CN101940624A - Chinese medicinal lotion for treating vitiligo - Google Patents
Chinese medicinal lotion for treating vitiligo Download PDFInfo
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- CN101940624A CN101940624A CN2010102688766A CN201010268876A CN101940624A CN 101940624 A CN101940624 A CN 101940624A CN 2010102688766 A CN2010102688766 A CN 2010102688766A CN 201010268876 A CN201010268876 A CN 201010268876A CN 101940624 A CN101940624 A CN 101940624A
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- vitiligo
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Abstract
The invention relates to a Chinese medicinal lotion for treating vitiligo. The conventional medicaments for treating the vitiligo have the disadvantages of only relief of surface symptoms, unsatisfactory curative effect, easy relapse after medicament discontinuance, and easy medicament resistance of patients due to long-term medicament continuance. The product comprises the following components by weight: 70 to 90g of mint, 90 to 110g of beautiful sweetgum fruit, 140 to 160g of parslane herb, 90 to 110g of pharbitis seed, 90 to 110g of processed tuber fleeceflower root, 90 to 110g of pomegranate rind, 90 to 110g of dock root and 90 to 110g of common cnidium fruit. The Chinese medicinal lotion is prepared by adding 5,000 to 6,000ml of water into the components, and decocting the mixture for 30 minutes. The Chinese medicinal lotion is used for treating the vitiligo.
Description
Technical field:
The present invention relates to the leukodermic Chinese medicine wash of a kind of treatment.
Background technology:
Vitiligo is worldwide difficult disease, claims " not dead cancer ".Morbidity in recent years has the trend that increases year by year.Its cardinal symptom is for being mainly in positions such as human body women's head-ornaments portion, cervical region, extremity, waist abdomen.From the beginning of being white dot, spread into patch for a long time, little (point, sheet) shape white macula, smooth surface, desquamation not, no sufferings, the course of disease is long, chosure of pores.Do not itch though the patient is painful, it is attractive in appearance to influence human body, and the harm people's is healthy, makes the patient overwhelmed with sorrow.The focus size is all very painful, has a strong impact on the normal live and work of patient.
The medicine of state's internal therapy primary disease is many based on psoralen, hormone etc. at present, mainly contains with several once:
1, psoralen: because this class external used medicine zest is bigger, therefore carrying out the phase white macula avoids usefulness, in order to avoid owing to bringing out isomorphic response skin lesion is enlarged even general whole body.Generally be applicable to resting stage and paracmastic patients with vitiligo.Can cause the reaction of erythema that the skin lesion place is more serious and vesicle, also can cause dizziness,, general reaction such as feel sick.Toxic and side effects has loss of appetite, anemia, leukopenia and toxic hepatitis.Diabetes, hepatopathy and photosensitive disease (as porphyria, lupus erythematosus etc.) patient forbidding.In addition, also can cause ocular injury and skin carcinoma, should note the protection of eyes, avoid intensive ultraviolet radiation.
2, glucocorticoid hormone: than other medication erious adverse reaction, clinical use should be held prudent attitude.Local injection easily causes the local atrophy of skin lesion in the glucocorticoid hormone skin lesion.Should notice that local skin atrophy, generation drug resistance, telangiectasis, acne, acne, folliculitis, fine hair on birds or animals hair that long-term external glucocorticoid hormone causes increase slightly, increase, even percutaneous absorbs the generation that causes systemic side effects.
3, trace element: the treatment vitiligo mechanism of action is not quite clear, may be because heavy metal combines with sulfydryl in the skin, gives tyrosinase activity, promotes melanocyte formation.This medicine is only applicable to the small size white macula of exposure portion, and the local skin atrophy that causes after pain and the injection when shortcoming is injection when therefore also loseing newborn pigment spot after 7～8 injections, is answered stopped treatment.
4, oxidase inhibitor: catecholamine can make the colour of skin of the frog skin that exsomatizes thin out, and the monoamine oxidase, MAO preparation can suppress the metabolism of SNE place catecholamine.Use such preparation for treating stage type white macula and obtain effect.Drug metabolism enzyme to liver also has inhibitory action, and these class side effects of pharmaceutical drugs are more, can produce central excitation.Lure phrenoplegia into, hepatotoxicity is arranged, cause postural hypotension.
5, lose ball in vain: having comprised Rhizoma Dioscoreae Bulbiferae etc. in the prescription because of white erosion ball has certain toxic medicine, to improve therapeutic effect.Main component is 14 flavors such as Fructus Psoraleae, Radix Polygoni Multiflori, Ganoderma, Radix Salviae Miltiorrhizae, Flos Carthami, Cortex Moutan, Lignum Dalbergiae Odoriferae, Radix Arnebiae (Radix Lithospermi), Rhizoma Dioscoreae Bulbiferae, Radix Glycyrrhizae.The case report of relevant white erosion ball is totally 8 examples, and wherein serious case report has hepatic injury 7 examples.Model case: the patient, the man, 24 years old, under physician guidance, take white erosion ball 2.5g because of suffering from vitiligo, day three times, surplus in the of 20 behind the sky inappetence appears, detest greasy.Through liver function test, be diagnosed as drug induced hepatitis in conjunction with medical history, the white erosion ball of stopping using is hospitalized for treatment, and gives Drug therapys such as diammonium glycyrrhizinate, A Tuo are not blue, promise is peaceful, and it is normal to look into liver function after 14 days, leaves hospital.In view of white erosion ball can cause hepatic injury, the suggestion patient must use under the doctor instructs, strict indication and the contraindication grasped.In the use, the strict control dosage and the course of treatment, avoid overdose, take for a long time; Simultaneously, in therapeutic process, note the liver function monitoring.The careful usefulness of child, old people and women breast-feeding their children; Anemia of pregnant woman, hepatic insufficiency patient's forbidding.
Above various kinds of drug can only be alleviated surface symptoms, and curative effect is undesirable, and drug withdrawal easily recurs, and patient such as long-term medicine are kept, and are easy to generate Drug resistance.And the operative treatment vitiligo is not suitable for older and is associated with the patient of other organ disease, and postoperative recurs easily and evokes complication, causes other organ disease, so invent the fervent expectation that this disease of treatment by Chinese herbs of a kind for the treatment of both the principal and secondary aspects of a disease has become extensive patients.
Summary of the invention:
The purpose of this invention is to provide the leukodermic Chinese medicine wash of a kind of treatment, evident in efficacy, and the difficult recurrence in recovery from illness back, the patient no longer needs the life-time service medicine to keep, and does not develop immunity to drugs.Avoided the misery of operative treatment, and evoke complication cause other organ disease.
Above-mentioned purpose realizes by following technical scheme:
Treat leukodermic Chinese medicine wash, its composition comprises: Herba Menthae, Fructus Liquidambaris, Herba Portulacae, Semen Pharbitidis, Radix Polygoni Multiflori Preparata, Pericarpium Granati, Radix Rumicis, Fructus Cnidii, its weight is: Herba Menthae 70-90g, Fructus Liquidambaris 90-110g, Herba Portulacae 140-160g, Semen Pharbitidis 90-110g, Radix Polygoni Multiflori Preparata 90-110g, Pericarpium Granati 90-110g, Radix Rumicis 90-110g, Fructus Cnidii 90-110g, above-mentioned composition is added 5000-6000ml water, decoct and got final product in 30 minutes.
Beneficial effect:
1. the applicant thinks, is body heat or heat in blood according to leukodermic pathogenic factor, is subjected to rheumatism outward, and rheumatism is invaded skin, causes local disorder of QI and blood, the not flourish skin of blockage of main and collateral channels, blood, and the stagnation of QI, occlusion of the pores of skin is so form vitiligo.Therapeutic Method then should be lacked of proper care with QI and blood regulating, hold concurrently heat clearing away, invigorate blood circulation, the meridian dredging, strengthening the body resistance, and promote the epidermis metabolism, open a mao key, qi and blood circulation promotion, Yin Yang balancing, dredging the meridian, blood circulation promoting and blood stasis dispelling, expelling wind and removing dampness, heat-clearing and toxic substances removing, support flourish granulation promoting, enhancing human body immunity power, the meridian dredging treating both the principal and secondary aspects of a disease.Determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, Special medicine for special disease, compatibility are precise and appropriate.The present invention is by famous and precious natural Chinese medicine, and compatibility forms meticulously, makes higher, the more remarkable treatment effect of composition of medicine availability under the synergism.
2. this product is a kind of external wash, and effect is good during the treatment, and is evident in efficacy, and the difficult recurrence in recovery from illness back, and the patient no longer needs the life-time service medicine to keep, and does not develop immunity to drugs.Avoided the misery of operative treatment, and evoke complication cause other organ disease.
3. this product does not contain additives such as any hormone, Fructus Psoraleae, advantage without any side effects.
4. medicine of the present invention has significant curative effect through the evidence safety non-toxic to the treatment vitiligo, and its toxicology and pharmacodynamic experiment data are as follows:
Skin irritation test: the stimulus intensity to rabbit skin belongs to nonirritant.The skin allergic reaction experiment: sensitization rate 0%, sensitization intensity belong to extremely slightly degree.
Long term toxicity test: respectively with 0.9g/kg, apply medicinal lotion or ointment to rat skin, every day three times, continuous 60 days, result of the test showed that general state, behavioral activity and the diet situation and the matched group that are tried rat do not have significant difference; Hematology, liver function, renal function and organ coefficient and matched group more all do not have significant difference, show that life-time service medicine of the present invention is safe.
5. it is as follows to carry out patient's clinical trial: 150 routine patients with vitiligo are offered the degree of minister dermatosis section hospital according to the state of an illness in Harbin, the patient of this medicine of clinical practice is divided into 3 groups, every group 50 people.Usage and dosage: described composition is added 5000-6000ml water, decocted 30 minutes, get final product.Clean the affected part with wash after waiting to reduce to preference temperature, washed every day 2-3 time at every turn 20-30 minute.Earlier the affected part is cleaned, dried before using wash, in order to avoid pollute medicinal liquid with clear water.
50 routine patients with vitiligo are ill in 1 year, and the affected part is at 5cm
2In.Offer minister dermatosis section hospital clinical practice 4 months in Harbin, therapeutic effect sees Table:
This medicine of table 1 is to the therapeutic effect of patients with vitiligo
50 routine patients with vitiligo are ill in 5 years, and the affected part is at 10cm
2In.Offer minister dermatosis section hospital clinical practice 6 months in Harbin, therapeutic effect sees Table 2:
This medicine of table 2 is to the therapeutic effect of patients with vitiligo
50 routine patients with vitiligo are ill in 10 years, and the affected part is at 50cm
2In.Offer minister dermatosis section hospital clinical practice 8 months in Harbin, therapeutic effect is as follows:
This medicine of table 3 is to the therapeutic effect of patients with vitiligo
Patient's clinical manifestation: the affected part is sent out in positions such as patient's women's head-ornaments portion, cervical region, extremity, waist abdomens.From the beginning of being white dot, spread into patch for a long time, do not itch though do not ache, it is attractive in appearance to influence human body, and the harm people's is healthy, makes the patient overwhelmed with sorrow.
The standard of medical effect evaluation: effectively: 1, the color of affected area obviously changes behind finger pressure.Be blood operation and the easypro logical sign of meridians.2, fine hair hole opens, and color shoals or the rubescent hair powder in affected part.3, focus is dwindled gradually.4, color changes gradually.5, occur the pigment island on the focus, increase gradually on the pigment island, density.Recovery from illness: the skin affected part is the normal colour of skin.
Statistical result: effective 98%, recovery from illness 80%, invalid 2%.
The result shows: medicine of the present invention can obviously be treated vitiligo.
The specific embodiment:
Embodiment 1:
Treat leukodermic Chinese medicine wash, its composition comprises: Herba Menthae, Fructus Liquidambaris, Herba Portulacae, Semen Pharbitidis, Radix Polygoni Multiflori Preparata, Pericarpium Granati, Radix Rumicis, Fructus Cnidii, its weight is: Herba Menthae 70g, Fructus Liquidambaris 90g, Herba Portulacae 160g, Semen Pharbitidis 110g, Radix Polygoni Multiflori Preparata 90g, Pericarpium Granati 110g, Radix Rumicis 90g, Fructus Cnidii 90g, described component is added 5000ml water, decoct and got final product in 30 minutes.
Embodiment 2:
Treat leukodermic Chinese medicine wash, its composition comprises: Herba Menthae, Fructus Liquidambaris, Herba Portulacae, Semen Pharbitidis, Radix Polygoni Multiflori Preparata, Pericarpium Granati, Radix Rumicis, Fructus Cnidii, its weight is: Herba Menthae 80g, Fructus Liquidambaris 100g, Herba Portulacae 150g, Semen Pharbitidis 100g, Radix Polygoni Multiflori Preparata 100g, Pericarpium Granati 100g, Radix Rumicis 100g, Fructus Cnidii 100g, described component is added 5000ml water, decoct and got final product in 30 minutes.
Embodiment 3:
Treat leukodermic Chinese medicine wash, its composition comprises: Herba Menthae, Fructus Liquidambaris, Herba Portulacae, Semen Pharbitidis, Radix Polygoni Multiflori Preparata, Pericarpium Granati, Radix Rumicis, Fructus Cnidii, its weight is: Herba Menthae 90g, Fructus Liquidambaris 110g, Herba Portulacae 160g, Semen Pharbitidis 90g, Radix Polygoni Multiflori Preparata 90g, Pericarpium Granati 90g, Radix Rumicis 110g, Fructus Cnidii 110g, described component is added 6000ml water, decoct and got final product in 30 minutes.
Claims (1)
1. treat leukodermic Chinese medicine wash for one kind, its composition comprises: Herba Menthae, Fructus Liquidambaris, Herba Portulacae, Semen Pharbitidis, Radix Polygoni Multiflori Preparata, Pericarpium Granati, Radix Rumicis, Fructus Cnidii, it is characterized in that: its weight is: Herba Menthae 70-90g, Fructus Liquidambaris 90-110g, Herba Portulacae 140-160g, Semen Pharbitidis 90-110g, Radix Polygoni Multiflori Preparata 90-110g, Pericarpium Granati 90-110g, Radix Rumicis 90-110g, Fructus Cnidii 90-110g, above-mentioned composition is added 5000-6000ml water, decoct and got final product in 30 minutes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010268876.6A CN101940624B (en) | 2010-09-01 | 2010-09-01 | Chinese medicinal lotion for treating vitiligo |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010268876.6A CN101940624B (en) | 2010-09-01 | 2010-09-01 | Chinese medicinal lotion for treating vitiligo |
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| CN101940624A true CN101940624A (en) | 2011-01-12 |
| CN101940624B CN101940624B (en) | 2014-12-10 |
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| CN201010268876.6A Expired - Fee Related CN101940624B (en) | 2010-09-01 | 2010-09-01 | Chinese medicinal lotion for treating vitiligo |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103405539A (en) * | 2013-08-22 | 2013-11-27 | 王爱枝 | Medicine for treating leucoderma and preparation method thereof |
| US11123390B2 (en) | 2018-09-18 | 2021-09-21 | Kuwait University | Method for treating vitiligo |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1814139A (en) * | 2005-12-06 | 2006-08-09 | 师瑞乐 | Baidianling capsule |
| CN101496844A (en) * | 2009-03-19 | 2009-08-05 | 董娜 | External preparation for treating leukoderma and method for preparing and using the same |
-
2010
- 2010-09-01 CN CN201010268876.6A patent/CN101940624B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1814139A (en) * | 2005-12-06 | 2006-08-09 | 师瑞乐 | Baidianling capsule |
| CN101496844A (en) * | 2009-03-19 | 2009-08-05 | 董娜 | External preparation for treating leukoderma and method for preparing and using the same |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103405539A (en) * | 2013-08-22 | 2013-11-27 | 王爱枝 | Medicine for treating leucoderma and preparation method thereof |
| US11123390B2 (en) | 2018-09-18 | 2021-09-21 | Kuwait University | Method for treating vitiligo |
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| Publication number | Publication date |
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| CN101940624B (en) | 2014-12-10 |
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