CN106565840B - 抗乙肝表面抗原的抗体及其用途 - Google Patents

抗乙肝表面抗原的抗体及其用途 Download PDF

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Publication number
CN106565840B
CN106565840B CN201610879693.5A CN201610879693A CN106565840B CN 106565840 B CN106565840 B CN 106565840B CN 201610879693 A CN201610879693 A CN 201610879693A CN 106565840 B CN106565840 B CN 106565840B
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seq
antibody
antigen
binding fragment
antibodies
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CN106565840A (zh
Inventor
罗文新
周兵
张娟
袁权
张天英
张军
夏宁邵
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Yang Sheng Tang Co Ltd
Xiamen University
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Yang Sheng Tang Co Ltd
Xiamen University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—DNA viruses
    • C07K16/082—Hepadnaviridae (F), e.g. hepatitis B virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201610879693.5A 2015-10-09 2016-10-09 抗乙肝表面抗原的抗体及其用途 Active CN106565840B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2015106479777 2015-10-09
CN201510647977 2015-10-09

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CN106565840A CN106565840A (zh) 2017-04-19
CN106565840B true CN106565840B (zh) 2020-09-01

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US (1) US10689434B2 (https=)
EP (1) EP3360896B1 (https=)
JP (2) JP6949012B2 (https=)
KR (1) KR102132604B1 (https=)
CN (1) CN106565840B (https=)
AU (1) AU2016334290B2 (https=)
BR (1) BR112018007121A2 (https=)
CA (1) CA3001231C (https=)
ES (1) ES3041684T3 (https=)
WO (1) WO2017059813A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6949012B2 (ja) * 2015-10-09 2021-10-13 シャアメン ユニバーシティ Ｂ型肝炎表面抗原に対する抗体及びその使用
EP3801766A1 (en) * 2018-05-31 2021-04-14 Novartis AG Hepatitis b antibodies
BR112020021266A2 (pt) * 2018-05-31 2021-01-26 Daiichi Sankyo Company, Limited anticorpo anti-tlr7 humano
JP7454855B2 (ja) * 2018-12-21 2024-03-25 国立大学法人広島大学 抗ｐｒｅＳ１抗体およびその用途
CN111978393B (zh) * 2019-05-23 2024-06-18 厦门大学 抗乙肝病毒新型抗体及其用途
CN111242107B (zh) * 2020-04-26 2021-03-09 北京外号信息技术有限公司 用于设置空间中的虚拟对象的方法和电子设备
PE20240080A1 (es) * 2020-06-08 2024-01-16 Hoffmann La Roche Anticuerpos anti-hbv y metodos de uso
WO2024148263A1 (en) * 2023-01-06 2024-07-11 Victorian Infectious Diseases Reference Laboratory Methods and compositions for antibody treatment of hepatitis b infection

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1560081A (zh) * 2004-02-17 2005-01-05 大连帝恩生物工程有限公司 用能产生人IgGl重链－κ轻链小鼠作为制备人源化单克隆抗体和应用
CN102906111A (zh) * 2009-12-24 2013-01-30 株式会社绿十字 特异性结合乙型肝炎病毒表面抗原的人抗体
CN103483421A (zh) * 2012-06-11 2014-01-01 厦门大学 用于治疗hbv感染及相关疾病的多肽及抗体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1395617A (zh) 2000-10-02 2003-02-05 韩国生命工学研究院 抗乙肝病毒表面抗原s的人源化抗体及其制备方法
EP2250198B1 (en) * 2008-01-23 2016-03-09 Department of Biotechnology A humanized high affinity recombinant antibody against hepatitis b surface antigen
CN102786592A (zh) 2011-05-17 2012-11-21 傅阳心 Hbv特异性抗体
AU2013287516B2 (en) * 2012-07-10 2016-07-07 Green Cross Corporation An antibody composition for prevention or treatment of mutant hepatitis B virus infection
US10167333B2 (en) 2014-01-16 2019-01-01 Mario Umberto Francesco Mondelli Neutralizing human monoclonal antibodies against hepatitis B virus surface antigen
JP6949012B2 (ja) * 2015-10-09 2021-10-13 シャアメン ユニバーシティ Ｂ型肝炎表面抗原に対する抗体及びその使用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1560081A (zh) * 2004-02-17 2005-01-05 大连帝恩生物工程有限公司 用能产生人IgGl重链－κ轻链小鼠作为制备人源化单克隆抗体和应用
CN102906111A (zh) * 2009-12-24 2013-01-30 株式会社绿十字 特异性结合乙型肝炎病毒表面抗原的人抗体
CN103483421A (zh) * 2012-06-11 2014-01-01 厦门大学 用于治疗hbv感染及相关疾病的多肽及抗体

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Human monoclonal antibody against Hepatitis B virus surface antigen (HBsAg);Yong-Won Shin等;《Antiviral Research》;20090831;第75卷(第2期);113-120 *

Also Published As

Publication number Publication date
WO2017059813A1 (zh) 2017-04-13
JP2021063092A (ja) 2021-04-22
JP2018533937A (ja) 2018-11-22
US20190389939A1 (en) 2019-12-26
JP6949012B2 (ja) 2021-10-13
ES3041684T3 (en) 2025-11-13
AU2016334290B2 (en) 2020-06-18
AU2016334290A1 (en) 2018-05-10
US10689434B2 (en) 2020-06-23
CA3001231A1 (en) 2017-04-13
BR112018007121A2 (pt) 2018-11-06
EP3360896B1 (en) 2025-07-23
EP3360896A4 (en) 2019-08-28
CN106565840A (zh) 2017-04-19
KR20180084045A (ko) 2018-07-24
EP3360896A1 (en) 2018-08-15
KR102132604B1 (ko) 2020-07-13
CA3001231C (en) 2022-07-12

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