CN101095724B - Technics for extracting lotus leaf flavone - Google Patents
Technics for extracting lotus leaf flavone Download PDFInfo
- Publication number
- CN101095724B CN101095724B CN2006100856262A CN200610085626A CN101095724B CN 101095724 B CN101095724 B CN 101095724B CN 2006100856262 A CN2006100856262 A CN 2006100856262A CN 200610085626 A CN200610085626 A CN 200610085626A CN 101095724 B CN101095724 B CN 101095724B
- Authority
- CN
- China
- Prior art keywords
- resin
- flavone
- ethanol
- extracting
- lotus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 229930003944 flavone Natural products 0.000 title claims abstract description 64
- 235000011949 flavones Nutrition 0.000 title claims abstract description 64
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 title claims abstract description 63
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 title claims abstract description 60
- 150000002212 flavone derivatives Chemical class 0.000 title claims abstract description 45
- 240000002853 Nelumbo nucifera Species 0.000 title claims abstract description 35
- 235000006508 Nelumbo nucifera Nutrition 0.000 title claims abstract description 35
- 235000006510 Nelumbo pentapetala Nutrition 0.000 title claims abstract description 35
- 229920005989 resin Polymers 0.000 claims abstract description 79
- 239000011347 resin Substances 0.000 claims abstract description 79
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 31
- 238000000605 extraction Methods 0.000 claims abstract description 20
- 238000005406 washing Methods 0.000 claims abstract description 16
- 238000010521 absorption reaction Methods 0.000 claims abstract description 15
- 238000001914 filtration Methods 0.000 claims abstract description 14
- 238000000034 method Methods 0.000 claims abstract description 14
- 239000012528 membrane Substances 0.000 claims abstract description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 54
- -1 flavonoid compounds Chemical class 0.000 claims description 38
- 239000012535 impurity Substances 0.000 claims description 29
- 239000007788 liquid Substances 0.000 claims description 27
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 26
- 238000000108 ultra-filtration Methods 0.000 claims description 25
- 238000005516 engineering process Methods 0.000 claims description 22
- 229930003935 flavonoid Natural products 0.000 claims description 17
- 235000017173 flavonoids Nutrition 0.000 claims description 17
- 239000000843 powder Substances 0.000 claims description 14
- HIXDQWDOVZUNNA-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxychromen-4-one Chemical compound C=1C(OC)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(OC)C(OC)=C1 HIXDQWDOVZUNNA-UHFFFAOYSA-N 0.000 claims description 10
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 10
- 239000000284 extract Substances 0.000 claims description 10
- 239000003208 petroleum Substances 0.000 claims description 10
- 239000011148 porous material Substances 0.000 claims description 10
- 230000001105 regulatory effect Effects 0.000 claims description 10
- 238000000502 dialysis Methods 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 8
- 239000002253 acid Substances 0.000 claims description 7
- 239000003513 alkali Substances 0.000 claims description 7
- 239000002244 precipitate Substances 0.000 claims description 7
- 238000010936 aqueous wash Methods 0.000 claims description 6
- 238000009835 boiling Methods 0.000 claims description 6
- 238000001179 sorption measurement Methods 0.000 claims description 6
- 239000003463 adsorbent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 5
- 235000013824 polyphenols Nutrition 0.000 claims description 5
- 229920003002 synthetic resin Polymers 0.000 claims description 5
- 239000000057 synthetic resin Substances 0.000 claims description 5
- 229920002521 macromolecule Polymers 0.000 claims description 4
- 238000010298 pulverizing process Methods 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 2
- 239000002932 luster Substances 0.000 claims description 2
- 238000001471 micro-filtration Methods 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 238000012856 packing Methods 0.000 claims description 2
- 229920006395 saturated elastomer Polymers 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- 238000001291 vacuum drying Methods 0.000 claims description 2
- 238000010792 warming Methods 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 1
- 230000008021 deposition Effects 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 18
- 239000000706 filtrate Substances 0.000 description 12
- 238000010828 elution Methods 0.000 description 5
- 238000010790 dilution Methods 0.000 description 4
- 239000012895 dilution Substances 0.000 description 4
- 239000003480 eluent Substances 0.000 description 4
- 150000002213 flavones Chemical class 0.000 description 4
- 230000008719 thickening Effects 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 238000011031 large-scale manufacturing process Methods 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 238000003916 acid precipitation Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 238000000247 postprecipitation Methods 0.000 description 2
- 238000000638 solvent extraction Methods 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000001077 hypotensive effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 238000000194 supercritical-fluid extraction Methods 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2006100856262A CN101095724B (en) | 2006-06-28 | 2006-06-28 | Technics for extracting lotus leaf flavone |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2006100856262A CN101095724B (en) | 2006-06-28 | 2006-06-28 | Technics for extracting lotus leaf flavone |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101095724A CN101095724A (en) | 2008-01-02 |
CN101095724B true CN101095724B (en) | 2010-07-28 |
Family
ID=39009944
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2006100856262A Expired - Fee Related CN101095724B (en) | 2006-06-28 | 2006-06-28 | Technics for extracting lotus leaf flavone |
Country Status (1)
Country | Link |
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CN (1) | CN101095724B (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101366829B (en) * | 2008-09-19 | 2011-03-02 | 杨红鸽 | Method for synchronously extracting flavone and alkaloid from folium nelumbinis |
CN102764304B (en) * | 2012-08-15 | 2013-07-24 | 泸州品创科技有限公司 | Method for improving non-oxidation rate of flavonoids in lotus leaves |
CN102764327B (en) * | 2012-08-15 | 2014-04-09 | 四川泰康药业有限公司 | Method for extracting lemon bioflavonoids |
CN102827220B (en) * | 2012-08-24 | 2015-04-15 | 湖州市食品药品检验所 | Method for separating rutin, hyperoside, isoquercitrin and quercetin from lotus leaves |
CN102875508A (en) * | 2012-10-05 | 2013-01-16 | 南通四海植物精华有限公司 | Process for extracting flavonoids of lotus leaves |
CN103285089A (en) * | 2013-05-13 | 2013-09-11 | 张娟 | Preparation process flow of lotus leaf extract |
CN103285088A (en) * | 2013-05-13 | 2013-09-11 | 张娟 | Preparation process of lotus leaf extract |
CN103479730B (en) * | 2013-09-27 | 2014-11-26 | 周爱琴 | Method for synchronously separating lotus leaf flavone and chlorophyll from fresh lotus leaves |
CN103479731B (en) * | 2013-09-27 | 2014-12-10 | 徐君 | Method for extracting high-purity lotus leaf flavones |
CN104194934B (en) * | 2014-08-29 | 2016-06-22 | 佘延英 | A kind of preparation method of Flos Nelumbinis extractum |
CN106749456B (en) * | 2016-12-20 | 2019-08-02 | 江苏宝莲生物科技股份有限公司 | A method of the separating high-purity Hyperoside from lotus leaf |
CN113624897B (en) * | 2021-08-23 | 2023-09-01 | 武汉轻工大学 | Method for measuring phenols in lotus root |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1482125A (en) * | 2002-09-13 | 2004-03-17 | 中国科学院武汉植物研究所 | Process for extracting lotus leaf flavone |
-
2006
- 2006-06-28 CN CN2006100856262A patent/CN101095724B/en not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1482125A (en) * | 2002-09-13 | 2004-03-17 | 中国科学院武汉植物研究所 | Process for extracting lotus leaf flavone |
Non-Patent Citations (4)
Title |
---|
陈海光等.荷叶黄酮及生物碱的提取研究.食品科学23 1.2002,23(1),69-71. |
陈海光等.荷叶黄酮及生物碱的提取研究.食品科学23 1.2002,23(1),69-71. * |
黄阿根等.荷叶黄酮提取工艺研究.食品与机械 5.2000,(5),14、15、18. |
黄阿根等.荷叶黄酮提取工艺研究.食品与机械 5.2000,(5),14、15、18. * |
Also Published As
Publication number | Publication date |
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CN101095724A (en) | 2008-01-02 |
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Owner name: JIANGSU BAOLIAN BIOTECHNOLOGY CO., LTD. Free format text: FORMER NAME: YANGZHOU BAOLIAN BIOTECHNOLOGY CO., LTD. |
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Address after: 225804, crystal Road No. 7, Xi'an industrial center, Baoying County, Yangzhou, Jiangsu, Fengzhen Patentee after: JIANGSU BAOLIAN BIOTECHNOLOGY CO.,LTD. Address before: 225804, crystal Road No. 1, Xi'an industrial center, Baoying County, Yangzhou, Jiangsu, Fengzhen Patentee before: YANGZHOU BAOLIAN BIOLOGICAL SCIENCE & TECHNOLOGY CO.,LTD. |
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Address after: 850000 building 1501, building A, building A, headquarters, Lhasa, Tibet economic and Technological Development Zone, Lhasa economic and Technological Development Zone Patentee after: BIOLOTUS Inc. Address before: 225804, crystal Road No. 7, Xi'an industrial center, Baoying County, Yangzhou, Jiangsu, Fengzhen Patentee before: JIANGSU BAOLIAN BIOTECHNOLOGY CO.,LTD. |
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Effective date of registration: 20190625 Address after: 225800 No. 1 Anfeng Avenue, Xianfeng Town Industrial Concentration Zone, Baoying County, Yangzhou City, Jiangsu Province Patentee after: Jiangsu Kelexin Biological Co.,Ltd. Address before: 850000 Room 1501, Building A, Building 5, Headquarters Economic Base Building, No. 5 Gesang Road, Lhasa Economic and Technological Development Zone, Tibet Autonomous Region Patentee before: BIOLOTUS Inc. |
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