティカ エヌ．ベー． 放射標識されたｍＧｌｕＲ２ ＰＥＴリガンド
EA037941B1 (ru) 2015-12-18 2021-06-09 Янссен Фармацевтика Нв ЛИГАНДЫ mGluR2/3 ДЛЯ PET, МЕЧЕННЫЕ РАДИОАКТИВНЫМИ ИЗОТОПАМИ
LT3389727T (lt) * 2015-12-18 2020-10-12 Janssen Pharmaceutica Nv Radioaktyviai pažymėti mglur2/3 pet ligandai
KR102688238B1 (ko) 2017-11-24 2024-07-25 스미토모 파마 가부시키가이샤 6, 7-디히드로 피라졸로[1, 5-a]피라지논 유도체 및 그 의약 용도

Citations (5)

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WO2006050803A1 (de) * 2004-11-12 2006-05-18 Bayer Cropscience Ag Substituierte bi- und tricyclische pyrazol-derivate verfahren zur herstellung und verwendung als herbizide und pflanzenwachstumsregulatoren
WO2012083224A1 (en) * 2010-12-17 2012-06-21 Vanderbilt University Bicyclic triazole and pyrazole lactams as allosteric modulators of mglur5 receptors
WO2013192343A1 (en) * 2012-06-20 2013-12-27 Vanderbilt University Substituted bicyclic alkoxy pyrazole analogs as allosteric modulators of mglur5 receptors
WO2013192350A1 (en) * 2012-06-20 2013-12-27 Vanderbilt University Substituted bicyclic aralkyl pyrazole lactam analogs as allosteric modulators of mglur5 receptors
WO2013192347A1 (en) * 2012-06-20 2013-12-27 Vanderbilt University Substituted bicyclic cycloalkyl pyrazole lactam analogs as allosteric modulators of mglur5 receptors

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DE602006012815D1 (de) * 2005-03-23 2010-04-22 Hoffmann La Roche Acetylenylpyrazolopyrimidinderivate als mglur2-antagonsten
CN102439008B (zh) 2009-05-12 2015-04-29 杨森制药有限公司 1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途
WO2012172093A1 (en) * 2011-06-17 2012-12-20 Merz Pharma Gmbh & Co. Kgaa Dihydroindolizine derivate as metabotropic glutamate receptor modulators
CN104010504B (zh) 2011-11-03 2016-04-06 默沙东公司 作为mGluR2负变构调节剂的喹啉甲酰胺和喹啉甲腈的衍生物、组合物、及其用途
EP2666775A1 (en) 2012-05-21 2013-11-27 Domain Therapeutics Substituted pyrazoloquinazolinones and pyrroloquinazolinones as allosteric modulators of group II metabotropic glutamate receptors
EP2925292A1 (en) * 2012-10-23 2015-10-07 F. Hoffmann-La Roche AG Mglu2/3 antagonists for the treatment of autistic disorders
WO2016016382A1 (en) * 2014-08-01 2016-02-04 Janssen Pharmaceutica Nv 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5h)-one compounds and their use as negative allosteric modulators of mglur2 receptors

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006050803A1 (de) * 2004-11-12 2006-05-18 Bayer Cropscience Ag Substituierte bi- und tricyclische pyrazol-derivate verfahren zur herstellung und verwendung als herbizide und pflanzenwachstumsregulatoren
WO2012083224A1 (en) * 2010-12-17 2012-06-21 Vanderbilt University Bicyclic triazole and pyrazole lactams as allosteric modulators of mglur5 receptors
WO2013192343A1 (en) * 2012-06-20 2013-12-27 Vanderbilt University Substituted bicyclic alkoxy pyrazole analogs as allosteric modulators of mglur5 receptors
WO2013192350A1 (en) * 2012-06-20 2013-12-27 Vanderbilt University Substituted bicyclic aralkyl pyrazole lactam analogs as allosteric modulators of mglur5 receptors
WO2013192347A1 (en) * 2012-06-20 2013-12-27 Vanderbilt University Substituted bicyclic cycloalkyl pyrazole lactam analogs as allosteric modulators of mglur5 receptors

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Publication number Publication date
AR101393A1 (es) 2016-12-14
JO3601B1 (ar) 2020-07-05
KR20170032464A (ko) 2017-03-22
JP2017523201A (ja) 2017-08-17
JP6615864B2 (ja) 2019-12-04
US10112949B2 (en) 2018-10-30
AU2015295299B2 (en) 2019-05-02
ES2702192T3 (es) 2019-02-27
WO2016016381A1 (en) 2016-02-04
BR112017001998A2 (pt) 2017-12-12
TWI696625B (zh) 2020-06-21
EP3174880A1 (en) 2017-06-07
EA201692496A1 (ru) 2017-06-30
TW201609742A (zh) 2016-03-16
MX2017001453A (es) 2017-05-11
US20180222908A1 (en) 2018-08-09
CA2954218A1 (en) 2016-02-04
CA2954218C (en) 2022-11-29
EA031038B1 (ru) 2018-11-30
AU2015295299A1 (en) 2017-01-19
CN106573935A (zh) 2017-04-19
EP3174880B1 (en) 2018-09-26
KR102531693B1 (ko) 2023-05-10

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