CN106565229A - 一种骨替代用致密羟磷灰质材料的制备方法 - Google Patents

一种骨替代用致密羟磷灰质材料的制备方法 Download PDF

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CN106565229A
CN106565229A CN201610880333.7A CN201610880333A CN106565229A CN 106565229 A CN106565229 A CN 106565229A CN 201610880333 A CN201610880333 A CN 201610880333A CN 106565229 A CN106565229 A CN 106565229A
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王胜利
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Luoyang Tripod Mstar Technology Ltd
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Abstract

本发明涉及一种骨替代用致密羟磷灰质材料的制备方法，将羟磷灰质粉末与四水硝酸钙按质量比混合均匀后模具成型，置入放电等离子烧结炉进行烧结，随炉自然冷却至室温，退模即得到骨替代用致密羟磷灰质材料。利用本发明制备骨替代用致密羟磷灰质材料，均匀性好,纯度高、颗粒小、晶形完整的纳米级致密代骨材料。成分纯净无有害杂质，具有良好的成骨诱导能力，并且工艺简单易行、快速高效、成本低廉且易于实现工业化生产，可以用于机体硬组织再生或重建的骨缺损替代材料。

Description

一种骨替代用致密羟磷灰质材料的制备方法
技术领域
本发明属于新型生物材料技术领域，特别涉及一种致密骨替代用羟磷灰质材料的制备方法。
背景技术
随着高新技术产业的发展，新型材料特别是仿生功能材料的种类和需求量不断增加，材料新的功能呼唤新的制备技术。一直以来，在活体生物救助过程中，经常遇到重建或再生因病或由于外伤造成的骨缺损情况，需要大量的骨缺损替代材料。
目前研究最多的骨替代材料是羟磷灰质(简称HA)。HA生物陶瓷材料因具有与人体骨骼晶体成分和结构基本一致，是一种仿生及界面活性的优异新材料，并且能够与骨直接形成键性结合等优点，现行应用表明，具有适合的力学性能，能与人体骨组织相似的互连致密结构。致密羟磷灰质骨替代材料通过代谢、营养传输和血管生长而促进加快骨替代过程。因此，亟需提出一种新的致密骨替代用羟磷灰质材料的制备方法。
发明内容
基于上述现状，本发明的目的在于提供一种致密骨替代用羟磷灰质材料的制备方法，满足在活体生物救助过程中，经常遇到的重建或再生因病或由于外伤造成的骨缺损情况，需要大量的骨缺损替代材料。
本发明提供一种致密骨替代用羟磷灰质材料的制备方法，所采用的技术方案为：其可采用将羟磷灰质35～60份、四水硝酸钙65～40份，按质量比，将其混合均匀，在高温下反应同时注入高压水蒸气，粉末经NH4Cl水溶液洗涤后干燥后模压成型；成型后在1300℃的范围内烧结而成致密型羟磷灰质骨替代材料；
再有，一般说来，材料大同小异，关键在于方法，本发明将脱模品置于放电等离子烧结炉中，加热至900～1300℃的温度下烧结后，烧结后再随炉自然冷却至恒温，退模即得到致密骨替代用羟磷灰质材料。放电等离子烧结(Spark Plasma Sintering，简称SPS)，是一种采用低温、短时的快速烧结的方法，其在新材料的研究和生产领域中发挥着重要的文明作用。是制备功能材料的一种全新技术，SPS是利用放电等离子体进行烧结的。等离子体是物质在高温或特定激励下的一种物质状态，它具有快速、短时、组织结构可控、节能环保等鲜明特点，是用来制备陶瓷等材料新方法。
针对上述需求现状的改进、发展、研究，本发明的有益之处在于，为了增加现有技术的产生的功用，提供一种可操作性强的、提供设计简约，多效共享，方便安全使用的致密骨替代用羟磷灰质材料的制备方法，适用范围广、成本较低，操作简单，本发明提供的一种致密骨替代用羟磷灰质材料的制备方法，，可以满足多元化日益增长的生产建设以及生活需要,为科学、生态、环保，可持续发展的多效能方案。
上述说明仅是本发明技术方案的概述，为了能更清楚了解本发明的技术手段，而可依照说明书的内容予以实施，并且为让本发明的上述和其他目的、特征和优点能够更明显易懂，以下特举较佳实施例,详细说明如下。
具体实施方式：
为更进一步阐述本发明为达成预定发明目的所采取的技术手段及功效，以下结合较佳实施例，对依据本发明提出的一种致密骨替代用羟磷灰质材料的制备方法，其具体实施方式、特征等，详细说明如后。
实施例1
本发明提供一种致密骨替代用羟磷灰质材料的制备方法，所采用的技术方案为：其可采用将羟磷灰质35～60份、四水硝酸钙65～40份，按质量比，将其混合均匀，在高温下反应同时注入高压水蒸气，粉末经NH4Cl水溶液洗涤后干燥后模压成型。
实施例2
发明提出的一种致密骨替代用羟磷灰质材料的制备方法，一般说来，材料大同小异，关键在于方法，只有高密度才能保证陶瓷的强度,本发明将脱模品置于放电等离子烧结炉中，加热至900～1300℃的温度范围内烧结，烧结后再随炉自然冷却至恒温，退模即得到致密骨替代用羟磷灰质材料。放电等离子烧结(Spark Plasma Sintering，简称SPS)，是一种采用低温、短时的快速烧结的方法，其在新材料的研究和生产领域中发挥着重要的文明作用。是制备功能材料的一种全新技术，SPS是利用放电等离子体进行烧结的。等离子体是物质在高温或特定激励下的一种物质状态，它具有快速、短时、组织结构可控、节能环保等鲜明特点，是用来制备陶瓷等材料新方法。SPS的工艺优势十分明显：加热均匀，升温速度快，烧结温度低，烧结时间短，生产效率高，产品组织细小均匀，能保持原材料的自然状态，可以得到高致密度的材料，SPS装置操作简单，与HP相比，SPS技术的烧结温度可降低100～200℃。
本发明的有益之处在于，满足在活体生物救助过程中，经常遇到的重建或再生因病或由于外伤造成的骨缺损情况，需要大量的骨缺损替代材料。为了增加现有技术的产生的功用，提供一种可操作性强的、提供设计简约，多效共享，方便安全使用的致密骨替代用羟磷灰质材料的制备方法，适用范围广、成本较低，操作简单，本发明提供的一种致密骨替代用羟磷灰质材料的制备方法，，可以满足多元化日益增长的生产建设以及生活需要,为科学、生态、环保，可持续发展的多效能方案。
以上所述，仅是本发明的较佳实施例而已，并非对本发明作任何形式上的限制，虽然本发明已以较佳实施例揭露如上，然而并非用以限定本发明,任何熟悉本专业的技术人员，在不脱离本发明技术方案范围内,当可利用上述揭示的技术内容作出些许更动或修饰为等同变化的等效实施例,但凡是未脱离本发明技术方案的内容，依据本发明的技术实质对以上实施例所作的任何简单修改、等同变化与修饰,均仍属于本发明技术方案的范围内。

Claims (2)

1.一种致密骨替代用羟磷灰质材料的制备方法，其特征在于，将羟磷灰质35～60份、四水硝酸钙65～40份，按质量比，将其混合均匀，且模压成型。
2.根据权利要求1所述的一种骨替代用致密羟磷灰质材料的制备方法，其特征在于：将脱模品置于放电等离子烧结炉中，加热至900～1300℃的温度范围内烧结，烧结后再随炉自然冷却至恒温，退模即得到致密骨替代用羟磷灰质材料。
CN201610880333.7A 2016-10-09 2016-10-09 一种骨替代用致密羟磷灰质材料的制备方法 Pending CN106565229A (zh)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN86108700A (zh) * 1986-12-18 1988-06-29 四川大学 致密多晶羟基磷灰石微粒的制作方法
CN1699270A (zh) * 2005-05-17 2005-11-23 杭州市萧山区中医院 一种羟基磷灰石/二氧化锆生物陶瓷复合材料的制备方法及其产品
CN1793042A (zh) * 2006-01-06 2006-06-28 清华大学 一种原位增韧氮化硅基陶瓷及其超快速烧结方法
CN101024571A (zh) * 2006-02-21 2007-08-29 西南交通大学 多孔羟基磷灰石和磷酸钙纳米陶瓷的制备方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN86108700A (zh) * 1986-12-18 1988-06-29 四川大学 致密多晶羟基磷灰石微粒的制作方法
CN1699270A (zh) * 2005-05-17 2005-11-23 杭州市萧山区中医院 一种羟基磷灰石/二氧化锆生物陶瓷复合材料的制备方法及其产品
CN1793042A (zh) * 2006-01-06 2006-06-28 清华大学 一种原位增韧氮化硅基陶瓷及其超快速烧结方法
CN101024571A (zh) * 2006-02-21 2007-08-29 西南交通大学 多孔羟基磷灰石和磷酸钙纳米陶瓷的制备方法

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