CN106551977A - 一种治疗烧烫伤药及其制作方法 - Google Patents
一种治疗烧烫伤药及其制作方法 Download PDFInfo
- Publication number
- CN106551977A CN106551977A CN201710032920.5A CN201710032920A CN106551977A CN 106551977 A CN106551977 A CN 106551977A CN 201710032920 A CN201710032920 A CN 201710032920A CN 106551977 A CN106551977 A CN 106551977A
- Authority
- CN
- China
- Prior art keywords
- burn
- scald
- rapeseed oil
- kind treats
- wound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010053615 Thermal burn Diseases 0.000 title claims abstract description 13
- 239000003814 drug Substances 0.000 title claims abstract description 10
- 238000002360 preparation method Methods 0.000 title description 3
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims abstract description 20
- 235000019484 Rapeseed oil Nutrition 0.000 claims abstract description 14
- SEEPANYCNGTZFQ-UHFFFAOYSA-N sulfadiazine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=NC=CC=N1 SEEPANYCNGTZFQ-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229960004306 sulfadiazine Drugs 0.000 claims abstract description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 claims 2
- 229960003405 ciprofloxacin Drugs 0.000 claims 1
- 231100000241 scar Toxicity 0.000 abstract description 8
- 229960001229 ciprofloxacin hydrochloride Drugs 0.000 abstract description 6
- DIOIOSKKIYDRIQ-UHFFFAOYSA-N ciprofloxacin hydrochloride Chemical compound Cl.C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 DIOIOSKKIYDRIQ-UHFFFAOYSA-N 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 5
- 230000035876 healing Effects 0.000 abstract description 5
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 3
- 206010052428 Wound Diseases 0.000 description 12
- 208000027418 Wounds and injury Diseases 0.000 description 12
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 7
- 235000017557 sodium bicarbonate Nutrition 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 6
- 238000002560 therapeutic procedure Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 238000011084 recovery Methods 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 206010039509 Scab Diseases 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 210000002919 epithelial cell Anatomy 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 206010015866 Extravasation Diseases 0.000 description 1
- 208000032456 Hemorrhagic Shock Diseases 0.000 description 1
- 235000011203 Origanum Nutrition 0.000 description 1
- 240000000783 Origanum majorana Species 0.000 description 1
- 206010049771 Shock haemorrhagic Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000001054 cortical effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000009429 distress Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000036251 extravasation Effects 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 210000001640 nerve ending Anatomy 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- BCQMBFHBDZVHKU-UHFFFAOYSA-N terbumeton Chemical compound CCNC1=NC(NC(C)(C)C)=NC(OC)=N1 BCQMBFHBDZVHKU-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000008467 tissue growth Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
本发明公开了一种治疗烧烫伤药，其特征在于：由下列组份和重量比混合而成，磺胺嘧啶5‑8，盐酸环丙沙星2‑3，碳酸氢钠5‑8，小榨菜籽油500。本发明使用方便，直接涂擦，见效快，抑菌力强，愈合后无疤痕，适用于各类烧伤、烫伤。
Description
技术领域
本发明涉及一种药物及其制备方法，尤其是一种治疗烧烫伤的药物及其制作方法。
背景技术
烧伤是外科的常见病之一，据相关资料报道，平均每年发病率为总人口的0.5-1%。烧伤是一种破坏人体防护屏障的表皮、真皮以至整个皮层的疾病，烧伤除直接损坏表皮、真皮及整个皮层细胞外，还因患部的组织细胞酸腐刺激产生大量的组织液外渗，产生酸败和水解，破坏细胞再生环境，损坏微循环系统。因此传统的治疗烧伤病人常用“干”性疗法，一般治疗过程是为了抗休克，保持脏器功能不衰竭，需要补液，保持水分和电介值平衡，然后用抗生素SD-Ag撒于烧伤创面，通过药物吸收外渗液和抗菌，形成干痂，由于结痂后不利于细菌生长，从而达到抗感染目的，这种疗法是以牺牲大量有机组织细胞而实现的，而且结痂后仍易发痂下集浓，限制和影响新生上皮细胞的生长，影响创面愈合，留下不美观的疤痕。同时，该方法用药量过大，药物没有发挥应有的作用，造成较大浪费，为了解决上述问题，人们研究出湿性暴露疗法及湿润烧伤膏（MEBO），目前该技术已成了治疗烧伤的主导治疗技术，湿性暴露疗法的药物是湿润烧伤膏，其治疗方法是首先用洗必泰，新洁尔灭或生理盐水冲洗创面，去除创面附着污物，然后将MEBO膏涂于整个创面，隔一段时间，去除创面液化物后，换药（涂MEBO膏）。虽然烧伤湿润暴露疗法大大减轻了烧伤病人的痛苦程度，方便了治疗工作开展，但由于其无抗抑菌作用，对相当数量的烧伤病人不适用，另其对创伤组织的恢复条件改善作用相对较弱，止痛效果仍不理想，另其制作工艺和生产费用较高。
发明内容
本发明的目的在于克服现有技术的不足，提供一种能更快速减轻烧伤病人痛苦、改善局部微循环、为烧伤组织恢复提供良好的环境，疗效高且不留疤痕的治疗烧烫伤药物及其生产方法，本发明的目的通过下述技术方案来实现，一种治疗烧伤的药物组合物，由下列组份和重量比混合而成：
磺胺嘧啶5-8，盐酸环丙沙星2-3，碳酸氢钠（小苏打）5-8，小榨菜籽油500。
一种治疗烧烫伤的药物组合物的生产方法是将固体物碾碎后与菜籽油混合后即可。
本发明含有微量SD-Ag和盐酸环丙沙星，可有效抑制细菌生长，有效解决烧烫伤感染问题，本发明通过小苏打调节烧伤局部PH值，有效解决创伤区坏死组织及其异物的酸解，酸败而不利新生组织生长的环境问题，同时小苏打有利于局部微血管扩张，改善局部微循环，促进上皮细胞生长，治愈后不留疤痕。还有小苏打可使坏死组织发泡，而提高其通透性，治疗时不需清理伤口。本发明中的菜籽油，有效隔离创面，避免了创面暴露和干燥空气直接对创面的刺激，保护了疼觉神经末梢。
本发明的使用方法，直接涂于烧烫伤创面，烫伤在30秒内涂上本发明产品，不红、不肿、不起泡，3分仲内无痛感。一次即痊愈，Ⅰ度烧伤，也直接将本发明产品涂于烧伤创面，6小时涂一次，3-5天痊愈，Ⅱ度烧伤，每4小时涂一次，5-6天痊愈，Ⅲ度烧伤，每1-3小时候涂一次，6-10天即可痊愈。
重度烧伤，起初3天，每半小时到1小时涂一次，其后第3-6小时涂一次。
与现有技术相比，本发明有以下优点：
1、使用方便，直接涂擦；2、见效快，涂上最多3-5分钟烧灼感减轻或消除；3、抑菌力强，愈合后无疤痕；4、Ⅰ度、Ⅱ度、Ⅲ度烧伤或烫伤的治愈率近100%，即使是重度烧烫伤15-18天即可完全治愈；5、可以在普通环境治疗，没有无菌环境的要求；6、适用于各类烧伤、烫伤；7、制备简单，成本低，利于大规模生产和推广。
本发明临床使用，收到以了十分理想的治疗效果，治愈时间短，治愈后无疤痕，总有效率达99%，详见表1。
注：痊愈是指：症状完全消失，组织外观下正常组织一样，无疤痕。好转是指：症状消失，但留有疤痕或痕迹。无效是指：症状无明显好转。
具体实施方式
实施例1，磺胺嘧啶5，盐酸环丙沙星2.5，碳酸氢钠（小苏打）5，小榨菜籽油500。所说小榨机榨取的菜籽油，其生产方法是将固体物碾碎后与菜籽油混合后即可。
实施例2，磺胺嘧啶6，盐酸环丙沙星2，碳酸氢钠（小苏打）8，小榨菜籽油500。所说小榨机榨取的菜籽油，其生产方法是将固体物碾碎后与菜籽油混合后即可。
实施例3，磺胺嘧啶8，盐酸环丙沙星3，碳酸氢钠（小苏打）6，小榨菜籽油500。所说小榨机榨取的菜籽油，其生产方法是将固体物碾碎后与菜籽油混合后即可。
Claims (1)
1.一种治疗烧烫伤药，其特征在于：由下列组份和重量比混合而成，磺胺嘧啶5-8，盐酸环丙沙星2-3，碳酸氢钠5-8，小榨菜籽油500。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710032920.5A CN106551977A (zh) | 2017-01-18 | 2017-01-18 | 一种治疗烧烫伤药及其制作方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710032920.5A CN106551977A (zh) | 2017-01-18 | 2017-01-18 | 一种治疗烧烫伤药及其制作方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106551977A true CN106551977A (zh) | 2017-04-05 |
Family
ID=58446370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710032920.5A Pending CN106551977A (zh) | 2017-01-18 | 2017-01-18 | 一种治疗烧烫伤药及其制作方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106551977A (zh) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101015589A (zh) * | 2007-03-04 | 2007-08-15 | 李怀保 | 一种治疗烧伤的外用中药制剂及其制备方法 |
| CN101422468A (zh) * | 2007-12-14 | 2009-05-06 | 北京琥珀光华医药科技开发有限公司 | 一种治疗伤口溃烂、烫伤、褥疮等的药用组合物 |
-
2017
- 2017-01-18 CN CN201710032920.5A patent/CN106551977A/zh active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101015589A (zh) * | 2007-03-04 | 2007-08-15 | 李怀保 | 一种治疗烧伤的外用中药制剂及其制备方法 |
| CN101422468A (zh) * | 2007-12-14 | 2009-05-06 | 北京琥珀光华医药科技开发有限公司 | 一种治疗伤口溃烂、烫伤、褥疮等的药用组合物 |
Non-Patent Citations (2)
| Title |
|---|
| 杨景俊: "《食物药用指南》", 31 August 1991, 知识出版社 * |
| 陈允斌: "《回家吃饭的智慧》", 31 May 2016, 吉林科学技术出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103393916B (zh) | 一种治疗皮炎的外用药膏及制备方法 | |
| CN103784659B (zh) | 一种治疗脚鸡眼的中药酊剂 | |
| CN102327419A (zh) | 一种治疗伤口愈合的外用药 | |
| CN104096047A (zh) | 一种治疗毒蛇咬伤的外敷解毒软膏及其制备方法 | |
| CN105362295A (zh) | 一种治疗急慢性咽喉炎、口腔溃疡的美洲大蠊药物组合物及其制备方法 | |
| CN105213256A (zh) | 一种舒敏祛红柔肤水及其制备方法 | |
| CN101332271A (zh) | 一种治疗烧烫伤的外用药物组合物 | |
| CN114177231B (zh) | 一种退热的药物组合物、退热凝胶及制备方法 | |
| CN107648444A (zh) | 一种用于外阴脂溢性皮炎的缓释性透皮给药贴 | |
| CN103830325A (zh) | 一种治疗膝骨性关节炎的中药熏蒸剂及护理方法 | |
| CN106551977A (zh) | 一种治疗烧烫伤药及其制作方法 | |
| CN102784355B (zh) | 急救药及其制备方法 | |
| CN101972360B (zh) | 一种治疗烧烫伤的药物 | |
| CN101274045B (zh) | 一种外用治疗牛皮癣的药物 | |
| CN106729672A (zh) | 一种治疗上呼吸道黏膜炎的组合物及其应用 | |
| CN103432320B (zh) | 一种促使开放性伤口和痈疽疮肿破溃愈合的外用祛腐生肌散 | |
| CN106138143A (zh) | 纯中药烧烫伤、褥疮液及其制备方法 | |
| CN105288325A (zh) | 一种治疗气阴两虚型心律失常的中药 | |
| CN117357608A (zh) | 一种治疗跌打损伤及骨折筋伤的外敷药 | |
| CN102600332B (zh) | 一种治疗烫伤的中药组合物 | |
| CN103784641A (zh) | 一种治疗牛皮癣的中药 | |
| CN107669926A (zh) | 烧伤生肌散 | |
| CN114886954A (zh) | 一种治疗过敏性紫癜皮疹的中药熏洗方 | |
| CN116211923A (zh) | 一种治疗皮肤癣的中药药浴制剂及其制备方法与应用 | |
| CN106139240A (zh) | 一种用于治疗皮肤溃疡的护创液的制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170405 |
|
| RJ01 | Rejection of invention patent application after publication |