CN106573907B - 喹啉衍生物及其用于神经退化性疾病的用途 - Google Patents

喹啉衍生物及其用于神经退化性疾病的用途 Download PDF

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Publication number
CN106573907B
CN106573907B CN201580041824.6A CN201580041824A CN106573907B CN 106573907 B CN106573907 B CN 106573907B CN 201580041824 A CN201580041824 A CN 201580041824A CN 106573907 B CN106573907 B CN 106573907B
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quinoline
amide
carboxylic acid
cyclohexylmethyl
difluoro
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Chinese (zh)
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CN106573907A (zh
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S·R·卡拉
Y·肖
J·希尼萨米
J·加雅德凡
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Merck Patent GmbH
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Merck Patent GmbH
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/08—Antiallergic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201580041824.6A 2014-06-05 2015-06-04 喹啉衍生物及其用于神经退化性疾病的用途 Expired - Fee Related CN106573907B (zh)

Applications Claiming Priority (3)

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US201462008012P 2014-06-05 2014-06-05
US62/008,012 2014-06-05
PCT/US2015/034108 WO2015187905A1 (en) 2014-06-05 2015-06-04 Novel quinoline derivatives and their use in neurodegenerative diseases

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CN106573907A CN106573907A (zh) 2017-04-19
CN106573907B true CN106573907B (zh) 2020-09-08

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US (2) US9399623B2 (enrdf_load_stackoverflow)
EP (1) EP3152192A1 (enrdf_load_stackoverflow)
JP (1) JP6692759B2 (enrdf_load_stackoverflow)
CN (1) CN106573907B (enrdf_load_stackoverflow)
AR (1) AR100724A1 (enrdf_load_stackoverflow)
AU (1) AU2015269598B2 (enrdf_load_stackoverflow)
CA (1) CA2948888A1 (enrdf_load_stackoverflow)
IL (1) IL249308B (enrdf_load_stackoverflow)
WO (1) WO2015187905A1 (enrdf_load_stackoverflow)

Families Citing this family (7)

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Publication number Priority date Publication date Assignee Title
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
ES2608474T3 (es) 2010-04-22 2017-04-11 Vertex Pharmaceuticals Incorporated Proceso de producción de compuestos indol cycloalkylcarboxamido
MX387720B (es) 2014-04-15 2025-03-12 Vertex Pharma Composiciones farmacéuticas para el tratamiento de enfermedades mediadas por el regulador de conductancia de transmembrana de fibrosis quística.
AU2015269598B2 (en) * 2014-06-05 2019-11-14 Merck Patent Gmbh Novel quinoline derivatives and their use in neurodegenerative diseases
SG11201906627YA (en) * 2017-03-13 2019-08-27 Raqualia Pharma Inc Tetrahydroquinoline derivatives as p2x7 receptor antagonists
BR112021005082A2 (pt) 2018-09-18 2021-06-08 Nikang Therapeutics, Inc. derivados de anel tricíclico fundido como inibidores de src homologia-2 fosfatase

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WO2003080579A1 (en) * 2002-03-25 2003-10-02 Astrazeneca Ab Novel adamantane derivatives
CN1829694A (zh) * 2003-07-28 2006-09-06 阿斯利康(瑞典)有限公司 喹啉衍生物和它们在治疗中的用途
CN1832925A (zh) * 2003-06-02 2006-09-13 阿斯利康(瑞典)有限公司 新的p2x7受体拮抗剂和它们的用途
CN101111488A (zh) * 2004-11-30 2008-01-23 阿斯利康(瑞典)有限公司 新型化合物
WO2008013494A1 (en) * 2006-07-27 2008-01-31 Astrazeneca Ab Quinoline derivatives as p2x7 receptor antagonist and their use in the treatment of rheumatoid arthritis, osteoarthritis, copd and ibd
WO2009070116A1 (en) * 2007-11-30 2009-06-04 Astrazeneca Ab A quinoline derivative acting as a p2x7-receptor antagonist
WO2009132000A1 (en) * 2008-04-22 2009-10-29 Janssen Pharmaceutica Nv Quinoline or isoquinoline substituted p2x7 antagonists

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WO2003080579A1 (en) * 2002-03-25 2003-10-02 Astrazeneca Ab Novel adamantane derivatives
CN1832925A (zh) * 2003-06-02 2006-09-13 阿斯利康(瑞典)有限公司 新的p2x7受体拮抗剂和它们的用途
CN1829694A (zh) * 2003-07-28 2006-09-06 阿斯利康(瑞典)有限公司 喹啉衍生物和它们在治疗中的用途
CN101111488A (zh) * 2004-11-30 2008-01-23 阿斯利康(瑞典)有限公司 新型化合物
WO2008013494A1 (en) * 2006-07-27 2008-01-31 Astrazeneca Ab Quinoline derivatives as p2x7 receptor antagonist and their use in the treatment of rheumatoid arthritis, osteoarthritis, copd and ibd
WO2009070116A1 (en) * 2007-11-30 2009-06-04 Astrazeneca Ab A quinoline derivative acting as a p2x7-receptor antagonist
WO2009132000A1 (en) * 2008-04-22 2009-10-29 Janssen Pharmaceutica Nv Quinoline or isoquinoline substituted p2x7 antagonists
CN102066360A (zh) * 2008-04-22 2011-05-18 詹森药业有限公司 喹啉或异喹啉取代的p2x7拮抗剂

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AU2015269598B2 (en) 2019-11-14
EP3152192A1 (en) 2017-04-12
US20150353497A1 (en) 2015-12-10
WO2015187905A1 (en) 2015-12-10
CN106573907A (zh) 2017-04-19
AR100724A1 (es) 2016-10-26
AU2015269598A1 (en) 2016-11-24
US9399623B2 (en) 2016-07-26
IL249308A0 (en) 2017-02-28
US20160296509A1 (en) 2016-10-13
JP6692759B2 (ja) 2020-05-13
IL249308B (en) 2020-02-27
CA2948888A1 (en) 2015-12-10
JP2017520538A (ja) 2017-07-27

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