CN106565229A - 一种骨替代用致密羟磷灰质材料的制备方法 - Google Patents

一种骨替代用致密羟磷灰质材料的制备方法 Download PDF

Info

Publication number
CN106565229A
CN106565229A CN201610880333.7A CN201610880333A CN106565229A CN 106565229 A CN106565229 A CN 106565229A CN 201610880333 A CN201610880333 A CN 201610880333A CN 106565229 A CN106565229 A CN 106565229A
Authority
CN
China
Prior art keywords
compact
hydroxyapatite
bone substitute
bone
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610880333.7A
Other languages
English (en)
Inventor
王胜利
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Luoyang Tripod Mstar Technology Ltd
Original Assignee
Luoyang Tripod Mstar Technology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Luoyang Tripod Mstar Technology Ltd filed Critical Luoyang Tripod Mstar Technology Ltd
Priority to CN201610880333.7A priority Critical patent/CN106565229A/zh
Publication of CN106565229A publication Critical patent/CN106565229A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/01—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics
    • C04B35/447—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on phosphates, e.g. hydroxyapatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/64—Burning or sintering processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/02—Composition of constituents of the starting material or of secondary phases of the final product
    • C04B2235/30—Constituents and secondary phases not being of a fibrous nature
    • C04B2235/44—Metal salt constituents or additives chosen for the nature of the anions, e.g. hydrides or acetylacetonate
    • C04B2235/443—Nitrates or nitrites
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/60—Aspects relating to the preparation, properties or mechanical treatment of green bodies or pre-forms
    • C04B2235/602—Making the green bodies or pre-forms by moulding
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/65—Aspects relating to heat treatments of ceramic bodies such as green ceramics or pre-sintered ceramics, e.g. burning, sintering or melting processes
    • C04B2235/66—Specific sintering techniques, e.g. centrifugal sintering
    • C04B2235/666—Applying a current during sintering, e.g. plasma sintering [SPS], electrical resistance heating or pulse electric current sintering [PECS]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Ceramic Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Health & Medical Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Structural Engineering (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)

Abstract

本发明涉及一种骨替代用致密羟磷灰质材料的制备方法，将羟磷灰质粉末与四水硝酸钙按质量比混合均匀后模具成型，置入放电等离子烧结炉进行烧结，随炉自然冷却至室温，退模即得到骨替代用致密羟磷灰质材料。利用本发明制备骨替代用致密羟磷灰质材料，均匀性好,纯度高、颗粒小、晶形完整的纳米级致密代骨材料。成分纯净无有害杂质，具有良好的成骨诱导能力，并且工艺简单易行、快速高效、成本低廉且易于实现工业化生产，可以用于机体硬组织再生或重建的骨缺损替代材料。

Description

一种骨替代用致密羟磷灰质材料的制备方法
技术领域
本发明属于新型生物材料技术领域，特别涉及一种致密骨替代用羟磷灰质材料的制备方法。
背景技术
随着高新技术产业的发展，新型材料特别是仿生功能材料的种类和需求量不断增加，材料新的功能呼唤新的制备技术。一直以来，在活体生物救助过程中，经常遇到重建或再生因病或由于外伤造成的骨缺损情况，需要大量的骨缺损替代材料。
目前研究最多的骨替代材料是羟磷灰质(简称HA)。HA生物陶瓷材料因具有与人体骨骼晶体成分和结构基本一致，是一种仿生及界面活性的优异新材料，并且能够与骨直接形成键性结合等优点，现行应用表明，具有适合的力学性能，能与人体骨组织相似的互连致密结构。致密羟磷灰质骨替代材料通过代谢、营养传输和血管生长而促进加快骨替代过程。因此，亟需提出一种新的致密骨替代用羟磷灰质材料的制备方法。
发明内容
基于上述现状，本发明的目的在于提供一种致密骨替代用羟磷灰质材料的制备方法，满足在活体生物救助过程中，经常遇到的重建或再生因病或由于外伤造成的骨缺损情况，需要大量的骨缺损替代材料。
本发明提供一种致密骨替代用羟磷灰质材料的制备方法，所采用的技术方案为：其可采用将羟磷灰质35～60份、四水硝酸钙65～40份，按质量比，将其混合均匀，在高温下反应同时注入高压水蒸气，粉末经NH4Cl水溶液洗涤后干燥后模压成型；成型后在1300℃的范围内烧结而成致密型羟磷灰质骨替代材料；
再有，一般说来，材料大同小异，关键在于方法，本发明将脱模品置于放电等离子烧结炉中，加热至900～1300℃的温度下烧结后，烧结后再随炉自然冷却至恒温，退模即得到致密骨替代用羟磷灰质材料。放电等离子烧结(Spark Plasma Sintering，简称SPS)，是一种采用低温、短时的快速烧结的方法，其在新材料的研究和生产领域中发挥着重要的文明作用。是制备功能材料的一种全新技术，SPS是利用放电等离子体进行烧结的。等离子体是物质在高温或特定激励下的一种物质状态，它具有快速、短时、组织结构可控、节能环保等鲜明特点，是用来制备陶瓷等材料新方法。
针对上述需求现状的改进、发展、研究，本发明的有益之处在于，为了增加现有技术的产生的功用，提供一种可操作性强的、提供设计简约，多效共享，方便安全使用的致密骨替代用羟磷灰质材料的制备方法，适用范围广、成本较低，操作简单，本发明提供的一种致密骨替代用羟磷灰质材料的制备方法，，可以满足多元化日益增长的生产建设以及生活需要,为科学、生态、环保，可持续发展的多效能方案。
上述说明仅是本发明技术方案的概述，为了能更清楚了解本发明的技术手段，而可依照说明书的内容予以实施，并且为让本发明的上述和其他目的、特征和优点能够更明显易懂，以下特举较佳实施例,详细说明如下。
具体实施方式：
为更进一步阐述本发明为达成预定发明目的所采取的技术手段及功效，以下结合较佳实施例，对依据本发明提出的一种致密骨替代用羟磷灰质材料的制备方法，其具体实施方式、特征等，详细说明如后。
实施例1
本发明提供一种致密骨替代用羟磷灰质材料的制备方法，所采用的技术方案为：其可采用将羟磷灰质35～60份、四水硝酸钙65～40份，按质量比，将其混合均匀，在高温下反应同时注入高压水蒸气，粉末经NH4Cl水溶液洗涤后干燥后模压成型。
实施例2
发明提出的一种致密骨替代用羟磷灰质材料的制备方法，一般说来，材料大同小异，关键在于方法，只有高密度才能保证陶瓷的强度,本发明将脱模品置于放电等离子烧结炉中，加热至900～1300℃的温度范围内烧结，烧结后再随炉自然冷却至恒温，退模即得到致密骨替代用羟磷灰质材料。放电等离子烧结(Spark Plasma Sintering，简称SPS)，是一种采用低温、短时的快速烧结的方法，其在新材料的研究和生产领域中发挥着重要的文明作用。是制备功能材料的一种全新技术，SPS是利用放电等离子体进行烧结的。等离子体是物质在高温或特定激励下的一种物质状态，它具有快速、短时、组织结构可控、节能环保等鲜明特点，是用来制备陶瓷等材料新方法。SPS的工艺优势十分明显：加热均匀，升温速度快，烧结温度低，烧结时间短，生产效率高，产品组织细小均匀，能保持原材料的自然状态，可以得到高致密度的材料，SPS装置操作简单，与HP相比，SPS技术的烧结温度可降低100～200℃。
本发明的有益之处在于，满足在活体生物救助过程中，经常遇到的重建或再生因病或由于外伤造成的骨缺损情况，需要大量的骨缺损替代材料。为了增加现有技术的产生的功用，提供一种可操作性强的、提供设计简约，多效共享，方便安全使用的致密骨替代用羟磷灰质材料的制备方法，适用范围广、成本较低，操作简单，本发明提供的一种致密骨替代用羟磷灰质材料的制备方法，，可以满足多元化日益增长的生产建设以及生活需要,为科学、生态、环保，可持续发展的多效能方案。
以上所述，仅是本发明的较佳实施例而已，并非对本发明作任何形式上的限制，虽然本发明已以较佳实施例揭露如上，然而并非用以限定本发明,任何熟悉本专业的技术人员，在不脱离本发明技术方案范围内,当可利用上述揭示的技术内容作出些许更动或修饰为等同变化的等效实施例,但凡是未脱离本发明技术方案的内容，依据本发明的技术实质对以上实施例所作的任何简单修改、等同变化与修饰,均仍属于本发明技术方案的范围内。

Claims (2)

1.一种致密骨替代用羟磷灰质材料的制备方法，其特征在于，将羟磷灰质35～60份、四水硝酸钙65～40份，按质量比，将其混合均匀，且模压成型。
2.根据权利要求1所述的一种骨替代用致密羟磷灰质材料的制备方法，其特征在于：将脱模品置于放电等离子烧结炉中，加热至900～1300℃的温度范围内烧结，烧结后再随炉自然冷却至恒温，退模即得到致密骨替代用羟磷灰质材料。
CN201610880333.7A 2016-10-09 2016-10-09 一种骨替代用致密羟磷灰质材料的制备方法 Pending CN106565229A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610880333.7A CN106565229A (zh) 2016-10-09 2016-10-09 一种骨替代用致密羟磷灰质材料的制备方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610880333.7A CN106565229A (zh) 2016-10-09 2016-10-09 一种骨替代用致密羟磷灰质材料的制备方法

Publications (1)

Publication Number Publication Date
CN106565229A true CN106565229A (zh) 2017-04-19

Family

ID=58531615

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610880333.7A Pending CN106565229A (zh) 2016-10-09 2016-10-09 一种骨替代用致密羟磷灰质材料的制备方法

Country Status (1)

Country Link
CN (1) CN106565229A (zh)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN86108700A (zh) * 1986-12-18 1988-06-29 四川大学 致密多晶羟基磷灰石微粒的制作方法
CN1699270A (zh) * 2005-05-17 2005-11-23 杭州市萧山区中医院 一种羟基磷灰石/二氧化锆生物陶瓷复合材料的制备方法及其产品
CN1793042A (zh) * 2006-01-06 2006-06-28 清华大学 一种原位增韧氮化硅基陶瓷及其超快速烧结方法
CN101024571A (zh) * 2006-02-21 2007-08-29 西南交通大学 多孔羟基磷灰石和磷酸钙纳米陶瓷的制备方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN86108700A (zh) * 1986-12-18 1988-06-29 四川大学 致密多晶羟基磷灰石微粒的制作方法
CN1699270A (zh) * 2005-05-17 2005-11-23 杭州市萧山区中医院 一种羟基磷灰石/二氧化锆生物陶瓷复合材料的制备方法及其产品
CN1793042A (zh) * 2006-01-06 2006-06-28 清华大学 一种原位增韧氮化硅基陶瓷及其超快速烧结方法
CN101024571A (zh) * 2006-02-21 2007-08-29 西南交通大学 多孔羟基磷灰石和磷酸钙纳米陶瓷的制备方法

Similar Documents

Publication Publication Date Title
Feng et al. Additive manufacturing of hydroxyapatite bioceramic scaffolds: Dispersion, digital light processing, sintering, mechanical properties, and biocompatibility
CN101265073B (zh) 复合硅砖及其制备方法
CN105859275B (zh) 用于牙齿、牙槽修复的复合生物陶瓷
Maier et al. Three-dimensional printing of flash-setting calcium aluminate cement
Papynov et al. Application of carbonaceous template for porous structure control of ceramic composites based on synthetic wollastonite obtained via Spark Plasma Sintering
CN107032794A (zh) 一种用于负极材料提纯的石墨坩埚的制备方法
Hafezi-Ardakani et al. Sol-gel synthesis and apatite-formation ability of nanostructure merwinite (Ca3MgSi2O8) as a novel bioceramic
CN106631074A (zh) 一种高氧化钙含量的氧化钙材料及其制备方法
Lin et al. Preparation and characterization of novel alkali‐activated nano silica cements for biomedical application
CN101113082A (zh) 含纳米碳酸钙的铝酸钙水泥及其制备方法
Qiu et al. Influences of gallium substitution on the phase stability, mechanical strength and cellular response of β-tricalcium phosphate bioceramics
CN102344276A (zh) 一种硅酸铝无机纤维板生产方法
Ben et al. PVB modified spherical granules of β-TCP by spray drying for 3D ceramic printing
Osuchukwu et al. A comparative study of the mechanical properties of sol-gel derived hydroxyapatite produced from a novel mixture of two natural biowastes for biomedical applications
CN104030686A (zh) 一种高韧性碳化硅陶瓷及其制备方法
Ismail et al. Effect of sintering temperature on the phase, microstructural, physical, mechanical, and in vitro biomineralisation properties of porous wollastonite ceramics fabricated using the gel casting method
KR20190068652A (ko) 인체 경조직 대체를 위한 3차원 프린팅용 원료 및 그 제조방법
CN102512706A (zh) 多聚磷酸钙/硫酸钙复相生物陶瓷材料及其制备方法
CN106565229A (zh) 一种骨替代用致密羟磷灰质材料的制备方法
CN104016708B (zh) 一种高抗折强度陶瓷管支撑体的制备方法
CN108484156B (zh) 一种基于粉体抗水解处理及凝胶注模成型的尖晶石固溶体透明陶瓷制备方法
CN105753485A (zh) 氮化硼复相陶瓷材料及其无压烧结工艺
de Melo Bernardino et al. Manufacturing of SiO2-coated b-TCP structures by 3D printing using a preceramic polymer as printing binder and silica source
Dong et al. Effects of calcination temperature of boron-containing magnesium oxide raw materials on properties of magnesium phosphate cement as a biomaterial
CN106007699A (zh) β-磷酸三钙/碳酸钙双相陶瓷材料及其制备方法

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20170419

WD01 Invention patent application deemed withdrawn after publication