CN106491800A - Renshen Guipi Wan - Google Patents

Renshen Guipi Wan Download PDF

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Publication number
CN106491800A
CN106491800A CN201610962684.2A CN201610962684A CN106491800A CN 106491800 A CN106491800 A CN 106491800A CN 201610962684 A CN201610962684 A CN 201610962684A CN 106491800 A CN106491800 A CN 106491800A
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parts
radix
ketone
guipi wan
renshen
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刘世超
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Shanghai Chen Song New Mstar Technology Ltd
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Shanghai Chen Song New Mstar Technology Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/285—Aucklandia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/69—Polygalaceae (Milkwort family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725—Ziziphus, e.g. jujube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Alternative & Traditional Medicine (AREA)
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  • Botany (AREA)
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  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a kind of Renshen Guipi Wan, the Renshen Guipi Wan is prepared from by the raw material of following weight parts：35 45 parts of Radix Ginseng, 75 85 parts of the Rhizoma Atractylodis Macrocephalae, 75 85 parts of Poria, 18 22 parts of Radix Glycyrrhizae Preparata, 35 45 parts of Radix Astragali Preparata, 75 85 parts of Radix Angelicae Sinensis, 18 22 parts of the Radix Aucklandiae, 75 85 parts of Radix Polygalae, 75 85 parts of Arillus Longan, 35 45 parts of Semen Ziziphi Spinosae, 0.09 0.9 parts of correctivess, 0.5 2.5 parts of antioxidant.Renshen Guipi Wan of the present invention, have functions that vigorate qi and replenish the blood, invigorating spleen and nourishing heart, can be used to treat insufficiency of vital energy and blood, and cardiopalmus, insomnia, lack of appetite are weak, shallow complexion, Hypomenorrhea, the light symptom of color, add antioxidant, it is ensured that the steady quality of medicine in its formula.

Description

Renshen Guipi Wan
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, and in particular to a kind of Renshen Guipi Wan.
Background technology
Renshen Guipi Wan is made up of the 10 taste Chinese crude drug such as Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis and Radix Astragali, with vigorate qi and replenish the blood, is good for The effect of spleen nourishing heart, for the cardiopalmus caused by deficiency of both the heart and spleen, insufficiency of vital energy and blood, palpitation with a distress feeling, insomnia forgetfulness, lack of appetite body be tired, shallow complexion, And having blood in stool caused by failure of the spleen to keep the blood flowing within the vessels, metrorrhagia, all diseases of leukorrhagia.From in terms of the composition of the party, Radix Ginseng, the sweet temperature gas supplementing of the Rhizoma Atractylodis Macrocephalae in side, with The Radix Astragali, Radix Glycyrrhizae match, and strengthen the work(of invigorating the spleen and replenishing QI；The sweet pungent tepor of Radix Angelicae Sinensis, nourishing blood and nutrient QI are matched with Arillus Longan, increase reinforcing the heart blood Effect；Poria, Semen Ziziphi Spinosae, Radix Polygalae reinforcing the heart blood, the beneficial motive, tranquilizing mind；Muxiangliqi is amusing, and matches with qi-invigorating, blood-nourishing medicinal, makes Benefit and not stagnant.All medicines share, plays the effect of invigorating the spleen and benefiting QI, replenishing blood for nourishing heart, intelligent promoting and the mind tranquilizing altogether.But Radix Ginseng prepared by prior art is returned Spleen ball less stable, and it is difficult long storage time.
Content of the invention
For above-mentioned deficiency present in prior art, the technical problem to be solved is to provide a kind of Radix Ginseng and returns Spleen ball.
The present invention seeks to be achieved through the following technical solutions：
A kind of Renshen Guipi Wan, is prepared from by the raw material of following weight parts：Radix Ginseng 35-45 parts, Rhizoma Atractylodis Macrocephalae 75-85 parts, Fu Siberian cocklebur 75-85 parts, Radix Glycyrrhizae Preparata 18-22 parts, Radix Astragali Preparata 35-45 parts, Radix Angelicae Sinensis 75-85 parts, Radix Aucklandiae 18-22 parts, Radix Polygalae 75-85 part, dragon Eye meat 75-85 part, Semen Ziziphi Spinosae 35-45 parts, correctivess 0.09-0.9 parts, antioxidant 0.5-2.5 parts.
Preferably, described correctivess be sodium alginate, sodium citrate, one or more mixed in sodium carboxymethyl cellulose Compound.
It is highly preferred that described correctivess are mixed by sodium alginate, sodium citrate, sodium carboxymethyl cellulose, described Sodium alginate, sodium citrate, the mass ratio of sodium carboxymethyl cellulose are (1-3)：(1-3)：(1-3).
Preferably, described antioxidant is phellinus ketone, Radix Glycyrrhizae looks into and one or more mixed in ketone A, podocarpusflavone A Compound.
It is highly preferred that described antioxidant is looked into by phellinus ketone, Radix Glycyrrhizae and ketone A, podocarpusflavone A are mixed, described Phellinus ketone, Radix Glycyrrhizae are looked into and ketone A, the mass ratio of podocarpusflavone A are (1-3)：(1-3)：(1-3).
Present invention also offers the preparation method of above-mentioned Renshen Guipi Wan, comprises the following steps：
(1) Radix Ginseng, Radix Angelicae Sinensis, the Radix Aucklandiae are crushed to 200-400 mesh respectively, remix uniformly, obtain medicated powder；
(2) Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae Preparata, Radix Astragali Preparata, Radix Polygalae, Arillus Longan, 7 taste Chinese medicine of Semen Ziziphi Spinosae are crushed, is sieved, mixed Uniformly, supercritical carbon dioxide extraction, extraction time 110-140 minutes, extraction temperature 32-48 DEG C, extracting pressure are carried out 23-47MPa, the flow of carbon dioxide is 10-20kg/h, and using 200 mesh filter-cloth filterings, filtering residue is standby, and filtrate reduced in volume is extremely Extraction clear paste of the density for 1.15-1.25 (50 DEG C)；
(3) water of medicinal residues amount 8-12 times is added in step (2) in gained medicinal residues, 1.5 hours are decocted, and adopts 200 while hot Mesh filter-cloth filtering, collects filtrate；The decocting for adding medicinal residues weight 6-10 times in medicinal residues boils 1 hour, using 200 mesh filter cloth mistakes Filter waste；Merge filtrate twice, concentrating under reduced pressure is concentrated into the water extraction clear paste that relative density is 1.15-1.25 (50 DEG C)；
(4) by medicated powder, extraction clear paste, water extraction clear paste, correctivess, antioxidant mix homogeneously, pill is dried, is obtained final product.
Specifically, in the present invention：
Radix Glycyrrhizae Preparata, Classification system：Glycyrrhizae., be Radix Glycyrrhizae Glycyrrhiza uralensis Fisch. big gun Processed goods processed.
Radix Astragali Preparata, is the Preparation process product of Radix Astragali Leguminosae.
Arillus Longan, is the aril of Sapindaceae Arillus Longan platymiscium Arillus Longan Dimocarpus longan Lour..Summer, autumn Two seasons harvested mature fruit, dried, and except shelling, core, shone to dry and comfortable and did not sticked.
Radix Ginseng, Classification system：Panax ginseng C.A.Mey., are Araliaceae Radix Ginseng Panax ginseng The dry root of C.A.Mey.
Radix Polygalae, is the dry root of milk wort Radix Polygalae Polygala tenuifolia Willd..
Semen Ziziphi Spinosae, Classification system：Ziziphus jujuba Mill.var.spinosa, are rhamnaceae plant wild jujube The dry mature seed of Ziziphus jujuba Mill.var.spinosa (Bunge) Hu ex H.F.Chou.
The Radix Aucklandiae, is feverfew Saussurea lappa Clarke (Classification system：Saussurea costus) root.
The Rhizoma Atractylodis Macrocephalae, Classification system：Atractylodes macrocephala, are a kind of plants of Compositae [WTBX, Dan Ye, Long and narrow, flower purple, head inflorescence are used as medicine with rhizome, another name art, winter art, Zhejiang art, kind art, Qi Shu etc..
Poria, Classification system：Wolfiporia cocos, also known as beautiful spirit, Poria, Wan Linggui, Fu Tu.Shi Ni shelf funguses section The dry sclerotia of funguses Poria.
Radix Angelicae Sinensis, Classification system：Angelica sinensis, call dry return, the Qin which, western Radix Angelicae Sinensis, Min Radix Angelicae Sinensis, Radix Angelicae Sinensis, when Return body, contain Radix Angelicae Sinensis, Radix Angelicae Sinensis song, Radix Angelicae Gigatiss, perennial herb.
Sodium alginate, No. CAS：31581-02-9.
Sodium citrate, No. CAS：6132-04-3.
Sodium carboxymethyl cellulose, No. CAS：9004-32-4.
Phellinus ketone, No. CAS：62949-77-3.
Radix Glycyrrhizae is looked into and ketone A, No. CAS：58749-22-7.
Podocarpusflavone A, No. CAS：22136-74-9.
Renshen Guipi Wan of the present invention, have functions that vigorate qi and replenish the blood, invigorating spleen and nourishing heart, can be used for treat insufficiency of vital energy and blood, cardiopalmus, Insomnia, lack of appetite are weak, shallow complexion, Hypomenorrhea, the light symptom of color, add antioxidant, it is ensured that the matter of medicine in its formula Amount is stable.
Specific embodiment
Embodiment 1
Renshen Guipi Wan raw material：41 parts of Radix Ginseng, 81 parts of the Rhizoma Atractylodis Macrocephalae, 81 parts of Poria, 20 parts of Radix Glycyrrhizae Preparata, 41 parts of Radix Astragali Preparata, Radix Angelicae Sinensis 81 parts, 20 parts of the Radix Aucklandiae, 81 parts of Radix Polygalae, 81 parts of Arillus Longan, 41 parts of Semen Ziziphi Spinosae, 0.15 part of correctivess, 0.9 part of antioxidant.
Described correctivess are 1 by sodium alginate, sodium citrate, sodium carboxymethyl cellulose in mass ratio：1：1 stirring mixing Uniformly obtain.
Described antioxidant is looked into by phellinus ketone, Radix Glycyrrhizae and ketone A, podocarpusflavone A are 1 in mass ratio：1：1 stirring mixing Uniformly obtain.
The preparation method of above-mentioned Renshen Guipi Wan, comprises the following steps：
(1) Radix Ginseng, Radix Angelicae Sinensis, the Radix Aucklandiae are crushed to 200 mesh respectively, remix uniformly, obtain medicated powder；
(2) it is 80 mesh to crush the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae Preparata, Radix Astragali Preparata, Radix Polygalae, Arillus Longan, 7 taste Chinese medicine of Semen Ziziphi Spinosae, mistake Sieve, mix homogeneously carry out supercritical carbon dioxide extraction, extraction time 132 minutes, 43 DEG C of extraction temperature, extracting pressure 33MPa, the flow of carbon dioxide is 15kg/h, and using 200 mesh filter-cloth filterings, filtering residue is standby, and filtrate reduced in volume to density is The extraction clear paste of 1.20 (50 DEG C)；
(3) water of 10 times of medicinal residues amount is added in step (2) in gained medicinal residues, 1.5 hours are decocted, and adopts 200 mesh while hot Filter-cloth filtering, collects filtrate；The decocting for adding 8 times of amounts of medicinal residues weight in medicinal residues boils 1 hour, using 200 mesh filter-cloth filterings Waste；Merge filtrate twice, concentrating under reduced pressure is concentrated into the water extraction clear paste that relative density is 1.20 (50 DEG C)；
(4) clear paste, water extraction clear paste, correctivess, antioxidant mix homogeneously will be extracted, and pill is dried.Obtain embodiment 1 Renshen Guipi Wan.
Embodiment 2
Substantially the same manner as Example 1, differ only in：Described correctivess are by sodium citrate, sodium carboxymethyl cellulose It is 1 in mass ratio：1 is uniformly mixed and obtains.Obtain the Renshen Guipi Wan of embodiment 2.
Embodiment 3
Substantially the same manner as Example 1, differ only in：Described correctivess are by sodium alginate, sodium carboxymethyl cellulose It is 1 in mass ratio：1 is uniformly mixed and obtains.Obtain the Renshen Guipi Wan of embodiment 3.
Embodiment 4
Substantially the same manner as Example 1, differ only in：Described correctivess press quality by sodium alginate, sodium citrate Than for 1：1 is uniformly mixed and obtains.Obtain the Renshen Guipi Wan of embodiment 4.
Embodiment 5
Substantially the same manner as Example 1, differ only in：Described antioxidant is looked into and ketone A, Semen Podocarpi Macrophylli bisflavone by Radix Glycyrrhizae A is 1 in mass ratio：1 is uniformly mixed and obtains.Obtain the Renshen Guipi Wan of embodiment 5.
Embodiment 6
Substantially the same manner as Example 1, differ only in：Described antioxidant presses matter by phellinus ketone, podocarpusflavone A Amount is than being 1：1 is uniformly mixed and obtains.Obtain the Renshen Guipi Wan of embodiment 6.
Embodiment 7
Substantially the same manner as Example 1, differ only in：Described antioxidant is looked into by phellinus ketone, Radix Glycyrrhizae and ketone A is by quality Than for 1：1 is uniformly mixed and obtains.Obtain the Renshen Guipi Wan of embodiment 7.
Test case 1
Renshen Guipi Wan prepared by embodiment 1-7, is placed in 25 DEG C, preservation half a year under 85% environment of relative humidity, then The test of escherichia coli (ATYCC 25922) total plate count is carried out, with reference to GBT 4789.2-2008 microbiological test of food hygiene Total plate count is determined.Concrete test result is shown in Table 1.
Table 1：Total plate count tests table cfu/g
Comparing embodiment 1 and embodiment 2-4, embodiment 1 (sodium alginate, sodium citrate, sodium carboxymethyl cellulose compounding) Antiseptic property is substantially better than embodiment 2-4 (arbitrarily the two compounding in sodium alginate, sodium citrate, sodium carboxymethyl cellulose)；Than Compared with embodiment 1 and embodiment 5-7, embodiment 1 (phellinus ketone, Radix Glycyrrhizae are looked into and ketone A, podocarpusflavone A compounding) antiseptic property is bright Show better than embodiment 5-7 (phellinus ketone, Radix Glycyrrhizae are looked into and arbitrarily the two compounds in ketone A, podocarpusflavone A).
Test case 2
Stability test is carried out to Renshen Guipi Wan prepared by embodiment 1-7.
The atractylenolide included in Renshen Guipi Wan of the present invention is the index composition of the Rhizoma Atractylodis Macrocephalae.Prepared by embodiment 1-7 Renshen Guipi Wan use aluminum-plastic composite membrane bag hermetic package respectively, place 3 months at a temperature of they are placed in 38 DEG C, determine each examination Atractylenolide in sample during March is relative to the residual content during sample 0 month.Master's thesis of the method for testing with reference to tinkling of pieces of jades 《Rhizoma Atractylodis Macrocephalae chemical composition and quality standard research》In Section four：The method of bighead atractylodes rhizome piece content assaying method research is determined.Concrete knot Fruit is shown in Table 2.
Table 2：Stability test result list position：%
Comparing embodiment 1 and embodiment 2-4, embodiment 1 (sodium alginate, sodium citrate, sodium carboxymethyl cellulose compounding) Stability is substantially better than embodiment 2-4 (arbitrarily the two compounding in sodium alginate, sodium citrate, sodium carboxymethyl cellulose)；Than Compared with embodiment 1 and embodiment 5-7, embodiment 1 (phellinus ketone, Radix Glycyrrhizae are looked into and ketone A, podocarpusflavone A compounding) stability is bright Show better than embodiment 5-7 (phellinus ketone, Radix Glycyrrhizae are looked into and arbitrarily the two compounds in ketone A, podocarpusflavone A).

Claims (1)

1. a kind of Renshen Guipi Wan, it is characterised in that be prepared from by the raw material of following weight parts：Radix Ginseng 35-45 parts, the Rhizoma Atractylodis Macrocephalae 75-85 parts, Poria 75-85 parts, Radix Glycyrrhizae Preparata 18-22 parts, Radix Astragali Preparata 35-45 parts, Radix Angelicae Sinensis 75-85 parts, Radix Aucklandiae 18-22 parts, Radix Polygalae 75-85 parts, Arillus Longan 75-85 parts, Semen Ziziphi Spinosae 35-45 parts, correctivess 0.09-0.9 parts, antioxidant 0.5-2.5 parts.
Described correctivess are mixed by sodium alginate, sodium citrate, sodium carboxymethyl cellulose, the sodium alginate, Fructus Citri Limoniae Sour sodium, the mass ratio of sodium carboxymethyl cellulose are (1-3)：(1-3)：(1-3).
Described antioxidant is looked into by phellinus ketone, Radix Glycyrrhizae and ketone A, podocarpusflavone A are mixed, and the phellinus ketone, Radix Glycyrrhizae are looked into And the mass ratio of ketone A, podocarpusflavone A is (1-3)：(1-3)：(1-3).
CN201610962684.2A 2016-11-04 2016-11-04 Renshen Guipi Wan Withdrawn CN106491800A (en)

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