CN106511909A - Medicine for treating paronychia, and preparation method thereof - Google Patents

Medicine for treating paronychia, and preparation method thereof Download PDF

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Publication number
CN106511909A
CN106511909A CN201611231727.6A CN201611231727A CN106511909A CN 106511909 A CN106511909 A CN 106511909A CN 201611231727 A CN201611231727 A CN 201611231727A CN 106511909 A CN106511909 A CN 106511909A
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medicine
dosage form
preparation
exterior
crude drug
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王于法
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/235—Foeniculum (fennel)
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/74—Rubiaceae (Madder family)
    • A—HUMAN NECESSITIES
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    • A61K36/83—Thymelaeaceae (Mezereum family), e.g. leatherwood or false ohelo
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9062—Alpinia, e.g. red ginger or galangal
    • A—HUMAN NECESSITIES
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    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
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    • A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
    • A—HUMAN NECESSITIES
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

Abstract

The invention relates to a medicine for treating paronychia. The medicine includes an external dosage form and oral dosage form which are combined for use, wherein the external dosage form is prepared from the following bulk pharmaceutical chemicals: fig, painted euphorbia herb, ed psychotria leaf, wikstroemia indica, artemisia anomala, falangal, aloe, inula flower, fennel, cortex cinnamomi, white spirit, brown sugar; and the oral dosage form is prepared from the following bulk pharmaceutical chemicals: fig, radix gentianae macrophyllae, sanguis draconis, folium artemisiae argyi, pollen, wikstroemia indica, honey, artemisia anomala, rhizoma curcumae, garlic oil, spina gleditsiae, fennel, cortex cinnamomi and falangal. In addition, the invention provides a preparation method of the medicine. The prepared medicine is safe and high in efficiency, can conduct both tonification and purgation in combination, the effects of the active ingredients can complement with each other and be synergistic, and the organism immunity functions can be enhanced.

Description

It is a kind of to treat medicine of carbuncle of the nape and preparation method thereof
Technical field
The present invention relates to technical field of Chinese medicines, and in particular to a kind of to treat medicine of carbuncle of the nape and preparation method thereof.
Background technology
Carbuncle of the nape, the i.e. pyogenic infection of digital tip finger pulp subcutaneous tissue, mostly microtrauma or spinule cause.Finger Minor details finger pulp distally refers to that band is subcutaneous has fiber every the gap for closing finger subcutaneous abdomen formation one, again by fiber rope in finger pulp Bar be divided into it is many closely-spaced, it is closely-spaced in be full of Oil globule.Skin is abundant, hard tough herein, lacks flexibility, and neural sensor is non- Often abundant, once there is infection, finger pulp tension force substantially increases, and pain is notable.Pathogenic bacterium mostly are staphylococcus aureuses.Doctor trained in Western medicine claims Be whitlow.
Early stage can give hot compress, potassium permanganate immersion, 3% iodine tincture embrocate, positive anti-infective therapy can make inflammatory resolution.Pus Before swollen formation, can be referred to ruyi jinhuang powder, ruyi jinhuang san application trouble.Incision and drainage as early as possible, because of infected area it is difficult to find fluctuation, therefore according to sense The time of dye, the incision and drainage at once when jumping pain occurs or affects sleep, it is impossible to wait.Even if there is no many puss after cutting, To relief of symptoms, controlling inflammation, to develop in depth be also beneficial.
The content of the invention
For solving the above problems, the present invention provides a kind of medicine for treating carbuncle of the nape, can improve wound surface week with eliminating the toxic material out by tonification The microcirculation of tissue is enclosed, regional flow is speeded.Remaining epithelial cell tissues growth, putrefaction-removing granulation-promoting can be promoted simultaneously.By plaster External application, removing toxic substances and promoting tissue regeneration, dredge the meridian passage, can stop rapidly virus spread, repair nerve, internal virus be excluded external.Make arteries and veins Network is unimpeded, and QI and blood is smooth, so as to not stay any sequela.Safe and efficient, reinforcement and elimination in combination, each medical material complement each other using, Synergism, enhancing human body immunity function.
A kind of medicine for treating carbuncle of the nape, is made up of the peroral dosage form and exterior-applied formulation that are used in combination；
The peroral dosage form is made up of the crude drug of following weight parts proportioning：Fructus Fici 10-20g Radix Gentianae Macrophyllae 4-8g, Sanguis Draxonis 4-8g, Folium Artemisiae Argyi 5-10g, pollen 10-15g, Radix Wikstroemae 1-4g, Mel 20-30g, Herba Artemisiae Anomalae 5-10g, Rhizoma Curcumae 1-10g, Oleum Bulbus Allii 5-10g, Spina Gleditsiae 1-5g, Fructus Foeniculi 1-5g, Cortex Cinnamomi 5-10g, Rhizoma Alpiniae Officinarum 20-30g；
The exterior-applied formulation is made up of the crude drug of following weight parts proportioning：Fructus Fici 1-10g, Herba Euphorbiae Heterophyllae 5-10g, Red Psychotria Leaf 1-10g, Radix Wikstroemae 5-10g, Herba Artemisiae Anomalae 5-10g, Rhizoma Alpiniae Officinarum 20-30g, Aloe 20-30g, Flos Inulae 1-10g, Fructus Foeniculi 10-20g, meat Osmanthus 5-10g, Chinese liquor 500-800g, brown sugar 20-30g.
Preferably, the peroral dosage form is made up of the crude drug of following weight parts proportioning：Radix Gentianae Macrophyllae 6g, Sanguis Draxonis 7g, Folium Artemisiae Argyi 8g, pollen 12g, Radix Wikstroemae 2g, Mel 28g, Herba Artemisiae Anomalae 5g, Rhizoma Curcumae 4g, Oleum Bulbus Allii 9g, Spina Gleditsiae 3g, Fructus Foeniculi 15g, Cortex Cinnamomi 6g, Rhizoma Alpiniae Officinarum 24g；
The exterior-applied formulation is made up of the crude drug of following weight parts proportioning：Fructus Fici 5g, Herba Euphorbiae Heterophyllae 6g, Red Psychotria Leaf 8g, Brother king 6g, Herba Artemisiae Anomalae 8g, Rhizoma Alpiniae Officinarum 25g, Aloe 27g, Flos Inulae 6g, Fructus Foeniculi 8g, Cortex Cinnamomi 7g, Chinese liquor 600g, brown sugar 23g.
The preparation method of above-described medicine is：
The preparation method of described peroral dosage form is：Each medicine is weighed according to quality proportioning, the water of gross mass 3-6 times is added, plus Heat adds the compound enzymic preparation mix homogeneously of oral dosage form medicament gross mass 0.5-2%, is heated to 90-100 to 40-50 DEG C DEG C, cooling filters to get filtrate, is dried to powder.
The preparation method of described exterior-applied formulation is：Each crude drug is weighed by proportioning, after crushing, respectively with mass ratio 2：5 The stifling 20-30min of the mixed solution of white vinegar and glycerol, in 35-45 DEG C of parch 30-40min, be warming up to 65-75 DEG C, parch After 5-10min, the medicine after parch is added in Chinese liquor, sealing, 28 DEG C ferment 6 months, and filtering and concentrating obtains relative density and is 1.35 thick paste.
Preferably, during the compound enzymic preparation is xylanase, glucoseoxidase, cellulase and T-5398 One or more.
It is highly preferred that xylanase, glucoseoxidase, cellulase and T-5398 are according to 1:2:2:1 enzyme Ratio composition compound enzymic preparation living.
Usage and consumption：
The daily peroral dosage form of patient is used cooperatively with exterior-applied formulation.It is within 7 days a course for the treatment of.
Peroral dosage form：The powder 10-20g of preparation is taken, the Rhizoma Fagopyri Dibotryiss powder of equivalent is added, adds appropriate warm water to take, often Day 2 times.
Exterior-applied formulation：Take thick paste 5-10g and be applied to affected part, it is daily 2-3 time.
Above medical material formula be according to clinical testing data, obtained from the screening of Jing scientific methods, to different situations patient, Such as patients whose symptoms were less severe, symptom very severe patient or the patient of different age group, for reaching same effect, match somebody with somebody in each raw material of guarantee Under conditions of constant, can accordingly increase and decrease dose, but dose amplitude of fluctuation is unsuitable excessive, is not to be exceeded dose 20%.
Its advantage is：
Exterior-applied formulation is made for fermentation, and middle the effective elements of the medicine is leached to greatest extent, carries out predigestion, decomposition to Chinese medicine and turns Change, the intermediate material of macromole, decomposition and inversion becomes the effective small-molecule substance that quickly can be utilized, thus curative effect it is fast, Definite effect.
（1）Pure Chinese medicine formula, during use without sense of discomfort, has no toxic side effect, safe ready；All medicine phases are closed, to post-abortion The rehabilitation effect of women is notable.
（2）Preparation method is simple, waits pretreatment to remove pained and part harmful components by stifling, does not stimulate harmonization of the stomach blood Pipe, alleviates and produces pessimal stimulation because taking Chinese medicine to patient, while avoiding because of toxic component present in raw material of Chinese medicine medicine Some untoward reaction caused after taking.
（3）The dissolution of effective ingredient is high, leaches that the time limit is short, and bioavailability is high, and good absorbing, curative effect are fast；Process is simple, Low cost, instant effect, short treating period, cure rate are high, persistent.
Specific embodiment
Embodiment 1
A kind of medicine for treating carbuncle of the nape, is made up of the peroral dosage form and exterior-applied formulation that are used in combination；
The peroral dosage form is made up of the crude drug of following weight parts proportioning：Radix Gentianae Macrophyllae 6g, Sanguis Draxonis 7g, Folium Artemisiae Argyi 8g, pollen 12g, Radix Wikstroemae 2g, Mel 28g, Herba Artemisiae Anomalae 5g, Rhizoma Curcumae 4g, Oleum Bulbus Allii 9g, Spina Gleditsiae 3g, Fructus Foeniculi 15g, Cortex Cinnamomi 6g, Rhizoma Alpiniae Officinarum 24g；
The exterior-applied formulation is made up of the crude drug of following weight parts proportioning：Fructus Fici 5g, Herba Euphorbiae Heterophyllae 6g, Red Psychotria Leaf 8g, Brother king 6g, Herba Artemisiae Anomalae 8g, Rhizoma Alpiniae Officinarum 25g, Aloe 27g, Flos Inulae 6g, Fructus Foeniculi 8g, Cortex Cinnamomi 7g, Chinese liquor 600g, brown sugar 23g.
The preparation method of described peroral dosage form is：Each medicine is weighed according to quality proportioning, the water of 5 times of gross mass is added, 45 DEG C are heated to, the compound enzymic preparation mix homogeneously of oral dosage form medicament gross mass 1% is added, 90 DEG C are heated to, are lowered the temperature, mistake Filtrate is filtered to obtain, powder is dried to.Xylanase, glucoseoxidase, cellulase and T-5398 are according to 1:2:2:1 enzyme Ratio composition compound enzymic preparation living.
The preparation method of described exterior-applied formulation is：Each crude drug is weighed by proportioning, after crushing, respectively with mass ratio 2：5 The stifling 25min of the mixed solution of white vinegar and glycerol, in 40 DEG C of parch 30min, be warming up to 75 DEG C, after parch 10min, will fry During medicine after system adds Chinese liquor, sealing, 28 DEG C ferment 6 months, and filtering and concentrating obtains the thick paste that relative density is 1.35.
Embodiment 2
A kind of medicine for treating carbuncle of the nape, is made up of the peroral dosage form and exterior-applied formulation that are used in combination；
The peroral dosage form is made up of the crude drug of following weight parts proportioning：Radix Gentianae Macrophyllae 4g, Sanguis Draxonis 4g, Folium Artemisiae Argyi 5g, pollen 10g, Radix Wikstroemae 1g, Mel 20g, Herba Artemisiae Anomalae 5g, Rhizoma Curcumae 1g, Oleum Bulbus Allii 5g, Spina Gleditsiae 1g, Fructus Foeniculi 1g, Cortex Cinnamomi 5g, Rhizoma Alpiniae Officinarum 20g；
The exterior-applied formulation is made up of the crude drug of following weight parts proportioning：Fructus Fici 10g, Herba Euphorbiae Heterophyllae 10g, Red Psychotria Leaf 10g, Radix Wikstroemae 10g, Herba Artemisiae Anomalae 10g, Rhizoma Alpiniae Officinarum 30g, Aloe 30g, Flos Inulae 10g, Fructus Foeniculi 20g, Cortex Cinnamomi 10g, Chinese liquor 800g, brown sugar 30g。
The preparation method of described peroral dosage form is：Each medicine is weighed according to quality proportioning, the water of 3 times of gross mass is added, 40 DEG C are heated to, the compound enzymic preparation mix homogeneously of oral dosage form medicament gross mass 0.5% is added, 90 DEG C are heated to, are lowered the temperature, Filter to get filtrate, be dried to powder.Xylanase, glucoseoxidase, cellulase and T-5398 are according to 1:2:2:1 Enzyme activity ratio constitutes compound enzymic preparation.
The preparation method of described exterior-applied formulation is：Each crude drug is weighed by proportioning, after crushing, respectively with mass ratio 2：5 The stifling 30min of the mixed solution of white vinegar and glycerol, in 45 DEG C of parch 40min, be warming up to 75 DEG C, after parch 10min, will fry During medicine after system adds Chinese liquor, sealing, 28 DEG C ferment 6 months, and filtering and concentrating obtains the thick paste that relative density is 1.35.
Embodiment 3
A kind of medicine for treating carbuncle of the nape, is made up of the peroral dosage form and exterior-applied formulation that are used in combination；
The peroral dosage form is made up of the crude drug of following weight parts proportioning：Radix Gentianae Macrophyllae 8g, Sanguis Draxonis 8g, Folium Artemisiae Argyi 10g, pollen 15g, Radix Wikstroemae 4g, Mel 30g, Herba Artemisiae Anomalae 10g, Rhizoma Curcumae 10g, Oleum Bulbus Allii 10g, Spina Gleditsiae 5g, Fructus Foeniculi 1-5g, Cortex Cinnamomi 10g, Rhizoma Alpiniae Officinarum 30g；
The exterior-applied formulation is made up of the crude drug of following weight parts proportioning：Fructus Fici 1g, Herba Euphorbiae Heterophyllae 5g, Red Psychotria Leaf 1g, Brother king 5g, Herba Artemisiae Anomalae 5g, Rhizoma Alpiniae Officinarum 20g, Aloe 20g, Flos Inulae 1g, Fructus Foeniculi 10g, Cortex Cinnamomi 5g, Chinese liquor 500g, brown sugar 20g.
The preparation method of described peroral dosage form is：Each medicine is weighed according to quality proportioning, the water of 6 times of gross mass is added, 50 DEG C are heated to, the compound enzymic preparation mix homogeneously of oral dosage form medicament gross mass 2% is added, 100 DEG C are heated to, are lowered the temperature, mistake Filtrate is filtered to obtain, powder is dried to.Xylanase, glucoseoxidase, cellulase and T-5398 are according to 1:2:2:1 enzyme Ratio composition compound enzymic preparation living.
The preparation method of described exterior-applied formulation is：Each crude drug is weighed by proportioning, after crushing, respectively with mass ratio 2：5 The stifling 20min of the mixed solution of white vinegar and glycerol, in 35-45 DEG C of parch 30min, be warming up to 65 DEG C, after parch 5min, will During medicine after parch adds Chinese liquor, sealing, 28 DEG C ferment 6 months, and filtering and concentrating obtains the thick paste that relative density is 1.35.
Toxicity test test method：SD rats 30 are taken, rat is equally divided into 3 by 180～220g of body weight, male and female half and half Group, respectively feeding and smear the embodiment of the present invention 1, compositionss prepared by embodiment 2 and embodiment 3.Medicine feeding method is：Will Powder made by the present invention, is made into suspension with water.Every group of rat gavage drug suspension three times a day, daily rat dosage For 1.5g/Kg, Rat Fast can't help water, like this method continuous gavage 15 days.As a result：During rat medication, rat is without in Poison, the phenomena of mortality, each group activities in rats, appetite are normal.Jing dissects kidney, liver, adrenal cortex, genitals without substantially change Change.Conclusion：It can be seen from the results above that medication amount used by zoopery is much higher by the dose of adult's clinical application, but greatly Mus occur without dead or organ variation situation, thus can draw medicine of the present invention human body using when have no toxic side effect.
Clinical laboratory data
Experimental group 1-3 and contrast groups 1-2 patient are each 80, age 12-70 year, two groups of situations without significant difference, with comparable Property.The Chinese medicine that experimental group 1-3 is made using embodiment of the present invention 1-3；Matched group 1 adopts western medicine；Matched group 2 adopts patent Treatment by Chinese herbs prepared by CN104784630.
Usage and consumption：
The daily peroral dosage form of patient is used cooperatively with exterior-applied formulation.It is within 7 days a course for the treatment of.
Peroral dosage form：The powder 10-20g of preparation is taken, the Rhizoma Fagopyri Dibotryiss powder of equivalent is added, adds appropriate warm water to take, often Day 2 times.
Exterior-applied formulation：Take thick paste 5-10g and be applied to affected part, it is daily 2-3 time.
Effectively：Without recurrence, pain disappears；
It is effective：Without recurrence, pain relief；
It is invalid：Recur repeatedly, symptom is without substantially mitigation.
Using vomica ulceration after ointment patient 2-3 days of the present invention, eliminating the toxic material out by tonification, swelling are tentatively gone down, pain relief, 4- Affected part incrustation after 5 days, swelling are wholly absent, and pain is wholly absent, cure rate more than 96% after a course for the treatment of.
Lee so-and-so, female, 35 years old, illness symptom：Patient's right hand forefinger end pain, that is, go to hospital admission, once use western medicine Invalid, and have development, swelling after 5 days is spread all referring to and having fever, Nausea and vomiting, check：Expression pain, right hand forefinger swell Swollen, color of the leather is slightly dim red, local it is scorching hot, by severe pain, finger joint can not be stretched in the wrong.Pulse condition：Sliding number, red tongue, thin white fur of tongue are diagnosed as Carbuncle of the nape.Treatment：Three times a day, check after treating 2 days, swelling, pain gradually delays, advise it is continuous take 7 days after, symptom disappears and fullys recover from an illness More.So far 3 years, do not recur.
Zhao, female, 60 years old, reason was failed to understand and starts left index finger end pain, and when sagging more very, pain connects with the heart, that is, go to certain Town hospital seeks medical advice, and once injects penicillin and streptomycin, but effect on driving birds is not good, and has development, after one day swelling spread all referring to, affect sleep, and Fever, Nausea and vomiting is mixed with, is received and is eaten not good, checked：Expression pain, left index finger swelling, color of the leather are slightly dim red, and local is scorching hot, presses Severe pain, finger joint can not be stretched in the wrong.Pulse condition：Sliding number, red tongue, thin white fur of tongue is carbuncle of the nape after diagnosing, takes 1 treatment of this prescription Cheng Hou, remission, after taking 2 courses for the treatment of, symptom is clearly better, after continue to take after 1 course for the treatment of consolidates, symptom is complete Disappear, fully recover.So far 2 years, do not recur.

Claims (5)

1. a kind of medicine for treating carbuncle of the nape, it is characterised in that be made up of the peroral dosage form and exterior-applied formulation that are used in combination；
The peroral dosage form is made up of the crude drug of following weight parts proportioning：Fructus Fici 10-20g Radix Gentianae Macrophyllae 4-8g, Sanguis Draxonis 4-8g, Folium Artemisiae Argyi 5-10g, pollen 10-15g, Radix Wikstroemae 1-4g, Mel 20-30g, Herba Artemisiae Anomalae 5-10g, Rhizoma Curcumae 1-10g, Oleum Bulbus Allii 5-10g, Spina Gleditsiae 1-5g, Fructus Foeniculi 1-5g, Cortex Cinnamomi 5-10g, Rhizoma Alpiniae Officinarum 20-30g；
The exterior-applied formulation is made up of the crude drug of following weight parts proportioning：Fructus Fici 1-10g, Herba Euphorbiae Heterophyllae 5-10g, Red Psychotria Leaf 1-10g, Radix Wikstroemae 5-10g, Herba Artemisiae Anomalae 5-10g, Rhizoma Alpiniae Officinarum 20-30g, Aloe 20-30g, Flos Inulae 1-10g, Fructus Foeniculi 10-20g, meat Osmanthus 5-10g, Chinese liquor 500-800g, brown sugar 20-30g.
2. medicine according to claim 1, it is characterised in that be made up of the peroral dosage form and exterior-applied formulation that are used in combination；
The peroral dosage form is made up of the crude drug of following weight parts proportioning：Radix Gentianae Macrophyllae 6g, Sanguis Draxonis 7g, Folium Artemisiae Argyi 8g, pollen 12g, Radix Wikstroemae 2g, Mel 28g, Herba Artemisiae Anomalae 5g, Rhizoma Curcumae 4g, Oleum Bulbus Allii 9g, Spina Gleditsiae 3g, Fructus Foeniculi 15g, Cortex Cinnamomi 6g, Rhizoma Alpiniae Officinarum 24g；
The exterior-applied formulation is made up of the crude drug of following weight parts proportioning：Fructus Fici 5g, Herba Euphorbiae Heterophyllae 6g, Red Psychotria Leaf 8g, Brother king 6g, Herba Artemisiae Anomalae 8g, Rhizoma Alpiniae Officinarum 25g, Aloe 27g, Flos Inulae 6g, Fructus Foeniculi 8g, Cortex Cinnamomi 7g, Chinese liquor 600g, brown sugar 23g.
3. the preparation method of the medicine described in a kind of claim 1 or 2, it is characterised in that：
The preparation method of described peroral dosage form is：Each medicine is weighed according to quality proportioning, the water of gross mass 3-6 times is added, plus Heat adds the compound enzymic preparation mix homogeneously of oral dosage form medicament gross mass 0.5-2%, is heated to 90-100 to 40-50 DEG C DEG C, cooling filters to get filtrate, is dried to powder；
The preparation method of described exterior-applied formulation is：Each crude drug is weighed by proportioning, after crushing, respectively with mass ratio 2：5 it is white The stifling 20-30min of the mixed solution of vinegar and glycerol, in 35-45 DEG C of parch 30-40min, is warming up to 65-75 DEG C, parch 5- After 10min, the medicine after parch is added in Chinese liquor, sealing, 28 DEG C ferment 6 months, and filtering and concentrating obtains relative density for 1.35 Thick paste.
4. preparation method according to claim 3, it is characterised in that the compound enzymic preparation is xylanase, glucose One or more in oxidase, cellulase and T-5398.
5. preparation method according to claim 4, it is characterised in that xylanase, glucoseoxidase, cellulase and T-5398 is according to 1:2:2:1 enzyme activity ratio composition compound enzymic preparation.
CN201611231727.6A 2016-12-28 2016-12-28 Medicine for treating paronychia, and preparation method thereof Pending CN106511909A (en)

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Publication number Priority date Publication date Assignee Title
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CN104000958A (en) * 2014-06-20 2014-08-27 四川金堂海纳生物医药技术研究所 External application ointment for treating panaritium and preparing method of external application ointment
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