CN106551990A - A kind of heat-clearing and toxic substances removing polysaccharide tablet - Google Patents
A kind of heat-clearing and toxic substances removing polysaccharide tablet Download PDFInfo
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- CN106551990A CN106551990A CN201510631377.1A CN201510631377A CN106551990A CN 106551990 A CN106551990 A CN 106551990A CN 201510631377 A CN201510631377 A CN 201510631377A CN 106551990 A CN106551990 A CN 106551990A
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- radix glycyrrhizae
- herb gynostemmae
- gynostemmae pentaphylli
- polysaccharide
- clearing
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Abstract
Entitled a kind of heat-clearing and toxic substances removing polysaccharide tablet of the present invention, belongs to health product technology field.It is mutually compounded with the adjuvant such as Herb Gynostemmae Pentaphylli, the extract of Radix Glycyrrhizae and Herb Gynostemmae Pentaphylli, the active ingredient of Radix Glycyrrhizae solution mainly with Jerusalem artichoke polysaccharide as main material, and it is ground, sieve, pelletize, tabletting is formed.Purpose is to adjust blood glucose, blood fat reducing, heat-clearing and toxic substances removing.The product to human body fanout free region, with the effect of health care, and taking convenience.It is primarily characterized in that using 50 70g of Jerusalem artichoke polysaccharide, 10 25g of Herb Gynostemmae Pentaphylli extract, 20 25g of Radix Glycyrrhizae extract；10 25ml of Herb Gynostemmae Pentaphylli solution, 20 25ml of Radix Glycyrrhizae solution；5 7g of disintegrating agent carboxymethyl base Starch Sodium；Magnesium stearate lubricant accounts for gross mass 0.1 0.2%（wt）；Adhesive PVPK30 ethanol solution concentrations 0.5 1.5%（wt）, 30 50ml of volume.Preparation process is as follows：(1) the extraction and purification of Jerusalem artichoke polysaccharide；(2) Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae active ingredient is extracted；(3) Herb Gynostemmae Pentaphylli, the preparation of Radix Glycyrrhizae solution；(4) a kind of preparation of heat-clearing and toxic substances removing polysaccharide tablet.
Description
Technical field
The invention belongs to a kind of nutrient and healthcare products technology category, it is related to one kind to match by feverfew Jerusalem artichoke tuber extraction polysaccharide and after purified with medicine-food two-purpose article or Chinese medicine health care product, and it is obtained can with heat-clearing and toxic substances removing, adjust blood glucose, the Technology of the green health care food preparation of blood fat reducing.
Background technology
Jerusalem artichoke property sweet taste, it is nontoxic, can diuretic dry, and middle stomach reinforcing, play the role of heat-clearing and toxic substances removing.Deeply developing Jerusalem artichoke can make resource high-valued, and land resources utilization is efficient.Jerusalem artichoke fresh tuber is rich in Jerusalem artichoke polysaccharide, can be widely used in the manufacture of functional food, medicine and health product as functional ingredient.Radix Glycyrrhizae is then medicine-food two-purpose article, energy eliminating fire and detoxication, lung moistening expelling phlegm for arresting cough, lipid-loweringing, cholesterol reducing, mediation property of medicine, liver protection, Antipyretic.Herb Gynostemmae Pentaphylli then has blood pressure lowering, and blood fat reducing, blood sugar lowering, arteriosclerosis, inhibition thrombosis are calmed the nerves and nourished one's nature, and slow down aging improves mental activity, improves the effects such as cerebral function, activating human body normal cell, calm, hypnosis, antitonic, treatment migraine.The present invention is with Jerusalem artichoke tuber as raw material, Jerusalem artichoke polysaccharide is obtained through extraction and purification, it is compatible with the Chinese medicine health care product and adjuvant of functional food and authorized by state etc. by a certain percentage again, the tablet of the confession oral taking chewy with Jerusalem artichoke polysaccharide as main material has been made, with auxiliary heat-clearing and toxic substances removing, the health-care effecies such as blood glucose, blood fat reducing has been adjusted.Product has no toxic side effect, and prepares overall process three wastes, is suitable for industrialized production.
The content of the invention
By extracting to Jerusalem artichoke tuber, purification obtains Jerusalem artichoke polysaccharide to the present invention.Extracted using water, ethanol or weak caustic solution Gynostemma pentaphyllum Makino, Radix Glycyrrhizae or supersound extraction is respectively obtained Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae extract and solution.Jerusalem artichoke polysaccharide, Herb Gynostemmae Pentaphylli extract and solution, Radix Glycyrrhizae extract and solution pressed suitable proportion compatible again, a kind of heat-clearing and toxic substances removing polysaccharide tablet for being available for oral taking chewy has been made.New health care of food preparation with Jerusalem artichoke polysaccharide as main material is proposed clearly, it is characterised in that the 50-70% of polysaccharide containing Jerusalem artichoke（wt）, other prescription raw material Herb Gynostemmae Pentaphylli extract contents are 10-25%（wt）, Radix Glycyrrhizae extract content is 20-25%（wt）.New formulation of the present invention for feature edible health care product, its pharmaceutical dosage form are can to adjust the multiple efficacies of blood glucose, blood fat reducing, heat-clearing and toxic substances removing etc. with auxiliary for oral chewable tablet.
Specific embodiment
Example
1
Jerusalem artichoke granule or powder 1000g are weighed, is added in 35L water at room temperature；Stirring is warmed up to 90 DEG C of reflux, extract, polysaccharide, and return time is 30 min, and sucking filtration takes filtrate, and residue repeats to extract 1 time with above-mentioned condition again, and united extraction liquid product obtains Jerusalem artichoke polysaccharide aqueous extract density 1.005g/cm3；Concentrated extracting solution obtains concentrated solution 8.5L, then is purified with natural clarifying agent ZTC1+1 component As, B component and obtain liquid volume number 7.9L after purification, then Jing precipitate with ethanol, cold drying obtain white solid Jerusalem artichoke polysaccharide powder 410g.Residual liquid ethanol is reclaimed using rectificating method, purity >=95%.
Herb Gynostemmae Pentaphylli powder 80-110 g, Radix Glycyrrhizae powder 20-30g being weighed respectively, boiling being heated in the weak alkaline medium of pH value 7-8, temperature 95-105 DEG C extracts 1 45min, solid-liquid ratio 1：6（Wt), Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae active ingredient extracting solution are obtained, is neutralized to after pH value 6 with food acids and is filtered, then with 1：8 (wt) 70% alcohol reflux 2 times, each 1-2 h.Concentrate respectively, merge precipitate with ethanol after concentrated solution, obtain Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae effective extract and solution.
A kind of preparation of heat-clearing and toxic substances removing polysaccharide tablet：Formula material, adjuvant, recipe ratio, preparation method, formulation principle are as follows：
Proportioning raw materials：Jerusalem artichoke polysaccharide 50g, Herb Gynostemmae Pentaphylli extract 25g, Radix Glycyrrhizae extract 25g, Herb Gynostemmae Pentaphylli solution 25ml, Radix Glycyrrhizae solution 25ml.Disintegrating agent is carboxymethyl starch sodium 5g；Lubricant accounts for gross mass 0.2% for magnesium stearate（wt）；Adhesive is PVPK30 ethanol solution concentrations 0.5%（wt）, volume 40ml.
Preparation method：It is standby that ground 120 mesh sieve of each mass fraction difference of raw material is taken in proportion；Mix homogeneously in mixer is placed on the equivalent interior addition that progressively increases, then Deca binding agent and Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae solution make soft material by a certain percentage；Soft material was placed in in granulation machine 16 mesh sieves and made granule, be dried under low temperature.By 40 mesh sieve granulate of dried granule Jing intrinsic pressure 100 in tablet machine.Meet the standard preparation requirement of 2010 editions States Pharmacopoeia specifications after testing.
Formulation principle：
Jerusalem artichoke polysaccharide -- it is heat to play the role of reduce blood glucose promotion sugar decomposition to make superfluous sugar transition, improves body fat balance.
Herb Gynostemmae Pentaphylli -- sweet in the mouth, hardship, cold nature.Return lung, spleen, kidney channel.Qi-restoratives, heat clearing away, removing toxic substances.It is weak for body void, nephrasthenia emission, leukopenia, hyperlipemia, viral hepatitis, chronic gastroenteritiss, chronic tracheitiss.
Radix Glycyrrhizae -- nature and flavor are sweet, flat.GUIXIN, lung, spleen, stomach.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, four limbs contraction, lipid-loweringing, cholesterol reducing, alleviate drug toxicity.
Example
2
Jerusalem artichoke Polyose extraction purification, Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae active ingredient are extracted, the preparation method and principle of a kind of heat-clearing and toxic substances removing polysaccharide tablet, with example 1.Composition of raw materials and proportioning are as follows：
Proportioning raw materials：Jerusalem artichoke polysaccharide 70g, Herb Gynostemmae Pentaphylli extract 10g, Radix Glycyrrhizae extract 20g, Herb Gynostemmae Pentaphylli solution 10ml, Radix Glycyrrhizae solution 20ml.Disintegrating agent is carboxymethyl starch sodium 7g；Lubricant accounts for gross mass 0.1% for magnesium stearate（wt）；Adhesive is PVPK30 ethanol solution concentrations 1.5%（wt）, volume 50ml.
A kind of heat-clearing and toxic substances removing polysaccharide tablet according to obtained in above-mentioned formula has the multiple efficacies such as auxiliary heat-clearing and toxic substances removing, blood sugar lowering, Adjust-blood lipid, and product meets the standard of Chinese 2010 editions States Pharmacopoeia specifications after testing and requires, is the health product of green health.
Claims (14)
1. a kind of preparation method of heat-clearing and toxic substances removing polysaccharide tablet, is made up of procedure below and step：
The extraction of Jerusalem artichoke polysaccharide is separated：The Jerusalem artichoke granule for weighing crushing extracts polysaccharide in water, then concentrated, natural clarifying agent ZTC1+1 A, B component purification, filters, and precipitate with ethanol, cold drying obtain off-white color Jerusalem artichoke polysaccharide powder.
2. Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae active ingredient is extracted：Herb Gynostemmae Pentaphylli powder 80-110 g, Radix Glycyrrhizae powder 20-30g being weighed respectively, boiling being heated in the weak alkaline medium of pH value 7-8, temperature 95-105 DEG C extracts 1 45min, solid-liquid ratio 1：6（Wt), respectively Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae active ingredient extracting solution, be neutralized to after pH value 6 with food acids and filtered, then with 1：8 (wt) 70% alcohol reflux is extracted 2 times respectively, each 1-2 h.
3. precipitate with ethanol after concentrating respectively, obtains Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae active ingredient extract and solution.
4. a kind of preparation of heat-clearing and toxic substances removing polysaccharide tablet：It is by integration of edible and medicinal herbs material and Chinese medicine health-care material Jerusalem artichoke polysaccharide, Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae active ingredient extract and Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae solution compatibility composition.
5. there is assisting in reducing blood sugar, the multi-efficiencies such as blood fat, heat-clearing and toxic substances removing are adjusted.
6. Jerusalem artichoke polyoses content 50-70% is characterised by（wt）, prescription raw material Herb Gynostemmae Pentaphylli active ingredient extract 10-25%（wt）, Radix Glycyrrhizae active ingredient extract 20-25%（wt）.
7. proportioning raw materials：Jerusalem artichoke polysaccharide 50-70g, Herb Gynostemmae Pentaphylli extract 10-25 g, Radix Glycyrrhizae extract 20-25g, Herb Gynostemmae Pentaphylli solution 10-25 ml, Radix Glycyrrhizae solution 20-25ml.
8. disintegrating agent is carboxymethyl starch sodium 5-7g；Lubricant accounts for gross mass 0.1-0.2% for magnesium stearate（wt）；Adhesive is PVPK30 ethanol solution concentration 0.5-1.5%（wt）, volume 30-50ml.
9. preparation method：Raw material is taken in proportion, and it is standby that each mass fraction of adjuvant distinguishes ground 120 mesh sieve；Mix homogeneously in mixer is placed on the equivalent interior addition that progressively increases, then Deca binding agent and Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae solution make soft material by a certain percentage；Soft material was placed in in granulation machine 16 mesh sieves and made granule, be dried under low temperature；By 40 mesh sieve granulate of dried granule Jing, and add lubricant intrinsic pressure 100 in tablet machine.
10. product meets the standard preparation requirement of 2010 editions States Pharmacopoeia specifications after testing.
A kind of 11. preparation methoies of heat-clearing and toxic substances removing polysaccharide tablet according to claim 1, Jerusalem artichoke polysaccharide is by water extraction, precipitate with ethanol, natural clarifying agent ZTC1+1
Component A and natural clarifying agent ZTC1+1
B component purification is obtained.
A kind of 12. preparation methoies of heat-clearing and toxic substances removing polysaccharide tablet according to claim 1, Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae active ingredient extract system using weak base and the mixed extracting method of alcohol, and two kinds of products of extract and solution are obtained respectively.
A kind of 13. preparation methoies of heat-clearing and toxic substances removing polysaccharide tablet according to claim 1, prescription raw material be Jerusalem artichoke polysaccharide, Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae extract and Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae solution active ingredient etc. compounding form, the main material Jerusalem artichoke polyoses content 50-70% of the product（wt）, other adjuvant contents 30-50%（wt）.
14. products are to act on certain blood lipid-reducing blood sugar-decreasing, and the green health care food with heat-clearing toxin-expelling functions.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201510631377.1A CN106551990A (en) | 2015-09-29 | 2015-09-29 | A kind of heat-clearing and toxic substances removing polysaccharide tablet |
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| CN201510631377.1A CN106551990A (en) | 2015-09-29 | 2015-09-29 | A kind of heat-clearing and toxic substances removing polysaccharide tablet |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109674015A (en) * | 2019-03-04 | 2019-04-26 | 江苏农牧科技职业学院 | A kind of soup-stock and preparation method thereof and one kind stew chop and preparation method thereof in soy sauce |
-
2015
- 2015-09-29 CN CN201510631377.1A patent/CN106551990A/en active Pending
Non-Patent Citations (3)
| Title |
|---|
| 李妍等: "菊芋多糖的最佳提取工艺研究", 《吉林医药学院学报》 * |
| 潘志明等: "绞股蓝甘草复合保健饮料配方的研究", 《保鲜与加工》 * |
| 王丽娜等: "ZTC1+1Ⅱ天然澄清剂在菊芋多糖提纯中的应用", 《食品研究与开发》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109674015A (en) * | 2019-03-04 | 2019-04-26 | 江苏农牧科技职业学院 | A kind of soup-stock and preparation method thereof and one kind stew chop and preparation method thereof in soy sauce |
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Application publication date: 20170405 |