CN106560218A - Medical high-molecular biological composite material for skin repair - Google Patents

Medical high-molecular biological composite material for skin repair Download PDF

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Publication number
CN106560218A
CN106560218A CN201610890816.5A CN201610890816A CN106560218A CN 106560218 A CN106560218 A CN 106560218A CN 201610890816 A CN201610890816 A CN 201610890816A CN 106560218 A CN106560218 A CN 106560218A
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parts
medical
scallop shell
seu herba
rhizoma seu
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CN106560218B (en
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李倩
张文丽
王丽萍
刘国荣
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North China University of Science and Technology
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North China University of Science and Technology
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/009—Materials resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Materials Engineering (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The invention discloses a medical high-molecular biological composite material for skin repair. The medical high-molecular biological composite material for skin repair is prepared from the following raw materials by weight: 10 to 15 parts of freeze-dried powder of lilac root, 0.3 to 0.6 part of epidermal growth factor, 10 to 15 parts of placentin, 25 to 30 parts of fan shell powder, 23 to 25 parts of hydrogenated castor oil PEG-40, 11 to 16 parts of alcohol-soluble resin, 2 to 9 parts of carboxymethylcellulose sodium, 5 to 9 parts of a film-forming auxiliary agent, 3 to 5 parts of hyaluronic acid, 3 to 9 parts of dipotassium glycyrrhizinate, 10 to 15 parts of palmityl pentapeptide, 5 to 9 parts of sodium alginate and 1.5 to 2.5 parts of polyglutamic acid. The medical high-molecular biological composite material can repair skin wounds and promote cell regeneration and has good sterilization and anti-inflammation functions, and most of the composite material can be absorbed by the human body.

Description

A kind of medical reparation dermal macromolecule Biocomposite material
Technical field
The present invention relates to medical material field, and in particular to a kind of medical reparation dermal macromolecule Biocomposite material.
Background technology
Skin is the important barrier of human body, and all kinds of operations, wound, burn, dermatitis etc. can cause skin disruption and defect, Cause various wounds, repair in trauma is the key areas of medical development, for sufferer pain is mitigated, early recovery and keep away After being excused from a college course again, scar has great significance.The process of repair in trauma is needed by means of new medical material, particularly Biomedical material, different according to material, biomedical material can be divided into medical macromolecular materials, medical metal material and civilian A few big class such as nonmetallic materials.
The content of the invention
To solve the above problems, the invention provides a kind of medical reparation dermal macromolecule Biocomposite material, can be very The good reparation for carrying out skin trauma, promotes the regeneration of cell, sterilizes and inflammation-diminishing function with preferable, and most material Can be absorbed by the body.
For achieving the above object, the technical scheme taken of the present invention is：
A kind of medical reparation dermal macromolecule Biocomposite material, is prepared from by the raw material of following weight portion：
Rhizoma Seu Herba Bergeniae lyophilized powder 10-15 parts, epithelical cell growth factor 0.3-0.6 parts, Placenta extract 10-15 parts, scallop shell powder 25- 30 parts, Cremophor RH40 23-35 parts, alcohol-soluble resin 11-16 parts, sodium carboxymethyl cellulose 2-9 parts, coalescents 5- 9 parts, hyaluronic acid 3-5 parts, glycyrrhizic acid dipotassium 3-9 parts, Matrixyl 10-15 parts, sodium alginate 5-9 parts, polyglutamic acid 1.5-2.5 part.
Preferably, it is prepared from by the raw material of following weight portion：
10 parts of Rhizoma Seu Herba Bergeniae lyophilized powder, 0.3 part of epithelical cell growth factor, 10 parts of Placenta extract, 25 parts of scallop shell powder, PEG-40 hydrogen Change 23 parts of Oleum Ricini, 11 parts of alcohol-soluble resin, 2 parts of sodium carboxymethyl cellulose, 5 parts of coalescents, 3 parts of hyaluronic acid, glycyrrhizic acid 3 parts of dipotassium, 10 parts of Matrixyl, 5 parts of sodium alginate, 1.5 parts of polyglutamic acid.
Preferably, it is prepared from by the raw material of following weight portion：
15 parts of Rhizoma Seu Herba Bergeniae lyophilized powder, 0.6 part of epithelical cell growth factor, 15 parts of Placenta extract, 30 parts of scallop shell powder, PEG-40 hydrogen Change 35 parts of Oleum Ricini, 16 parts of alcohol-soluble resin, 9 parts of sodium carboxymethyl cellulose, 9 parts of coalescents, 5 parts of hyaluronic acid, glycyrrhizic acid 9 parts of dipotassium, 15 parts of Matrixyl, 9 parts of sodium alginate, 2.5 parts of polyglutamic acid.
Preferably, it is prepared from by the raw material of following weight portion：
12.5 parts of Rhizoma Seu Herba Bergeniae lyophilized powder, 0.45 part of epithelical cell growth factor, 12.5 parts of Placenta extract, 27.5 parts of scallop shell powder, 29 parts of Cremophor RH40,13.5 parts of alcohol-soluble resin, 5.5 parts of sodium carboxymethyl cellulose, 7 parts of coalescents, hyalomitome 4 parts of acid, 6 parts of glycyrrhizic acid dipotassium, 12.5 parts of Matrixyl, 7 parts of sodium alginate, 2 parts of polyglutamic acid.
Preferably, the Rhizoma Seu Herba Bergeniae lyophilized powder is as obtained by prepared by following steps：
Take the Rhizoma Seu Herba Bergeniae cleaned after draining to be placed in steam-explosion jar, it is 0.8-1.6MPa to be first passed through nitrogen to steam explosion pressure inside the tank, Explosion treatment 6-22min；Then it is 1.6-2.3MPa, Steam explosion treatment 0.9- to be passed through rapidly steam to steam explosion pressure inside the tank After 2.7min, according to the ratio microbe inoculation leaven of inoculum concentration 1.6-1.8%, keeping temperature 25-35 DEG C, ferment 46-54 After hour, high temperature sterilize, lyophilization obtain Rhizoma Seu Herba Bergeniae lyophilized powder.
Preferably, the scallop shell powder is as obtained by prepared by following steps：
S1, by scallop shell clean dry rear loading of kiln after be fired, under nitrogen atmosphere, control kiln temperature with 100-200 DEG C/h heating rate from room temperature to 1500-1900 DEG C, after 1500-1900 DEG C of high-temperature calcination 10-20min, be naturally cooling to 150-250 DEG C, open wicket；
S2, be down to room temperature after, by through firing scallop shell carry out micronizing, obtain scallop shell powder.
The invention has the advantages that：
Can be very good to carry out the reparation of skin trauma, promote the regeneration of cell, with preferably sterilization and inflammation-diminishing function, And most material can be absorbed by the body.
Specific embodiment
In order that objects and advantages of the present invention become more apparent, with reference to embodiments the present invention is carried out further Describe in detail.It should be appreciated that specific embodiment described herein is not used to limit this only to explain the present invention It is bright.
In following examples, the Rhizoma Seu Herba Bergeniae lyophilized powder for being used is as obtained by prepared by following steps：
Take the Rhizoma Seu Herba Bergeniae cleaned after draining to be placed in steam-explosion jar, it is 0.8-1.6MPa to be first passed through nitrogen to steam explosion pressure inside the tank, Explosion treatment 6-22min；Then it is 1.6-2.3MPa, Steam explosion treatment 0.9- to be passed through rapidly steam to steam explosion pressure inside the tank After 2.7min, according to the ratio microbe inoculation leaven of inoculum concentration 1.6-1.8%, keeping temperature 25-35 DEG C, ferment 46-54 After hour, high temperature sterilize, lyophilization obtain Rhizoma Seu Herba Bergeniae lyophilized powder.
The scallop shell powder for being used is as obtained by prepared by following steps：
S1, by scallop shell clean dry rear loading of kiln after be fired, under nitrogen atmosphere, control kiln temperature with 100-200 DEG C/h heating rate from room temperature to 1500-1900 DEG C, after 1500-1900 DEG C of high-temperature calcination 10-20min, be naturally cooling to 150-250 DEG C, open wicket；
S2, be down to room temperature after, by through firing scallop shell carry out micronizing, obtain scallop shell powder.
Embodiment 1
A kind of medical reparation dermal macromolecule Biocomposite material, is prepared from by the raw material of following weight portion：
10 parts of Rhizoma Seu Herba Bergeniae lyophilized powder, 0.3 part of epithelical cell growth factor, 10 parts of Placenta extract, 25 parts of scallop shell powder, PEG-40 hydrogen Change 23 parts of Oleum Ricini, 11 parts of alcohol-soluble resin, 2 parts of sodium carboxymethyl cellulose, 5 parts of coalescents, 3 parts of hyaluronic acid, glycyrrhizic acid 3 parts of dipotassium, 10 parts of Matrixyl, 5 parts of sodium alginate, 1.5 parts of polyglutamic acid.
Embodiment 2
A kind of medical reparation dermal macromolecule Biocomposite material, is prepared from by the raw material of following weight portion：
15 parts of Rhizoma Seu Herba Bergeniae lyophilized powder, 0.6 part of epithelical cell growth factor, 15 parts of Placenta extract, 30 parts of scallop shell powder, PEG-40 hydrogen Change 35 parts of Oleum Ricini, 16 parts of alcohol-soluble resin, 9 parts of sodium carboxymethyl cellulose, 9 parts of coalescents, 5 parts of hyaluronic acid, glycyrrhizic acid 9 parts of dipotassium, 15 parts of Matrixyl, 9 parts of sodium alginate, 2.5 parts of polyglutamic acid.
Embodiment 3
A kind of medical reparation dermal macromolecule Biocomposite material, is prepared from by the raw material of following weight portion：
12.5 parts of Rhizoma Seu Herba Bergeniae lyophilized powder, 0.45 part of epithelical cell growth factor, 12.5 parts of Placenta extract, 27.5 parts of scallop shell powder, 29 parts of Cremophor RH40,13.5 parts of alcohol-soluble resin, 5.5 parts of sodium carboxymethyl cellulose, 7 parts of coalescents, hyalomitome 4 parts of acid, 6 parts of glycyrrhizic acid dipotassium, 12.5 parts of Matrixyl, 7 parts of sodium alginate, 2 parts of polyglutamic acid.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should It is considered as protection scope of the present invention.

Claims (6)

1. one kind is medical repairs dermal macromolecule Biocomposite material, it is characterised in that by the raw material preparation of following weight portion Into：
Rhizoma Seu Herba Bergeniae lyophilized powder 10-15 parts, epithelical cell growth factor 0.3-0.6 parts, Placenta extract 10-15 parts, scallop shell powder 25-30 Part, Cremophor RH40 23-35 parts, alcohol-soluble resin 11-16 parts, sodium carboxymethyl cellulose 2-9 parts, coalescents 5-9 Part, hyaluronic acid 3-5 parts, glycyrrhizic acid dipotassium 3-9 parts, Matrixyl 10-15 parts, sodium alginate 5-9 parts, polyglutamic acid 1.5- 2.5 part.
2. one kind as claimed in claim 1 is medical repairs dermal macromolecule Biocomposite material, it is characterised in that by following heavy The raw material of amount part is prepared from：
10 parts of Rhizoma Seu Herba Bergeniae lyophilized powder, 0.3 part of epithelical cell growth factor, 10 parts of Placenta extract, 25 parts of scallop shell powder, PEG-40 hydrogenation castors 23 parts of Oleum Sesami, 11 parts of alcohol-soluble resin, 2 parts of sodium carboxymethyl cellulose, 5 parts of coalescents, 3 parts of hyaluronic acid, glycyrrhizic acid dipotassium 3 Part, 10 parts of Matrixyl, 5 parts of sodium alginate, 1.5 parts of polyglutamic acid.
3. one kind as claimed in claim 1 is medical repairs dermal macromolecule Biocomposite material, it is characterised in that by following heavy The raw material of amount part is prepared from：
15 parts of Rhizoma Seu Herba Bergeniae lyophilized powder, 0.6 part of epithelical cell growth factor, 15 parts of Placenta extract, 30 parts of scallop shell powder, PEG-40 hydrogenation castors 35 parts of Oleum Sesami, 16 parts of alcohol-soluble resin, 9 parts of sodium carboxymethyl cellulose, 9 parts of coalescents, 5 parts of hyaluronic acid, glycyrrhizic acid dipotassium 9 Part, 15 parts of Matrixyl, 9 parts of sodium alginate, 2.5 parts of polyglutamic acid.
4. one kind as claimed in claim 1 is medical repairs dermal macromolecule Biocomposite material, it is characterised in that by following heavy The raw material of amount part is prepared from：
12.5 parts of Rhizoma Seu Herba Bergeniae lyophilized powder, 0.45 part of epithelical cell growth factor, 12.5 parts of Placenta extract, 27.5 parts of scallop shell powder, PEG- 40 29 parts of castor oil hydrogenated, 13.5 parts of alcohol-soluble resin, 5.5 parts of sodium carboxymethyl cellulose, 7 parts of coalescents, hyaluronic acid 4 Part, 6 parts of glycyrrhizic acid dipotassium, 12.5 parts of Matrixyl, 7 parts of sodium alginate, 2 parts of polyglutamic acid.
5. one kind as claimed in claim 1 is medical repairs dermal macromolecule Biocomposite material, it is characterised in that the Rhizoma Seu Herba Bergeniae Lyophilized powder is as obtained by prepared by following steps：
Take clean drain after Rhizoma Seu Herba Bergeniae be placed in steam-explosion jar, be first passed through nitrogen to steam explosion pressure inside the tank be 0.8-1.6MPa, explosion Process 6-22min；Then it is 1.6-2.3MPa, Steam explosion treatment 0.9-2.7min to be passed through rapidly steam to steam explosion pressure inside the tank Afterwards, according to the ratio microbe inoculation leaven of inoculum concentration 1.6-1.8%, keeping temperature 25-35 DEG C, after fermentation 46-54 hours, High temperature sterilize, lyophilization obtain Rhizoma Seu Herba Bergeniae lyophilized powder.
6. one kind as claimed in claim 1 is medical repairs dermal macromolecule Biocomposite material, it is characterised in that the scallop Shell powder is as obtained by prepared by following steps：
S1, by scallop shell clean dry rear loading of kiln after be fired, under nitrogen atmosphere, control kiln temperature with 100-200 DEG C/it is little When heating rate from room temperature to 1500-1900 DEG C, after 1500-1900 DEG C of high-temperature calcination 10-20min, be naturally cooling to 150- 250 DEG C, open wicket；
S2, be down to room temperature after, by through firing scallop shell carry out micronizing, obtain scallop shell powder.
CN201610890816.5A 2016-10-09 2016-10-09 A kind of medical reparation dermal macromolecule Biocomposite material Active CN106560218B (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108398495A (en) * 2018-02-08 2018-08-14 兰州大学 A kind of metal affinity adsorbent is for removing the albumen in serum and detecting the nucleosides in serum
CN109453410A (en) * 2018-11-24 2019-03-12 李小军 A kind of degradable dressing of animal doctor's antibiotic-free and preparation method thereof
WO2020016732A1 (en) * 2018-07-18 2020-01-23 Farmigea S.P.A. Composition comprising glycyrrhin and cosmetic and pharmaceutical uses thereof

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Publication number Priority date Publication date Assignee Title
CN1682689A (en) * 2005-02-22 2005-10-19 湖南省昂利科技发展有限公司 Placental agent tender-white repairing liquid
CN104043145A (en) * 2014-06-28 2014-09-17 青岛国航祥玉技术服务有限公司 Medical skin-repairing polymer biocomposite
CN104814921A (en) * 2015-05-13 2015-08-05 朱敏 Acne-removing scar-lightening mask solution, manufacturing method and acne-removing scar-lightening mask
CN105662980A (en) * 2016-03-29 2016-06-15 广州九美仟惠生物科技有限公司 Facial mask with abundant enzyme active components and ability of delaying skin aging

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1682689A (en) * 2005-02-22 2005-10-19 湖南省昂利科技发展有限公司 Placental agent tender-white repairing liquid
CN104043145A (en) * 2014-06-28 2014-09-17 青岛国航祥玉技术服务有限公司 Medical skin-repairing polymer biocomposite
CN104814921A (en) * 2015-05-13 2015-08-05 朱敏 Acne-removing scar-lightening mask solution, manufacturing method and acne-removing scar-lightening mask
CN105662980A (en) * 2016-03-29 2016-06-15 广州九美仟惠生物科技有限公司 Facial mask with abundant enzyme active components and ability of delaying skin aging

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108398495A (en) * 2018-02-08 2018-08-14 兰州大学 A kind of metal affinity adsorbent is for removing the albumen in serum and detecting the nucleosides in serum
CN108398495B (en) * 2018-02-08 2020-07-03 兰州大学 A metal affinity adsorbent for removing protein and detecting nucleoside in serum
WO2020016732A1 (en) * 2018-07-18 2020-01-23 Farmigea S.P.A. Composition comprising glycyrrhin and cosmetic and pharmaceutical uses thereof
CN112423723A (en) * 2018-07-18 2021-02-26 阿特戈20有限责任公司 Composition containing glycyrrhizin and its cosmetic and pharmaceutical use
JP2021530521A (en) * 2018-07-18 2021-11-11 エーティージー ２０ エス．アール．エル Compositions containing glycyrrhizin and its cosmetic and pharmaceutical use
US11406658B2 (en) 2018-07-18 2022-08-09 Atg 20 S.R.L. Composition comprising glycyrrhizin and cosmetic and pharmaceutical uses thereof
CN112423723B (en) * 2018-07-18 2024-03-08 阿特戈20有限责任公司 Composition containing glycyrrhizin and cosmetic and pharmaceutical uses thereof
IL280109B1 (en) * 2018-07-18 2024-04-01 Atg 20 S R L Composition comprising glycyrrhizin and cosmetic and pharmaceutical uses thereof
CN109453410A (en) * 2018-11-24 2019-03-12 李小军 A kind of degradable dressing of animal doctor's antibiotic-free and preparation method thereof

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