CN105031491A - Tablet for curing malaria and preparation method for tablet - Google Patents
Tablet for curing malaria and preparation method for tablet Download PDFInfo
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- CN105031491A CN105031491A CN201510483152.6A CN201510483152A CN105031491A CN 105031491 A CN105031491 A CN 105031491A CN 201510483152 A CN201510483152 A CN 201510483152A CN 105031491 A CN105031491 A CN 105031491A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 77
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Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a tablet for curing malaria and a preparation method for the tablet, and belongs to the technical field of Chinese drug preparation. The tablet is prepared from the following raw materials: starch, gypsum, cane sugar, honey, magnesium stearate and Chinese drugs preparation; the tablet is prepared by steps of crude product preparation, drying, sterilizing and the like. The tablet disclosed by the invention integrates the effects of various Chinese drugs, and can serve for the actions of resisting bacteria, eliminating inflammation, clearing away heat and toxic materials, reducing phlegm, resisting malaria, clearing heat and inducing dieresis and the like, and has a significant curative effect on the malaria and has a fast effect; the Chinese drugs preparation is convenient in preparation and use and safe and has no side effects; the tablet disclosed by the invention is sterilized under high temperature and high pressure; the sterilizing time is short, the sterilizing effect is good, and the storage time of the tablet is long; the preparation method for the tablet, disclosed by the invention, is simple in operation, low in production cost and in favor of being popularized and applied.
Description
[technical field]
The invention belongs to Chinese drug preparation technique field, be specifically related to a kind of tablet for the treatment of malaria and preparation method thereof.
[background technology]
Malaria is a kind of popular disease more widely with particularity, occasionally has generation in some areas.Record according to motherland's medical literature, be generally divided into the types such as pyrexial malaria, intermittent high fever, the malaria of YIN type, subtertian malaria, malaria with general debility.Because this sick pathogenesis is complicated, the Typical onset of primary disease has shiver with cold, high heat, perspiration three phases, and has interval rule of onset, generally has one and sends out, that interval is sent out, within 3rd, send out etc. is dissimilar.The traditional Chinese medical science thinks that this disease is the pathological changes of shaoyang channel in dialectical, usually the evil of few sun is evacuated to conciliate, once certain effect was had to the treatment of primary disease, but due to the special pathogenesis of primary disease, curative effect of medication existing used is poor, onset is slow, therefore, a kind of medicine being used for the treatment of malaria of necessary research and development.
[summary of the invention]
The invention provides a kind of tablet for the treatment of malaria and preparation method thereof, to solve the problems such as treatment malaria weak curative effect, onset be slow, the present invention combines plurality of Chinese effect, anti-inflammation, heat-clearing and toxic substances removing can be played, the effect such as malaria, clearing away heat and promoting diuresis of reducing phlegm,, instant effect evident in efficacy to treatment malaria, Chinese medicine preparation make, easy to use, safely, have no side effect.
For solving above technical problem, the present invention by the following technical solutions:
A kind of tablet for the treatment of malaria, in units of weight portion, comprise following raw material: starch 400-2000 part, Gypsum Fibrosum 100-900 part, sucrose 100-500 part, Mel 100-500 part, magnesium stearate 100-500 part, Chinese medicine preparation 100-600 part, described Chinese medicine preparation comprises following raw material: Radix Scutellariae 8-48 part, Rhizoma Pinelliae 8-48 part, Cortex Magnoliae Officinalis 8-48 part, Radix Puerariae 8-48 part, Rhizoma Et Radix Notopterygii 8-48 part, Herba Artemisiae Annuae 6-36 part, Semen Plantaginis 6-36 part, Radix Dichroae 6-36 part, Fructus Tsaoko 6-36 part, Fructus Xanthii 6-36 part, Radix Aconiti Kusnezoffii Preparata 4-24 part, Herba Ranunculi Japonici 4-24 part, Resina Ferulae 4-24 part, Semen Phaseoli 4-24 part, Radix Polygoni Multiflori 4-24 part, Radix Bupleuri 2-12 part, Herba Lobeliae Chinensis 2-12 part, Herba Verbenae 2-12 part, Herba Siegesbeckiae 2-12 part, Herba Lysimachiae 2-12 part.
Preferably, the tablet of described treatment malaria, in units of weight portion, comprise following raw material: starch 600-1800 part, Gypsum Fibrosum 200-800 part, sucrose 150-450 part, Mel 150-450 part, magnesium stearate 150-450 part, Chinese medicine preparation 200-500 part, described Chinese medicine preparation comprises following raw material: Radix Scutellariae 16-40 part, Rhizoma Pinelliae 16-40 part, Cortex Magnoliae Officinalis 16-40 part, Radix Puerariae 16-40 part, Rhizoma Et Radix Notopterygii 16-40 part, Herba Artemisiae Annuae 12-30 part, Semen Plantaginis 12-30 part, Radix Dichroae 12-30 part, Fructus Tsaoko 12-30 part, Fructus Xanthii 12-30 part, Radix Aconiti Kusnezoffii Preparata 8-20 part, Herba Ranunculi Japonici 8-20 part, Resina Ferulae 8-20 part, Semen Phaseoli 8-20 part, Radix Polygoni Multiflori 8-20 part, Radix Bupleuri 4-10 part, Herba Lobeliae Chinensis 4-10 part, Herba Verbenae 4-10 part, Herba Siegesbeckiae 4-10 part, Herba Lysimachiae 4-10 part.
Preferably, the tablet of described treatment malaria, in units of weight portion, comprise following raw material: starch 1200 parts, 500 parts, Gypsum Fibrosum, sucrose 300 parts, Mel 300 parts, magnesium stearate 300 parts, Chinese medicine preparation 350 parts, described Chinese medicine preparation comprises following raw material: Radix Scutellariae 28 parts, the Rhizoma Pinelliae 28 parts, Cortex Magnoliae Officinalis 28 parts, Radix Puerariae 28 parts, Rhizoma Et Radix Notopterygii 28 parts, Herba Artemisiae Annuae 21 parts, Semen Plantaginis 21 parts, Radix Dichroae 21 parts, Fructus Tsaoko 21 parts, Fructus Xanthii 21 parts, Radix Aconiti Kusnezoffii Preparata 14 parts, Herba Ranunculi Japonici 14 parts, Resina Ferulae 14 parts, Semen Phaseoli 14 parts, Radix Polygoni Multiflori 14 parts, Radix Bupleuri 7 parts, Herba Lobeliae Chinensis 7 parts, Herba Verbenae 7 parts, Herba Siegesbeckiae 7 parts, Herba Lysimachiae 7 parts.
The present invention also provides a kind of preparation method for the treatment of the tablet of malaria, comprises the following steps:
S1, crude product are produced: starch, Gypsum Fibrosum, sucrose, Mel, magnesium stearate, Chinese medicine preparation mixing, add 200-1200 part water and make lamellar after stirring, the tablet crude product of obtained treatment malaria;
S2, oven dry, sterilizing: the tablet crude product of the treatment malaria that step S1 is obtained is dried, after sterilizing, the tablet of obtained treatment malaria.
Preferably, the temperature of drying in step S2 is 80-100 DEG C, dries to water content≤6%, and the pressure of sterilizing is 210-230KPa, and the temperature of sterilizing is 134-136 DEG C, and the time of sterilizing is 6-8min.
Preferably, the preparation method of Chinese medicine preparation described in step S1 comprises the following steps:
S11: Radix Scutellariae, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Radix Puerariae, Rhizoma Et Radix Notopterygii, Herba Artemisiae Annuae, Semen Plantaginis, Radix Dichroae, Fructus Tsaoko, Fructus Xanthii, Radix Aconiti Kusnezoffii Preparata, Herba Ranunculi Japonici, Resina Ferulae, Semen Phaseoli, Radix Polygoni Multiflori, Radix Bupleuri, Herba Lobeliae Chinensis, Herba Verbenae, Herba Siegesbeckiae, Herba Lysimachiae are extracted in ultrasonic assistant ethanol extraction FAXIA, obtain medicinal liquid, the condition extracted is: solid-liquid ratio is 1:8-16, ultrasonic power is 120-180W, concentration of alcohol is 50%-80%, Extracting temperature is 40-70 DEG C, and extraction time is 30-90min;
S12: the medical filtration obtained by step S11, be condensed into paste;
S13: the paste of step S12 dried, pulverizes, sieve, sterilizing, obtained described Chinese medicine preparation.
Preferably, in step S12, the water content of paste is 40%-50%.
Preferably, the condition of drying in step S13 is: dry to water content≤6% at 90-105 DEG C.
Preferably, the condition of sieving in step S13 is: cross 200-400 object sieve.
Preferably, in step S13, the condition of sterilizing is: temperature is 134-136 DEG C, and pressure is 210-230KPa, and the time is 4-6min.
Chinese medicine preparation pharmacology of the present invention is as follows:
Radix Scutellariae has the effects such as heat clearing and damp drying, removing heat from blood are antiabortive, removing toxic substances, cures mainly the symptoms such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.
The Rhizoma Pinelliae has the effects such as drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass, can control the symptoms such as cough due to damp-phlegm, dizziness due to wind-phlegm, syncope due to accumulation of phlegm headache, vomiting regurgitation.
Cortex Magnoliae Officinalis has circulation of qi promoting removing food stagnancy, dampness except effects such as full, lowering the adverse QI to relieve asthmas, the symptom such as cure mainly stagnation of QI due to dyspepsia, abdominal distention constipation, retention of dampness in middle-JIAO, gastral cavity painful abdominal mass is vomited and diarrhoea, expectorant stops up QI rising in reverse order, fullness in the chest is breathed with cough.
Radix Puerariae has expelling pathogenic factors from muscles for reducing heat, deliver examine, the effect such as promoting the production of body fluid to quench thirst, yang invigorating antidiarrheal, fever caused by exogenous pathogens can be controlled, rigidity pain on the head and nape, measles go out the symptoms such as smooth, epidemic febrile disease is thirsty, diabetes from the beginning of, rash.
The effects such as Rhizoma Et Radix Notopterygii has expelling pathogenic wind from the body surface, removing dampness pain relieving, cure mainly the diseases such as the heating of cold, aversion to cold, headache, rheumatic arthralgia.
Herba Artemisiae Annuae has heat clearing away, expelling summer-heat, except effects such as steamings, can control the diseases such as epidemic febrile disease, summer-heat, hectic fever due to YIN-deficiency consumptive fever, malaria, dysentery, jaundice, scabies, pruritus.
The effect such as Semen Plantaginis has clearing away heat and promoting diuresis, eliminating dampness by diuresis antidiarrheal, improving eyesight, eliminate the phlegm, the disease such as can control dysuria, stranguria with turbid discharge leukorrhagia, edema distension, heat-damp in summer dysentery, conjunctival congestion is hidden from view, expectorant heat syndrome cough is breathed heavily.
Radix Dichroae has effect such as malaria, clearing away heat and promoting diuresis of reducing phlegm, can treating malaria disease, accumulated heat in the intestinal that disappears, except diseases such as distension and fullness of the chest and abdomen.
Fructus Tsaoko has dampness except preventing the attack (or recurrence) of malaria of trembling with fear, eliminate the phlegm, digestion-promoting effect such as disorderly, can the disease such as treating malaria disease, phlegm retention feeling of fullness, coldness and pain in the epigastrium, regurgitation, vomiting, dysentery, food stagnation.
Fructus Xanthii has the effects such as dispersing wind-cold, clearing the nasal passage, wind-damp dispelling, pain relieving, can control the diseases such as lumbago and skelalgia, parotitis, malaria.
Radix Aconiti Kusnezoffii Preparata have dispel the wind, dehumidify, cold expelling, the effect such as pain relieving, can treating malaria disease, anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type have a pain, the disease such as narcotic analgesic.
Herba Ranunculi Japonici has the effect such as wind-damp dispelling, removing toxic substances and promoting subsidence of swelling, can treating malaria disease, rheumatic arthralgia, the arthroncus of knee, malignant boil carbuncle, pain do not burst, the disease such as jaundice.
The effects such as having of Resina Ferulae disease removing food stagnancy, parasite killing, preventing the attack (or recurrence) of malaria, can control the diseases such as food stagnation, distension and fullness of the chest and abdomen, cold type of pain, malaria, dysentery.
Semen Phaseoli has the effects such as diuretic disappears kind, removing toxic substances and promoting pus discharge, the diseases such as swelling of can harnessing the river is full, beriberi edema, jaundice dark coloured urine, beriberoid pyretic arthralgia, carbuncle sore tumefacting virus, abdominalgia with intestinal abscess.
Radix Polygoni Multiflori has tonifying liver, kidney tonifying, nourish blood, the effect such as to dispel the wind, and can control hepatic and renal YIN deficiency, early whitening of beard and hair, blood deficiency dizziness, soreness of the waist and knees, muscles and bones are ached, pass out semen, the disease such as metrorrhagia and leukorrhagia, chronic dysentery.
Radix Bupleuri have induce sweat bring down a fever, the effect such as dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy, the diseases such as fever caused by exogenous pathogens, alternate attack of chill and fever, malaria, hypochondriac pain due to stagnation of liverQI, mammary swelling, headache dizziness can be controlled.
Herba Lobeliae Chinensis has the effect such as inducing diuresis to remove edema, heat-clearing and toxic substances removing, can control the diseases such as dysuria, the edema of the face, snake bite and insect sting, gastric cancer intestinal cancer, the esophageal carcinoma, hepatocarcinoma.
Herba Verbenae have refresh oneself, mild emotion, eliminate exert one's utmost effort, the effect such as facilitating digestion, the diseases such as lump in the abdomen, amenorrhea dysmenorrhea, malaria, sore throat, carbuncle, edema, pyretic stranguria can be controlled.
Herba Siegesbeckiae has the effect such as wind-damp dispelling, relieving rigidity of muscles and joints, can control the diseases such as quadriplegia, bones and muscles pain, weakness of the waist and knees, malaria, acute hepatitis, hypertension, furuncle swelling toxin.
Gold silver grass has the effect such as heat-clearing and toxic substances removing, dispelling wind and heat pathogens, cures mainly red and swollen heat pain, malaria, affection due to external wind and heat, epidemic febrile disease from the beginning of, the symptom such as toxic-heat and blood stasis, summer-heat excessive thirst, laryngopharynx swelling and pain.
The present invention has following beneficial effect:
(1) the present invention combines Radix Scutellariae, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Radix Puerariae, Rhizoma Et Radix Notopterygii, Herba Artemisiae Annuae, Semen Plantaginis, Radix Dichroae, Fructus Tsaoko, Fructus Xanthii, Radix Aconiti Kusnezoffii Preparata, Herba Ranunculi Japonici, Resina Ferulae, Semen Phaseoli, Radix Polygoni Multiflori, Radix Bupleuri, Herba Lobeliae Chinensis, Herba Verbenae, Herba Siegesbeckiae, Herba Lysimachiae plurality of Chinese effect, anti-inflammation, heat-clearing and toxic substances removing can be played, the effect such as malaria, clearing away heat and promoting diuresis of reducing phlegm, to evident in efficacy, the instant effect for the treatment of malaria, safely, have no side effect;
(2) tablet of the present invention carries out sterilizing at high temperature under high pressure, and the time is short, effective, the holding time is long;
(3) tablet manufacturing method of the present invention is simple to operate, and production cost is low, is conducive to applying.
[detailed description of the invention]
Be specifically described below in conjunction with specific embodiment.
Embodiment 1
A kind of tablet for the treatment of malaria, in units of weight portion, comprise following raw material: starch 400 parts, 100 parts, Gypsum Fibrosum, sucrose 100 parts, Mel 100 parts, magnesium stearate 100 parts, Chinese medicine preparation 100 parts, described Chinese medicine preparation comprises following raw material: Radix Scutellariae 8 parts, the Rhizoma Pinelliae 8 parts, Cortex Magnoliae Officinalis 8 parts, Radix Puerariae 8 parts, Rhizoma Et Radix Notopterygii 8 parts, Herba Artemisiae Annuae 6 parts, Semen Plantaginis 6 parts, Radix Dichroae 6 parts, Fructus Tsaoko 6 parts, Fructus Xanthii 6 parts, Radix Aconiti Kusnezoffii Preparata 4 parts, Herba Ranunculi Japonici 4 parts, Resina Ferulae 4 parts, Semen Phaseoli 4 parts, Radix Polygoni Multiflori 4 parts, Radix Bupleuri 2 parts, Herba Lobeliae Chinensis 2 parts, Herba Verbenae 2 parts, Herba Siegesbeckiae 2 parts, Herba Lysimachiae 2 parts.
The preparation method of the tablet of described treatment malaria, comprises the following steps:
S1, crude product are produced: starch, Gypsum Fibrosum, sucrose, Mel, magnesium stearate, Chinese medicine preparation mixing, add 200 parts of water and make lamellar after stirring, the tablet crude product of obtained treatment malaria;
S2, oven dry, sterilizing: it is 6% that the tablet crude product of the treatment malaria that step S1 is obtained is dried to water content at temperature is 80 DEG C, and be 210KPa at pressure, temperature is 134 DEG C, and the time is under 8min after sterilizing, the tablet of obtained treatment malaria.
The preparation method of above-mentioned Chinese medicine preparation, comprises the following steps:
S11: Radix Scutellariae, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Radix Puerariae, Rhizoma Et Radix Notopterygii, Herba Artemisiae Annuae, Semen Plantaginis, Radix Dichroae, Fructus Tsaoko, Fructus Xanthii, Radix Aconiti Kusnezoffii Preparata, Herba Ranunculi Japonici, Resina Ferulae, Semen Phaseoli, Radix Polygoni Multiflori, Radix Bupleuri, Herba Lobeliae Chinensis, Herba Verbenae, Herba Siegesbeckiae, Herba Lysimachiae are extracted in ultrasonic assistant ethanol extraction FAXIA, obtain medicinal liquid, the condition extracted is: solid-liquid ratio is 1:14, ultrasonic power is 150W, concentration of alcohol is 50%, Extracting temperature is 60 DEG C, and extraction time is 60min;
S12: the medical filtration obtained by step S11, to be condensed into paste water content be 50%;
S13: being dried by the paste of step S12 to water content at 105 DEG C is 5%, crosses 400 object sieves after pulverizing, be finally 136 DEG C the powder of the gained that sieves in temperature, pressure is 230KPa, and the time is sterilizing under 4min, obtained Chinese medicine preparation.
Embodiment 2
A kind of tablet for the treatment of malaria, in units of weight portion, comprise following raw material: starch 2000 parts, 900 parts, Gypsum Fibrosum, sucrose 500 parts, Mel 500 parts, magnesium stearate 500 parts, Chinese medicine preparation 600 parts, described Chinese medicine preparation comprises following raw material: Radix Scutellariae 48 parts, the Rhizoma Pinelliae 48 parts, Cortex Magnoliae Officinalis 48 parts, Radix Puerariae 48 parts, Rhizoma Et Radix Notopterygii 48 parts, Herba Artemisiae Annuae 36 parts, Semen Plantaginis 36 parts, Radix Dichroae 36 parts, Fructus Tsaoko 36 parts, Fructus Xanthii 36 parts, Radix Aconiti Kusnezoffii Preparata 24 parts, Herba Ranunculi Japonici 24 parts, Resina Ferulae 24 parts, Semen Phaseoli 24 parts, Radix Polygoni Multiflori 24 parts, Radix Bupleuri 12 parts, Herba Lobeliae Chinensis 12 parts, Herba Verbenae 12 parts, Herba Siegesbeckiae 12 parts, Herba Lysimachiae 12 parts.
The preparation method of the tablet of described treatment malaria, comprises the following steps:
S1, crude product are produced: starch, Gypsum Fibrosum, sucrose, Mel, magnesium stearate, Chinese medicine preparation mixing, add 1200 parts of water and make lamellar after stirring, the tablet crude product of obtained treatment malaria;
S2, oven dry, sterilizing: it is 5% that the tablet crude product of the treatment malaria that step S1 is obtained is dried to water content at temperature is 100 DEG C, and be 230KPa at pressure, temperature is 136 DEG C, and the time is under 6min after sterilizing, the tablet of obtained treatment malaria.
The preparation method of above-mentioned Chinese medicine preparation, comprises the following steps:
S11: Radix Scutellariae, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Radix Puerariae, Rhizoma Et Radix Notopterygii, Herba Artemisiae Annuae, Semen Plantaginis, Radix Dichroae, Fructus Tsaoko, Fructus Xanthii, Radix Aconiti Kusnezoffii Preparata, Herba Ranunculi Japonici, Resina Ferulae, Semen Phaseoli, Radix Polygoni Multiflori, Radix Bupleuri, Herba Lobeliae Chinensis, Herba Verbenae, Herba Siegesbeckiae, Herba Lysimachiae are extracted in ultrasonic assistant ethanol extraction FAXIA, obtain medicinal liquid, the condition extracted is: solid-liquid ratio is 1:16, ultrasonic power is 180W, concentration of alcohol is 80%, Extracting temperature is 70 DEG C, and extraction time is 50min;
S12: the medical filtration obtained by step S11, to be condensed into paste water content be 40%;
S13: being dried by the paste of step S12 to water content at 100 DEG C is 5%, crosses 400 object sieves after pulverizing, be finally 135 DEG C the powder of the gained that sieves in temperature, pressure is 220KPa, and the time is sterilizing under 5min, obtained Chinese medicine preparation.
Embodiment 3
A kind of tablet for the treatment of malaria, in units of weight portion, comprise following raw material: starch 1200 parts, 500 parts, Gypsum Fibrosum, sucrose 300 parts, Mel 300 parts, magnesium stearate 300 parts, Chinese medicine preparation 350 parts, described Chinese medicine preparation comprises following raw material: Radix Scutellariae 28 parts, the Rhizoma Pinelliae 28 parts, Cortex Magnoliae Officinalis 28 parts, Radix Puerariae 28 parts, Rhizoma Et Radix Notopterygii 28 parts, Herba Artemisiae Annuae 21 parts, Semen Plantaginis 21 parts, Radix Dichroae 21 parts, Fructus Tsaoko 21 parts, Fructus Xanthii 21 parts, Radix Aconiti Kusnezoffii Preparata 14 parts, Herba Ranunculi Japonici 14 parts, Resina Ferulae 14 parts, Semen Phaseoli 14 parts, Radix Polygoni Multiflori 14 parts, Radix Bupleuri 7 parts, Herba Lobeliae Chinensis 7 parts, Herba Verbenae 7 parts, Herba Siegesbeckiae 7 parts, Herba Lysimachiae 7 parts.
The preparation method of the tablet of described treatment malaria, comprises the following steps:
S1, crude product are produced: starch, Gypsum Fibrosum, sucrose, Mel, magnesium stearate, Chinese medicine preparation mixing, add 700 parts of water and make lamellar after stirring, the tablet crude product of obtained treatment malaria;
S2, oven dry, sterilizing: it is 4% that the tablet crude product of the treatment malaria that step S1 is obtained is dried to water content at temperature is 90 DEG C, and be 220KPa at pressure, temperature is 135 DEG C, and the time is under 7min after sterilizing, the tablet of obtained treatment malaria.
The preparation method of above-mentioned Chinese medicine preparation, comprises the following steps:
S11: Radix Scutellariae, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Radix Puerariae, Rhizoma Et Radix Notopterygii, Herba Artemisiae Annuae, Semen Plantaginis, Radix Dichroae, Fructus Tsaoko, Fructus Xanthii, Radix Aconiti Kusnezoffii Preparata, Herba Ranunculi Japonici, Resina Ferulae, Semen Phaseoli, Radix Polygoni Multiflori, Radix Bupleuri, Herba Lobeliae Chinensis, Herba Verbenae, Herba Siegesbeckiae, Herba Lysimachiae are extracted in ultrasonic assistant ethanol extraction FAXIA, obtain medicinal liquid, the condition extracted is: solid-liquid ratio is 1:12, ultrasonic power is 160W, concentration of alcohol is 60%, Extracting temperature is 50 DEG C, and extraction time is 30min;
S12: the medical filtration obtained by step S11, to be condensed into paste water content be 45%;
S13: being dried by the paste of step S12 to water content at 105 DEG C is 4%, crosses 300 object sieves after pulverizing, be finally 136 DEG C the powder of the gained that sieves in temperature, pressure is 30KPa, and the time is sterilizing under 4min, obtained Chinese medicine preparation.
Embodiment 4
A kind of tablet for the treatment of malaria, in units of weight portion, comprise following raw material: starch 600 parts, 200 parts, Gypsum Fibrosum, sucrose 150 parts, Mel 150 parts, magnesium stearate 150 parts, Chinese medicine preparation 200 parts, described Chinese medicine preparation comprises following raw material: Radix Scutellariae 16 parts, the Rhizoma Pinelliae 16 parts, Cortex Magnoliae Officinalis 16 parts, Radix Puerariae 16 parts, Rhizoma Et Radix Notopterygii 16 parts, Herba Artemisiae Annuae 12 parts, Semen Plantaginis 12 parts, Radix Dichroae 12 parts, Fructus Tsaoko 12 parts, Fructus Xanthii 12 parts, Radix Aconiti Kusnezoffii Preparata 8 parts, Herba Ranunculi Japonici 8 parts, Resina Ferulae 8 parts, Semen Phaseoli 8 parts, Radix Polygoni Multiflori 8 parts, Radix Bupleuri 4 parts, Herba Lobeliae Chinensis 4 parts, Herba Verbenae 4 parts, Herba Siegesbeckiae 4 parts, Herba Lysimachiae 4 parts.
The preparation method of the tablet of described treatment malaria, comprises the following steps:
S1, crude product are produced: starch, Gypsum Fibrosum, sucrose, Mel, magnesium stearate, Chinese medicine preparation mixing, add 600 parts of water and make lamellar after stirring, the tablet crude product of obtained treatment malaria;
S2, oven dry, sterilizing: it is 6% that the tablet crude product of the treatment malaria that step S1 is obtained is dried to water content at temperature is 80 DEG C, and be 210KPa at pressure, temperature is 134 DEG C, and the time is under 8min after sterilizing, the tablet of obtained treatment malaria.
The preparation method of above-mentioned Chinese medicine preparation, comprises the following steps:
S11: Radix Scutellariae, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Radix Puerariae, Rhizoma Et Radix Notopterygii, Herba Artemisiae Annuae, Semen Plantaginis, Radix Dichroae, Fructus Tsaoko, Fructus Xanthii, Radix Aconiti Kusnezoffii Preparata, Herba Ranunculi Japonici, Resina Ferulae, Semen Phaseoli, Radix Polygoni Multiflori, Radix Bupleuri, Herba Lobeliae Chinensis, Herba Verbenae, Herba Siegesbeckiae, Herba Lysimachiae are extracted in ultrasonic assistant ethanol extraction FAXIA, obtain medicinal liquid, the condition extracted is: solid-liquid ratio is 1:10, ultrasonic power is 140W, concentration of alcohol is 70%, Extracting temperature is 60 DEG C, and extraction time is 70min;
S12: the medical filtration obtained by step S11, to be condensed into paste water content be 48%;
S13: being dried by the paste of step S12 to water content at 95 DEG C is 6%, crosses 200 object sieves after pulverizing, be finally 134 DEG C the powder of the gained that sieves in temperature, pressure is 210KPa, and the time is sterilizing under 6min, obtained Chinese medicine preparation.
Embodiment 5
A kind of tablet for the treatment of malaria, in units of weight portion, comprise following raw material: starch 1800 parts, 800 parts, Gypsum Fibrosum, sucrose 450 parts, Mel 450 parts, magnesium stearate 450 parts, Chinese medicine preparation 500 parts, described Chinese medicine preparation comprises following raw material: Radix Scutellariae 40 parts, the Rhizoma Pinelliae 40 parts, Cortex Magnoliae Officinalis 40 parts, Radix Puerariae 40 parts, Rhizoma Et Radix Notopterygii 40 parts, Herba Artemisiae Annuae 30 parts, Semen Plantaginis 30 parts, Radix Dichroae 30 parts, Fructus Tsaoko 30 parts, Fructus Xanthii 30 parts, Radix Aconiti Kusnezoffii Preparata 20 parts, Herba Ranunculi Japonici 20 parts, Resina Ferulae 20 parts, Semen Phaseoli 20 parts, Radix Polygoni Multiflori 20 parts, Radix Bupleuri 10 parts, Herba Lobeliae Chinensis 10 parts, Herba Verbenae 10 parts, Herba Siegesbeckiae 10 parts, Herba Lysimachiae 10 parts.
The preparation method of the tablet of described treatment malaria, comprises the following steps:
S1, crude product are produced: starch, Gypsum Fibrosum, sucrose, Mel, magnesium stearate, Chinese medicine preparation mixing, add 900 parts of water and make lamellar after stirring, the tablet crude product of obtained treatment malaria;
S2, oven dry, sterilizing: it is 5% that the tablet crude product of the treatment malaria that step S1 is obtained is dried to water content at temperature is 100 DEG C, and be 230KPa at pressure, temperature is 136 DEG C, and the time is under 6min after sterilizing, the tablet of obtained treatment malaria.
The preparation method of above-mentioned Chinese medicine preparation, comprises the following steps:
S11: Radix Scutellariae, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Radix Puerariae, Rhizoma Et Radix Notopterygii, Herba Artemisiae Annuae, Semen Plantaginis, Radix Dichroae, Fructus Tsaoko, Fructus Xanthii, Radix Aconiti Kusnezoffii Preparata, Herba Ranunculi Japonici, Resina Ferulae, Semen Phaseoli, Radix Polygoni Multiflori, Radix Bupleuri, Herba Lobeliae Chinensis, Herba Verbenae, Herba Siegesbeckiae, Herba Lysimachiae are extracted in ultrasonic assistant ethanol extraction FAXIA, obtain medicinal liquid, the condition extracted is: solid-liquid ratio is 1:8, ultrasonic power is 120W, concentration of alcohol is 50%, Extracting temperature is 40 DEG C, and extraction time is 90min;
S12: the medical filtration obtained by step S11, to be condensed into paste water content be 43%;
S13: being dried by the paste of step S12 to water content at 90 DEG C is 6%, crosses 200 object sieves after pulverizing, be finally 134 DEG C the powder of the gained that sieves in temperature, pressure is 210KPa, and the time is sterilizing under 6min, obtained Chinese medicine preparation.
As follows through clinical test results: treatment malaria patients 205 example, male 101 example, women 104 example, the age be 8-82 year, usage is: the tablet taking embodiment 3, every day three times, be 1-3 sheet g, consumption takes the circumstances into consideration to add and subtract dosage according to the concrete condition of patient at every turn, it within two days, is a course for the treatment of, take observe the curative effect after two courses for the treatment of, recovery from illness 175 example, accounts for 85.37%; Effective 14 examples, account for 6.83%; Take a turn for the better 11 examples, accounts for 5.37%; Invalid 5 examples, account for 2.44%; Total effective rate reaches 97.56%, and after two course of therapy, the malaria shape of patient all has clear improvement or fully recovers, and patient is without any untoward reaction.
Above content can not assert that the present invention specifically implements to be confined to these explanations; for general technical staff of the technical field of the invention; do not departing under concept thereof of the present invention; some simple deduction or replace can also be made, all should be considered as belonging to the scope of patent protection that the present invention is determined by submitted to claims.
Claims (10)
1. treat the tablet of malaria for one kind, it is characterized in that, in units of weight portion, comprise following raw material: starch 400-2000 part, Gypsum Fibrosum 100-900 part, sucrose 100-500 part, Mel 100-500 part, magnesium stearate 100-500 part, Chinese medicine preparation 100-600 part, described Chinese medicine preparation comprises following raw material: Radix Scutellariae 8-48 part, Rhizoma Pinelliae 8-48 part, Cortex Magnoliae Officinalis 8-48 part, Radix Puerariae 8-48 part, Rhizoma Et Radix Notopterygii 8-48 part, Herba Artemisiae Annuae 6-36 part, Semen Plantaginis 6-36 part, Radix Dichroae 6-36 part, Fructus Tsaoko 6-36 part, Fructus Xanthii 6-36 part, Radix Aconiti Kusnezoffii Preparata 4-24 part, Herba Ranunculi Japonici 4-24 part, Resina Ferulae 4-24 part, Semen Phaseoli 4-24 part, Radix Polygoni Multiflori 4-24 part, Radix Bupleuri 2-12 part, Herba Lobeliae Chinensis 2-12 part, Herba Verbenae 2-12 part, Herba Siegesbeckiae 2-12 part, Herba Lysimachiae 2-12 part.
2. the tablet for the treatment of malaria according to claim 1, it is characterized in that, in units of weight portion, comprise following raw material: starch 600-1800 part, Gypsum Fibrosum 200-800 part, sucrose 150-450 part, Mel 150-450 part, magnesium stearate 150-450 part, Chinese medicine preparation 200-500 part, described Chinese medicine preparation comprises following raw material: Radix Scutellariae 16-40 part, Rhizoma Pinelliae 16-40 part, Cortex Magnoliae Officinalis 16-40 part, Radix Puerariae 16-40 part, Rhizoma Et Radix Notopterygii 16-40 part, Herba Artemisiae Annuae 12-30 part, Semen Plantaginis 12-30 part, Radix Dichroae 12-30 part, Fructus Tsaoko 12-30 part, Fructus Xanthii 12-30 part, Radix Aconiti Kusnezoffii Preparata 8-20 part, Herba Ranunculi Japonici 8-20 part, Resina Ferulae 8-20 part, Semen Phaseoli 8-20 part, Radix Polygoni Multiflori 8-20 part, Radix Bupleuri 4-10 part, Herba Lobeliae Chinensis 4-10 part, Herba Verbenae 4-10 part, Herba Siegesbeckiae 4-10 part, Herba Lysimachiae 4-10 part.
3. the tablet for the treatment of malaria according to claim 2, it is characterized in that, in units of weight portion, comprise following raw material: starch 1200 parts, 500 parts, Gypsum Fibrosum, sucrose 300 parts, Mel 300 parts, magnesium stearate 300 parts, Chinese medicine preparation 350 parts, described Chinese medicine preparation comprises following raw material: Radix Scutellariae 28 parts, the Rhizoma Pinelliae 28 parts, Cortex Magnoliae Officinalis 28 parts, Radix Puerariae 28 parts, Rhizoma Et Radix Notopterygii 28 parts, Herba Artemisiae Annuae 21 parts, Semen Plantaginis 21 parts, Radix Dichroae 21 parts, Fructus Tsaoko 21 parts, Fructus Xanthii 21 parts, Radix Aconiti Kusnezoffii Preparata 14 parts, Herba Ranunculi Japonici 14 parts, Resina Ferulae 14 parts, Semen Phaseoli 14 parts, Radix Polygoni Multiflori 14 parts, Radix Bupleuri 7 parts, Herba Lobeliae Chinensis 7 parts, Herba Verbenae 7 parts, Herba Siegesbeckiae 7 parts, Herba Lysimachiae 7 parts.
4. the preparation method of the tablet of the treatment malaria according to any one of claim 1-3, is characterized in that, comprise the following steps:
S1, crude product are produced: starch, Gypsum Fibrosum, sucrose, Mel, magnesium stearate, Chinese medicine preparation mixing, add 200-1200 part water and make lamellar after stirring, the tablet crude product of obtained treatment malaria;
S2, oven dry, sterilizing: the tablet crude product of the treatment malaria that step S1 is obtained is dried, after sterilizing, the tablet of obtained treatment malaria.
5. the preparation method of the tablet for the treatment of malaria according to claim 4, is characterized in that, the temperature of drying in step S2 is 80-100 DEG C, dry to water content≤6%, the pressure of sterilizing is 210-230KPa, and the temperature of sterilizing is 134-136 DEG C, and the time of sterilizing is 6-8min.
6. the preparation method of the tablet for the treatment of malaria according to claim 4, is characterized in that, the preparation method of Chinese medicine preparation described in step S1 comprises the following steps:
S11: Radix Scutellariae, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Radix Puerariae, Rhizoma Et Radix Notopterygii, Herba Artemisiae Annuae, Semen Plantaginis, Radix Dichroae, Fructus Tsaoko, Fructus Xanthii, Radix Aconiti Kusnezoffii Preparata, Herba Ranunculi Japonici, Resina Ferulae, Semen Phaseoli, Radix Polygoni Multiflori, Radix Bupleuri, Herba Lobeliae Chinensis, Herba Verbenae, Herba Siegesbeckiae, Herba Lysimachiae are extracted in ultrasonic assistant ethanol extraction FAXIA, obtain medicinal liquid, the condition extracted is: solid-liquid ratio is 1:8-16, ultrasonic power is 120-180W, concentration of alcohol is 50%-80%, Extracting temperature is 40-70 DEG C, and extraction time is 30-90min;
S12: the medical filtration obtained by step S11, be condensed into paste;
S13: the paste of step S12 dried, pulverizes, sieve, sterilizing, obtained described Chinese medicine preparation.
7. the preparation method of the tablet for the treatment of malaria according to claim 6, is characterized in that, in step S12, the water content of paste is 40%-50%.
8. the preparation method of the tablet for the treatment of malaria according to claim 6, is characterized in that, the condition of drying in step S13 is: dry to water content≤6% at 90-105 DEG C.
9. the preparation method of the tablet for the treatment of malaria according to claim 6, is characterized in that, the condition of sieving in step S13 is: cross 200-400 object sieve.
10. the preparation method of the tablet for the treatment of malaria according to claim 6, is characterized in that, in step S13, the condition of sterilizing is: temperature is 134-136 DEG C, and pressure is 210-230KPa, and the time is 4-6min.
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| CN106309757A (en) * | 2016-09-29 | 2017-01-11 | 许超群 | Passion fruit buccal tablets with function of refreshing |
| CN106344796A (en) * | 2016-09-29 | 2017-01-25 | 许超群 | Passion fruit buccal tablet capable of lowering blood sugar level |
| CN106420995A (en) * | 2016-09-29 | 2017-02-22 | 许超群 | Buccal tablet used for reducing blood pressure and containing passion fruits |
| CN106421330A (en) * | 2016-09-29 | 2017-02-22 | 许超群 | Passion fruit lozenge capable of improving immunity |
| CN106491901A (en) * | 2016-09-29 | 2017-03-15 | 许超群 | A kind of heat-clearing and toxic substances removing Passifolra edulis buccal tablet |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106309757A (en) * | 2016-09-29 | 2017-01-11 | 许超群 | Passion fruit buccal tablets with function of refreshing |
| CN106344796A (en) * | 2016-09-29 | 2017-01-25 | 许超群 | Passion fruit buccal tablet capable of lowering blood sugar level |
| CN106420995A (en) * | 2016-09-29 | 2017-02-22 | 许超群 | Buccal tablet used for reducing blood pressure and containing passion fruits |
| CN106421330A (en) * | 2016-09-29 | 2017-02-22 | 许超群 | Passion fruit lozenge capable of improving immunity |
| CN106491901A (en) * | 2016-09-29 | 2017-03-15 | 许超群 | A kind of heat-clearing and toxic substances removing Passifolra edulis buccal tablet |
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Application publication date: 20151111 |