CN107445974A - A kind of method that qinghaosu is extracted using NF membrane - Google Patents
A kind of method that qinghaosu is extracted using NF membrane Download PDFInfo
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- CN107445974A CN107445974A CN201710526213.1A CN201710526213A CN107445974A CN 107445974 A CN107445974 A CN 107445974A CN 201710526213 A CN201710526213 A CN 201710526213A CN 107445974 A CN107445974 A CN 107445974A
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- membrane
- qinghaosu
- permeate
- ceramic
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/20—Spiro-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a kind of method that qinghaosu is extracted using NF membrane, comprise the following steps：1）Stock, artemisia leaf are put into drying plant, and temperature control is smashed between 70 80 DEG C after drying with pulverizer；2）Filtering, by step 1）In obtained artemisia leaf powder add water, be heated to 100 DEG C, stand 24 hours, take supernatant, filter residue is washed twice with water；By supernatant with ceramic film process seperation film permeate, ceramic membrane permeate and ceramic membrane dope are obtained, collects ceramic membrane permeate；3）Purification, by step 2）In ceramic membrane permeate, carry out separating treatment with NF membrane, obtain NF membrane concentrate and NF membrane permeate, collect NF membrane concentrate；4）Prepare, by step 3）In NF membrane concentrate insert in drying plant, after fully drying, be ground into pulverizer powdered, obtain finished product qinghaosu, the present invention has that preparation technology is simple, purification efficiency is higher, prepares the advantages of cost is relatively low in a word.
Description
Technical field
The invention belongs to qinghaosu fabricating technology field, and in particular to a kind of side that qinghaosu is extracted using NF membrane
Method.
Background technology
Qinghaosu, also known as arteannuin, it is that to be extracted from plant Artemisia annua cauline leaf have the sesquiterpene lactone of peroxy-radical
Medicine.Its influence to mouse Blood-stage Plasmodium ultra microstructure, the mainly change of plasmodium film structure, the medicine act on first
In food vacuolar membrane, pellicle, mitochondria, endoplasmic reticulum, chromatin in core is also had a certain impact in addition.Prompt the effect of qinghaosu
Mode is mainly to disturb the function of pellicle-mitochondria；In addition artemisinine also showed that in the treatment of other diseases it is tempting before
Scape；Such as anti-schistosome, regulation suppress the immunologic function of body fluid, improve the conversion ratio of lymphocyte, cholagogic, eliminating the phlegm, antibechic, put down
Asthma etc., therefore qinghaosu has great medical market prospect；It is more using concentration cooling mother liquor during qinghaosu is prepared
The method of crystallization, this will produce a certain amount of mother liquor, wherein containing major part qinghaosu, its proportion is about mother liquor knot
The mass ratio of crystalline substance 80%, if this partial mother liquid, which is directly discarded, will cause larger loss, it is therefore necessary to production
The recrystallization mother liquor of qinghaosu is extracted again prepares the purpose of qinghaosu again to reach.
The content of the invention
The invention aims to overcome the deficiencies in the prior art, and provide and a kind of extract qinghaosu using NF membrane
Method.
The object of the present invention is achieved like this：A kind of method that qinghaosu is extracted using NF membrane, is comprised the following steps：
1）Stock, artemisia leaf are put into drying plant, and temperature control is smashed between 70-80 DEG C after drying with pulverizer；
2）Filtering, by step 1）In obtained artemisia leaf powder add water, be heated to 100 DEG C, stand 24 hours, take supernatant,
Filter residue is washed twice with water；By supernatant with ceramic film process seperation film permeate, obtain ceramic membrane permeate and ceramic membrane is dense
Liquid, collect ceramic membrane permeate；
3）Purification, by step 2）In ceramic membrane permeate, carry out separating treatment with NF membrane, obtain NF membrane concentrate and receiving
Filter membrane permeate, collect NF membrane concentrate；
4）Prepare, by step 3）In NF membrane concentrate insert in drying plant, fully dry after, be ground into powder with pulverizer
Last shape, obtain finished product qinghaosu.
Described step 3）In ceramic membrane be plate type ceramic film.
Described step 4）In nanofiltration retaining molecular weight be 800-1000 NF membrane.
Described step 1）With step 4）In drying plant be SY-KRK-28II models Chinese herbal medicine dedicated drying machine.
Beneficial effects of the present invention：The present invention crushes raw material stoving, dense using extraction filtering, membrane filtration, UF membrane, film
The technologies such as contracting, the extraction recovery of qinghaosu can be greatly improved, save raw material, and the present invention, which has, in a word prepares work
Skill is simple, purification efficiency is higher, prepares the advantages of cost is relatively low.
Embodiment
Embodiment 1
A kind of method that qinghaosu is extracted using NF membrane, is comprised the following steps：
1）Stock, artemisia leaf are put into drying plant, and temperature control is smashed between 70-80 DEG C after drying with pulverizer；
2）Filtering, by step 1）In obtained artemisia leaf powder add water, be heated to 100 DEG C, stand 24 hours, take supernatant,
Filter residue is washed twice with water；By supernatant with ceramic film process seperation film permeate, obtain ceramic membrane permeate and ceramic membrane is dense
Liquid, collect ceramic membrane permeate；
3）Purification, by step 2）In ceramic membrane permeate, carry out separating treatment with NF membrane, obtain NF membrane concentrate and receiving
Filter membrane permeate, collect NF membrane concentrate；
4）Prepare, by step 3）In NF membrane concentrate insert in drying plant, fully dry after, be ground into powder with pulverizer
Last shape, obtain finished product qinghaosu.
The present invention crushes raw material stoving when implementing, and utilizes the skills such as extraction filtering, membrane filtration, UF membrane, film concentration
Art, the extraction recovery of qinghaosu can be greatly improved, save raw material, the present invention has preparation technology letter in a word
List, purification efficiency are higher, prepare the advantages of cost is relatively low.
Embodiment 2
A kind of method that qinghaosu is extracted using NF membrane, is comprised the following steps：
1）Stock, artemisia leaf are put into drying plant, and temperature control is smashed between 70-80 DEG C after drying with pulverizer；
2）Filtering, by step 1）In obtained artemisia leaf powder add water, be heated to 100 DEG C, stand 24 hours, take supernatant,
Filter residue is washed twice with water；By supernatant with ceramic film process seperation film permeate, obtain ceramic membrane permeate and ceramic membrane is dense
Liquid, collect ceramic membrane permeate；
3）Purification, by step 2）In ceramic membrane permeate, carry out separating treatment with NF membrane, obtain NF membrane concentrate and receiving
Filter membrane permeate, collect NF membrane concentrate；
4）Prepare, by step 3）In NF membrane concentrate insert in drying plant, fully dry after, be ground into powder with pulverizer
Last shape, obtain finished product qinghaosu.
Described step 3）In ceramic membrane be plate type ceramic film.
Described step 4）In nanofiltration retaining molecular weight be 800-1000 NF membrane.
Described step 1）With step 4）In drying plant be SY-KRK-28II models Chinese herbal medicine dedicated drying machine.
The present invention crushes raw material stoving when implementing, and utilizes the skills such as extraction filtering, membrane filtration, UF membrane, film concentration
Art, the extraction recovery of qinghaosu can be greatly improved, save raw material, the present invention has preparation technology letter in a word
List, purification efficiency are higher, prepare the advantages of cost is relatively low.
Claims (4)
- A kind of 1. method that qinghaosu is extracted using NF membrane, it is characterised in that：Comprise the following steps：1）Stock, artemisia leaf are put into drying plant, and temperature control is smashed between 70-80 DEG C after drying with pulverizer；2）Filtering, by step 1）In obtained artemisia leaf powder add water, be heated to 100 DEG C, stand 24 hours, take supernatant, Filter residue is washed twice with water；By supernatant with ceramic film process seperation film permeate, obtain ceramic membrane permeate and ceramic membrane is dense Liquid, collect ceramic membrane permeate；3）Purification, by step 2）In ceramic membrane permeate, carry out separating treatment with NF membrane, obtain NF membrane concentrate and receiving Filter membrane permeate, collect NF membrane concentrate；4）Prepare, by step 3）In NF membrane concentrate insert in drying plant, fully dry after, be ground into powder with pulverizer Last shape, obtain finished product qinghaosu.
- A kind of 2. method that qinghaosu is extracted using NF membrane as claimed in claim 1, it is characterised in that：Described step 3） In ceramic membrane be plate type ceramic film.
- A kind of 3. method that qinghaosu is extracted using NF membrane as claimed in claim 1, it is characterised in that：Described step 4） In nanofiltration retaining molecular weight be 800-1000 NF membrane.
- A kind of 4. method that qinghaosu is extracted using NF membrane as claimed in claim 1, it is characterised in that：Described step 1） With step 4）In drying plant be SY-KRK-28II models Chinese herbal medicine dedicated drying machine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710526213.1A CN107445974A (en) | 2017-06-30 | 2017-06-30 | A kind of method that qinghaosu is extracted using NF membrane |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710526213.1A CN107445974A (en) | 2017-06-30 | 2017-06-30 | A kind of method that qinghaosu is extracted using NF membrane |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107445974A true CN107445974A (en) | 2017-12-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710526213.1A Pending CN107445974A (en) | 2017-06-30 | 2017-06-30 | A kind of method that qinghaosu is extracted using NF membrane |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106543199A (en) * | 2016-09-24 | 2017-03-29 | 合肥信达膜科技有限公司 | A kind of arteannuin film extraction process |
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2017
- 2017-06-30 CN CN201710526213.1A patent/CN107445974A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106543199A (en) * | 2016-09-24 | 2017-03-29 | 合肥信达膜科技有限公司 | A kind of arteannuin film extraction process |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20171208 |