CN103655655A - Method for separating active ingredients from medicinal material by membrane technology - Google Patents
Method for separating active ingredients from medicinal material by membrane technology Download PDFInfo
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- CN103655655A CN103655655A CN201310724632.8A CN201310724632A CN103655655A CN 103655655 A CN103655655 A CN 103655655A CN 201310724632 A CN201310724632 A CN 201310724632A CN 103655655 A CN103655655 A CN 103655655A
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Abstract
The invention relates to a method for extracting active ingredients from a medicinal material by a membrane separation technology. The method is mainly characterized by comprising the steps of performing pretreatment, such as precipitation, press filtration or centrifugation and microfiltration membrane coarse filtration, on the medicinal material, obtaining crude products of the active ingredients of the medicinal material by a series of membrane separation and adjustment of medicine liquor characters, including microfiltration membrane, ultrafiltration membrane and nanofiltration membrane treatment as well as pH (potential of hydrogen) adjustment and dilution of the medicine liquor, and performing simple distillation on the crude products to form the purer active ingredients in the medicinal material. A separation process of the method is physical; no organic reagent is consumed; no chemical reaction happens; no heating is required; the method is applicable to separating thermosensitive substances, is high in efficiency, low in environmental pollution and high in separating selectivity, can realize automatic and continuous production, meets modern production requirements of the medicinal material and has an important application in extracting and refining the medicinal material.
Description
Technical field
The present invention relates to the separating and extracting process of effective ingredient in a kind of medical material, be specifically related to a kind of method of utilizing effective ingredient in the separated medical material of membrane technology.
Background technology
Medical material can, for the raw material of pharmacy, be espespecially Chinese crude drug in China, without the raw material of Chinese medicine of processing or do not make finished product.Chinese crude drug is the important succession of our Chinese nation culture in several thousand, and it is with the curative effect of self uniqueness, in field of medicaments in occupation of consequence very.At present, the shortcomings such as China's Chinese medicine product ubiquity dose is large, preparation is coarse, quality is unstable, its basic reason is that the chemical composition of Chinese medicine is very complicated, conventionally contain the high molecule mass materials such as the compounds such as inorganic salt, aminoacid, organic acid, alkaloid, phenols, ketone, saponin and protein, polysaccharide, starch, cellulose and bio oil, and traditional Chinese medicine extraction separation method exists complex process, separation efficiency is low, cost is expensive, the seriously polluted deficiency that waits.Therefore, Chinese medicine really be pushed to world market, realize the modernization of Chinese medicine, must use new technique to improve Chinese medicine product quality, this is a problem anxious to be resolved.
Membrane separation technique refers to that the mixture of different-grain diameter molecule on molecular level is when by semipermeable membrane, with semipermeable membrane as selecting barrier layer, then utilize the selectivity (aperture) of film, using energy difference that the both sides of film exist as power, allow some component to see through and retain other components in mixture, thereby reaching separation, purification or concentrated technology.Wherein the membrane separation technique such as microfiltration, ultrafiltration, nanofiltration and reverse osmosis is applied in medical industry.Because the features such as membrane separation technique is energy-conservation, efficient, environmental protection have more and more caused the concern of Chinese medicine production research worker.Application of membrane separation technology has the incomparable advantage of many traditional methods in Chinese medicine extraction: physical separation, do not consume organic reagent, and there is not chemical reaction; Do not need heating, be applicable to the separation of heat-sensitive materials; Efficiency is high, and environmental pollution is little; Separation selectivity is high, can realize automatic continuous production, meets modernization of Chinese medicine Production requirement, in the extraction of Chinese crude drug, has important application aspect refining.
Summary of the invention
The membrane separation technique that the object of the invention is application of advanced is carried out separation to the effective ingredient of Chinese herbal medicine, reaches to extract to isolate purer effective ingredient effect.The present invention utilizes novel synthetic membrane, mainly take pressure differential as motive force, and when film both sides exist certain pressure reduction, the component that can make a part of solvent and be less than membrane aperture is through film, and the tunicles such as microgranule, macromole, salt are retained down, thereby reach the object of effective ingredient separation.
The present invention mainly technical scheme by once realizes:
First carry out the pretreatment such as flocculation sediment, filter pressing or centrifugal and microporous filter membrane coarse filtration, owing to containing the colloid that more solid impurity and relative molecular mass are larger, many sugar and starches etc. in Chinese medicine extraction liquid, directly by membrane separation technique, divide defection to cause the pollution of film, reduce membrane flux, shorten the service life of film etc.; Pretreated medicinal liquid, regulate its pH value for neutral, make medicinal liquid gentle, also can better protecting film material, increase the service life of membrane material, utilize the screening principle of micro-filtration membrane to carry out separation to medicinal liquid, realize the clarification of medicinal liquid, to solid particle, colloidal particle etc., carry out separated with water soluble ingredient; Add suitable solvent to turn down its concentration the medicinal liquid that sees through micro-filtration membrane, reduce the absorption of film to some composition, and reduce the permeability of film, affect its separated effect.The relative molecular mass great majority of Effective Component of Chinese Medicine are no more than 1000, invalid components is if the relative molecular masses such as starch, protein, resin, pectin are more than 50000, select the ultrafilter membrane of certain trapped molecular weight to realize the separated of effective ingredient and impurity, can retain the original compound recipe characteristic of Chinese medicine, bring into play to the full extent drug effect; Further by NF membrane, carry out the smaller impurity of separated relative molecular mass and invalid components, the basic like this effective ingredient that has just obtained purer Chinese patent medicine; The finally simple distillation of recycling concentrates medicinal liquid, obtains the effective ingredient of medical material.
Advantage of the present invention and effect:
The present invention is separated by utilizing novel film materials to extract the effective ingredient of medical material, and this separation process is easy, and does not need heating, is applicable to the separation of heat-sensitive substance; Separation efficiency is high; Do not consume organic solvent, can shorten the production cycle, reduce costs, reduce environmental pollution; Separation selectivity is high; Can realize the advantages such as serialization and automation mechanized operation.
Accompanying drawing explanation
For allowing preparation process of the present invention become apparent, the description of the drawings is as follows:
Fig. 1 illustrates a kind of preparation flow figure according to an embodiment of the present invention.
The specific embodiment
By following examples, the present invention will be further described:
Embodiment:
Chinese medicine Radix Notoginseng is a precious Chinese medicine, there is hemostasis, invigorate blood circulation, enrich blood, protect cardiac muscle, resisting coronary heart disease, protection cerebral tissue, expand blood vessel and blood pressure lowering, raising memory, anti-inflammatory analgesic, calmness, protect the liver, all multiple pharmacological effect such as defying age, nourishing, strong, immunomodulating.Utilize novel membrane separation technique can obtain effective ingredient Radix Notoginseng total arasaponins and dencichine purer in Radix Notoginseng.
Get Radix Notoginseng 3kg, 70oC hot water leaching 2h, then add the decocting of 2 times to boil 2h, standing decoction liquor, goes out large impurity with filter screen, by the micro-filtration membrane of 10 μ m, 05 μ m, 1 μ m and 0.5 μ m, removes less impurity and invalid components wherein, realizes the clarification of medicinal liquid.By medicinal liquid, with after pure water dilution, with molecular cut off, be that NF membrane that 10000,5000,3000 ultrafilter membrane is 500 with molecular cut off is carried out level Four and held back separatedly, be dried, obtain the crude product of Radix Notoginseng total arasaponins and dencichine.Finally recycle simple heating evaporation medicinal liquid is concentrated, obtain the effective ingredient Radix Notoginseng total arasaponins of Radix Notoginseng and the finished product of dencichine.
Claims (4)
1. the method for effective ingredient in the separated medical material of membrane technology, it is characterized in that: first medical material is carried out to pretreatment, remove large solid impurity and the larger polymer substance of relative molecular mass wherein, again medicinal liquid is carried out to separation through micro-filtration membrane, ultrafilter membrane and NF membrane successively, progressively the impurity in medicinal liquid and the descending separation of invalid components are removed, finally by simple distillation, medicinal liquid is concentrated, obtain the effective ingredient in medical material.
2. method according to claim 1, is characterized in that: described pretreatment comprises flocculation sediment, filter pressing or centrifugal and microporous filter membrane coarse filtration etc.
3. method according to claim 1, is characterized in that: described medicinal liquid is by before membrance separation, and it is neutral that medicinal liquid is regulated to pH value.
4. method according to claim 1, is characterized in that: with before ultrafilter membrane separation, medicinal liquid is diluted.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201310724632.8A CN103655655A (en) | 2013-12-18 | 2013-12-18 | Method for separating active ingredients from medicinal material by membrane technology |
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| CN201310724632.8A CN103655655A (en) | 2013-12-18 | 2013-12-18 | Method for separating active ingredients from medicinal material by membrane technology |
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| CN103655655A true CN103655655A (en) | 2014-03-26 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103830298A (en) * | 2014-03-26 | 2014-06-04 | 南京中医药大学 | Method for preparing panax notoginseng saponins by adopting membrane coupling technology |
| CN106422787A (en) * | 2016-10-20 | 2017-02-22 | 合肥创想能源环境科技有限公司 | Membrane-method integrated technology for traditional Chinese medicine deep processing production |
| CN106831932A (en) * | 2016-12-29 | 2017-06-13 | 陕西嘉禾生物科技股份有限公司 | It is a kind of that the method for separating bacopa monnieri saponin is extracted from bacopa monnieri |
| CN111991525A (en) * | 2020-09-02 | 2020-11-27 | 中国药科大学 | Effective component group of Simiao pills and preparation method and application thereof |
-
2013
- 2013-12-18 CN CN201310724632.8A patent/CN103655655A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103830298A (en) * | 2014-03-26 | 2014-06-04 | 南京中医药大学 | Method for preparing panax notoginseng saponins by adopting membrane coupling technology |
| CN106422787A (en) * | 2016-10-20 | 2017-02-22 | 合肥创想能源环境科技有限公司 | Membrane-method integrated technology for traditional Chinese medicine deep processing production |
| CN106831932A (en) * | 2016-12-29 | 2017-06-13 | 陕西嘉禾生物科技股份有限公司 | It is a kind of that the method for separating bacopa monnieri saponin is extracted from bacopa monnieri |
| CN111991525A (en) * | 2020-09-02 | 2020-11-27 | 中国药科大学 | Effective component group of Simiao pills and preparation method and application thereof |
| CN111991525B (en) * | 2020-09-02 | 2022-05-03 | 中国药科大学 | Effective component group of Simiao pills and preparation method and application thereof |
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Application publication date: 20140326 |
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