CN106543199A - A kind of arteannuin film extraction process - Google Patents
A kind of arteannuin film extraction process Download PDFInfo
- Publication number
- CN106543199A CN106543199A CN201610845291.3A CN201610845291A CN106543199A CN 106543199 A CN106543199 A CN 106543199A CN 201610845291 A CN201610845291 A CN 201610845291A CN 106543199 A CN106543199 A CN 106543199A
- Authority
- CN
- China
- Prior art keywords
- film
- membrane
- arteannuin
- concentration
- permeate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/20—Spiro-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/10—Process efficiency
Abstract
The invention discloses a kind of arteannuin film extraction process, including raw material stoving is crushed, extraction filtration, membrane filtration, membrance separation, membrance concentration and is dried series of steps, and concrete operation step is as follows：Step one, the plant material containing arteannuin is put into baking oven dries at a temperature of 50 ~ 70 DEG C, then stir broken with machine；Step 2, water is added, heated and boiled, with filtered through gauze, filtering residue is washed twice with water；Step 3, ceramic film process, collect ceramic membrane permeate；Step 4, separating treatment is carried out with NF membrane, collect NF membrane concentrated solution；Step 5, NF membrane concentrated solution is carried out into concentration by concentrating film, collect concentration film permeate；Step 6, concentration film dope is carried out into low-temperature vacuum drying, be dried to powder and take out, obtain finished product arteannuin.The present invention is a kind of arteannuin element film extraction process, process is simple, reasonable in design, and arteannuin DNA purity is high, treatment effect is stable, and energy consumption is low, pollution-free.
Description
Technical field
The invention belongs to technical field of membrane separation, and in particular to a kind of arteannuin film extraction process.
Background technology
Arteannuin is that what is extracted from plant Artemisia annua stem and leaf have the sesquiterpene lactoness medicine of peroxy-radical.Between being mainly used in
The symptom control of day malaria, subtertian malaria, and the treatment of resistance to chloroquine worm strain, it is also possible to treat dangerous type subtertian malaria, such as brain type, Huang
Subcutaneous ulcer type etc., also may be used to systemic lupus erythematosus and discoid lupus erythematosuss.At present, the arteannuin industry of China just has
Scale, but the existing extracting method complex operation for preparing arteannuin, apparatus expensive, DNA purity be not high, and yield is relatively low.
The content of the invention
It is an object of the invention to provide a kind of simple to operate, reasonable in design, DNA purity is high, effect stability, yield
High arteannuin film extraction process.
The technical scheme is that a kind of arteannuin film extraction process, including raw material stoving is crushed, extraction is filtered, film mistake
Filter, membrance separation, membrance concentration and series of steps is dried, concrete operation step is as follows：
Step one, the plant material containing arteannuin is put into baking oven dries at a temperature of 50 ~ 70 DEG C, then stirred with machine
It is broken；
Step 2, the broken shape raw material for obtaining step one add water, heated and boiled, and with filtered through gauze, filtering residue is washed twice with water；
Step 3, under the high temperature conditions with ceramic film process seperation film permeate, obtain ceramic membrane permeate and ceramic membrane dope,
Collect ceramic membrane permeate；
Step 4, separating treatment is carried out with NF membrane, obtain NF membrane concentrated solution and NF membrane permeate, collect nanofiltration membrance concentration
Liquid；
Step 5, by NF membrane concentrated solution by concentrate film carry out concentration, obtain concentrate membrance concentration liquid and concentration film pass through
Liquid, collects concentration film permeate；
Step 6, concentration film dope is carried out into low-temperature vacuum drying, be dried to powder and take out, obtain finished product arteannuin.
Preferably, ceramic membrane described in step 3 is tubular ceramic membrane.
Preferably, the nanofiltration retaining molecular weight in step 4 is 200～800 NF membrane.
Preferably, it is rolling organic membrane film to be concentrated described in step 5.
The present invention is a kind of arteannuin film extraction process, by raw material stoving crush, extraction filtration, membrane filtration, membrance separation,
Membrance concentration and dried finally give highly purified arteannuin finished product, carry out sealing stored under refrigeration.
Beneficial effects of the present invention：
The present invention is a kind of arteannuin film extraction process, process is simple, reasonable in design, and arteannuin element DNA purity is high, process effect
Fruit is stable, and energy consumption is low, pollution-free, and the arteannuin and its derivant of extraction can eliminate rapidly plasmodium in human body, to pernicious malaria
There is good therapeutic effect.
Specific embodiment
For ease of skilled artisan understands that the present invention program, in conjunction with specific embodiment to technical solution of the present invention
It is further described in detail.
The present invention is a kind of arteannuin film extraction process, including raw material stoving crush, extraction filtration, membrane filtration, membrance separation,
Membrance concentration and series of steps is dried, concrete operation step is as follows：
Step one, the plant material containing arteannuin is put into baking oven dries at a temperature of 50 ~ 70 DEG C, then stirred with machine
It is broken；
Step 2, the broken shape raw material for obtaining step one add water, heated and boiled, and with filtered through gauze, filtering residue is washed twice with water；
Step 3, under the high temperature conditions with ceramic film process seperation film permeate, obtain ceramic membrane permeate and ceramic membrane dope,
Collect ceramic membrane permeate；
Step 4, separating treatment is carried out with NF membrane, obtain NF membrane concentrated solution and NF membrane permeate, collect nanofiltration membrance concentration
Liquid；
Step 5, by NF membrane concentrated solution by concentrate film carry out concentration, obtain concentrate membrance concentration liquid and concentration film pass through
Liquid, collects concentration film permeate；
Step 6, concentration film dope is carried out into low-temperature vacuum drying, be dried to powder and take out, obtain finished product arteannuin.Step
Ceramic membrane described in three is tubular ceramic membrane, and the nanofiltration retaining molecular weight in step 4 is 200～800 NF membrane,
It is rolling organic membrane that film is concentrated described in step 5.
The present invention is a kind of arteannuin film extraction process, by raw material stoving crush, extraction filtration, membrane filtration, membrance separation,
Membrance concentration and dried finally give highly purified arteannuin finished product, carry out sealing stored under refrigeration, the arteannuin of extraction
The malaria mechanism of action is essentially consisted in and produces free radical, free radical and malaria original egg by arteannuin activation in the process for treating malaria
It is white to combine, act on plasmodial film structure so as to which vacuolar membrane, nuclear membrane and plasma membrane are destroyed, mitochondrial swelling is inside and outside
Film comes off, so as to damage to plasmodial cellularity and its function.
The present invention program is exemplarily described above, it is clear that the present invention is implemented and do not limited by aforesaid way
System, as long as the various unsubstantialities for employing method of the present invention design and technical scheme and carrying out are improved, or not improved will send out
Bright design and technical scheme directly apply to other occasions, within protection scope of the present invention.
Claims (4)
1. a kind of arteannuin film extraction process, including raw material stoving is crushed, extracts filtration, membrane filtration, membrance separation, membrance concentration and do
Dry series of steps, concrete operation step are as follows：
Step one, the plant material containing arteannuin is put into baking oven dries at a temperature of 50 ~ 70 DEG C, then stirred with machine
It is broken；
Step 2, the broken shape raw material for obtaining step one add water, heated and boiled, and with filtered through gauze, filtering residue is washed twice with water；
Step 3, under the high temperature conditions with ceramic film process seperation film permeate, obtain ceramic membrane permeate and ceramic membrane dope,
Collect ceramic membrane permeate；
Step 4, separating treatment is carried out with NF membrane, obtain NF membrane concentrated solution and NF membrane permeate, collect nanofiltration membrance concentration
Liquid；
Step 5, by NF membrane concentrated solution by concentrate film carry out concentration, obtain concentrate membrance concentration liquid and concentration film pass through
Liquid, collects concentration film permeate；
Step 6, concentration film dope is carried out into low-temperature vacuum drying, be dried to powder and take out, obtain finished product arteannuin.
2. a kind of arteannuin film extraction process according to claim 1, it is characterised in that ceramic membrane is described in step 3
Tubular ceramic membrane.
3. a kind of arteannuin film extraction process according to claim 1, it is characterised in that the NF membrane retention in step 4
Molecular weight is 200～800 NF membrane.
4. a kind of arteannuin film extraction process according to claim 1, it is characterised in that film is concentrated described in step 5 is
Rolling organic membrane.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610845291.3A CN106543199A (en) | 2016-09-24 | 2016-09-24 | A kind of arteannuin film extraction process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610845291.3A CN106543199A (en) | 2016-09-24 | 2016-09-24 | A kind of arteannuin film extraction process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106543199A true CN106543199A (en) | 2017-03-29 |
Family
ID=58368339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610845291.3A Pending CN106543199A (en) | 2016-09-24 | 2016-09-24 | A kind of arteannuin film extraction process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106543199A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107319100A (en) * | 2017-08-20 | 2017-11-07 | 合肥信达膜科技有限公司 | A kind of method that soybean lecithin is extracted from soybean |
| CN107383049A (en) * | 2017-08-20 | 2017-11-24 | 合肥信达膜科技有限公司 | A kind of qinghaosu film extraction process |
| CN107445974A (en) * | 2017-06-30 | 2017-12-08 | 禹州市天源生物科技有限公司 | A kind of method that qinghaosu is extracted using NF membrane |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101805353A (en) * | 2009-12-04 | 2010-08-18 | 南京泽朗医药科技有限公司 | Preparation method of artemisinin |
| CN103073561A (en) * | 2013-02-07 | 2013-05-01 | 湖南威嘉生物科技有限公司 | Process of extracting artemisinin by biological enzyme-percolation method |
| CN103242335A (en) * | 2013-04-28 | 2013-08-14 | 四川省裕通生物技术有限公司 | Method for extracting and purifying artemisinin |
| CN103641842A (en) * | 2013-12-02 | 2014-03-19 | 无锡合众信息科技有限公司 | Device for extracting artemisinin from artemisia annua |
-
2016
- 2016-09-24 CN CN201610845291.3A patent/CN106543199A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101805353A (en) * | 2009-12-04 | 2010-08-18 | 南京泽朗医药科技有限公司 | Preparation method of artemisinin |
| CN103073561A (en) * | 2013-02-07 | 2013-05-01 | 湖南威嘉生物科技有限公司 | Process of extracting artemisinin by biological enzyme-percolation method |
| CN103242335A (en) * | 2013-04-28 | 2013-08-14 | 四川省裕通生物技术有限公司 | Method for extracting and purifying artemisinin |
| CN103641842A (en) * | 2013-12-02 | 2014-03-19 | 无锡合众信息科技有限公司 | Device for extracting artemisinin from artemisia annua |
Non-Patent Citations (4)
| Title |
|---|
| 徐朝辉等: "超声提取-膜过滤-超临界萃取联合技术提取青蒿素", 《化工进展》 * |
| 杭太俊: "《药物分析》", 31 August 2011 * |
| 梁晓媛等: "青蒿中青蒿素提取工艺研究进展", 《重庆理工大学学报（自然科学）》 * |
| 饶毅等: "《呦呦有蒿：屠呦呦与青蒿素》", 31 October 2015 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107445974A (en) * | 2017-06-30 | 2017-12-08 | 禹州市天源生物科技有限公司 | A kind of method that qinghaosu is extracted using NF membrane |
| CN107319100A (en) * | 2017-08-20 | 2017-11-07 | 合肥信达膜科技有限公司 | A kind of method that soybean lecithin is extracted from soybean |
| CN107383049A (en) * | 2017-08-20 | 2017-11-24 | 合肥信达膜科技有限公司 | A kind of qinghaosu film extraction process |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101130548B (en) | Method for extracting and producing high content arteannuin | |
| CN105272956B (en) | A kind of industrial method preparing roselle anthocyanidin from roselle | |
| CN105061526B (en) | A kind of extracting method of high-purity Rubusoside | |
| CN106543199A (en) | A kind of arteannuin film extraction process | |
| CN102993154A (en) | Method for extracting purple sweet potato anthocyanin | |
| CN103012544B (en) | A kind of method extracting saponin and polysaccharide from tea seed grouts | |
| CN107098942B (en) | Method for subcritical water extraction of kaempferitrin in radish leaves | |
| CN107383228A (en) | A kind of method for extracting high purity of tremella polysaccharides | |
| CN104557819A (en) | Method for preparing andrographolide and application of andrographolide | |
| CN101007905A (en) | Method of extracting and preparing Ma chestnut shell brown pigment | |
| CN106518830A (en) | Method for extracting anthocyanins | |
| CN106432752A (en) | Preparing method of coal fulvic acid with high purity | |
| CN105859675A (en) | Preparation method of high-purity anthocyanins by extracting from roselle | |
| CN101973983A (en) | Method for extracting orientins from Chinese globeflower flowers | |
| CN106518863A (en) | Berberine film extraction technique | |
| CN103819572A (en) | Extraction technology for production of polysaccharide from mulberry leaf | |
| CN103288900A (en) | Icariin preparation process flow | |
| CN103387501B (en) | Method for preparing high-purity L-synephrine | |
| CN105294631A (en) | Industrial method for preparing anthocyanidin from sambucus williamsii fruits | |
| CN104172179A (en) | Extraction method of tea polyphenol | |
| CN104211667A (en) | Plant extract applied in taxol preparation and preparation method thereof | |
| CN102408368A (en) | Method for preparing xanthophyll from calendula extract | |
| CN107673958A (en) | A kind of method that Co-Q10 isolates and purifies | |
| WO2017185281A1 (en) | Fritillary flower extractive preparation method | |
| CN104974202B (en) | A kind of method of the extraction separation Vitexin xyloside from natural products |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170329 |
|
| WD01 | Invention patent application deemed withdrawn after publication |