CN106492169A - 一种治疗婴幼儿阴黄症的药物组合物 - Google Patents

一种治疗婴幼儿阴黄症的药物组合物 Download PDF

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CN106492169A
CN106492169A CN201611082526.4A CN201611082526A CN106492169A CN 106492169 A CN106492169 A CN 106492169A CN 201611082526 A CN201611082526 A CN 201611082526A CN 106492169 A CN106492169 A CN 106492169A
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王万奎
王克荣
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9064—Amomum, e.g. round cardamom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
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Abstract

本发明公开一种治疗婴幼儿阴黄症的药物组合物，其特征是：包括如下药物：炒白术、茯苓、薏苡仁、砂仁、干姜、青蒿、甘草、滑石粉、山药。本发明的有益效果是此方清利湿热，疏肝利胆，对重症患者有特别好的疗效。

Description

一种治疗婴幼儿阴黄症的药物组合物
技术领域
本发明属于中药技术领域，涉及一种治疗婴幼儿阴黄症的药物组合物。
背景技术
近几年婴幼儿黄疸的发病率有升高趋势，这与现今的环境、饮食有，比如：孕妇吃过量的油腻，辛辣之品，凉物，再加各类食品添加剂，残留于食物的化肥，农药等因素。
黄疸中医学分为两种：
（一）阴黄：多为湿热蕴结肝胆而致，肝胆失其通降，外溢发黄，阴黄发病率多，易治。黄如橘子色，黄色鲜明易见，小儿易哭闹，善乳，小便黄，大便黄白，少数有腹胀，呕吐，口疮，指纹多青，舌偏红。
（二）阴黄：多为先天脾阴不足，湿热内困，脾失健运，导致胎黄不易发出，经久不退，阴黄发病率低，但不易治疗。其黄暗青，重则青黔，腹胀满，呕吐，便溏色白，手足冰凉，萎靡不振，精神怠倦，食少舌质淡，指纹淡伏，脉弱微。
目前治疗方法有光疗和药物疗。光疗是使用波长420～460mm的蓝光(冷光源)，可持续或间接照射24～48小时。光照疗法治疗新生儿黄疸使用方便，不良反应小，在临床中得到广泛应用。药物治疗有用锡中卟啉治疗，其代号为(SnMP)。它是目前美国食品和药物管理局(FDA)认可用于临床惟一的血红素类似物。血红素加氧酶(HO)是血红素代谢产生胆红素的限速酶，抑制血红素加氧酶(H0)活性可减少胆红素的生成，因此在新生儿肝脏对胆红素处理功能尚未成熟时，使用该药具有合理性。
临床上光疗有的效果不好，锡中卟啉类型单一，作用时间段有限。
发明内容
本发明目的是提供一种疗效好，副作用低的药物，用来治疗婴幼儿阴黄症。
本发明的技术方案是：一种治疗婴幼儿阴黄症的药物组合物，包括如下药物：炒白术、茯苓、薏苡仁、砂仁、干姜、青蒿、甘草、滑石粉、山药。
具体的，各药物重量份配比为炒白术6-10份、茯苓6-8份、薏苡仁5-10份、砂仁1-3份、干姜1-2份、青蒿2-10份、甘草1-4份、滑石粉3-6份、山药3-6份。
进一步的，各药物重量份配比为炒白术8份、茯苓7份、薏苡仁7份、砂仁2份、干姜1份、青蒿6份、甘草2份、滑石粉5份、山药4份。
其中，炒白术：苦，甘，温；归脾、胃经。功能：补气健脾，燥湿利水。
茯苓：甘，淡，平；归心、脾、肾经。功能：利水渗湿，健脾。
薏苡仁：甘，淡，微寒；归脾、胃、肺经。功能：利水渗湿，健脾。
砂仁：辛，温；归脾胃经。功能：化湿行气，温中止泻。
干姜：辛，热，归脾胃，心肺经。功能：温中，回阳。
青蒿：辛，苦，温；归肝、胆经。功能：清热利湿，退黄。
甘草：甘，平；归心、肺、脾、胃经。补脾益气，清热解毒，调和诸药。
山药：甘，平；归脾、胃、肾经。益气养阴，补益肝肾。
滑石粉：甘，淡，寒，归胃、膀胱经。功能：清热利湿。
药理分析：炒白术健脾升阳。茯苓、薏苡仁、砂仁芳香化湿，理气健脾。干姜温中散寒。青蒿清利湿热，利胆退黄。甘草清热解毒，调和诸药。山药，补肝肾。石粉，清热利湿。诸药配伍，补气健脾，利胆退黄。
本发明的有益效果是：此方清利湿热，疏肝利胆，对重症患者有特别好的疗效。
具体实施方式
以下结合实施例对本发明加以说明
实施例1
一种治疗婴幼儿阴黄症的药物组合物，包括如下药物：各药物重量份配比为炒白术6-10份、茯苓6-8份、薏苡仁5-10份、砂仁1-3份、干姜1-2份、青蒿2-10份、甘草1-4份、滑石粉3-6份、山药3-6份；青蒿与红糖伴炒，其它为市售干药。各组分根据病人具体病情在上述范围内微调。可煎服，或煎煮、过滤药液加其它辅料制成丸剂、冲剂。
根据治疗病例统计，以黄色褪去、精神好不哭闹作为显效的观察标准，服用本方剂的总有效率为90%。
实施例2
张某，出生45天后黄还没退。来诊。其母述：小儿生下后发黄，在医院烤（光疗）了4天后不见效出院，期间又到别的医院前后又烤了三次，脸面上基本看不来黄，但在阳光下看还是微微发黄，黄疸指数也不正常。来诊前的几天，小儿哭闹、惊风、精神怠倦。初诊：该儿面黄暗青，腹胀满，呕吐，手足冰凉，萎靡不振，指纹淡伏，脉弱微。此为典型的阴黄。给药；以重量份计，炒白术6份、茯苓6份、薏苡仁5份、砂仁1份、干姜1份、青蒿2份、甘草1份、滑石粉3份、山药3份。煎药，药液分多次喂服。阴黄是重病，服药四五天后，病情得以遏制，继续用药，15剂才治愈。
实施例3
重症病例。允某，男。2005年收治，患儿病情危重。家人自述；初生三天见胎黄，本地（大靖镇）治疗无效，转至武威地区医院治疗20天左右，黄不退病情加重，医院告知病危，通知家属再转它院治疗。家人见小儿病情严重，就放弃转院，带小儿回家。带着试试看的念想，来我处看看。诊断：小儿30天，面色青暗，无神，目不睁，点穴不哭，呼吸微弱，允乳而无力，吐乳，腹胀，大便不畅，色白而少，小便少而赤，舌淡，指纹青暗，脉微难寻，乃是一系列危重之象。我并无十足把握，人命关天，劝其家人另求他医，但其家属别无他处寻医，承诺医生尽力治疗即可（家人也是万般无奈，就抱着死马当活马医的想法了）。冲着医生治病救人的天职，于是自拟方药：以重量份计，炒白术6-10份、茯苓6-8份、薏苡仁5-10份、砂仁1-3份、干姜1-2份、青蒿2-10份、甘草1-4份、滑石粉3-6份、山药3-6份。给一剂水煎煮得药液约100ml，少量多次服两天。服完一剂后，又来诊疗，吾见病有好转之象，大便通利了，一日三次，吃奶有所增加，小儿看似少有烦躁现象。于是又给以了一剂，对家属说再试试看，服用方法同上。两日后，又来诊，小儿面色由青转黄，微暗，已有神色，时而哭啼，吃乳大增，原方继续加减治疗两月多，治愈，至今10岁多，再没复发，体质中等。

Claims (3)

1.一种治疗婴幼儿阴黄症的药物组合物，其特征是：包括如下药物：炒白术、茯苓、薏苡仁、砂仁、干姜、青蒿、甘草、滑石粉、山药。
2.根据权利要求1所述的治疗婴幼儿阴黄症的药物组合物，其特征是：各药物重量份配比为炒白术6-10份、茯苓6-8份、薏苡仁5-10份、砂仁1-3份、干姜1-2份、青蒿2-10份、甘草1-4份、滑石粉3-6份、山药3-6份。
3.根据权利要求2所述的治疗婴幼儿阴黄症的药物组合物，其特征是：各药物重量份配比为炒白术8份、茯苓7份、薏苡仁7份、砂仁2份、干姜1份、青蒿6份、甘草2份、滑石粉5份、山药4份。
CN201611082526.4A 2016-11-30 2016-11-30 一种治疗婴幼儿阴黄症的药物组合物 Withdrawn CN106492169A (zh)

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Application publication date: 20170315