CN106539747A - A kind of face mask for eliminating macula and whitening skin and preparation method thereof - Google Patents
A kind of face mask for eliminating macula and whitening skin and preparation method thereof Download PDFInfo
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- CN106539747A CN106539747A CN201611149158.0A CN201611149158A CN106539747A CN 106539747 A CN106539747 A CN 106539747A CN 201611149158 A CN201611149158 A CN 201611149158A CN 106539747 A CN106539747 A CN 106539747A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Abstract
The invention belongs to cosmetic field, and in particular to a kind of face mask for eliminating macula and whitening skin and preparation method thereof.The face mask for eliminating macula and whitening skin is by Gypsum Fibrosum Preparatum, Radix Angelicae Sinensis, Semen Armeniacae Amarum, Poria, Radix Ampelopsis, Flos Rosae Rugosae, Radix Pseudostellariae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Notoginseng, Margarita, Fructus Crataegi and Radix Glycyrrhizae Jing supercritical COs2Extract, ethanol is extracted, macroporous adsorbent resin is isolated and purified, extract crushed after being dried is remixed and is prepared from, and the facial film has whitening and speckle dispelling, desalinates effect of pigment, it is adaptable to pigmentation spots etc. after chloasma, senile plaque, sunburn, freckle and inflammation.
Description
Technical field
The invention belongs to cosmetic field, and in particular to a kind of face mask for eliminating macula and whitening skin and preparation method thereof.
Background technology
The formation of mottle is primarily due to various factors causes melanocyte function to be strengthened, and melanic accretion rate is weak
In its aggregate velocity, abnormal melanin is caused to be absorbed by the cell of skin basal layer, when environmental stimuli is repeatedly subjected to, melanin
Epidermis is revealed in gradually, so as to form mottle.Common mottle includes color after chloasma, senile plaque, sunburn, freckle, inflammation
Plain calmness speckle etc..
Endogenous cause of ill and exopathogenic factor that chloasma is produced.For endogenous cause of ill, primary disease is how dirty with liver,spleen,kidney three in close relations, with QI and blood not
On energy it is flourish in face be the important pathogenesis.Chloasma is also referred to as chloasma hepaticum, and the effect of regulating liver-QI in theory of Chinese medical science is main catharsis, and what cries
Decide catharsisThere is dredging, tune to reach to refer to irritability, rises to send out and waits comprehensive physiological function.The function of liver controlling conveyance and dispersion is mainly manifested in
Spiritual feelings will is adjusted, facilitating digestion absorbs, and in terms of maintaining QI and blood, the operation three of body fluid.If women's is happy, essence
God's pleasure, then irritability is just dredged, and the digestion of taste and absorption function are also all very normal.Liver storing blood, liver storage and discharge
Blood volume it is also normal, can ensure that the blood supply and normal menstruation of skin of face completely, skin seems ruddy glossy, sleep
With defecation also all very well, such women is healthy.The pressure for can also have many women to work at ordinary times, living is all very big, Jing
Often love is angry, stays up late, so irritability will pent-up in body, show as spirit depressing, it is many it is anxious it is kind consider, oppressiveness is intended to cry,
Pain that gas is sighed, chest side of body portion swells, as the pent-up of irritability, the function of blood stored in the liver can also be affected, liver is it cannot be guaranteed that face
Sufficient blood supply, can cause face insufficiency of vital energy and blood Gu Er generate many diffuse distribution dark brown patch, while there is also the moon
Premenstrual distending pain of the breast, the symptom of menoxenia.In addition, the pent-up of irritability can also affect spleen and stomach function, there is inappetence, disappear
Change bad, belch acid regurgitation, the symptom of abdominal distention diarrhoea, the traditional Chinese medical science is referred to as hyperactive liver-QI attacking the spleen, and such patient's speckle color mostly is grey brown
Color, such as one layer dust attachment face of shape, just as not having wash clean face.The color of feminine menstrual is thin out simultaneously, and leucorrhea amount is more.It is long
Phase pressure is big, and the women for staying up late with the passing of time also results in the deficiency of the weakness of kidney qi, liver blood and kidney qi and complexion color can be caused dark and gloomy,
There is brown-black patch in blocks, whole body fatigue is powerless, the normal dizziness and tinnitus of Jing, waist and knee it is aching and limp powerless, insomnia forgetfulness, Shou Zuxin
Heat.It is more than the endogenous cause of ill of chloasma generation.
The exopathogenic factor of chloasma is caused to include：Ultraviolet irradiation etc., therefore, or we are it is however emphasized that sun-proof, because, when us
When irradiation ultraviolet radiation, in order to protect skin, the melanocyte that can constantly activate skin base layer goes to absorb purple human body by which
Outside line, so as to protect skin.But can there is substantial amounts of black speck on skin with the disorder of function in increasing for melanocyte quantity.Institute
With the skin Jing often exposed generations that can not only cause chloasma, freckle, sunburn under sunburst, can also promote the old of skin
Change, produce wrinkle.
Also include inherited genetic factorss in causing the factor of chloasma, when long speckle, especially freckle in father and mother, the probability of heredity
It is very big, so when elder has long speckle, should be noted the ultraviolet irradiation for avoiding causing one of speckle key factor, will also selecting
It is adapted to the Skin whitening care cosmeticses of oneself, it is to avoid the calmness of pigment occurs in the cosmetics rear face of improper use.
Present speckle dispelling product star sieve chess portions various on the market, some products can make whiteness of skin within the extremely short time, but
Once disabling, skin becomes more black immediately, and pigment occurs bounce-back, and wrinkle is deepened.Reason is that cosmetics often with the addition of
The materials poisonous to human body skin, nervous system such as exceeded lead, hydrargyrum, hormone.The heavy metal ion such as lead and hydrargyrum can act on black
TYR enzyme in pigment generating process so as to lose activity, so as to prevent the formation of mottle, allows whiteness of skin.But this work
With being of short duration, the consequence for ultimately causing is TYR enzyme or is unrestrictedly catalyzed melanic generation, skin is become on the contrary
Get Geng Hei, pigment bounce-back increase, and dusty blue metal poisoning speckle occur in lead, mercury content severe overweight in blood, tooth boundary.And contain sharp
The cosmetics of element, occur steroid-dependent dermatitis, body are caused damage after deactivation.
There is the normal oral contraceptive of some women Jing, contained female estrogen in contraceptive can activation of melanocyte
And uneven speckle is formed, because of the speckle that contraceptive is formed, although have no progeny in medication and can stop, but still can there is skin
Upper a very long time.In addition, the female estrogen of pregnancy can increase, some women started face from pregnant 4-5 month will
There is chloasma, also referred to as " cyasma ".Pregnancy period occur speckle typically puerperal major part can disappear.But, because metabolism
It is abnormal, look after the children daily, rest bad, the reason such as stress is big often leads to deficiency of qi and blood, and the chloasma of face is not
But it is even more and more to disappear, and this is accomplished by the conditioning of system.There is the patient of some endocrine dysfunctions in addition
The patient of such as hyperthyroidism also easy long speckle.
, although speckle dispelling product is varied in the market, but still to lack natural safely and effectively speckle dispelling beautiful therefore
White product.
The content of the invention
It is an object of the present invention to provide a kind of face mask for eliminating macula and whitening skin, which is prepared from by the following raw material medicine：Gypsum Fibrosum Preparatum
10-20 gram, 9-15 gram of Radix Angelicae Sinensis, 2-4 gram of Semen Armeniacae Amarum, 2-4 gram of Poria, 2-4 gram of Radix Ampelopsis, 10-20 gram of Flos Rosae Rugosae, 3-7 gram of Radix Pseudostellariae,
3-7 gram of 2-4 gram of the Pseudobulbus Bletillae (Rhizoma Bletillae), 6-12 gram of Radix Notoginseng, 12-24 gram of Margarita, 5-11 gram of Fructus Crataegi and Radix Glycyrrhizae.
Preferably, the face mask for eliminating macula and whitening skin, is prepared from by the following raw material medicine：15 grams of Gypsum Fibrosum Preparatum, 12 grams of Radix Angelicae Sinensis, bitter Fructus Pruni
3 grams of core, 3 grams of Poria, 3 grams of Radix Ampelopsis, 15 grams of Flos Rosae Rugosae, 5 grams of Radix Pseudostellariae, 3 grams of the Pseudobulbus Bletillae (Rhizoma Bletillae), 9 grams of Radix Notoginseng, 18 grams of Margarita, 6 grams of Fructus Crataegi and
5 grams of Radix Glycyrrhizae.
The speckle is pigmentation spots after chloasma, senile plaque, sunburn, freckle and/or inflammation.
In crude drug in face mask for eliminating macula and whitening skin of the present invention, plaster of paris has functions that heat clearing away, dampness removing, sore.To chloasma
The easy pathogenic fire derived from stagnation of liver-QI of women, there is facial Hot flash symptoms effect preferable.
Radix Angelicae Sinensis have blood-nourishing, the effect of promoting blood circulation, warm in nature, can play a part of blood circulation promoting, Radix Angelicae Sinensis with its deposited face
Aqueous solution play the role of extremely strong suppression TYR enzyme activity, moreover it is possible to make skin fine and smooth, be tackle chloasma ' trump card ".
The fatty oil contained in Semen Armeniacae Amarum softens can keratodermatitis, and the Semen Armeniacae Amarum after hydrolysis can also suppress internal network
Propylhomoserin enzyme, eliminates mottle, reaches the effect of whitening.
Poria can be with dispelling speckles and whitening face, skin of moistening, and can also increase skin immune function controlling, and expansion facial vessels improve face
The blood circulation in portion, ancient medicine think that Poria can dissolve all black speck, Poria it is mild-natured and, be not susceptible to allergic phenomena.
Radix Ampelopsis, come from《This Jing》.TAO Hong-Jing：Radix Ampelopsis shortcut has it everywhere.Make rattan life, the root such as Radix Angelicae Dahuricae.Life takes root and smashes deposited carbuncle
It is swollen also to imitate, with heat-clearing and toxic substances removing；Removing obstruction for relieving pain；Effect of promoting tissue regeneration and ulcer healing, cures mainly：Sore swollen toxin, scrofula are scalded, eczema, temperature
Malaria, infantile convulsion, dysentery, hemorrhoidal hamorrhage, anal fistula, leucorrhea, traumatic injury, traumatic hemorrhage etc..
Flos Rosae Rugosae Regulate the flow of vital energy Xie Yu, promoting blood circulation to remove blood stasis have the effect of relieving to hepatic depression, can also replenishing blood and vital energy, U.S. face skin protection, orally
And external.
Radix Pseudostellariae mild in medicine property and, with QI invigorating, effect of blood-nourishing, for the chloasma of caused by liver and kidney deficiency, deficiency of qi and blood is played
The effect of benefiting qi and nourishing blood can external also oral administration, and the promoting blood circulation effect of Radix Notoginseng complements each other.
The Pseudobulbus Bletillae (Rhizoma Bletillae) exists《Haigoushen》Record：Skin ulcer on face is controlled, makes us the record of flesh cunning,《Compendium of Materia Medica》Record " wash one's face it is black, dispel
Speckle.The also abundant starch of the Pseudobulbus Bletillae (Rhizoma Bletillae), glucose.The compositions such as phlegmatic temperament, with whitening and speckle dispelling, effect of detumescence and promoting granulation, from ancient times with
It is exactly beauty good medicine.
Radix Notoginseng is warm in nature, enter liver, stomach, has functions that promoting blood circulation, stops blooding, enriches blood, for depression of liver-QI, facial coagulation of QI-blood and
The chloasma that insufficiency of vital energy and blood is caused is taken orally, external has very good effect.
Margarita exists《Compendium of Materia Medica》In have functions that solve pox treat poison, except face secretly namely remove mottle, modern study
Which has slow down aging, the effect of freckle removing and whitening.
The acid of Fructus Crataegi property is sweet, tepor, enters spleen, stomach, Liver Channel, and liquor can wash dermatitis rhus, treatment chilblain etc..
Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, can be used for ulcer sores, laryngopharynx swelling and pain etc., and has similar adrenocortical hormone sample effect,
Antiinflammatory, anti-allergic effects etc..
It is a further object to provide a kind of preparation method of face mask for eliminating macula and whitening skin, which comprises the following steps：
(1) get the raw materials ready；
(2) volatilize oil extract and cyclodextrin inclusion compound：Semen Armeniacae Amarum is adopted steam distillation or is surpassed and faced after being mixed with Flos Rosae Rugosae
Boundary CO2Extraction method, extracts volatile oil, and Semen Armeniacae Amarum is standby with Flos Rosae Rugosae medicinal residues, and the ring of its weight 10-15 times is added in volatile oil
Dextrin is included, and obtains cyclodextrin of volatile oil clathrate；
(3) alcohol extracting and concentrating：After Semen Armeniacae Amarum is mixed with Radix Angelicae Sinensis, Poria, Radix Ampelopsis, Fructus Crataegi, Radix Glycyrrhizae with Flos Rosae Rugosae medicinal residues, add
After the ethanol of the 35%-90% of mixture weight 5-10 times, ethanol extraction, second are obtained by alcohol steep or heating and refluxing extraction
Macroporous adsorptive resins in alcohol extracting thing, using 5-10 times of 20%-30% alcohol flushings after, using the ethanol of 35%-90%
Eluting is carried out, eluent is collected, after the recovered ethanol of eluent, relative density is 1.05- when heating is concentrated into room temperature (25 DEG C)
1.35 alcohol extraction concentrate；
(4) crush：After alcohol extraction concentrate and the Pseudobulbus Bletillae (Rhizoma Bletillae), panax mixed, Jing freezing and pulverizing obtains mixed powder to 1000-2000 mesh
End, Gypsum Fibrosum Preparatum, Margarita are crushed to 1000-2000 mesh respectively, obtain Gypsum Fibrosum powder (calcined) and Margarita powder, standby；
(5) mix：After Gypsum Fibrosum powder (calcined), Margarita powder and cyclodextrin of volatile oil clathrate are added in mixed-powder, mixing is equal
It is even, obtain final product.
Preferably, supercritical CO is adopted in the step (2)2Extraction method extracts volatile oil, and the cyclodextrin is volatile oil
The beta-schardinger dextrin-that 15 times of weight, alcohol extraction in the step (3) is that 75% ethanol for adding 8 times of mixture weight is heated to reflux
Extract, on ethanol extraction after macroporous adsorptive resins, be rinsed using 30% ethanol of 5 times of amounts, using 75% ethanol
Eluting, eluent reclaim the alcohol extraction concentrate that relative density when ethanol post-heating is concentrated into room temperature (25 DEG C) is 1.25, the step
Suddenly mixed-powder described in (4), Gypsum Fibrosum powder (calcined), the fineness of Margarita powder are 1000 mesh.
It is also another object of the present invention to provide a kind of using method of face mask for eliminating macula and whitening skin, in the face mask for eliminating macula and whitening skin
Pasty state is tuned into after middle addition proper honey, is applied to mottle region, surface application 20-30 minutes, every 10 points after adding appropriate amount of purified water
Appropriate amount of purified water is sprayed on clockwise facial film, is cleaned with warm clear water after surface application, is used once daily, be within six weeks a cycle
Preferably, the surface application time be 20 minutes, the mottle be chloasma, senile plaque, sunburn, freckle and/or
Pigmentation spots after inflammation.
Beneficial effects of the present invention：
The face mask for eliminating macula and whitening skin of the present invention has advantages below：(1) raw material of face mask for eliminating macula and whitening skin of the invention is day
So material, has no toxic side effect, and adds without any hormone, natural pollution-free；(2) present invention uses special preparation method, retains
Active ingredients of essential oils in Semen Armeniacae Amarum, Flos Rosae Rugosae, be effectively prevented facial film prepare, preserve and use during quintessence oil activity
The loss of composition, significantly improves the effect of facial film freckle removing and whitening；(3) freezing and pulverizing technology is introduced, further alcohol extraction is concentrated
The smashing fineness of thing, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Notoginseng and extract is promoted to 1000-2000 mesh, makes the nutritional labeling easily precipitation in facial film,
And it is not easily blocked pore.
Specific embodiment
Also the present invention can be understood by embodiment further, wherein the embodiment illustrates that some are prepared or user
Method.It is to be appreciated, however, that these embodiments do not limit the present invention.The change of the present invention that is currently known or further developing
Change is considered within the scope of the invention described herein and claimed below.
A kind of 1 face mask for eliminating macula and whitening skin of embodiment
15 grams of Gypsum Fibrosum Preparatum, 12 grams of Radix Angelicae Sinensis, 3 grams of Semen Armeniacae Amarum, 3 grams of Poria, 3 grams of Radix Ampelopsis, 15 grams of Flos Rosae Rugosae, 5 grams of Radix Pseudostellariae, in vain
5 grams of 3 grams of splendid achnatherum, 9 grams of Radix Notoginseng, 18 grams of Margarita, 6 grams of Fructus Crataegi and Radix Glycyrrhizae.
The face mask for eliminating macula and whitening skin is prepared by the following method：
(1) get the raw materials ready；
(2) volatilize oil extract and cyclodextrin inclusion compound：Semen Armeniacae Amarum is adopted steam distillation or is surpassed and faced after being mixed with Flos Rosae Rugosae
Boundary CO2Extraction method, extracts volatile oil, and Semen Armeniacae Amarum is standby with Flos Rosae Rugosae medicinal residues, adds the ring of 10 times of its weight to paste in volatile oil
Progress greatly row inclusion, obtains cyclodextrin of volatile oil clathrate；
(3) alcohol extracting and concentrating：After Semen Armeniacae Amarum is mixed with Radix Angelicae Sinensis, Poria, Radix Ampelopsis, Fructus Crataegi, Radix Glycyrrhizae with Flos Rosae Rugosae medicinal residues, add
After the ethanol of the 75% of 10 times of mixture weight, ethanol extraction is obtained by alcohol steep or heating and refluxing extraction, ethanol is extracted
Macroporous adsorptive resins on thing, using 5 times of 30% alcohol flushing after, carry out eluting using 85% ethanol, collect eluent,
After the recovered ethanol of eluent, when heating is concentrated into room temperature (25 DEG C), relative density is 1.25 alcohol extraction concentrate；
(4) crush：After alcohol extraction concentrate and the Pseudobulbus Bletillae (Rhizoma Bletillae), panax mixed, Jing freezing and pulverizing obtains mixed-powder, Calx to 1000 mesh
Cream, Margarita are crushed to 1000 mesh respectively, obtain Gypsum Fibrosum powder (calcined) and Margarita powder, standby；
(5) mix：After Gypsum Fibrosum powder (calcined), Margarita powder and cyclodextrin of volatile oil clathrate are added in mixed-powder, mixing is equal
It is even, obtain final product the face mask for eliminating macula and whitening skin of the present invention.
A kind of 2 face mask for eliminating macula and whitening skin of embodiment
10 grams of Gypsum Fibrosum Preparatum, 9 grams of Radix Angelicae Sinensis, 2 grams of Semen Armeniacae Amarum, 2 grams of Poria, 2 grams of Radix Ampelopsis, 10 grams of Flos Rosae Rugosae, 3 grams of Radix Pseudostellariae, in vain
3 grams of 2 grams of splendid achnatherum, 6 grams of Radix Notoginseng, 12 grams of Margarita, 5 grams of Fructus Crataegi and Radix Glycyrrhizae.
The face mask for eliminating macula and whitening skin is prepared by the following method：
(1) get the raw materials ready；
(2) volatilize oil extract and cyclodextrin inclusion compound：Semen Armeniacae Amarum is adopted steam distillation or is surpassed and faced after being mixed with Flos Rosae Rugosae
Boundary CO2Extraction method, extracts volatile oil, and Semen Armeniacae Amarum is standby with Flos Rosae Rugosae medicinal residues, adds the ring of 15 times of its weight to paste in volatile oil
Progress greatly row inclusion, obtains cyclodextrin of volatile oil clathrate；
(3) alcohol extracting and concentrating：After Semen Armeniacae Amarum is mixed with Radix Angelicae Sinensis, Poria, Radix Ampelopsis, Fructus Crataegi, Radix Glycyrrhizae with Flos Rosae Rugosae medicinal residues, add
After the ethanol of the 85% of 8 times of mixture weight, ethanol extraction, ethanol extraction are obtained by alcohol steep or heating and refluxing extraction
Upper macroporous adsorptive resins, using 5 times of 30% alcohol flushing after, carry out eluting using 90% ethanol, collect eluent, wash
After the recovered ethanol of de- liquid, when heating is concentrated into room temperature (25 DEG C), relative density is 1.25 alcohol extraction concentrate；
(4) crush：After alcohol extraction concentrate and the Pseudobulbus Bletillae (Rhizoma Bletillae), panax mixed, Jing freezing and pulverizing obtains mixed-powder, Calx to 1500 mesh
Cream, Margarita are crushed to 1500 mesh respectively, obtain Gypsum Fibrosum powder (calcined) and Margarita powder, standby；
(5) mix：After Gypsum Fibrosum powder (calcined), Margarita powder and cyclodextrin of volatile oil clathrate are added in mixed-powder, mixing is equal
It is even, obtain final product the face mask for eliminating macula and whitening skin of the present invention.
A kind of 3 face mask for eliminating macula and whitening skin of embodiment
20 grams of Gypsum Fibrosum Preparatum, 15 grams of Radix Angelicae Sinensis, 4 grams of Semen Armeniacae Amarum, 4 grams of Poria, 4 grams of Radix Ampelopsis, 20 grams of Flos Rosae Rugosae, 7 grams of Radix Pseudostellariae, in vain
7 grams of 4 grams of splendid achnatherum, 12 grams of Radix Notoginseng, 24 grams of Margarita, 11 grams of Fructus Crataegi and Radix Glycyrrhizae.
The face mask for eliminating macula and whitening skin is prepared by the following method：
(1) get the raw materials ready；
(2) volatilize oil extract and cyclodextrin inclusion compound：Semen Armeniacae Amarum is adopted steam distillation or is surpassed and faced after being mixed with Flos Rosae Rugosae
Boundary CO2Extraction method, extracts volatile oil, and Semen Armeniacae Amarum is standby with Flos Rosae Rugosae medicinal residues, adds the ring of 15 times of its weight to paste in volatile oil
Progress greatly row inclusion, obtains cyclodextrin of volatile oil clathrate；
(3) alcohol extracting and concentrating：After Semen Armeniacae Amarum is mixed with Radix Angelicae Sinensis, Poria, Radix Ampelopsis, Fructus Crataegi, Radix Glycyrrhizae with Flos Rosae Rugosae medicinal residues, add
After the ethanol of the 75% of 10 times of mixture weight, ethanol extraction is obtained by alcohol steep or heating and refluxing extraction, ethanol is extracted
Macroporous adsorptive resins on thing, using 5 times of 30% alcohol flushing after, carry out eluting using 80% ethanol, collect eluent,
After the recovered ethanol of eluent, when heating is concentrated into room temperature (25 DEG C), relative density is 1.25 alcohol extraction concentrate；
(4) crush：After alcohol extraction concentrate and the Pseudobulbus Bletillae (Rhizoma Bletillae), panax mixed, Jing freezing and pulverizing obtains mixed-powder, Calx to 2000 mesh
Cream, Margarita are crushed to 2000 mesh respectively, obtain Gypsum Fibrosum powder (calcined) and Margarita powder, standby；
(5) mix：After Gypsum Fibrosum powder (calcined), Margarita powder and cyclodextrin of volatile oil clathrate are added in mixed-powder, mixing is equal
It is even, obtain final product the face mask for eliminating macula and whitening skin of the present invention.
Comparative example 1：A kind of face mask for eliminating macula and whitening skin not comprising volatile oil component
There is identical crude drug and preparation method with 1 face mask for eliminating macula and whitening skin of embodiment, when difference is that step (5) mixes
It is added without the volatile oil of beta-cyclodextrin inclusion compound.
Comparative example 2：A kind of fineness of powder is the face mask for eliminating macula and whitening skin of 200 mesh
There is identical crude drug and preparation method with 1 face mask for eliminating macula and whitening skin of embodiment, difference is alcohol extraction in step (4)
After concentrate, the Pseudobulbus Bletillae (Rhizoma Bletillae), panax mixed, to 200 mesh, Gypsum Fibrosum Preparatum, Margarita are crushed to 200 mesh to Jing freezing and pulverizing respectively.
Effect example：Impact of the face mask for eliminating macula and whitening skin to Cavia porcelluss ultra-vioket radiation model total color difference
(1) modeling：4 week old male brown guinea pigs 30 are taken, 6 groups are randomly divided into：Blank group, 1 group of embodiment, embodiment 2
Group and 3 groups of embodiment, 1 group of comparative example, 2 groups of comparative example, every guinea pig back same area unhairing form two 2*2cm regions,
The total color difference (Δ E) in two unhairing regions of every Cavia porcelluss is measured using Lab color difference meters, as initial Δ E, continuous 7 days, daily one
It is secondary, the one of unhairing region of ultra-vioket radiation, exposure rate 2mW/cm2, irradiation time 10 minutes, and other regions are prevented
Shield, after irradiating 7 days, measures the total color difference (Δ E) in two unhairing regions of every Cavia porcelluss using Lab color difference meters, after calculating irradiation 7 days
Δ E rate of increase；
7 days Δ E rate of increase=(the initial Δ E of Δ E- after irradiating 7 days)/initial Δ E of irradiation
(2) coat：After irradiation 7 days, the corresponding present invention is respectively coated with Cavia porcelluss UV-illuminated region once a day and is implemented
Then face mask for eliminating macula and whitening skin in example 1-3, comparative example 1-2, coating time 20 minutes is cleaned using warm water, and blank group is used
Clear water, is coated 14 days altogether；
(3) chromatism measurement：After coating 14 days, the Δ E in same two regions of guinea pig back, meter are measured using Lab color difference meters
14 days Δ E reduction rates of coating are calculated, concrete outcome is referring to table 1.
14 days Δ E reduction rates=7 days Δ E of (Δ E- coats 14 days Δ E after irradiating 7 days)/irradiation of coating
Impact of 1 face mask for eliminating macula and whitening skin of table to Cavia porcelluss ultra-vioket radiation model total color difference
By 1 experimental result of table, guinea pig back unhairing region Jing after ultraviolet irradiation in 7 days, blank group, embodiment 1-
3 groups and comparative example 1-2 group Cavia porcelluss ultraviolet radiation zone domain produce significant skin aberration relative to without ultraviolet radiation zone domain,
Show model modeling success.
After coated face mask for eliminating macula and whitening skin 14 days, embodiment 1-3 group ultraviolet radiation zone domain is relative to irradiating without ultraviolet
Area skin aberration is significantly reduced, and is significantly higher than blank group, and comparative example 1-2 group, ultraviolet radiation zone domain is relative to without ultraviolet
Although line irradiation area skin aberration decreases, and reduction rate is higher than blank group, but still is significantly lower than embodiment 1-3 group, table
In bright face mask for eliminating macula and whitening skin of the present invention, volatile oil compositions and fineness of powder have appreciable impact for freckle removing and whitening effect.
The invention provides a kind of face mask for eliminating macula and whitening skin, and by retaining Semen Armeniacae Amarum and Flos Rosae Rugosae in face mask for eliminating macula and whitening skin
Volatile oil compositions, and the fineness of alcohol extraction concentrate, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Notoginseng, Gypsum Fibrosum Preparatum and Margarita is reduced using freezing and pulverizing technology,
The effect of face mask for eliminating macula and whitening skin is significantly improved, with unforeseeable technique effect, chloasma, senile plaque, day is can be applicable to
The freckle removing and whitening of pigmentation spots etc. after sunburn, freckle and/or inflammation.
Claims (10)
1. a kind of face mask for eliminating macula and whitening skin, it is characterised in that be prepared from by the following raw material medicine：10-20 gram of Gypsum Fibrosum Preparatum, Radix Angelicae Sinensis 9-15
Gram, 2-4 gram of Semen Armeniacae Amarum, 2-4 gram of Poria, 2-4 gram of Radix Ampelopsis, 10-20 gram of Flos Rosae Rugosae, 3-7 gram of Radix Pseudostellariae, 2-4 gram of the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Notoginseng 6-
12 grams, 12-24 gram of Margarita, 3-7 gram of 5-11 gram of Fructus Crataegi and Radix Glycyrrhizae.
2. face mask for eliminating macula and whitening skin according to claim 1, it is characterised in which is prepared from by the following raw material medicine：Calx
15 grams of cream, 12 grams of Radix Angelicae Sinensis, 3 grams of Semen Armeniacae Amarum, 3 grams of Poria, 3 grams of Radix Ampelopsis, 15 grams of Flos Rosae Rugosae, 5 grams of Radix Pseudostellariae, 3 grams of the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Notoginseng 9
Gram, 18 grams of Margarita, 5 grams of 6 grams of Fructus Crataegi and Radix Glycyrrhizae.
3. face mask for eliminating macula and whitening skin according to claim 1 and 2, it is characterised in that the speckle is chloasma, senile plaque, day
Pigmentation spots after sunburn, freckle and/or inflammation.
4. the preparation method of the face mask for eliminating macula and whitening skin described in any one of claim 1-3, it is characterised in that comprise the following steps：
(1) get the raw materials ready；
(2) volatilize oil extract and cyclodextrin inclusion compound：Semen Armeniacae Amarum adopts steam distillation or supercritical CO after mixing with Flos Rosae Rugosae2
Extraction method, extracts volatile oil, and Semen Armeniacae Amarum is standby with Flos Rosae Rugosae medicinal residues, and the cyclodextrin of its weight 10-15 times is added in volatile oil
Included, obtained cyclodextrin of volatile oil clathrate；
(3) alcohol extracting and concentrating：After Semen Armeniacae Amarum is mixed with Radix Angelicae Sinensis, Poria, Radix Ampelopsis, Fructus Crataegi, Radix Glycyrrhizae with Flos Rosae Rugosae medicinal residues, mixing is added
After the ethanol of the 35%-90% of thing weight 5-10 times, ethanol extraction is obtained by alcohol steep or heating and refluxing extraction, ethanol is carried
Take macroporous adsorptive resins on thing, using 5-10 times of 20%-30% alcohol flushings after, carried out using the ethanol of 35%-90%
Eluting, collects eluent, and after the recovered ethanol of eluent, when heating is concentrated into room temperature (25 DEG C), relative density is 1.05-1.35
Alcohol extraction concentrate；
(4) crush：After alcohol extraction concentrate and the Pseudobulbus Bletillae (Rhizoma Bletillae), panax mixed, Jing freezing and pulverizing obtains mixed-powder, forges to 1000-2000 mesh
Gypsum Fibrosum, Margarita are crushed to 1000-2000 mesh respectively, obtain Gypsum Fibrosum powder (calcined) and Margarita powder, standby；
(5) mix：After Gypsum Fibrosum powder (calcined), Margarita powder and cyclodextrin of volatile oil clathrate are added in mixed-powder, mix homogeneously, i.e.,
.
5. preparation method according to claim 4, it is characterised in that adopt supercritical CO in the step (2)2Extraction method
Volatile oil is extracted, the cyclodextrin is the beta-schardinger dextrin-of 15 times of weight of oil of volatilization.
6. preparation method according to claim 4, it is characterised in that alcohol extraction is to add mixture weight in the step (3)
75% ethanol of 8 times of amount carries out heating and refluxing extraction, on ethanol extraction after macroporous adsorptive resins, using the 30% of 5 times of amounts
Ethanol is rinsed, and using 75% ethanol elution, eluent recovery ethanol post-heating is concentrated into relatively close during room temperature (25 DEG C)
Spend the alcohol extraction concentrate for 1.25.
7. preparation method according to claim 4, it is characterised in that mixed-powder, Gypsum Fibrosum Preparatum described in the step (4)
Powder, the fineness of Margarita powder are 1000 mesh.
8. the using method of the face mask for eliminating macula and whitening skin described in any one of claim 1-3, it is characterised in that：In the freckle removing and whitening
Pasty state is tuned into after proper honey is added in facial film, apply to mottle region, surface application 20-30 minutes after adding appropriate amount of purified water, every
Appropriate amount of purified water is sprayed on facial film within 10 minutes, cleaned with warm clear water after surface application, used once daily, be within six weeks a cycle.
9. using method according to claim 8, it is characterised in that surface application 20 minutes.
10. using method according to claim 8, it is characterised in that the mottle be chloasma, senile plaque, sunburn,
Pigmentation spots after freckle and/or inflammation.
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| CN106539747B (en) | 2018-07-31 |
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