CN102816169B - Extraction method and extraction system for bergenin - Google Patents
Extraction method and extraction system for bergenin Download PDFInfo
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- CN102816169B CN102816169B CN201210332157.5A CN201210332157A CN102816169B CN 102816169 B CN102816169 B CN 102816169B CN 201210332157 A CN201210332157 A CN 201210332157A CN 102816169 B CN102816169 B CN 102816169B
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Abstract
The invention relates to the field of Chinese herbal medicine, in particular to an extraction method and an extraction system for bergenin. The extraction method includes placing medicinal material powders in an extracting tank, adding ethanol in the extracting tank, heating to enable effective components in the medicinal material powders to be dissolved in the ethanol, heating until the ethanol boils to obtain a mixture, filtering the mixture to obtain a first filter liquor, subjecting the first filter liquor to evaporation and concentration to obtain an extracting liquor and a first gas which has a major component of the ethanol, keeping a first filtering medium in the extracting tank, cooling the first gas to a first liquid, real-timely adding the first liquid in the extracting tank, subjecting the extracting liquor to recrystallization, performing centrifugal separation to obtain a bergenin crude product, and refining the bergenin crude product. The extraction system comprises a coarse extraction device and a refining device, and the coarse extraction device includes a first heating device, a circulating concentration extraction unit, a first recrystallization device and a first solid-liquid separation device. According to the extraction method and the extraction system for the bergenin, low cost and high efficiency production is achieved.
Description
Technical field
The present invention relates to the field of Chinese medicines, relate in particular to extracting method and the extraction system thereof of Bergeninum.
Background technology
Bergeninum is the extract of including in a kind of Effective Component of Chinese Medicine of " Chinese Pharmacopoeia ", has antibechic and stop the effect of phlegm, can be used for treating chronic bronchitis.Bergeninum is as a kind of extract of Effective Component of Chinese Medicine, and mainly from the medicinal material plants such as saxifragaceae plant Rhizome or herb of Purple Bergenia, rodgersflower rhizome, Japanese Ardisia Herb, Herba astilbes chinensis, southwestern terrible lamp medicine, extraction is refined and obtained.
At present, the extraction system of Bergeninum comprises thick extraction element and refining plant, thick extraction element mainly comprises traditional heating unit (water bath heating device, electromagnetic heater etc.), Heated container (round-bottomed flask etc.) and filtration unit, its extracting method is that medicinal material is ground to form after medicinal powder, be placed in Heated container, add ethanol, by heating unit heating for dissolving, obtain mixture, mixture is filtered, collect respectively filtrate and filtering medium, filtrate is as extracting solution, extracting solution comprises that Bergeninum and some are dissolved in the impurity of ethanol, in filtering medium, contain the dregs of a decoction and other impurity, the filtering medium of gained is placed in to Heated container, rejoin ethanol, repeat above process, further extracting effective components, conventionally in triplicate, finally extract by three times the extracting solution obtaining and merge, evaporation concentration to extracting solution reaches certain density, then recrystallization obtains Bergeninum crude product, after in refining plant, add dissolve with ethanol Bergeninum crude product, after recrystallization, can obtain Bergeninum.
Wherein, in the process that makes crude product, use traditional extraction system and method, extract concentrated interruption and carry out, need to consume the plenty of time, limited the raising of production efficiency.
Summary of the invention
The invention provides extracting method and the extraction system thereof of Bergeninum, can save time, enhance productivity.
For achieving the above object, technical scheme of the present invention is specifically achieved in that
The extracting method of Bergeninum, comprises the following steps:
Medicinal powder is placed in to extractor, and adds ethanol;
Heating is dissolved in ethanol the effective constituent in medicinal powder, is heated to ethanol boiling, obtains mixture;
Described mixture is filtered and obtains the first filtrate and the first filtering medium, heat described the first filtrate and make its evaporation concentration, obtaining extracting solution and main component is the first gas of ethanol, and described the first filtering medium continues to stay in extractor;
Described the first gas cooling is become to first liquid, described first liquid is joined in described extractor in real time;
By described extracting solution recrystallization at 0-30 DEG C, centrifugation, obtains Bergeninum crude product and the second liquid of solid state;
Described Bergeninum crude product is refined.
Further, by described extracting solution recrystallization at 0-30 DEG C, centrifugation, obtains the Bergeninum crude product of solid state and the step of second liquid and described Bergeninum crude product is carried out, between refining step, also comprising:
Reclaim described second liquid.
Further, described heating is dissolved in ethanol the effective constituent in medicinal powder, is heated to ethanol boiling, obtains the step of mixture; Described mixture is filtered and obtains the first filtrate, heat described the first filtrate and make its evaporation concentration, the step of the first gas that to obtain extracting solution be ethanol with main component and described the first gas cooling is become to first liquid, described first liquid is joined to these three steps in described extractor in real time and carry out simultaneously, and the time length is 3-6h.
Further, by described extracting solution recrystallization at 0-30 DEG C, centrifugation, obtains in the Bergeninum crude product of solid state and the step of second liquid, and described extracting solution is recrystallization 48-96h at 0-30 DEG C.
It is further, described that described Bergeninum crude product to be carried out to refining step as follows:
In described Bergeninum crude product, add water, and be heated to boiling, obtain solution;
In described solution, add gac, and filter, obtain the second filtrate;
By described the second filtrate recrystallization at 0-30 DEG C, centrifugation, obtains the first solid and the 3rd liquid, and dry described the first solid, obtains Bergeninum.
Further, adding water in described Bergeninum crude product, and be heated to boiling, obtain in the step of solution, by weight, the add-on of water be described Bergeninum crude product 6-12 doubly.
Further, in described solution, add gac, and filter, obtain in the step of the second filtrate, by weight, the add-on of gac is the 10%-18% of described Bergeninum crude product.
Further, adding water in described Bergeninum crude product, and be heated to boiling, obtain in the step of solution, after boiling, continue heating 1-2h.
Further, by described the second filtrate recrystallization at 0-30 DEG C, centrifugation, obtains the first solid and the 3rd liquid, and dry described the first solid, obtains in the step of Bergeninum, dry described the first solid at 105 DEG C.
The extraction system of Bergeninum, comprises thick extraction element and the refining plant for the Bergeninum crude product of preparing at described thick extraction element is further purified;
Described thick extraction element comprises first heater, extractor, the first filtration unit, evaporation concentration device, refrigerating unit, the first recrystallization device and the first equipment for separating liquid from solid; Described extractor is connected with described mistake the first filtration unit; Described the first filtration unit is connected with described evaporation concentration device; Described evaporation concentration device is connected with described refrigerating unit; Described refrigerating unit is connected with described extractor; Described first heater is connected with described extractor; Described first heater is connected with described evaporation concentration device.
Compared with prior art, the extracting method of Bergeninum provided by the invention and extraction system thereof, in thick extraction element, adopt first heater, extractor, the first filtration unit, evaporation concentration device and refrigerating unit, completing circulation extracts, obtain extracting solution, detailed process is: medicinal powder is placed in to extractor, and add ethanol, ethanol in first heater heating extractor, Bergeninum in medicinal powder is dissolved in ethanol, and then obtain Bergeninum and the ethanolic soln of impurity composition that is dissolved in ethanol, the mixture of the dregs of a decoction and other impurity composition, mixture is filtered in the first filtration unit, obtain the first filtering medium and the first filtrate, the first filtering medium main component is the dregs of a decoction and other impurity, the first filtering medium continues to stay in extractor, and the composition of the first filtrate is the ethanolic soln of Bergeninum and the impurity that is dissolved in ethanol composition, the first filtrate enters into evaporation concentration device, being concentrated into the first filtrate by first heater heating evaporation is certain density, obtain extracting solution, it is cooling that the gas producing in evaporating concentration process enters refrigerating unit, is converted into first liquid, and first liquid enters in extractor in real time, make the ethanol in first liquid continue to dissolve the dregs of a decoction, extract Bergeninum wherein.Constantly circulation according to this, completed extraction and concentration simultaneously, in this process, ethanol only need add once, can recycle, and has greatly reduced ethanol usage quantity, avoided the inconvenience that adds discontinuously solvent to bring simultaneously, and extraction and concentration carries out, and has saved the time simultaneously, thereby realize the object of low cost, high efficiency production.
Described extracting solution is at the first recrystallization device recrystallization, then enters the first equipment for separating liquid from solid and separate, and obtains Rhizome or herb of Purple Bergenia crude product and the second liquid of solid state, and Bergeninum crude product is refined and made Bergeninum in refining plant.
In addition, the extracting method of Bergeninum provided by the invention and extraction system thereof also have following technique effect:
(1) in the time that centrifugation obtains Bergeninum crude product, the second liquid main component of gained is ethanol, can recycle, and extract Bergeninum, thereby the low cost of realization, environment-friendly type is produced so the second liquid reclaiming can be used for next time.
(2), when 3-6h is extracted in circulation, the extraction rate reached of Bergeninum, to the highest, can make full use of medicinal powder.
(3) by described extracting solution cooling 48-96h at 0-30 DEG C, extracting solution crystallization is complete.
(4) in order to obtain highly purified Bergeninum, need to refine, experiment showed, in treating process, taking water as solvent, the extraction yield can reach taking ethanol as solvent time.But adopt water can avoid the use of ethanol, reduce production costs, and can improve the security of production, so selection water is solvent.
In addition, adopt gac as sorbent material, both can improve Bergeninum purity, again can recycle, further reduce costs.
(5) by weight,, when the add-on of water is 6-12 times of described Bergeninum crude product, the extraction yield of Bergeninum is higher.
(6) by weight,, when the add-on of gac is the 10%-18% of described Bergeninum crude product, the extraction yield of Bergeninum is higher.
(7) in described Bergeninum crude product, add water, and be heated to boiling, while continuing heating 1-2h, the water-soluble impurity in crude product and effective constituent composition can fully be dissolved in water.
(8) dry the first solid at 105 DEG C, the Bergeninum obtaining can meet medicament and produce the requirement to medicine material.
Brief description of the drawings
Fig. 1 is the schema of preparing Bergeninum crude product in the embodiment of the present invention one.
Fig. 2 is the rectification flow figure of Bergeninum in the embodiment of the present invention one.
Fig. 3 is the structural representation of the thick extraction element of Bergeninum in the embodiment of the present invention one.
Reference numeral: 1-first heater, 2-extractor, 3-the first filtration unit, 4-evaporation concentration device, 5-refrigerating unit, 6-the first recrystallization device, 7-the first equipment for separating liquid from solid.
Embodiment
For making the object, technical solutions and advantages of the present invention clearer; to technical scheme of the present invention be carried out to clear, complete description below; based on the specific embodiment in the present invention; all other embodiment that those of ordinary skill in the art obtain under the prerequisite of not making creative work, belong to the scope that the present invention protects.
The extracting method of Bergeninum, comprises the following steps:
The first step: medicinal powder is placed in to extractor, and adds ethanol;
Second step: heating is dissolved in ethanol the effective constituent in medicinal powder, is heated to ethanol boiling, obtains mixture;
The 3rd step: described mixture is filtered and obtains the first filtrate and the first filtering medium, heat described the first filtrate and make its evaporation concentration, obtaining extracting solution and main component is the first gas of ethanol, and described the first filtering medium continues to stay in extractor;
The 4th step: described the first gas cooling is become to first liquid, described first liquid is joined in described extractor in real time;
The 5th step: by described extracting solution recrystallization at 0-30 DEG C, centrifugation, obtains Bergeninum crude product and the second liquid of solid state;
The 6th step: described Bergeninum crude product is refined.
Wherein, the first step adds ethanol for dissolving the Bergeninum of medicinal powder in extractor.
Second step, the 3rd step and the 4th step are carried out simultaneously, Bergeninum in medicinal powder fully can be dissolved in ethanol in circulation extraction concentration group, be heated to the ethanol boiling in extractor, Bergeninum in medicinal powder is dissolved in ethanol, and then obtain Bergeninum and the mixture of ethanolic soln, the dregs of a decoction and other impurity composition of impurity composition that is dissolved in ethanol, mixture is filtered, obtain the first filtering medium and the first filtrate, the first filtering medium main component is the dregs of a decoction and other impurity, and the first filtering medium continues to stay in extractor; And the composition of the first filtrate is the ethanolic soln of Bergeninum and the impurity that is dissolved in ethanol composition, the first filtrate heating evaporation is concentrated into certain density, obtain extracting solution, in evaporating concentration process, producing main component is the first gas of ethanol, be cooled to first liquid, and enter in real time extractor, and make the ethanol in first liquid continue to dissolve the dregs of a decoction, extract Bergeninum wherein.Constantly circulation according to this, completed extraction and concentration simultaneously, in this process, ethanol only need add once, can recycle, greatly reduce ethanol usage quantity, ethanol aequum be only traditional method required 1/3, avoided the inconvenience that adds discontinuously solvent to bring, and extraction and concentration carries out simultaneously simultaneously, save the time, thereby realized the object of low cost, high efficiency production.And extraction time also shortens, for extracting next time, reach the object of environmental protection, low cost, high efficiency production.
Under high temperature, the solubleness of Bergeninum is higher, so by the 5th step, at 0-30 DEG C, extracting solution is cooling, the solubleness of Bergeninum reduces, thereby Bergeninum and a small amount of impurity are separated out in saturated solution, by centrifugation, obtain Bergeninum crude product again.
By the 6th step, refining Bergeninum crude product, the purity of raising Bergeninum.
When concrete enforcement, because the main component of second liquid is ethanol, reclaim described second liquid, can be used for extracting Bergeninum next time, save solvent, reduce costs.
It is 3-6h that second step, the 3rd step and the 4th step continue the time of carrying out simultaneously, i.e. 3-6h is extracted in circulation, and the extraction yield of Bergeninum is higher.
By described extracting solution recrystallization 48-96h at 0-30 DEG C, extracting solution crystallization is complete.
In order further to improve the purity of Bergeninum, by described described Bergeninum crude product is refined, step is as follows:
In described Bergeninum crude product, add water, and be heated to boiling, obtain solution;
In described solution, add gac, and filter, obtain the second filtrate;
By described the second filtrate recrystallization at 0-30 DEG C, centrifugation, obtains the first solid and the 3rd liquid, and dry described the first solid, obtains Bergeninum.
In above treating process, taking water as solvent, the extraction yield can reach taking ethanol as solvent time.But adopt water can avoid the use of ethanol, reduce production costs, and can improve the security of production, so selection water is solvent.
In addition, adopt gac as sorbent material, both can improve Bergeninum purity, again can recycle, further reduce costs.
In each embodiment of the present invention, as preferred version, by weight, the add-on of water is 6-12 times of described Bergeninum crude product, and the extraction yield of Bergeninum is higher.
In each embodiment of the present invention, as preferred version, by weight, the add-on of gac is the 10%-18% of described Bergeninum crude product, and the extraction yield of Bergeninum is higher.
In each embodiment of the present invention, as preferred version, adding water in described Bergeninum crude product, and be heated to boiling, obtain in the step of solution, after boiling, continue heating 1-2h, the water-soluble impurity in crude product and effective constituent composition can fully be dissolved in water.
When concrete enforcement, dry described the first solid at 105 DEG C, the Bergeninum obtaining can meet medicament and produce the requirement to medicine material.
In addition, because the main component in the 3rd liquid is water, can also reclaim, for refining Bergeninum crude product next time.
The extraction system of Bergeninum, is characterized in that:
Comprise thick extraction element and the refining plant for the Bergeninum crude product of preparing at described thick extraction element is further purified;
Described thick extraction element comprises first heater, extractor, the first filtration unit, evaporation concentration device, refrigerating unit, the first recrystallization device and the first equipment for separating liquid from solid; Described extractor is connected with described mistake the first filtration unit; Described the first filtration unit is connected with described evaporation concentration device; Described evaporation concentration device is connected with described refrigerating unit; Described refrigerating unit is connected with described extractor; Described first heater is connected with described extractor; Described first heater is connected with described evaporation concentration device.
While utilizing said system to extract Bergeninum, medicinal powder is placed in to described extractor, and add ethanol, described first heater heats the ethanol in described extractor, Bergeninum in medicinal powder is dissolved in ethanol, and then obtain Bergeninum and the mixture of ethanolic soln, the dregs of a decoction and other impurity composition of impurity composition that is dissolved in ethanol, mixture is filtered in described the first filtration unit, obtain the first filtering medium and the first filtrate, the first filtering medium main component is the dregs of a decoction and other impurity, and the first filtering medium continues to stay in described extractor; And the composition of the first filtrate is the ethanolic soln of Bergeninum and the impurity that is dissolved in ethanol composition, the first filtrate enters into described evaporation concentration device, being concentrated into the first filtrate by described first heater heating evaporation is certain density, obtain extracting solution, it is cooling that the gas producing in evaporating concentration process enters described refrigerating unit, is converted into first liquid, and first liquid enters in described extractor in real time, make the ethanol in first liquid continue to dissolve the dregs of a decoction, extract Bergeninum wherein.Constantly circulation according to this, completed extraction and concentration simultaneously, in this process, ethanol only need add once, can recycle, and has greatly reduced ethanol usage quantity, avoided the inconvenience that adds discontinuously solvent to bring simultaneously, and extraction and concentration carries out, and has saved the time simultaneously, thereby realize the object of low cost, high efficiency production.
Described extracting solution is at the first recrystallization device recrystallization, then enters the first equipment for separating liquid from solid and separate, and obtains Rhizome or herb of Purple Bergenia crude product and the second liquid of solid state, and Bergeninum crude product is refined and made Bergeninum in refining plant.
When concrete enforcement, described refining plant can comprise Heated container, secondary heating mechanism, the second filtration unit, the second recrystallization device, the second equipment for separating liquid from solid and drying installation.
In above-mentioned refining plant, Bergeninum crude product is placed in to Heated container, add water, be heated to water boiling by secondary heating mechanism, adding gac, absorption impurity, adds by the second filtration unit and filters out gac and impurity, obtain the second filtrate, by the second filtrate recrystallization in the second recrystallization device, then centrifugation in the second equipment for separating liquid from solid, the first solid and the 3rd liquid obtained, in drying installation, dry the first solid, obtains highly purified Bergeninum.
The present invention provide specific embodiment to describe below for better explaining.
Embodiment mono-:
As depicted in figs. 1 and 2, the extracting method of Bergeninum, comprises the following steps:
Step 101: medicinal powder is placed in to extractor, and adds ethanol;
Step 102: heating is dissolved in ethanol the effective constituent in medicinal powder, is heated to ethanol boiling, obtains mixture;
Step 103: described mixture is filtered and obtains the first filtrate and the first filtering medium, heat described the first filtrate and make its evaporation concentration, obtaining extracting solution and main component is the first gas of ethanol, and described the first filtering medium continues to stay in extractor;
Step 104: described the first gas cooling is become to first liquid, described first liquid is joined in described extractor in real time;
Step 105: by described extracting solution recrystallization 96h at 30 DEG C, centrifugation, obtains Bergeninum crude product and the second liquid of solid state;
Step 106: reclaim described second liquid;
Step 107: described Bergeninum crude product is refined;
Described treating process specifically comprises the following steps:
Step 107-1: add water in described Bergeninum crude product, by weight, the add-on of water is 12 times of described Bergeninum crude product, and be heated to boiling, continue heating 2h, obtain solution;
Step 107-2: add gac in described solution, by weight, the add-on of gac is 18% of described Bergeninum crude product, and filter, the second filtrate obtained;
Step 107-3: by described the second filtrate recrystallization at 30 DEG C, centrifugation, obtains the first solid and the 3rd liquid, at 105 DEG C, dry described the first solid, obtains Bergeninum;
Step 107-4: reclaim described the 3rd liquid.
As shown in Figure 3, can realize the extraction system of the extracting method of above-mentioned Bergeninum, comprise:
Thick extraction element and the refining plant for the Bergeninum crude product of preparing at described thick extraction element is further purified;
Described thick extraction element comprises first heater 1, extractor 2, the first filtration unit 3, evaporation concentration device 4, refrigerating unit 5, the first recrystallization device 6 and the first equipment for separating liquid from solid 7; Described extractor 2 is connected with described mistake the first filtration unit 3; Described the first filtration unit 3 is connected with described evaporation concentration device 4; Described evaporation concentration device 4 is connected with described refrigerating unit 5; Described refrigerating unit 5 is connected with described extractor 2; Described first heater 1 is connected with described extractor 2; Described first heater 1 is connected with described evaporation concentration device 4.
Embodiment bis-:
The extracting method of another kind of Bergeninum, comprises the following steps:
Step 201: medicinal powder is placed in to extractor, and adds ethanol;
Step 202: heating is dissolved in ethanol the effective constituent in medicinal powder, is heated to ethanol boiling, obtains mixture;
Step 203: described mixture is filtered and obtains the first filtrate and the first filtering medium, heat described the first filtrate and make its evaporation concentration, obtaining extracting solution and main component is the first gas of ethanol, and described the first filtering medium continues to stay in extractor;
Step 204: described the first gas cooling is become to first liquid, described first liquid is joined in described extractor in real time;
Step 205: by described extracting solution recrystallization 48h at 0 DEG C, centrifugation, obtains Bergeninum crude product and the second liquid of solid state;
Step 206: reclaim described second liquid;
Step 207: described Rhizome or herb of Purple Bergenia crude product is refined;
Described treating process specifically comprises the following steps:
Step 207-1: add water in described Bergeninum crude product, by weight, the add-on of water is 6 times of described Bergeninum crude product, and be heated to boiling, continue heating 1h, obtain solution;
Step 207-2: add gac in described solution, by weight, the add-on of gac is 10% of described Bergeninum crude product, and filter, the second filtrate obtained;
Step 207-3: by described the second filtrate recrystallization at 0 DEG C, centrifugation, obtains the first solid and the 3rd liquid, at 105 DEG C, dry described the first solid, obtains Bergeninum;
Step 207-4: reclaim described the 3rd liquid.
Finally it should be noted that: above specific embodiment only, in order to technical scheme of the present invention to be described, is not intended to limit; Although the present invention is had been described in detail with reference to aforementioned specific embodiment, those of ordinary skill in the art is to be understood that: its technical scheme that still can record aforementioned embodiments is modified, or part technical characterictic is wherein equal to replacement; And these amendments or replacement do not make the essence of appropriate technical solution depart from the spirit and scope of the each embodiment of the present invention and specific embodiment technical scheme.
Claims (5)
1. the extracting method of Bergeninum, is characterized in that: the method adopts and comprises thick extraction element and the refining plant for the Bergeninum crude product of preparing at described thick extraction element is further purified; Described thick extraction element comprises first heater, extractor, the first filtration unit, evaporation concentration device, refrigerating unit, the first recrystallization device and the first equipment for separating liquid from solid; Described extractor is connected with described mistake the first filtration unit; Described the first filtration unit is connected with described evaporation concentration device; Described evaporation concentration device is connected with described refrigerating unit; Described refrigerating unit is connected with described extractor; Described first heater is connected with described extractor; Described first heater is connected with described evaporation concentration device; While utilizing said apparatus to extract Bergeninum, comprise the following steps:
Medicinal powder is placed in to extractor, and adds ethanol;
Heating is dissolved in ethanol the effective constituent in described medicinal powder, is heated to ethanol boiling, obtains mixture;
Described mixture is filtered and obtains the first filtrate and the first filtering medium, heat described the first filtrate and make its evaporation concentration, obtaining extracting solution and main component is the first gas of ethanol, and described the first filtering medium continues to stay in extractor;
Described the first gas cooling is become to first liquid, described first liquid is joined in described extractor in real time;
By described extracting solution recrystallization at 0-30 DEG C, centrifugation, obtains Bergeninum crude product and the second liquid of solid state;
Wherein, described heating is dissolved in ethanol the effective constituent in medicinal powder, is heated to ethanol boiling, obtains the step of mixture; Described mixture is filtered and obtains the first filtrate, heat described the first filtrate and make its evaporation concentration, the step of the first gas that to obtain extracting solution be ethanol with main component and described the first gas cooling is become to first liquid, described first liquid is joined to these three steps in described extractor in real time and carry out simultaneously, and the time length is 3-6h;
In described Bergeninum crude product, add water, the weight that adds of water is 6-12 times of described Bergeninum crude product, and is heated to boiling, obtains solution;
In described solution, add gac, and filter, obtain the second filtrate;
By described the second filtrate recrystallization at 0-30 DEG C, centrifugation, obtains the first solid and the 3rd liquid, and at 105 DEG C, dry described the first solid, obtains Bergeninum.
2. the extracting method of Bergeninum as claimed in claim 1, it is characterized in that, by described extracting solution recrystallization at 0-30 DEG C, centrifugation, obtain the Bergeninum crude product of solid state and the step of second liquid and described Bergeninum crude product carried out, between refining step, also comprising:
Reclaim described second liquid.
3. the extracting method of Bergeninum as claimed in claim 1, it is characterized in that, by described extracting solution recrystallization at 0-30 DEG C, centrifugation, obtain in the Bergeninum crude product of solid state and the step of second liquid, described extracting solution is recrystallization 48-96h at 0-30 DEG C.
4. the extracting method of Bergeninum as claimed in claim 1, is characterized in that, in described solution, adds gac, and filters, and obtains in the step of the second filtrate, and by weight, the add-on of gac is the 10%-18% of described Bergeninum crude product.
5. the extracting method of Bergeninum as claimed in claim 1, is characterized in that, adding water in described Bergeninum crude product, and is heated to boiling, obtains in the step of solution, after boiling, continues heating 1-2h.
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| CN106749298B (en) * | 2016-11-18 | 2019-03-29 | 文县嘉诚农副产品有限公司 | A kind of Bergenin extracts and refining methd |
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| CN101712684A (en) * | 2009-11-18 | 2010-05-26 | 陕西白云制药有限公司 | Process for quickly and demicontinuously extracting bergenin |
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