CN106491901A - A kind of heat-clearing and toxic substances removing Passifolra edulis buccal tablet - Google Patents

A kind of heat-clearing and toxic substances removing Passifolra edulis buccal tablet Download PDF

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CN106491901A
CN106491901A CN201610869656.6A CN201610869656A CN106491901A CN 106491901 A CN106491901 A CN 106491901A CN 201610869656 A CN201610869656 A CN 201610869656A CN 106491901 A CN106491901 A CN 106491901A
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parts
extraction
buccal tablet
clearing
toxic substances
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许超群
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    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
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Abstract

The invention discloses a kind of heat-clearing and toxic substances removing Passifolra edulis buccal tablet, in units of weight portion, including following raw material：500 1500 parts of starch, 200 600 parts of Gypsum Fibrosum, 100 300 parts of crystal sugar, 100 300 parts of Mel, 100 300 parts of magnesium stearate, 10 30 parts of ginkgetin, 1,000 3000 parts of Passion Fruit Juice, 100 200 parts of Chinese medicine preparation, per part of the Chinese medicine preparation include following raw material：20 40 parts of Flos Lonicerae, 20 40 parts of Flos Chrysanthemi Indici, 20 40 parts of Folium Sennae, 10 20 parts of Semen Persicae, 10 20 parts of Radix Puerariae, 10 20 parts of Radix Scutellariae, 10 20 parts of Rhizoma Dioscoreae Nipponicae.The present invention combines plurality of Chinese effect, can play the effect such as heat-clearing and toxic substances removing, lipid-loweringing, blood pressure lowering, beauty skin moistening, and buccal tablet removing toxic substances is evident in efficacy, and safety and stability, without any side effects；The buccal tablet low production cost of the present invention, is conducive to popularization and application.

Description

A kind of heat-clearing and toxic substances removing Passifolra edulis buccal tablet
【Technical field】
The invention belongs to drug preparation technique field, and in particular to a kind of heat-clearing and toxic substances removing Passifolra edulis buccal tablet.
【Background technology】
Passifolra edulis, also known as Herba Passiflorae Caeruleae, brazilnut, are the common names of the perennial bejuco fruit of Passifloraceae, because of its fruit Juice can give out the strong fragrance of the various fruits such as Fructus Ananadis comosi, Fructus Musae, Fructus Mangifera Indicae, Punica granatum L., Fructus Citri Limoniae, therefore Passifolra edulis of gaining the name.According to open text Offer report, several amino acids of the Passifolra edulis rich in needed by human body, vitamin, carotenoid and trace element.Its nutritive value And it is early known to the beneficial effect of health.Passifolra edulis are in food, not only direct-edible, and are also For making the raw material of numerous food.
Ginkgoaceae plant Ginkgo biloba is the endemic tree of China, also known as maidenhair tree, and the age of tree, up to more than thousand, is to fold in ancient times two Discipline Relict Plant, the title of " living fossil " that have in plant kingdom is most ancient Relict Plant in existing seed plant.Modern science Show, the chemical composition of Folium Ginkgo is sufficiently complex, wherein in Folium Ginkgo containing flavonoid, terpenoid, phenols, healthy trace elements with household and The effective ingredient such as several amino acids.Ginkgo Biloba Extract contains substantial amounts of ginkgetin, and ginkgetin is highly resistant to and prevents The infringement that the electromagnetic radiations such as computer, mobile phone are caused to human body, particularly substantially, also has to the protective effect of brain cell soft Change blood vessel, remove rubbish in blood, three fat of drop, remove the effect such as free radical.In active substance, the content of flavone decides Semen Ginkgo The medical value of leaf, it is desirable to obtain more flavone, it is critical only that the extracting method of Folium Ginkgo；In traditional extraction process, molten Agent is easily accessible cell under conditions of heating, but solable matter is higher in the condition dissolubility of heat, is successively dissolved and goes out Existing very high permeability, causes that extraction ratio is low, active component is low, and technique is loaded down with trivial details, long the production cycle.
Modern civilization give people class bring unprecedented convenient, while also bringing air pollution, noise pollution, chemistry Medicament, electromagnetic radiation；With the raising of living standards of the people, the nutrition in food is chronically at superfluous state, adds quantity of motion Few, therefore accumulate a lot of high energy capacity materials in human body, these electrodeposition substances make narrowed blood vessels in blood vessel wall, cause height The disease such as blood pressure and arteriosclerosis, and increasingly increasing with pollutions such as various food additive, pesticide and atmospheric pollution, food In increasing noxious substance accumulate in human body and can not discharge, day and night accumulation forms stool, and stool is human body intestinal canal row The root of poison, can be immersed body again by re-absorbed toxin, reduce body immunity.External malicious and interior raw poison is resided in In vivo, mechanism of qi can be blocked, hinders the normal operation of QI and blood, gas consumption impairment of body fluid to destroy phase between the normal function and internal organs of internal organs The relation of the coordinating and unifying is mutually grown, restricted, yin and yang imbalance is finally made and disease is occurred, accelerate human senility.Savings is a large amount of in vivo Toxin rubbish usually externalize dark and gloomy skin, prurituss, easily long chloasma, acne, acne rosacea etc.；Except affecting appearance, also lure Send out obesity, halitosis, constipation, chronic gastritiss, gastric ulcer etc., the health of the serious harm mankind.
At present, also there are a lot of toxin expelling products on market, but be all only to arrange not mend or only mend not arranging, do not reach preferably effect Really.
【Content of the invention】
The present invention provides a kind of heat-clearing and toxic substances removing Passifolra edulis buccal tablet, with solve to prepare in prior art ginkgetin extraction ratio and Active component is low, and technique is loaded down with trivial details, long the production cycle；The problems such as existing product effect of ejecting poison is undesirable.The present invention combines multiple Herbal function, can play the effect such as heat-clearing and toxic substances removing, lipid-loweringing, blood pressure lowering, beauty skin moistening, and the buccal tablet removing toxic substances is evident in efficacy, and pacifies Entirely stable, without any side effects；The buccal tablet low production cost of the present invention, is conducive to popularization and application.
For solving above technical problem, the present invention is employed the following technical solutions：
A kind of heat-clearing and toxic substances removing Passifolra edulis buccal tablet, in units of weight portion, including following raw material：Starch 500-1500 parts, stone Cream 200-600 parts, crystal sugar 100-300 parts, Mel 100-300 parts, magnesium stearate 100-300 part, ginkgetin 10-30 parts, hundred Oleum Linderae juice 1000-3000 parts, Chinese medicine preparation 100-200 parts, per part of the Chinese medicine preparation include following raw material：Flos Lonicerae 20-40 Part, Flos Chrysanthemi Indici 20-40 parts, Folium Sennae 20-40 parts, Semen Persicae 10-20 parts, Radix Puerariae 10-20 parts, Radix Scutellariae 10-20 parts, Rhizoma Dioscoreae Nipponicae 10- 20 parts.
The preparation method of the heat-clearing and toxic substances removing Passifolra edulis buccal tablet, comprises the following steps：
S1, the preparation of Chinese medicine preparation：Comprise the following steps：
S11：Flos Lonicerae, Flos Chrysanthemi Indici, Folium Sennae, Semen Persicae, Radix Puerariae, Radix Scutellariae, Rhizoma Dioscoreae Nipponicae are extracted in ultrasonic assistant ethanol FAXIA extracts medicinal liquid, and the condition of extraction is：Solid-liquid ratio is 1:8-18, ultrasonic power are 100-180W, and concentration of alcohol is 45%- 80%, Extracting temperature is 40-75 DEG C, and extraction time is 30-80min；
S12：Step S11 is extracted medical filtration, is condensed into paste；
S13：The paste of step S12 is dried, crushes, sieves, sterilized, the Chinese medicine preparation is obtained；
S2, the preparation of Passion Fruit Juice：Passifolra edulis are squeezed the juice filtration after cleaning, and filtrate is standby；
S3, the preparation of ginkgetin：Comprise the following steps：
S31：Dry Folium Ginkgo is crushed and is crossed 40-80 mesh sieve, Ginkgo Leaf is obtained；
S32：Ginkgo Leaf obtained in step S31 is extracted using 38-62 DEG C of water, in extraction, solid-to-liquid ratio is 1: 12-14 (W/V), extraction time is 2.5-3.5h, extracts 2-3 time, filtration, merging filtrate after extraction, and mixing lixiviating solution is obtained；
S33：Lixiviating solution concentrate drying will be mixed obtained in step S32, extraction cream will be obtained, be adopted and 5.5-6 times of cream of extraction The water of 45-55 DEG C of volume is dissolved, and carries out extraction 2-3 time using anhydrous ethyl acetate solvent, continues to use anhydrous acetic acid second Ester carries out multiple crystallization treatment, and in crystallization process, solid-to-liquid ratio is 1:5.2-5.4 (W/V), is obtained crystal crude product；
S34：By crystal crude product obtained in step S33 through supercritical CO2Extraction, the condition of extraction：Extraction kettle pressure is 12-18MPa, extraction temperature are 42-45 DEG C, and extraction time is 32-40min, and ginkgetin is obtained；
S4, buccal tablet crude product are produced：By starch, Gypsum Fibrosum, crystal sugar, Mel, magnesium stearate, ginkgetin, Chinese medicine preparation mixing, Adding Passion Fruit Juice and lamellar being made after stirring, buccal tablet crude product is obtained；
S5, drying, sterilizing：Obtained in step S4 buccal tablet crude product dry, sterilizing after, be obtained heat-clearing and toxic substances removing Passifolra edulis contain Piece.
Further, it is 1.1-1.4 to extract concentration of liquid medicine in step S12 into paste to relative density.
Further, in step S13, the condition of drying is：Dry to water content≤7% at 95-105 DEG C.
Further, the condition that sieves in step S13 is：Cross the sieve of 200-400 mesh.
Further, in step S13, the condition of sterilizing is：Temperature is 134-136 DEG C, and pressure is 210-230KPa, the time For 1-3min.
Further, the temperature that dries in step S5 is 90-100 DEG C, dries to water content≤6%.
Further, the pressure for sterilizing in step S5 is 210-230KPa, and the temperature of sterilizing is 134-136 DEG C, sterilizing Time is 3-5min.
Pharmacological action of the present invention is as follows：
Flos Lonicerae, also known as Radix Ophiopogoniss (scientific name：Lonicera japonica)." Flos Lonicerae " one is come from《Compendium of Materia Medica》, by In opening at the beginning of Flos Lonicerae as white, after switch to yellow, hence obtain one's name Flos Lonicerae.Medical material Flos Lonicerae is Caprifoliaceae woodbine Radix Ophiopogoniss And the flower that congener dry flower or band are just opened.Flos Lonicerae is cold in nature, sweet in the mouth, enters lung, the heart, stomach, with heat-clearing and toxic substances removing, resists Scorching, qi-restoratives treats effect of wind, cures mainly the diseases such as disease under distension, warm disease heating, heat toxin large carbuncle and tumor.Modern study proves, gold silver Flower contains the pharmacological components such as chlorogenic acid, cyanidenon glycosides, to various pathogens such as Hemolytic streptococcuss, staphylococcus aureus And upper respiratory tract infection Causative viruss etc. have stronger restraint, in addition can also enhancing immunity, antiearly pregnancy, hepatoprotective, antitumor, Antiinflammatory, antipyretic, hemostasis (blood coagulation), suppression intestinal absorption cholesterol etc., its clinical application is widely.
Flos Chrysanthemi Indici, is the head inflorescence of feverfew Herba Dendranthematis indici, and main component is yejuhua lactone, chrysanthemol, flavonoid glycoside Deng, cold nature, tool dispelling wind and heat pathogens, subduing swelling and detoxicating, infection, effect of antiviral.The traditional Chinese medical science thinks that Flos Chrysanthemi Indici is cool in nature, has dispelling wind The effects such as heat clearing away, removing toxic substances and promoting subsidence of swelling, brain nourishing and eyesight improving, coronary heart disease, hypertension, anemopyretic cold, pneumonia, rhinitis, a gas can be treated The diseases such as Guan Yan, laryngopharynx swelling and pain, conjunctival congestion are fuzzy, lymphadenitises, carbuncle furuncle furunculosis, eczema, skin pruritus, aphtha, erysipelas.
Folium Sennae, property are sweet, bitter, tremble with fear, return large intestine channel, rush down lower intestinal stasis relieving：Constipation with heat retention is cured mainly, habitual constipation, additionally, this product And can water-filling harness the river swollen abdominal distention.
Semen Persicae, property bitter, sweet, flat.GUIXIN, liver, large intestine channel, energy blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, relieving cough and asthma.For amenorrhea, Dysmenorrhea, abdominal mass mass in the abdomen, injury from falling down, dry constipation of intestines.
Radix Puerariae, is the tuber of liana Herba Gelsemii Elegantis, and by the long bristle of sparse brown, Radix Puerariae hyoscine, Radix Puerariae extract class to stem Flavonoid substance combines to form a kind of novel substance with Folium Mori extract deoxynojirimycin and washes clear sugar element (cics) of pancreas, with drop Blood glucose, blood fat, antiinflammatory etc. are acted on.Radix Puerariae have induce sweat bring down a fever, the function of promoting the production of body fluid to quench thirst, antidiarrheal, and hypertensive diabetes can be improved The symptoms such as the stiffness of the nape of patient, dizziness, headache.Effective ingredient is daizeol, yellow glycoside and puerarin etc..
Radix Scutellariae, another name Radix Scutellariae, tsuchikane tea root.For labiate Radix Scutellariae (Scutellariabaicalensis Georgi), it is used as medicine with root.There is heat clearing and damp drying, removing heat from blood is antiabortive, detoxicating functions.Cure mainly epidemic febrile disease, upper respiratory tract infection, lung-heat to cough Cough, the disease such as neonatal jaundice caused by dampness-heat, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle swells furuncle sore.
Rhizoma Dioscoreae Nipponicae, is the rhizome of Dioscoreaceae plant Dioscorea nipponica Mak. Ningpo Yam Rhizome and bavin Dioscorea zingiberensis, and mild-natured, bitter in the mouth, with promoting blood circulation to remove obstruction in the collateral, wind-dispelling Dehumidifying, the effect of invigorating the stomach and promoting digestion, to dyspepsia, suffer from diarrhoea, hiccup, nausea and vomiting, and flatulence has good promoting digestion and removing stagnation effect.
Ginkgetin is extracted from the leaf of " living fossil " ginkgo, is highly resistant to and prevents computer, mobile phone etc. The infringement that electromagnetic radiation is caused to human body, particularly substantially, also has vessel softening, removing to the protective effect of brain cell The effect such as rubbish, three fat of drop, removing free radical in blood.
Passifolra edulis have anti-inflammatory analgetic, promoting blood circulation are kept fit, blood fat-reducing blood pressure-decreasing, enriching yin and nourishing kidney, relieving alcoholic intoxication of refreshing oneself, allaying tiredness, skin protection The effects such as skin care, the symptoms such as comedo, hemorrhoid, gastroenteritis can be treated.
The invention has the advantages that：
(1) present invention combines Flos Lonicerae, Flos Chrysanthemi Indici, Folium Sennae, Semen Persicae, Radix Puerariae, Radix Scutellariae, Rhizoma Dioscoreae Nipponicae plurality of Chinese work( Effect, can play the effect such as heat-clearing and toxic substances removing, lipid-loweringing, blood pressure lowering, beauty skin moistening, and the buccal tablet removing toxic substances is evident in efficacy, and safety and stability, Without any side effects；
(2) buccal tablet of the invention is sterilized at high temperature under high pressure, and the time is short, effect is good, the holding time is long；
(3) buccal tablet low production cost of the invention, is conducive to popularization and application；
(4) present invention extracts ginkgetin rate and active component is high, and process is simple is with short production cycle.
【Specific embodiment】
For ease of more fully understanding the present invention, it is illustrated by following instance, these embodiments belong to the guarantor of the present invention Shield scope, but do not limit the scope of the invention.
In an embodiment, heat-clearing and toxic substances removing Passifolra edulis buccal tablet, in units of weight portion, including following raw material：Starch 500- 1500 parts, Gypsum Fibrosum 200-600 parts, crystal sugar 100-300 parts, Mel 100-300 parts, magnesium stearate 100-300 part, ginkgetin 10-30 parts, Passion Fruit Juice 1000-3000 parts, Chinese medicine preparation 100-200 parts, per part of the Chinese medicine preparation include following raw material：Gold Flos Lonicerae 20-40 parts, Flos Chrysanthemi Indici 20-40 parts, Folium Sennae 20-40 parts, Semen Persicae 10-20 parts, Radix Puerariae 10-20 parts, Radix Scutellariae 10-20 parts, Rhizoma Dioscoreae Nipponicae 10-20 parts.
The preparation method of the heat-clearing and toxic substances removing Passifolra edulis buccal tablet, comprises the following steps：
S1, the preparation of Chinese medicine preparation：Comprise the following steps：
S11：Flos Lonicerae, Flos Chrysanthemi Indici, Folium Sennae, Semen Persicae, Radix Puerariae, Radix Scutellariae, Rhizoma Dioscoreae Nipponicae are extracted in ultrasonic assistant ethanol FAXIA extracts medicinal liquid, and the condition of extraction is：Solid-liquid ratio is 1:8-18, ultrasonic power are 100-180W, and concentration of alcohol is 45%- 80%, Extracting temperature is 40-75 DEG C, and extraction time is 30-80min；
S12：It is 1.1-1.4 to extract medical filtration, be condensed into paste to relative density step S11；
S13：It is≤7% that the paste of step S12 is dried to water content at 95-105 DEG C, crosses 200-400 after crushing Purpose sieve, is finally 134-136 DEG C the powder of the gained that sieves in temperature, and pressure is 210-230KPa, and the time is 1- Sterilize under 3min, Chinese medicine preparation is obtained；
S2, the preparation of Passion Fruit Juice：Passifolra edulis are squeezed the juice filtration after cleaning, and filtrate is standby；
S3, the preparation of ginkgetin：Comprise the following steps：
S31：Dry Folium Ginkgo is crushed and is crossed 40-80 mesh sieve, Ginkgo Leaf is obtained；
S32：Ginkgo Leaf obtained in step S31 is extracted using 38-62 DEG C of water, in extraction, solid-to-liquid ratio is 1: 12-14 (W/V), extraction time is 2.5-3.5h, extracts 2-3 time, filtration, merging filtrate after extraction, and mixing lixiviating solution is obtained；
S33：Lixiviating solution concentrate drying will be mixed obtained in step S32, extraction cream will be obtained, be adopted and 5.5-6 times of cream of extraction The water of 45-55 DEG C of volume is dissolved, and carries out extraction 2-3 time using anhydrous ethyl acetate solvent, continues to use anhydrous acetic acid second Ester carries out multiple crystallization treatment, and in crystallization process, solid-to-liquid ratio is 1:5.2-5.4 (W/V), is obtained crystal crude product；
S34：By crystal crude product obtained in step S33 through supercritical CO2Extraction, the condition of extraction：Extraction kettle pressure is 12-18MPa, extraction temperature are 42-45 DEG C, and extraction time is 32-40min, and ginkgetin is obtained；
S4, buccal tablet crude product are produced：By starch, Gypsum Fibrosum, crystal sugar, Mel, magnesium stearate, ginkgetin, Chinese medicine preparation mixing, Adding Passion Fruit Juice and lamellar being made after stirring, buccal tablet crude product is obtained；
S5, drying, sterilizing：Buccal tablet crude product crude product obtained in step S4 is dried to water content in the case where temperature is for 90-100 DEG C ≤ 6%, it is 210-230KPa in pressure, temperature is 134-136 DEG C, and the time is under 3-5min after sterilizing, and heat-clearing and toxic substances removing hundred is obtained Oleum Linderae buccal tablet.
Embodiment 1
A kind of heat-clearing and toxic substances removing Passifolra edulis buccal tablet, in units of weight portion, including following raw material：1000 parts of starch, Gypsum Fibrosum 400 Part, 200 parts of crystal sugar, 200 parts of Mel, 200 parts of magnesium stearate, 20 parts of ginkgetin, 2000 parts of Passion Fruit Juice, Chinese medicine preparation 160 Part, per part of the Chinese medicine preparation includes following raw material：35 parts of Flos Lonicerae, 35 parts of Flos Chrysanthemi Indici, 30 parts of Folium Sennae, 15 parts of Semen Persicae, Pueraria lobota 15 parts of root, 15 parts of Radix Scutellariae, 15 parts of Rhizoma Dioscoreae Nipponicae.
The preparation method of the heat-clearing and toxic substances removing Passifolra edulis buccal tablet, comprises the following steps：
S1, the preparation of Chinese medicine preparation：Comprise the following steps：
S11：Flos Lonicerae, Flos Chrysanthemi Indici, Folium Sennae, Semen Persicae, Radix Puerariae, Radix Scutellariae, Rhizoma Dioscoreae Nipponicae are extracted in ultrasonic assistant ethanol FAXIA extracts medicinal liquid, and the condition of extraction is：Solid-liquid ratio is 1:12, ultrasonic power is 150W, and concentration of alcohol is 70%, extracts temperature Spend for 60 DEG C, extraction time is 60min；
S12：It is 1.2 to extract medical filtration, be condensed into paste to relative density step S11；
S13：It is 6% that the paste of step S12 is dried to water content at 100 DEG C, crosses the sieve of 300 mesh after crushing Son, is finally 135 DEG C the powder of the gained that sieves in temperature, and pressure is 220KPa, and the time is to sterilize under 2min, and Chinese medicine is obtained Preparation；
S2, the preparation of Passion Fruit Juice：Passifolra edulis are squeezed the juice filtration after cleaning, and filtrate is standby；
S3, the preparation of ginkgetin：Comprise the following steps：
S31：Dry Folium Ginkgo is crushed and is crossed 60 mesh sieve, Ginkgo Leaf is obtained；
S32：Ginkgo Leaf obtained in step S31 is extracted using 50 DEG C of water, in extraction, solid-to-liquid ratio is 1:13 (W/V), extraction time is 3h, extracts 3 times, filtration, merging filtrate after extraction, and mixing lixiviating solution is obtained；
S33：Lixiviating solution concentrate drying will be mixed obtained in step S32, extraction cream will be obtained, be adopted and extraction 5.8 times of bodies of cream The water of long-pending 50 DEG C is dissolved, and carries out extracting 3 times using anhydrous ethyl acetate solvent, and continuation anhydrous ethyl acetate carries out many Secondary crystallization treatment, in crystallization process, solid-to-liquid ratio is 1:5.3 (W/V), are obtained crystal crude product；
S34：By crystal crude product obtained in step S33 through supercritical CO2Extraction, the condition of extraction：Extraction kettle pressure is 15MPa, extraction temperature are 43 DEG C, and extraction time is 36min, and ginkgetin is obtained；
S4, buccal tablet crude product are produced：By starch, Gypsum Fibrosum, crystal sugar, Mel, magnesium stearate, ginkgetin, Chinese medicine preparation mixing, Adding Passion Fruit Juice and lamellar being made after stirring, buccal tablet crude product is obtained；
S5, drying, sterilizing：Buccal tablet crude product crude product obtained in step S4 is dried to water content in the case where temperature is for 95 DEG C and is 5%, it is 220KPa in pressure, temperature is 135 DEG C, and the time is under 4min after sterilizing, and heat-clearing and toxic substances removing Passifolra edulis buccal tablet is obtained.
Embodiment 2
A kind of heat-clearing and toxic substances removing Passifolra edulis buccal tablet, in units of weight portion, including following raw material：500 parts of starch, Gypsum Fibrosum 200 Part, 100 parts of crystal sugar, 100 parts of Mel, 100 parts of magnesium stearate, 10 parts of ginkgetin, 1000 parts of Passion Fruit Juice, Chinese medicine preparation 100 Part, per part of the Chinese medicine preparation includes following raw material：20 parts of Flos Lonicerae, 20 parts of Flos Chrysanthemi Indici, 20 parts of Folium Sennae, 10 parts of Semen Persicae, Pueraria lobota 10 parts of root, Radix Scutellariae 10- parts, 10 parts of Rhizoma Dioscoreae Nipponicae.
The preparation method of the heat-clearing and toxic substances removing Passifolra edulis buccal tablet, comprises the following steps：
S1, the preparation of Chinese medicine preparation：Comprise the following steps：
S11：Flos Lonicerae, Flos Chrysanthemi Indici, Folium Sennae, Semen Persicae, Radix Puerariae, Radix Scutellariae, Rhizoma Dioscoreae Nipponicae are extracted in ultrasonic assistant ethanol FAXIA extracts medicinal liquid, and the condition of extraction is：Solid-liquid ratio is 1:8, ultrasonic power is 100W, and concentration of alcohol is 45%, extracts temperature Spend for 40 DEG C, extraction time is 80min；
S12：It is 1.1 to extract medical filtration, be condensed into paste to relative density step S11；
S13：It is 7% that the paste of step S12 is dried to water content at 95 DEG C, crosses the sieve of 200 mesh, most after crushing It is 134 DEG C the powder of the gained that sieves in temperature afterwards, pressure is 210KPa, and the time is to sterilize under 3min, and Chinese medicine preparation is obtained；
S2, the preparation of Passion Fruit Juice：Passifolra edulis are squeezed the juice filtration after cleaning, and filtrate is standby；
S3, the preparation of ginkgetin：Comprise the following steps：
S31：Dry Folium Ginkgo is crushed and is crossed 40 mesh sieve, Ginkgo Leaf is obtained；
S32：Ginkgo Leaf obtained in step S31 is extracted using 38 DEG C of water, in extraction, solid-to-liquid ratio is 1:12 (W/V), extraction time is 2.5h, extracts 3 times, filtration, merging filtrate after extraction, and mixing lixiviating solution is obtained；
S33：Lixiviating solution concentrate drying will be mixed obtained in step S32, extraction cream will be obtained, be adopted and extraction 5.5 times of bodies of cream The water of long-pending 45 DEG C is dissolved, and carries out extracting 3 times using anhydrous ethyl acetate solvent, and continuation anhydrous ethyl acetate carries out many Secondary crystallization treatment, in crystallization process, solid-to-liquid ratio is 1:5.2 (W/V), are obtained crystal crude product；
S34：By crystal crude product obtained in step S33 through supercritical CO2Extraction, the condition of extraction：Extraction kettle pressure is 12MPa, extraction temperature are 42 DEG C, and extraction time is 32min, and ginkgetin is obtained；
S4, buccal tablet crude product are produced：By starch, Gypsum Fibrosum, crystal sugar, Mel, magnesium stearate, ginkgetin, Chinese medicine preparation mixing, Adding Passion Fruit Juice and lamellar being made after stirring, buccal tablet crude product is obtained；
S5, drying, sterilizing：Buccal tablet crude product crude product obtained in step S4 is dried to water content in the case where temperature is for 90 DEG C and is 6%, it is 210KPa in pressure, temperature is 134 DEG C, and the time is under 5min after sterilizing, and heat-clearing and toxic substances removing Passifolra edulis buccal tablet is obtained.
Embodiment 3
A kind of heat-clearing and toxic substances removing Passifolra edulis buccal tablet, in units of weight portion, including following raw material：1500 parts of starch, Gypsum Fibrosum 600 Part, 300 parts of crystal sugar, 300 parts of Mel, 300 parts of magnesium stearate, 30 parts of ginkgetin, 3000 parts of Passion Fruit Juice, Chinese medicine preparation 200 Part, per part of the Chinese medicine preparation includes following raw material：40 parts of Flos Lonicerae, 40 parts of Flos Chrysanthemi Indici, 40 parts of Folium Sennae, 20 parts of Semen Persicae, Pueraria lobota 20 parts of root, 20 parts of Radix Scutellariae, 20 parts of Rhizoma Dioscoreae Nipponicae.
The preparation method of the heat-clearing and toxic substances removing Passifolra edulis buccal tablet, comprises the following steps：
S1, the preparation of Chinese medicine preparation：Comprise the following steps：
S11：Flos Lonicerae, Flos Chrysanthemi Indici, Folium Sennae, Semen Persicae, Radix Puerariae, Radix Scutellariae, Rhizoma Dioscoreae Nipponicae are extracted in ultrasonic assistant ethanol FAXIA extracts medicinal liquid, and the condition of extraction is：Solid-liquid ratio is 1:18, ultrasonic power is 180W, and concentration of alcohol is 80%, extracts temperature Spend for 75 DEG C, extraction time is 30min；
S12：It is 1.4 to extract medical filtration, be condensed into paste to relative density step S11；
S13：It is 5% that the paste of step S12 is dried to water content at 105 DEG C, crosses the sieve of 400 mesh after crushing, It is finally 136 DEG C the powder of the gained that sieves in temperature, pressure is 230KPa, and the time is to sterilize under 1min, and Chinese medicine system is obtained Agent；
S2, the preparation of Passion Fruit Juice：Passifolra edulis are squeezed the juice filtration after cleaning, and filtrate is standby；
S3, the preparation of ginkgetin：Comprise the following steps：
S31：Dry Folium Ginkgo is crushed and is crossed 80 mesh sieve, Ginkgo Leaf is obtained；
S32：Ginkgo Leaf obtained in step S31 is extracted using 62 DEG C of water, in extraction, solid-to-liquid ratio is 1:14 (W/V), extraction time is 3.5h, extracts 2 times, filtration, merging filtrate after extraction, and mixing lixiviating solution is obtained；
S33：Lixiviating solution concentrate drying will be mixed obtained in step S32, extraction cream will be obtained, be adopted and extraction 6 times of volumes of cream 55 DEG C of water dissolved, carry out extracting 2 times using anhydrous ethyl acetate solvent, continuation is carried out repeatedly with anhydrous ethyl acetate Crystallization treatment, in crystallization process, solid-to-liquid ratio is 1:5.4 (W/V), are obtained crystal crude product；
S34：By crystal crude product obtained in step S33 through supercritical CO2Extraction, the condition of extraction：Extraction kettle pressure is 18MPa, extraction temperature are 45 DEG C, and extraction time is 32min, and ginkgetin is obtained；
S4, buccal tablet crude product are produced：By starch, Gypsum Fibrosum, crystal sugar, Mel, magnesium stearate, ginkgetin, Chinese medicine preparation mixing, Adding Passion Fruit Juice and lamellar being made after stirring, buccal tablet crude product is obtained；
S5, drying, sterilizing：Buccal tablet crude product crude product obtained in step S4 is dried to water content in the case where temperature is for 100 DEG C and is 6%, it is 230KPa in pressure, temperature is 136 DEG C, and the time is under 3min after sterilizing, and heat-clearing and toxic substances removing Passifolra edulis buccal tablet is obtained.
Above content it cannot be assumed that the present invention is embodied as being confined to these explanations, for the technical field of the invention Those of ordinary skill for, under the premise of without departing from present inventive concept, some simple deduction or replace can also be made, all answered When being considered as belonging to the scope of patent protection that determined by the claims that is submitted to of the present invention.

Claims (7)

1. a kind of heat-clearing and toxic substances removing Passifolra edulis buccal tablet, it is characterised in that in units of weight portion, including following raw material：Starch 500- 1500 parts, Gypsum Fibrosum 200-600 parts, crystal sugar 100-300 parts, Mel 100-300 parts, magnesium stearate 100-300 part, ginkgetin 10-30 parts, Passion Fruit Juice 1000-3000 parts, Chinese medicine preparation 100-200 parts, per part of the Chinese medicine preparation include following raw material：Gold Flos Lonicerae 20-40 parts, Flos Chrysanthemi Indici 20-40 parts, Folium Sennae 20-40 parts, Semen Persicae 10-20 parts, Radix Puerariae 10-20 parts, Radix Scutellariae 10-20 parts, Rhizoma Dioscoreae Nipponicae 10-20 parts.
The preparation method of the heat-clearing and toxic substances removing Passifolra edulis buccal tablet, comprises the following steps：
S1, the preparation of Chinese medicine preparation：Comprise the following steps：
S11：By Flos Lonicerae, Flos Chrysanthemi Indici, Folium Sennae, Semen Persicae, Radix Puerariae, Radix Scutellariae, Rhizoma Dioscoreae Nipponicae under ultrasonic assistant ethanol extraction method Medicinal liquid is extracted, the condition of extraction is：Solid-liquid ratio is 1:8-18, ultrasonic power are 100-180W, and concentration of alcohol is 45%- 80%, Extracting temperature is 40-75 DEG C, and extraction time is 30-80min；
S12：Step S11 is extracted medical filtration, is condensed into paste；
S13：The paste of step S12 is dried, crushes, sieves, sterilized, the Chinese medicine preparation is obtained；
S2, the preparation of Passion Fruit Juice：Passifolra edulis are squeezed the juice filtration after cleaning, and filtrate is standby；
S3, the preparation of ginkgetin：Comprise the following steps：
S31：Dry Folium Ginkgo is crushed and is crossed 40-80 mesh sieve, Ginkgo Leaf is obtained；
S32：Ginkgo Leaf obtained in step S31 is extracted using 38-62 DEG C of water, in extraction, solid-to-liquid ratio is 1:12- 14 (W/V), extraction time is 2.5-3.5h, extracts 2-3 time, filtration, merging filtrate after extraction, and mixing lixiviating solution is obtained；
S33：Lixiviating solution concentrate drying will be mixed obtained in step S32, extraction cream will be obtained, be adopted and extraction 5.5-6 times of volume of cream 45-55 DEG C of water dissolved, extraction 2-3 time is carried out using anhydrous ethyl acetate solvent, continuation is entered with anhydrous ethyl acetate The multiple crystallization treatment of row, in crystallization process, solid-to-liquid ratio is 1:5.2-5.4 (W/V), is obtained crystal crude product；
S34：By crystal crude product obtained in step S33 through supercritical CO2Extraction, the condition of extraction：Extraction kettle pressure is 12- 18MPa, extraction temperature are 42-45 DEG C, and extraction time is 32-40min, and ginkgetin is obtained；
S4, buccal tablet crude product are produced：By starch, Gypsum Fibrosum, crystal sugar, Mel, magnesium stearate, ginkgetin, Chinese medicine preparation mixing, add Passion Fruit Juice simultaneously makes lamellar after stirring, and buccal tablet crude product is obtained；
S5, drying, sterilizing：Buccal tablet crude product obtained in step S4 is dried, after sterilizing, heat-clearing and toxic substances removing Passifolra edulis buccal tablet is obtained.
2. heat-clearing and toxic substances removing Passifolra edulis buccal tablet according to claim 1, it is characterised in that extract concentration of liquid medicine in step S12 It is 1.1-1.4 into paste to relative density.
3. heat-clearing and toxic substances removing Passifolra edulis buccal tablet according to claim 1, it is characterised in that the condition that dries in step S13 is： Dry to water content≤7% at 95-105 DEG C.
4. heat-clearing and toxic substances removing Passifolra edulis buccal tablet according to claim 1, it is characterised in that the condition that sieves in step S13 is： Cross the sieve of 200-400 mesh.
5. heat-clearing and toxic substances removing Passifolra edulis buccal tablet according to claim 1, it is characterised in that the condition sterilized in step S13 is： Temperature is 134-136 DEG C, and pressure is 210-230KPa, and the time is 1-3min.
6. heat-clearing and toxic substances removing Passifolra edulis buccal tablet according to claim 1, it is characterised in that the temperature that dries in step S5 is 90-100 DEG C, dry to water content≤6%.
7. heat-clearing and toxic substances removing Passifolra edulis buccal tablet according to claim 1, it is characterised in that the pressure sterilized in step S5 is 210-230KPa, the temperature of sterilizing is 134-136 DEG C, and the time of sterilizing is 3-5min.
CN201610869656.6A 2016-09-29 2016-09-29 A kind of heat-clearing and toxic substances removing Passifolra edulis buccal tablet Pending CN106491901A (en)

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CN105031491A (en) * 2015-08-07 2015-11-11 石东秀 Tablet for curing malaria and preparation method for tablet
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CN104387356B (en) * 2013-11-15 2016-05-04 广西莱吉生物工程有限公司 In ginkgo leaf, extract the method for flavones
CN104886682A (en) * 2015-05-07 2015-09-09 陈玲华 Health-care passion fruit beverage and preparation method thereof
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Application publication date: 20170315