CN1065435C - Efficient low-side effect external use medicine for curing seborrheic baldness - Google Patents

Efficient low-side effect external use medicine for curing seborrheic baldness Download PDF

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CN1065435C
CN1065435C CN96109964A CN96109964A CN1065435C CN 1065435 C CN1065435 C CN 1065435C CN 96109964 A CN96109964 A CN 96109964A CN 96109964 A CN96109964 A CN 96109964A CN 1065435 C CN1065435 C CN 1065435C
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gram
fructus
radix
medicine
acutane
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CN1150043A (en
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梅晓春
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Priority to PCT/CN1997/000077 priority patent/WO1998006412A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/234—Cnidium (snowparsley)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/638—Ligustrum, e.g. Chinese privet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The present invention relates to an efficient low-side effect external use medicine recipe for curing seborrheic baldness, which is composed of fleece-flower roots, glossy privet fruit, mulberry seeds, dried radix rehmanniae, eclipta alba, salvia miltiorrhiza, safflower, cnidium monnieri fruit, khosam, dittany, broom cypress fruit, 13-Ro retinoic acid (or any kind of vitamin amine grease, trimethyl methoxy benzene retinoic acid, trichloromethyl methoxy benzene retinoic acid, etretinate, tasmadem, Ro-13-6298), a proper antioxidant and 70% of alcohol. The present invention has a good curative effect on seborrheic baldness and can be popularized and applied by large range.

Description

A kind of modified model external used medicine for the treatment of the efficient low side effect of seborrheic alopecia
The present invention relates to a kind of efficient lower pair drugs with function of modified model for the treatment of seborrheic alopecia, specifically a kind of medicine for external use made from Chinese herbal medicine and Ro acutane cooperation has efficient low side effect, is suitable for applying on a large scale.
Alopecia is a kind of dermatosis of common pilosity, mainly is divided into two types, promptly non-seborrheic alopecia (taking off as speckle) and seborrheic alopecia.The treatment of non-seborrheic alopecia is easier, existing many effective patent medicine.As the medicine of making by Chinese medicines such as Radix Polygoni Multiflori, Fructus Mori non-seborrheic alopecia such as alopecia areata just there is curative effect preferably.Yet for seborrheic alopecia, these medicines we can say that curative effect is very little.The treatment of seborrheic alopecia can be described as a difficult problem of dermatology circle, though people have done many effort, does not still have real effectively medicine and Therapeutic Method so far and comes out.
The essential cause of disease of seborrheic alopecia it be not immediately clear, the traditional Chinese medical science thinks that the empty doctor trained in Western medicine of human body kidney anemia thinks the prosperous excessively seborrheic alopecia that causes of androgen secretion at present, but in medical blood rearing interpolating kidney medicine doctor trained in Western medicine with antiandrogen treatment seborrheic alopecia unsatisfactory curative effect all.The immediate cause that it is considered herein that seborrheic alopecia is because the human endocrine imbalance causes that sebum secretion is prosperous excessively, and in the too much sebum contained some material such as oleic acid, linoleic acid, Squalene etc. to the toxic effect of hair follicle, cause hair to poison, wither, come off, promptly to cross prosperous may be the immediate cause of seborrheic alopecia to sebum secretion.Therefore, at first should want to suppress effectively or to reduce the excessive secretion of scalp fat to the real effectively medicine of seborrheic alopecia.
In addition from the forties, just have the human vitamin A to treat acne, acne also is because sebum secretion is crossed prosperous and dermatosis that this rises, but the ability of vitamin A inhibition sebum secretion is very not strong, and life-time service has bigger toxic and side effects, as headache, osteodynia, alopecia etc.People have successively synthesized hundreds of kind retinoid material on the basis of vitamin A in recent decades, seek safer and more effective Retinoids, Retin-A, Renova, Accutane.These materials all have the effect of obvious suppression sebum secretion.Yet, also be incomplete only with retinoid material treatment seborrheic alopecia, it can not make hair replacement.The most scalp hair follicle of seborrheic alopecia patient is impaired serious in addition, and the atrophy of scalp blood capillary causes hair malnutrition.The inventor observation on Clinical Application to the fact be, if only treat with the retinoid material, many patients' hair still can continue to occur undesired alopecia, if treat seborrheic alopecia with the Chinese medicine associating prescription that hair growth is had facilitation, effect can strengthen greatly.
The inventor had once applied for a kind of Recipe of external-use medicine for the treatment of seborrheic alopecia in 95 years, and had obtained patent (patent No. is ZL95103687.4).This prescription adopts Ro acutane and has the Chinese medicine of facilitation to combine prescription to hair growth.The invention reside in and propose a kind of new modified model prescription, except having better peeling fat anticreep outbreak usefulness, also have side effect still less, help the patient and accept.
Pharmaceutical formulation of the present invention consists of:
Radix Polygoni Multiflori 20-40 gram Fructus Ligustri Lucidi 10-20 gram Fructus Mori 10-20 gram Radix Rehmanniae 10-20 gram
Herba Ecliptae 10-20 gram Radix Salviae Miltiorrhizae 5-15 gram Flos Carthami 5-15 gram Fructus Cnidii 10-30 gram
Radix Sophorae Flavescentis 5-15 gram Cortex Dictamni 5-15 gram Fructus Kochiae 5-15 gram
2.6-ditertbutylparacresol 0.05-5 gram Ro acutane 0.05-5 restrains 70% ethanol 1000-1500 milliliter
Preparation method is:
Radix Polygoni Multiflori in the above-mentioned prescription, Fructus Ligustri Lucidi, Fructus Mori, the Radix Rehmanniae, Herba Ecliptae, Radix Salviae Miltiorrhizae, Flos Carthami, Fructus Cnidii, Radix Sophorae Flavescentis, Cortex Dictamni, the Fructus Kochiae are added one week of 70% soak with ethanol after pulverizing, filter and remove residue, add the Ro acutane and the antioxidant (2.6-ditertbutylparacresol) of formula ratio in filtrate, mix homogeneously can make medicine for external use of the present invention.
Preparing optimization formula of the present invention is:
The Radix Polygoni Multiflori 30 gram Fructus Ligustri Lucidi 15 gram Fructus Mori 15 gram Radix Rehmanniae 15 grams
Herba Ecliptae 15 gram Radix Salviae Miltiorrhizaes 10 gram Flos Carthamis 10 gram Fructus Cnidiis 20 grams
The Radix Sophorae Flavescentis 10 gram Cortex Dictamnis 10 gram Fructus Kochiae 10 grams
2.6-1200 milliliters of ditertbutylparacresol 1 gram Ro acutane 1 gram 70% alcohol
Make 1000 milliliters of medicinal liquids.
A large amount of clinical practices show, the treatment that medicine for external use of the present invention is used for seborrheic alopecia has very clear and definite effect, because Ro acutane has very strong inhibitory action to sebum, the patient uses and can feel that the scalp oils and fats obviously reduced in several days, the alopecia degree reduces greatly, uses about tens ten or twenty skies and just can prevent undesired alopecia substantially.Contained composition has the effect of good promotion natural on-off cycles of hair growth in while Chinese medicine Radix Polygoni Multiflori, Fructus Ligustri Lucidi, Fructus Mori, the Radix Rehmanniae, the Herba Ecliptae.Radix Salviae Miltiorrhizae, Flos Carthami can play and invigorate blood circulation, and promote the scalp blood circulation, improve the effect of scalp nutrient delivery.
The concentration of Ro acutane in lotion has bigger influence to the effect of control alopecia in addition, and the anti-alopecia effect of the high more peeling fat of concentration is strong more.Can make skin produce Pruritus, erythra and stimulation when concentration is big but then, thereby limit the raising of concentration.The present inventor finds that symptoms such as skin Pruritus that Chinese medicines such as Fructus Cnidii, Radix Sophorae Flavescentis, Cortex Dictamni, the Fructus Kochiae cause Ro acutane, erythra, stimulation have good inhibitory effect, can reduce the adverse side effect of Ro acutane effectively so in medicine for external use, add these several Chinese medicinal ingredients to scalp, thereby can improve the concentration of Ro acutane in the medicine for external use greatly, thereby improve curative effect greatly.A large amount of clinical practices show that the curative effect of the present invention's prescription has a bigger raising than the curative effect of the similar medicine of inventor's application in 95 years.The patent formulation of application in 95 years is not enough because of the concentration of Ro acutane season at summer high-temperature, curative effect obviously reduces (the high more patient's sebum secretion of temperature is many more), and prescription of the present invention still can keep better curative effect at high temperature season, and lower side effect is arranged simultaneously.Therefore we can say that medicine of the present invention is a kind of even more ideal medicine for the treatment of seborrheic alopecia, be worth large-scale promotion application.
The retinoid side effects of pharmaceutical drugs are mainly reflected on skin and the mucosa, can cause that when concentration is higher skin sends out ancient term for country school, stimulate, and dry, desquamation, and erythra etc.The Chinese medicine Radix Sophorae Flavescentis, Fructus Cnidii, the Fructus Kochiae, Cortex Dictamni can remove ancient term for country school, scurf removing, antiinflammatory, detoxifcation, this is known.But Radix Sophorae Flavescentis, Fructus Cnidii, the Fructus Kochiae especially have the elimination of inhibition effect for along the skin symptom that retinoic acid causes the effect of clearing up being arranged by 13-when the side effect of medicine source exists, and this is what not appear in the newspapers.Utilize the Chinese medicine Radix Sophorae Flavescentis, Fructus Cnidii, the Fructus Kochiae, Cortex Dictamni are eliminated the skin symptom that 13-causes along retinoic acid, thereby can improve the concentration of 13-along retinoic acid greatly, make medicine more efficient, and this has embodied the novelty and the creative part of this drug invention.
Below provide embodiment, the present invention be described in further detail:
Get Radix Polygoni Multiflori 30 grams, Fructus Ligustri Lucidi 15 grams, Fructus Mori 15 restrains, the Radix Rehmanniae 15 grams, Herba Ecliptae 15 grams, Radix Salviae Miltiorrhizae 10 grams, Flos Carthami 10 grams, Fructus Cnidii 20 restrains, Radix Sophorae Flavescentis 10 grams, Cortex Dictamni 10 grams, the Fructus Kochiae 10 grams are pulverized mixing with them, add 1200 milliliters of 70% ethanol.Soak a week, filter and remove residue.Accurately measure 1000 milliliters of filtrates, add 2.6-ditertbutylparacresol 1 gram, Ro acutane 1 gram, dissolving and mixing makes 1000 milliliters of medicinal liquids of the present invention.

Claims (3)

1. modified model medicine for external use for the treatment of seborrheic alopecia is characterized in that the topical agent that it is made by following raw material:
Radix Polygoni Multiflori 20-40 gram Fructus Ligustri Lucidi 10-20 gram Fructus Mori 10-20 gram Radix Rehmanniae 10-20 gram
Herba Ecliptae 10-20 gram Radix Salviae Miltiorrhizae 5-15 gram Flos Carthami 5-15 gram Fructus Cnidii 10-30 gram
Radix Sophorae Flavescentis 5-15 gram Cortex Dictamni 5-15 gram Fructus Kochiae 5-15 gram
2.6-ditertbutylparacresol 0.05-5 gram Ro acutane 0.05-5 restrains 70% ethanol 1000-1500 milliliter.
2. medicine according to claim 1 is characterized in that it is the topical agent of being made by following raw material:
The Radix Polygoni Multiflori 30 gram Fructus Ligustri Lucidi 15 gram Fructus Mori 15 gram Radix Rehmanniae 15 grams
Herba Ecliptae 15 gram Radix Salviae Miltiorrhizaes 10 gram Flos Carthamis 10 gram Fructus Cnidiis 20 grams
The Radix Sophorae Flavescentis 10 gram Cortex Dictamnis 10 gram Fructus Kochiae 10 grams
2.6-1200 milliliters of ditertbutylparacresol 1 gram Ro acutane 1 gram 70% ethanol.
3. preparation method for the treatment of the modified model external used medicine of seborrheic alopecia is characterized in that proportioning raw materials is:
Radix Polygoni Multiflori 20-40 gram Fructus Ligustri Lucidi 10-20 gram Fructus Mori 10-20 gram Radix Rehmanniae 10-20 gram
Herba Ecliptae 10-20 gram Radix Salviae Miltiorrhizae 5-15 gram Flos Carthami 5-15 gram Fructus Cnidii 10-30 gram
Radix Sophorae Flavescentis 5-15 gram Cortex Dictamni 5-15 gram Fructus Kochiae 5-15 gram
2.6-ditertbutylparacresol 0.05-5 gram Ro acutane 0.05-5 restrains 70% ethanol 1000-1500 milliliter
Its processing technique is as follows: with Chinese medicine Radix Polygoni Multiflori, Fructus Ligustri Lucidi, Fructus Mori, the Radix Rehmanniae, Herba Ecliptae, Radix Salviae Miltiorrhizae, Flos Carthami, Fructus Cnidii, Radix Sophorae Flavescentis, Cortex Dictamni, the Fructus Kochiae, be mixed in proportion, pulverize, add one week of 70% soak with ethanol, filter, get filtrate, add the Ro acutane and the 2.6-ditertbutylparacresol of formula ratio, stir, bottling promptly can be made into external used medicine of the present invention.
CN96109964A 1996-08-09 1996-08-09 Efficient low-side effect external use medicine for curing seborrheic baldness Expired - Fee Related CN1065435C (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN96109964A CN1065435C (en) 1996-08-09 1996-08-09 Efficient low-side effect external use medicine for curing seborrheic baldness
AU36914/97A AU3691497A (en) 1996-08-09 1997-08-01 A medicine of external use for treating seborrheic baldness with high efficacy and low side effect and preparation thereof
PCT/CN1997/000077 WO1998006412A1 (en) 1996-08-09 1997-08-01 A medicine of external use for treating seborrheic baldness with high efficacy and low side effect and preparation thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN96109964A CN1065435C (en) 1996-08-09 1996-08-09 Efficient low-side effect external use medicine for curing seborrheic baldness

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CN1150043A CN1150043A (en) 1997-05-21
CN1065435C true CN1065435C (en) 2001-05-09

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WO (1) WO1998006412A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6261566B1 (en) * 1999-10-22 2001-07-17 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Cosmetic compositions containing mulberry extract and retinoids
KR20030070686A (en) * 2002-02-26 2003-09-02 정성인 External use medicine for promotion of wearing hair and prevention of fallen hair
KR100953278B1 (en) * 2008-02-25 2010-04-19 보령메디앙스 주식회사 Cosmetic composition
CN111084726A (en) * 2020-01-08 2020-05-01 北京幸福益生再生医学科技有限公司 Hair loss prevention and hair growth composition and preparation method thereof
DE102022100053A1 (en) 2022-01-03 2023-07-06 Snejan Dimitrov Ivantchev Topical Agent for Treatment of Alopecia Areata (SNEZHALIN))

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1097140A (en) * 1994-01-19 1995-01-11 柴瑞霞 The Rongfa Wan-a medicinal pill of mainly curing poliosis and alopecia

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1087267A (en) * 1992-11-23 1994-06-01 梅晓春 A kind of prescription for the treatment of seborrheic alopecia
CN1051464C (en) * 1994-04-14 2000-04-19 梅晓春 Oral medicine for curing seborrheic baldness
CN1133714A (en) * 1995-01-04 1996-10-23 马水旺 Health bath lotion
CN1051465C (en) * 1995-04-11 2000-04-19 梅晓春 External use medicine for seborrheic alopecia
CN1051466C (en) * 1995-04-18 2000-04-19 梅晓春 Extrior-use medicine for treatment of alopecia seborrhoeica

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1097140A (en) * 1994-01-19 1995-01-11 柴瑞霞 The Rongfa Wan-a medicinal pill of mainly curing poliosis and alopecia

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CN1150043A (en) 1997-05-21
WO1998006412A1 (en) 1998-02-19

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