CN103815405B - The production system of cistanche extracts - Google Patents
The production system of cistanche extracts Download PDFInfo
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- CN103815405B CN103815405B CN201410084004.2A CN201410084004A CN103815405B CN 103815405 B CN103815405 B CN 103815405B CN 201410084004 A CN201410084004 A CN 201410084004A CN 103815405 B CN103815405 B CN 103815405B
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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Abstract
The invention discloses a kind of production system of cistanche extracts, it comprises batch can, the first cartridge filter, ultra filtration unit, adsorbent exchange resin column, the second cartridge filter and the reverse osmosis units arranged successively; The input of described first cartridge filter connects the output of batch can, and the output of the first cartridge filter connects the input of ultra filtration unit; The input of described adsorbent exchange resin column connects the filtrate (liquid of ultra filtration unit, and the output of adsorbent exchange resin column connects the input of the second cartridge filter; The input of described reverse osmosis units connects the output of the second cartridge filter, and the concentrated solution outlet of reverse osmosis units connects spray-drying installation.Filtered by ultra filtration unit, adsorbent exchange resin column is separated and the combination of reverse osmosis units concentration technique, effectively can improve the purity of product, produce the cistanche extracts obtained and reach food-grade requirement.
Description
Technical field
The present invention relates to chemical technology field, be specifically related to a kind of production system of cistanche extracts.
Background technology
Saline cistanche is Orobanchaceae plant, it has tonifying kidney and strengthening yang, anti-ageing, enhancing is remembered, improve the several functions such as immunity, from the eighties in 20th century, large quantity research is carried out to the chemical composition of saline cistanche both at home and abroad, along with the develop rapidly of separation and Extraction and detection technique, current researcher successfully from saline cistanche separation and Extraction go out various active material, wherein benzyl carbinol glycosides compounds is the main active in saline cistanche.
In prior art, method for the production of cistanche extracts mainly contains water extraction and alcohol precipitation method, namely be first the effective active composition in solvent extraction saline cistanche with water, undertaken shaking standing filtration to remove impurity by adding high concentration ethanol in extract again, thus obtain cistanche extracts, mainly benzyl carbinol glycosides compounds in described cistanche extracts, but the method exists that solvent-oil ratio is large, the production cycle is long, production cost is high and the problem such as impurity content in cistanche extracts is high.
Chinese patent literature discloses the patent of invention (document number is CN101041677) that a kind of name is called " raw material containing benzyl carbinol glycosides that using membrane separating technology is produced from saline cistanche ", this patent have employed the production and processing that method that water extract-alcohol precipitation and UF membrane combine carries out cistanche extracts, concrete steps are: first collect extract with water extraction and alcohol precipitation method, then extract is carried out centrifugal filtration, the supernatant that filtration obtains is through ceramic membrane and ultrafiltration membrance filter, then filtrate is passed through nanofiltration membrane, namely cistanche extracts is obtained after finally the trapped fluid of nanofiltration being carried out drying, adopting the method to prepare cistanche extracts, to there is the production cycle equally long, the problem that product purity is low, moreover, the equipment cost of centrifuge and ceramic membrane is relatively high, economic pressures are caused to enterprise investment.
Summary of the invention
The object of this invention is to provide the production system of a kind of low cost, high efficiency cistanche extracts, the purity that this production system produces the cistanche extracts obtained is high.
For achieving the above object, the technical solution used in the present invention is: a kind of production system of cistanche extracts, is characterized in that: comprise batch can, the first cartridge filter, ultra filtration unit, adsorbent exchange resin column, the second cartridge filter and the reverse osmosis units arranged successively; The input of described first cartridge filter connects the output of batch can, and the output of the first cartridge filter connects the input of ultra filtration unit; The input of described adsorbent exchange resin column connects the filtrate (liquid of ultra filtration unit, and the output of adsorbent exchange resin column connects the input of the second cartridge filter; The input of described reverse osmosis units connects the output of the second cartridge filter, and the concentrated solution outlet of reverse osmosis units connects spray-drying installation.
The beneficial effect that technique scheme produces is: filtered by ultra filtration unit, adsorbent exchange resin column is separated and the combination of reverse osmosis units concentration technique, effectively can improve the purity of product, produce the cistanche extracts obtained and reach food-grade requirement.Compare than prior art, present invention eliminates alcohol precipitation, centrifuge is separated and the operation of microfiltration of ceramic membrane, not only reduce production cost, and effectively enhance productivity.
Accompanying drawing explanation
Fig. 1 is structural representation of the present invention.
Detailed description of the invention
A production system for cistanche extracts, it comprises batch can 10, first cartridge filter 20, ultra filtration unit 30, adsorbent exchange resin column 60, second cartridge filter 70 and the reverse osmosis units 80 arranged successively; The input of described first cartridge filter 20 connects the output of batch can 10, and the output of the first cartridge filter 20 connects the input of ultra filtration unit 30; The input of described adsorbent exchange resin column 60 connects the filtrate (liquid of ultra filtration unit 30, and the output of adsorbent exchange resin column 60 connects the input of the second cartridge filter 70; The input of described reverse osmosis units 80 connects the output of the second cartridge filter 70, and the concentrated solution outlet of reverse osmosis units 80 connects spray-drying installation 90.During use, large molecule soluble impurity such as the suspension in saline cistanche Aqueous extracts, bacterium and protein, polysaccharide, pectin etc. can be retained after saline cistanche Aqueous extracts in batch can 10 is carried out ultrafiltration by ultra filtration unit 30, filtrate after ultrafiltration adsorbing separation can go out main active benzyl carbinol glycosides compounds in saline cistanche by adsorbent exchange resin column 60, then carries out spraying dry namely obtain cistanche extracts by being separated the concentrate obtained after the active component obtained carries out thickening filtration by reverse osmosis units 80.Compare than prior art, present invention eliminates alcohol precipitation, centrifuge is separated and the operation of microfiltration of ceramic membrane, not only reduce production cost, and effectively enhance productivity, the more important thing is, filtered by ultra filtration unit 30, adsorbent exchange resin column 60 is separated and the combination of reverse osmosis units 80 concentration technique, effectively can improve the purity of product, to detect, and produce the cistanche extracts obtained and reach food-grade requirement.
As further preferred version: the connecting line between described ultra filtration unit 30 and adsorbent exchange resin column 60 is provided with the 3rd cartridge filter 40 and nano-filtration unit 50, the input of described 3rd cartridge filter 40 connects the filtrate (liquid of ultra filtration unit 30, the output of the 3rd cartridge filter 40 connects the input of nano-filtration unit 50, the concentrated solution outlet of described nano-filtration unit 50 connects the input of adsorbent exchange resin column 60, in fact, described ultra filtration unit 30, the input end of nano-filtration unit 50 and reverse osmosis units 80 is provided with delivery pump, to guarantee effective conveying of feed liquid.After thickening filtration being carried out to the filtrate of ultra filtration unit by nano-filtration unit, the solubility small-molecule substances such as the monose of ultrafiltrate, disaccharides, inorganic salts can be removed, not only remove impurity, improve the purity of product, and target feed liquid is effectively concentrated, be conducive to the adsorbing separation of subsequent adsorbtion exchange resin column 60.
Further, the concentrated solution outlet of described ultra filtration unit 30 and the filtrate (liquid of nano-filtration unit 50 all lead to collection processing system implementing, the suspension that the concentrate of ultra filtration unit 30 is mainly retained by ultrafiltration from the Aqueous extracts of saline cistanche, bacterium and the large molecule soluble impurity such as protein, polysaccharide, pectin, and the filtrate of nano-filtration unit 50 mainly filters the solubility small molecular weight impurity such as monose, disaccharides, inorganic salts removed by nano-filtration unit 50, these impurity are all imported collection processing system implementing, facilitate the centralized collection process of impurity, improve process efficiency.
Further, the filtering accuracy of described first cartridge filter 20 is 50 ~ 500 μm, described second, 3rd cartridge filter 40, the filtering accuracy of 70 is 5 ~ 50 μm, the selection of the filtering accuracy of above-mentioned cartridge filter is all that staff gropes through a large amount of tests, fixed in conjunction with self physics and chemistry feature of passed through material, technique scheme is adopted can effectively to avoid insoluble impurities to the blocking of technique runner, be conducive to the continuous production of technique, and effectively extend ultra filtration unit 30, the service life of the membrane component in nano-filtration unit 50 and reverse osmosis units 70.
Further, the membrane component in described ultra filtration unit 30 is organic tubular ultra-filtration membrane or organic board-like film or organic hollow tunica fibrosa, and the molecular cut off of membrane component in ultra filtration unit 30 is 50-500kD; Membrane component in described nano-filtration unit 50 is organic rolling NF membrane or organic tubular nanofiltration membrane, and the molecular cut off of membrane component in nano-filtration unit 50 is 100-1000D; Membrane component in described reverse osmosis units 80 is the reverse osmosis membrane of rolling.
Below by way of two embodiments, technical scheme disclosed by the invention is further described:
Embodiment 1:
Cut into slices by Desert Herba Cistanches, use pure water by its lixiviate 4 hours under 80 DEG C of conditions, the mass ratio of saline cistanche and pure water is 1:20;
The hollow fiber ultrafiltration membrane that the first cartridge filter 20 filters, molecular cut off is 10000D that the extract obtained after lixiviate is 500 μm by filtering accuracy is successively filtered, and entering membrane operations pressure is 3Bar;
The 3rd cartridge filter 40 being 50um by filtering accuracy successively by the filtrate of hollow-fibre membrane ultrafiltration filters, molecular cut off is that the nano-filtration unit of 100D concentrates, then by macroporous absorption exchange resin column 60 on the concentrate after concentrated 6 times, glycoside active material in resin adsorption saline cistanche, ethanol water resolves glycoside active material, the second cartridge filter 70 that the desorbed solution exported from the output of adsorbent exchange resin column 60 is 50um by filtering accuracy successively filters, reverse osmosis units 80 concentrates, concentrate after reverse osmosis units 80 is concentrated carries out spraying dry and namely obtains cistanche extracts, after testing, the cistanche extracts of above-mentioned preparation reaches food grade standard.
Embodiment 2:
Cut into slices by Cistanche tubulosa, use pure water by its lixiviate 4 hours under 80 DEG C of conditions, the mass ratio of saline cistanche and pure water is 1:20;
The tubular ultra-filtration membrane that the first cartridge filter 20 filters, molecular cut off is 10000D that the extract obtained after lixiviate is 100 μm by filtering accuracy successively filters, and entering membrane operations pressure is 2.5Bar;
The 3rd cartridge filter 40 being 20um by filtering accuracy successively by the filtrate of hollow-fibre membrane ultrafiltration filters, molecular cut off is that the nano-filtration unit of 200D concentrates, then by macroporous absorption exchange resin column 60 on the concentrate after concentrated 8 times, glycoside active material in resin adsorption saline cistanche, ethanol water resolves glycoside active material, the second cartridge filter 70 that the desorbed solution exported from the output of adsorbent exchange resin column 60 is 20um by filtering accuracy successively filters, reverse osmosis units 80 concentrates, concentrate after reverse osmosis units 80 is concentrated carries out spraying dry and namely obtains cistanche extracts, after testing, the cistanche extracts of above-mentioned preparation reaches food grade standard.
Claims (3)
1. a production system for cistanche extracts, is characterized in that: comprise batch can (10), the first cartridge filter (20), ultra filtration unit (30), adsorbent exchange resin column (60), the second cartridge filter (70) and the reverse osmosis units (80) arranged successively;
The input of described first cartridge filter (20) connects the output of batch can (10), and the output of the first cartridge filter (20) connects the input of ultra filtration unit (30);
The input of described adsorbent exchange resin column (60) connects the filtrate (liquid of ultra filtration unit (30), and the output of adsorbent exchange resin column (60) connects the input of the second cartridge filter (70);
The input of described reverse osmosis units (80) connects the output of the second cartridge filter (70), and the concentrated solution outlet of reverse osmosis units (80) connects spray-drying installation (90);
The filtering accuracy of described first cartridge filter (20) is 50 ~ 500 μm; The filtering accuracy of described second cartridge filter (70) is 5 ~ 50 μm; Membrane component in described ultra filtration unit (30) is organic tubular ultra-filtration membrane or organic board-like film or organic hollow tunica fibrosa, and the molecular cut off of membrane component in ultra filtration unit (30) is 50-500kD; Membrane component in described reverse osmosis units (80) is the reverse osmosis membrane of rolling.
2. the production system of cistanche extracts according to claim 1, it is characterized in that: the connecting line between described ultra filtration unit (30) and adsorbent exchange resin column (60) is provided with the 3rd cartridge filter (40) and nano-filtration unit (50), the input of described 3rd cartridge filter (40) connects the filtrate (liquid of ultra filtration unit (30), the output of the 3rd cartridge filter (40) connects the input of nano-filtration unit (50), and the concentrated solution outlet of described nano-filtration unit (50) connects the input of adsorbent exchange resin column (60); The filtering accuracy of described 3rd cartridge filter (40) is 5 ~ 50 μm, and the membrane component in described nano-filtration unit (50) is organic rolling NF membrane or organic tubular nanofiltration membrane, and the molecular cut off of membrane component in nano-filtration unit (50) is 100-1000D.
3. the production system of cistanche extracts according to claim 2, is characterized in that: the concentrated solution outlet of described ultra filtration unit (30) and the filtrate (liquid of nano-filtration unit (50) all lead to collection processing system implementing.
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| CN201410084004.2A CN103815405B (en) | 2014-03-07 | 2014-03-07 | The production system of cistanche extracts |
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| CN201410084004.2A CN103815405B (en) | 2014-03-07 | 2014-03-07 | The production system of cistanche extracts |
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| CN103815405B true CN103815405B (en) | 2015-08-12 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104926954A (en) * | 2015-06-19 | 2015-09-23 | 中国科学院过程工程研究所 | Method for separating and preparing polysaccharide, oligosaccharide and mannitol from cistanche |
| CN104926955A (en) * | 2015-06-19 | 2015-09-23 | 中国科学院过程工程研究所 | Method for fractionating polysaccharide from cistanche |
| CN110495546A (en) * | 2019-03-12 | 2019-11-26 | 温通平 | One kind preparing solid beverage method based on Herba Cistanches |
| CN115227741A (en) * | 2022-06-09 | 2022-10-25 | 新疆汇峰农业科技有限公司 | Cistanche deserticola extract purification method and equipment |
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| CN101214282A (en) * | 2007-12-28 | 2008-07-09 | 中山大学 | Method for extracting active component from cistanche salsa |
| CN202124582U (en) * | 2011-07-01 | 2012-01-25 | 安徽普朗膜技术有限公司 | Membrane treatment system capable of extracting levodopa from velvet beans |
| CN101665448B (en) * | 2009-09-30 | 2012-09-05 | 江西农业大学 | Method for extracting coronatine from fermentation liquor by using membrane separation technique |
| CN203353611U (en) * | 2013-06-20 | 2013-12-25 | 安徽普朗膜技术有限公司 | Soy sauce filtering system |
| CN203828006U (en) * | 2014-03-07 | 2014-09-17 | 安徽普朗膜技术有限公司 | Production system of cistanche extract |
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2014
- 2014-03-07 CN CN201410084004.2A patent/CN103815405B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101214282A (en) * | 2007-12-28 | 2008-07-09 | 中山大学 | Method for extracting active component from cistanche salsa |
| CN101665448B (en) * | 2009-09-30 | 2012-09-05 | 江西农业大学 | Method for extracting coronatine from fermentation liquor by using membrane separation technique |
| CN202124582U (en) * | 2011-07-01 | 2012-01-25 | 安徽普朗膜技术有限公司 | Membrane treatment system capable of extracting levodopa from velvet beans |
| CN203353611U (en) * | 2013-06-20 | 2013-12-25 | 安徽普朗膜技术有限公司 | Soy sauce filtering system |
| CN203828006U (en) * | 2014-03-07 | 2014-09-17 | 安徽普朗膜技术有限公司 | Production system of cistanche extract |
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