CN106521699A - 共混与同轴静电纺载药纳米纤维的制备方法 - Google Patents

共混与同轴静电纺载药纳米纤维的制备方法 Download PDF

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CN106521699A
CN106521699A CN201611012445.7A CN201611012445A CN106521699A CN 106521699 A CN106521699 A CN 106521699A CN 201611012445 A CN201611012445 A CN 201611012445A CN 106521699 A CN106521699 A CN 106521699A
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王耀斌
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Abstract

本发明涉及医学药品技术领域，具体涉及一种共混与同轴静电纺载药纳米纤维的制备方法。共混与同轴静电纺载药纳米纤维的制备方法，采用如下方法：（1）制备同轴纺的外层溶液;（2）制备同轴纺的芯层溶液；（3）分别将外层和芯层溶液倒入带有同轴针头的注射器中,常温下进行同轴静电纺丝；（4）纺丝结束后将所有样品干燥，即得到共混和同轴纺PVA‑SbQ/Zein载药纳米纤维膜；（5）然后将纤维膜于功紫外灯下照射得到光交联复合纳米纤维膜。本发明采用共混和同轴静电纺丝制备负载药物盐酸四环素的PVA‑SbQ/Zein复合纳米纤维膜。同轴静电纺复合纳米纤维较静电纺复合纳米纤维力学性能更佳。

Description

共混与同轴静电纺载药纳米纤维的制备方法
技术领域
本发明涉及医学药品技术领域，具体涉及一种共混与同轴静电纺载药纳米纤维的制备方法。
背景技术
随着人类社会的发展，人们对医疗药品方面的要求也日益增长，而传统给药方式的问题和缺点如药物利用率低、血药浓度不稳定、给药频繁等也逐渐表现出来。近年来，通过静电纺丝制备的载药纳米纤维因其小尺寸效应、多功能性、高效性等特性，受到了广泛的关注。纳米纤维在载药以及药物缓释方面具有一定的应用优势。具有生物相容性的纳米纤维在结构上可以模仿人体细胞外基质EMC，避免排异反应;纳米纤维本身的尺寸小，较高的孔隙率、极大的比表面积，使得纳米纤维作为良好的药物载体，能让药物更易被人体吸收;静电纺纳米纤维载药不破坏药物的活性，能很好地包载药物;在制备纺丝液和静电纺过程中，药物能够以无定形的形式均匀地分散在纳米纤维中，有利于药物的平缓释放和吸收利用。另外，基于传统静电纺丝基础上发展起来的同轴静电纺技术，为药物的包载和缓释提供了更好的载体结构，同轴静电纺可以制备具有皮芯结构的纳米纤维，将药物包载在纤维的内层，既能很好地贮存药物，保持药物活性，又有利于缓解药物的突释现象。
发明内容
本发明旨在提供一种共混与同轴静电纺载药纳米纤维的制备方法。
本发明的技术方案在于：
共混与同轴静电纺载药纳米纤维的制备方法，采用如下方法：
（1）将m (PVA-SbQ)/m (Zein)为1：1的混合体系4g加入到12g 冰乙酸中，常温下搅拌2h，制得PVASbQ/Zein前驱体溶液作为同轴纺的外层溶液；
（2）将药物盐酸四环素0.5g溶解于10mL无水乙醇溶液中，常温下搅拌1h，制得盐酸四环素前驱体溶液作为同轴纺的芯层溶液；
（3）分别将外层和芯层溶液倒入带有同轴针头的注射器中，常温下进行同轴静电纺丝；
（4）纺丝结束后将所有样品干燥，即得到共混和同轴纺PVA-SbQ/Zein 载药纳米纤维膜；
（5）然后将纤维膜于紫外灯下照射得到光交联复合纳米纤维膜。
所述的注射器针头内外层直径分别为0.51和0.81mm。
所述的步骤（3）同轴静电纺丝中，滚筒转速200r/min，纺丝条件为电压15kV，芯层速度0.5mL/h，外层速度1 mL/h，接收距离20cm。
所述的步骤（4）中干燥的温度为60℃，干燥时间为12h。
所述的步骤（5）中紫外灯的功率为400W，照射时间为2h。
本发明的技术效果在于：
本发明采用共混和同轴静电纺丝制备负载药物盐酸四环素的PVA-SbQ/Zein 复合纳米纤维膜。通过红外进行观察，同轴静电纺复合纳米纤维较静电纺复合纳米纤维力学性能更佳。药物释放行为比较可以得出同轴静电纺载药PVA-SbQ/Zein 纳米纤维药物缓释效果更好，该复合纳米纤维在药物缓释和创伤敷料等领域具有潜在应用价值。
具体实施方式
共混与同轴静电纺载药纳米纤维的制备方法，采用如下方法：
（1）将m (PVA-SbQ)/m (Zein)为1：1的混合体系4g加入到12g 冰乙酸中，常温下搅拌2h，制得PVASbQ/Zein前驱体溶液作为同轴纺的外层溶液；
（2）将药物盐酸四环素0.5g溶解于10mL无水乙醇溶液中，常温下搅拌1h，制得盐酸四环素前驱体溶液作为同轴纺的芯层溶液；
（3）分别将外层和芯层溶液倒入带有同轴针头的注射器中，常温下进行同轴静电纺丝；
（4）纺丝结束后将所有样品干燥，即得到共混和同轴纺PVA-SbQ/Zein 载药纳米纤维膜；
（5）然后将纤维膜于紫外灯下照射得到光交联复合纳米纤维膜。
其中，所述的注射器针头内外层直径分别为0.51和0.81mm。所述的步骤（3）同轴静电纺丝中，滚筒转速200r/min，纺丝条件为电压15kV，芯层速度0.5mL/h，外层速度1 mL/h，接收距离20cm。所述的步骤（4）中干燥的温度为60℃，干燥时间为12h。所述的步骤（5）中紫外灯的功率为400W，照射时间为2h。
纳米纤维平均直径为(345±59)nm纤维表面光滑，没有串珠，在此基础上负载药物盐酸四环素得到共混静电纺载药PVA-SbQ/Zein，纤维表面更光滑平整，纤维平均直径变大约为(765±21)nm，这是由于负载药物后纺丝液的粘度和电导率改变导致的。采用同轴静电纺制备的以药物为芯层聚合物为外层的载药PVA-SbQ/Zein纤维直径更大，甚至达到微米级，而且纤维不均率很高，这是由于喷丝头端芯外层复合液滴被牵伸时不稳定造成的。

Claims (5)

1.共混与同轴静电纺载药纳米纤维的制备方法，其特征在于：采用如下方法：
（1）将m (PVA-SbQ)/m (Zein)为1：1的混合体系4g加入到12g 冰乙酸中,常温下搅拌2h,制得PVASbQ/Zein前驱体溶液作为同轴纺的外层溶液；
（2）将药物盐酸四环素0.5g溶解于10mL无水乙醇溶液中，常温下搅拌1h,制得盐酸四环素前驱体溶液作为同轴纺的芯层溶液；
（3）分别将外层和芯层溶液倒入带有同轴针头的注射器中，常温下进行同轴静电纺丝；
（4）纺丝结束后将所有样品干燥，即得到共混和同轴纺PVA-SbQ/Zein 载药纳米纤维膜；
（5）然后将纤维膜于紫外灯下照射得到光交联复合纳米纤维膜。
2.根据权利要求1所述的共混与同轴静电纺载药纳米纤维的制备方法，其特征在于：所述的注射器针头内外层直径分别为0.51和0.81mm。
3.根据权利要求1所述的共混与同轴静电纺载药纳米纤维的制备方法，其特征在于：所述的步骤（3）同轴静电纺丝中，滚筒转速200r/min，纺丝条件为电压15kV，芯层速度0.5mL/h，外层速度1 mL/h，接收距离20cm。
4.根据权利要求1所述的共混与同轴静电纺载药纳米纤维的制备方法，其特征在于：所述的步骤（4）中干燥的温度为60℃，干燥时间为12h。
5.根据权利要求1所述的共混与同轴静电纺载药纳米纤维的制备方法，其特征在于：所述的步骤（5）中紫外灯的功率为400W，照射时间为2h。
CN201611012445.7A 2016-11-17 2016-11-17 共混与同轴静电纺载药纳米纤维的制备方法 Pending CN106521699A (zh)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114794613A (zh) * 2021-01-27 2022-07-29 宁波方太厨具有限公司 一种口罩及其制备方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114794613A (zh) * 2021-01-27 2022-07-29 宁波方太厨具有限公司 一种口罩及其制备方法

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