CN105267269A - Method using membrane technology to separate effective constituents in medicinal materials - Google Patents
Method using membrane technology to separate effective constituents in medicinal materials Download PDFInfo
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- CN105267269A CN105267269A CN201510711627.2A CN201510711627A CN105267269A CN 105267269 A CN105267269 A CN 105267269A CN 201510711627 A CN201510711627 A CN 201510711627A CN 105267269 A CN105267269 A CN 105267269A
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Abstract
The invention relates to a method using the membrane separation technology to extract effective constituents in medicinal materials. The method is mainly characterized in that pretreatments such as sedimentation, filter pressing or centrifugation and micro-pore filter membrane coarse filtration are performed on the medicinal materials; a series of membrane separation which includes micro-filtration membrane treatment, ultrafiltration membrane treatment and nano-filtration membrane treatment are performed, the property of the liquid medicine is adjusted, pH of liquid medicine is adjusted, the liquid medicine is diluted to obtain the coarse products of the effective constituents of the medicinal materials, and simple distillation is performed on the coarse products to obtain the relatively-pure effective constituents in the medicinal materials. The method has the advantages that physical separation is used, consumption of organic reagents is avoided, and chemical reaction is avoided; heating is not needed, and the method is suitable for separating thermosensitive substances; the method is high in efficiency, low in environment pollution, high in separation selectivity, capable of achieving automatic and continuous production, capable of satisfying the modern production requirements of the medicinal materials, and significantly applicable to medicinal material extraction and refining.
Description
Technical field
The present invention relates to the separating and extracting process of effective ingredient in a kind of medical material, be specifically related to a kind of method utilizing membrane technology to be separated effective ingredient in medical material.
Background technology
Medical material can, for the raw material of pharmacy, be espespecially Chinese crude drug in China, namely without processing or the raw material of Chinese medicine not making finished product.Chinese crude drug is the important succession of our Chinese nation culture in several thousand, and it is with the curative effect of self uniqueness, in occupation of very consequence in field of medicaments.At present, the shortcomings such as China's Chinese medicine product ubiquity dose is large, preparation is coarse, quality is unstable, its basic reason is that the chemical composition of Chinese medicine is very complicated, usually containing high molecular mass material such as compound and protein, polysaccharide, starch, cellulose and bio oil such as inorganic salt, aminoacid, organic acid, alkaloid, phenols, ketone, saponin, and traditional Chinese medicine extraction separation method also exists complex process, separation efficiency is low, cost intensive, and seriously polluted grade is not enough.Therefore, Chinese medicine really be pushed to world market, realize the modernization of Chinese medicine, new technique must be used to improve Chinese medicine product quality, and this is a problem anxious to be resolved.
Membrane separation technique refers to that the mixture of different-grain diameter molecule is on a molecular scale when by semipermeable membrane, with semipermeable membrane as selection barrier layer, then the selectivity (aperture) of film is utilized, the energy difference existed using the both sides of film is as power, allow some component through and other components of retaining in mixture, thus reach separation, purify or concentrated technology.Wherein the membrane separation technique such as microfiltration, ultrafiltration, nanofiltration and reverse osmosis is applied in medical industry.Because the features such as membrane separation technique is energy-conservation, efficient, environmental protection have more and more caused the concern of Chinese medicine PRODUCTION TRAITS personnel.The advantage that application of membrane separation technology has many traditional methods incomparable in Chinese medicine extraction: physical separation, does not consume organic reagent, chemical reaction does not occur; Do not need heating, be applicable to the separation of heat-sensitive materials; Efficiency is high, and environmental pollution is little; Separation selectivity is high, can realize automatic continuous production, meets modernization of Chinese medicine Production requirement, in the Hydrolysis kinetics of Chinese crude drug, have important application.
Summary of the invention
The effective ingredient of membrane separation technique to Chinese herbal medicine that the object of the invention is application of advanced is separated, and reaches extraction and isolation and goes out purer effective ingredient effect.The present invention utilizes novel synthetic membrane, main is motive force with pressure differential, and when film both sides exist certain pressure reduction, the component that can make a part of solvent and be less than membrane aperture is through film, and the tunicles such as microgranule, macromole, salt are retained down, thus reach the object of effective ingredient separation.
The present invention realizes mainly through technical scheme once:
First the pretreatment such as flocculation sediment, filter pressing or centrifugal and microporous filter membrane coarse filtration are carried out, due in Chinese medicine extraction liquid containing more solid impurity and the larger colloid, many sugar and starches etc. of relative molecular mass, direct membrane separation technique divides defection to cause the pollution of film, reduce membrane flux, shorten the service life etc. of film; Pretreated medicinal liquid, regulate its pH value for neutral, make medicinal liquid gentle, also can better Protective coatings, increase the service life of membrane material, utilize the screening principle of micro-filtration membrane to be separated medicinal liquid, realize the clarification of medicinal liquid, solid particle, colloidal particle etc. are separated with water soluble ingredient; Medicinal liquid through micro-filtration membrane is added suitable solvent to turn down its concentration, reduce film to the absorption of some composition, and reduce the permeability of film, affect the effect that it is separated.The relative molecular mass great majority of Effective Component of Chinese Medicine are no more than 1000, invalid components is if the relative molecular masses such as starch, protein, resin, pectin are then more than 50000, select the ultrafilter membrane of certain trapped molecular weight to realize being separated of effective ingredient and impurity, the original compound recipe characteristic of Chinese medicine can be retained, play drug effect to the full extent; Undertaken being separated the smaller impurity of relative molecular mass and invalid components, the basic like this effective ingredient just obtaining purer Chinese patent medicine by NF membrane further; The finally simple distillation of recycling concentrates medicinal liquid, obtains the effective ingredient of medical material.
Advantage of the present invention and effect:
The present invention carries out extraction and isolation by utilizing novel film materials to the effective ingredient of medical material, and this separation process is easy, and does not need heating, is applicable to the separation of heat-sensitive substance; Separation efficiency is high; Do not consume organic solvent, can the production cycle be shortened, reduce costs, reduce environmental pollution; Separation selectivity is high; The advantage such as serialization and automation mechanized operation can be realized.
Accompanying drawing explanation
For allowing preparation process of the present invention become apparent, the description of the drawings is as follows:
Fig. 1 illustrates a kind of preparation flow figure according to an embodiment of the present invention.
Detailed description of the invention
By following examples, the present invention will be further described:
Embodiment:
Chinese medicine Radix Notoginseng is a precious Chinese medicine, there is hemostasis, invigorate blood circulation, enrich blood, protect cardiac muscle, resisting coronary heart disease, protection cerebral tissue, expand blood vessel and blood pressure lowering, raising memory, anti-inflammatory analgesic, calmness, protect the liver, defying age, nourishing, all multiple pharmacological effect such as strong, immunomodulating.Utilize novel membrane separation technique can obtain effective ingredient Radix Notoginseng total arasaponins purer in Radix Notoginseng and dencichine.
Get Radix Notoginseng 3kg, 70 DEG C of hot water leaching 2h, then add the soak by water 2h of 2 times, leave standstill decoction liquor, go out large impurity with filter screen, remove less impurity and invalid components wherein by the micro-filtration membrane of 10 μm, 05 μm, 1 μm and 0.5 μm, realize the clarification of medicinal liquid.By medicinal liquid with after pure water dilution, be that ultrafilter membrane and the molecular cut off NF membrane that is 500 of 10000,5000,3000 is carried out level Four and retained and be separated with molecular cut off, dry, obtain the crude product of Radix Notoginseng total arasaponins and dencichine.Finally recycle simple heating evaporation to concentrate medicinal liquid, obtain the effective ingredient Radix Notoginseng total arasaponins of Radix Notoginseng and the finished product of dencichine.
Claims (4)
1. membrane technology is separated the method for effective ingredient in medical material, it is characterized in that: first pretreatment is carried out to medical material, removing large solid impurity wherein and the larger polymer substance of relative molecular mass, again medicinal liquid is separated through micro-filtration membrane, ultrafilter membrane and NF membrane successively, progressively by the impurity in medicinal liquid and the descending separation removing of invalid components, finally by simple distillation, medicinal liquid is concentrated, obtain the effective ingredient in medical material.
2. method according to claim 1, is characterized in that: described pretreatment comprises flocculation sediment, filter pressing or centrifugal and microporous filter membrane coarse filtration etc.
3. method according to claim 1, is characterized in that: medicinal liquid adjust ph, by before membrance separation, is neutral by described medicinal liquid.
4. method according to claim 1, is characterized in that: before with Ultra filtration membrane, is diluted by medicinal liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510711627.2A CN105267269A (en) | 2015-10-27 | 2015-10-27 | Method using membrane technology to separate effective constituents in medicinal materials |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510711627.2A CN105267269A (en) | 2015-10-27 | 2015-10-27 | Method using membrane technology to separate effective constituents in medicinal materials |
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| CN105267269A true CN105267269A (en) | 2016-01-27 |
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| CN201510711627.2A Pending CN105267269A (en) | 2015-10-27 | 2015-10-27 | Method using membrane technology to separate effective constituents in medicinal materials |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109550006A (en) * | 2018-11-16 | 2019-04-02 | 怀化学院 | The impurity-removing method of clean yin itching-relieving lotion |
-
2015
- 2015-10-27 CN CN201510711627.2A patent/CN105267269A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109550006A (en) * | 2018-11-16 | 2019-04-02 | 怀化学院 | The impurity-removing method of clean yin itching-relieving lotion |
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| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20160127 |
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| WD01 | Invention patent application deemed withdrawn after publication |