CN103641842A - Device for extracting artemisinin from artemisia annua - Google Patents

Device for extracting artemisinin from artemisia annua Download PDF

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Publication number
CN103641842A
CN103641842A CN201310626387.7A CN201310626387A CN103641842A CN 103641842 A CN103641842 A CN 103641842A CN 201310626387 A CN201310626387 A CN 201310626387A CN 103641842 A CN103641842 A CN 103641842A
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CN
China
Prior art keywords
tank
strainer
artemisinin
herba artemisiae
artemisiae annuae
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Application number
CN201310626387.7A
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Chinese (zh)
Inventor
唐豪
王香兵
周桃英
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WUXI HEZHONG INFORMATION TECHNOLOGY Co Ltd
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WUXI HEZHONG INFORMATION TECHNOLOGY Co Ltd
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Priority to CN201310626387.7A priority Critical patent/CN103641842A/en
Publication of CN103641842A publication Critical patent/CN103641842A/en
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/20—Spiro-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention provides a device for extracting artemisinin from artemisia annua. The device comprises an ultrasonic disruption tank, a constant temperature oscillator, a first filter, a concentrating tank, a second filter, a bleaching tank, a ceramic microfiltration membrane and a crystallizing tank, which are connected with each other in sequence, wherein a dehydrating agent tank is connected on the concentrating tank and then is connected on the concentrating tank via a recovery tank; and a cooling device is also arranged on the recovery tank. The device provided by the invention effectively combines crude extraction, concentration and solvent reflux, increases the yield and reduces the solvent dosage and consumption.

Description

A kind of Herba Artemisiae annuae Artemisinin extraction element
Technical field
The invention belongs to natural product extracting technique field, be specifically related to a kind of Herba Artemisiae annuae Artemisinin extraction element.
Background technology
Artemisinin-based drug is a large class the most conventional in antimalarial agent, and it is that first China find and manufacture.The conventional method of preparing artemisinin-based drug mainly contains organic synthesis and carries out separation and Extraction by sweet wormwood raw material.Extracting method to Artemisinin, mainly contain at present the methods such as hot formulation, ultrasonic method, carbon dioxide upercritical fluid extraction, although these method extraction yields are high, but industrial equipments is had relatively high expectations, and more expensive than common equipment, therefore, mostly domestic a lot of enterprise is to adopt hot formulation to extract, yet adopt hot formulation, not only extraction time is many, complex operation, and solvent load is large, energy consumption is high.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art and a kind of Herba Artemisiae annuae Artemisinin extraction element is provided.
A kind of Herba Artemisiae annuae Artemisinin extraction element, include the ultrasonication tank, constant temperature oscillator, the first strainer, concentration tank, the second strainer, bleacher, ceramic capillary filter membrane, the crystallizer that connect successively, on concentration tank, be connected with dewatering agent tank, dewatering agent tank is connected on concentration tank by withdrawing can again, is also provided with refrigerating unit on withdrawing can.
As the further improvement of foregoing invention, the first strainer is filter cloth.
As the further improvement of foregoing invention, the first strainer is macromolecular filter membrane.
Compared with prior art, its remarkable advantage is in the present invention: will slightly carry, concentrate and the effective combination of solvent refluxing, and improve yield, reduce solvent load, reduce consumption.
Accompanying drawing explanation
Fig. 1 is the structural representation of Herba Artemisiae annuae Artemisinin extraction element.
Wherein, 1 is ultrasonication tank, and 2 is constant temperature oscillator, and 3 is the first strainer, and 4 is concentration tank, and 5 is the second strainer, and 6 is bleacher, and 7 is ceramic capillary filter membrane, and 8 is crystallizer, and 9 is dewatering agent tank, and 10 is withdrawing can, and 11 is refrigerating unit.
Embodiment
As shown in Figure 1, a kind of Herba Artemisiae annuae Artemisinin extraction element, include the ultrasonication tank 1, constant temperature oscillator 2, the first strainer 3, concentration tank 4, the second strainer 5, bleacher 6, ceramic capillary filter membrane 7, the crystallizer 8 that connect successively, on concentration tank 4, be connected with dewatering agent tank 9, dewatering agent tank 9 is connected on concentration tank 4 by withdrawing can 10 again, is also provided with refrigerating unit 11 on withdrawing can 10.Wherein, the first strainer is filter cloth, and the first strainer is macromolecular filter membrane.
Below in conjunction with leaching process, this device is described further:
Get after Herba Artemisiae annuae cleans, put into ultrasonication tank, then add the sherwood oil of 2 times of volumes, ultrasonic 2 hours, ultrasound intensity was 3.0～4.5W/cm 2; Raw material after ultrasonic is imported to constant temperature oscillator, then add 18 times of volumes sherwood oil, the 24h that vibrates under 30 ℃ of conditions, oscillation frequency is 120 beats/min; Then vibration liquid is filtered by the first strainer, filtrate enters into concentration tank; In concentration tank, filtrate is reduced pressure to heat and concentrate, the sherwood oil steam of evaporation is after dewatering agent tank, wherein most of moisture is removed, sherwood oil after dehydration enters in withdrawing can, by refrigerating unit, recovery sherwood oil is cooled to 2-4 ℃, then these is reclaimed to sherwood oil and put into back concentration tank; Being concentrated into feed liquid in tank is that original volume one half stops; Then, after feed liquid being filtered by the second strainer, enter to activated carbon decolorizing tank; Feed liquid after decolouring is filtered by ceramic microfiltration membrane, and filtrate liquid, after recrystallization, obtains Artemisinin.
Through lot of experiments, prove, the purity of preparation-obtained Artemisinin can be controlled at 60%-65%.

Claims (3)

1. a Herba Artemisiae annuae Artemisinin extraction element, it is characterized in that: include the ultrasonication tank (1), constant temperature oscillator (2), the first strainer (3), concentration tank (4), the second strainer (5), bleacher (6), ceramic capillary filter membrane (7), the crystallizer (8) that connect successively, on concentration tank (4), be connected with dewatering agent tank (9), it is upper that dewatering agent tank (9) is connected in concentration tank (4) by withdrawing can (10) again, is also provided with refrigerating unit (11) on withdrawing can.
2. Herba Artemisiae annuae Artemisinin extraction element according to claim 1, is characterized in that: described the first strainer (3) is filter cloth.
3. Herba Artemisiae annuae Artemisinin extraction element according to claim 1, is characterized in that: described the second strainer (5) is macromolecular filter membrane.
CN201310626387.7A 2013-12-02 2013-12-02 Device for extracting artemisinin from artemisia annua Withdrawn CN103641842A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201310626387.7A CN103641842A (en) 2013-12-02 2013-12-02 Device for extracting artemisinin from artemisia annua

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201310626387.7A CN103641842A (en) 2013-12-02 2013-12-02 Device for extracting artemisinin from artemisia annua

Publications (1)

Publication Number Publication Date
CN103641842A true CN103641842A (en) 2014-03-19

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106543199A (en) * 2016-09-24 2017-03-29 合肥信达膜科技有限公司 A kind of arteannuin film extraction process
CN107383050A (en) * 2017-09-13 2017-11-24 禹州市天源生物科技有限公司 A kind of technological process of safe and efficient energy-conservation extraction Artemisia extract or qinghaosu
CN107383049A (en) * 2017-08-20 2017-11-24 合肥信达膜科技有限公司 A kind of qinghaosu film extraction process

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4952603A (en) * 1988-06-20 1990-08-28 Elferaly Farouk S Method for the isolation of artemisinin from Artemisia annua
CN1092073A (en) * 1993-03-09 1994-09-14 云南省药物研究所 The extracting method of Artemisinin
CN1680388A (en) * 2005-01-25 2005-10-12 商丘市明清制药有限责任公司 Extraction of artemisine
CN1931860A (en) * 2006-09-28 2007-03-21 上海交通大学 process of extracting separating and purifying artemisinin from sweet wormwood herb
CN1935810A (en) * 2006-10-18 2007-03-28 韦湖田 Method for extracting artemisine by enriched supercritical fluid
CN101130548A (en) * 2006-08-25 2008-02-27 上海诺德生物实业有限公司 Method for extracting and producing high content arteannuin
CN101205232A (en) * 2006-12-19 2008-06-25 浙江大学宁波理工学院 Technical new method for extracting artemisinin from sweet wormwood plants by ultrasonic assistance
CN101805353A (en) * 2009-12-04 2010-08-18 南京泽朗医药科技有限公司 Preparation method of artemisinin
CN101899055A (en) * 2010-08-12 2010-12-01 湖南农业大学 Method for rapidly extracting artemisinin
CN103059039A (en) * 2013-01-24 2013-04-24 湖北民族学院 Method for extracting artemisine
CN103408566A (en) * 2013-07-17 2013-11-27 张家港威胜生物医药有限公司 New artemisinin extraction process

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4952603A (en) * 1988-06-20 1990-08-28 Elferaly Farouk S Method for the isolation of artemisinin from Artemisia annua
CN1092073A (en) * 1993-03-09 1994-09-14 云南省药物研究所 The extracting method of Artemisinin
CN1680388A (en) * 2005-01-25 2005-10-12 商丘市明清制药有限责任公司 Extraction of artemisine
CN101130548A (en) * 2006-08-25 2008-02-27 上海诺德生物实业有限公司 Method for extracting and producing high content arteannuin
CN1931860A (en) * 2006-09-28 2007-03-21 上海交通大学 process of extracting separating and purifying artemisinin from sweet wormwood herb
CN1935810A (en) * 2006-10-18 2007-03-28 韦湖田 Method for extracting artemisine by enriched supercritical fluid
CN101205232A (en) * 2006-12-19 2008-06-25 浙江大学宁波理工学院 Technical new method for extracting artemisinin from sweet wormwood plants by ultrasonic assistance
CN101805353A (en) * 2009-12-04 2010-08-18 南京泽朗医药科技有限公司 Preparation method of artemisinin
CN101899055A (en) * 2010-08-12 2010-12-01 湖南农业大学 Method for rapidly extracting artemisinin
CN103059039A (en) * 2013-01-24 2013-04-24 湖北民族学院 Method for extracting artemisine
CN103408566A (en) * 2013-07-17 2013-11-27 张家港威胜生物医药有限公司 New artemisinin extraction process

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
梁晓媛，等: "青蒿中青蒿素提取工艺研究进展", 《重庆理工大学学报（自然科学）》, vol. 27, no. 2, 28 February 2013 (2013-02-28), pages 32 - 38 *
韦国锋，等: "提取青蒿素实验条件的研究", 《右江民族医学院学报》, vol. 17, no. 2, 30 June 1995 (1995-06-30), pages 137 - 139 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106543199A (en) * 2016-09-24 2017-03-29 合肥信达膜科技有限公司 A kind of arteannuin film extraction process
CN107383049A (en) * 2017-08-20 2017-11-24 合肥信达膜科技有限公司 A kind of qinghaosu film extraction process
CN107383050A (en) * 2017-09-13 2017-11-24 禹州市天源生物科技有限公司 A kind of technological process of safe and efficient energy-conservation extraction Artemisia extract or qinghaosu

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Application publication date: 20140319