CN106474452A - For improving Chinese medicine composition and the preparation method and applications of halitosis - Google Patents

For improving Chinese medicine composition and the preparation method and applications of halitosis Download PDF

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CN106474452A
CN106474452A CN201611268834.6A CN201611268834A CN106474452A CN 106474452 A CN106474452 A CN 106474452A CN 201611268834 A CN201611268834 A CN 201611268834A CN 106474452 A CN106474452 A CN 106474452A
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chinese medicine
medicine composition
halitosis
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improving
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不公告发明人
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Hunan Hua Hua Biological Technology Co Ltd
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Hunan Hua Hua Biological Technology Co Ltd
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
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    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/07Basidiomycota, e.g. Cryptococcus
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    • A61K36/575Magnolia
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718Coptis (goldthread)
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    • A61K36/8968Ophiopogon (Lilyturf)
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    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8994Coix (Job's tears)
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    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
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    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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Abstract

The invention discloses a kind of Chinese medicine composition for improving halitosis and preparation method and applications, the active ingredient of the Chinese medicine composition is prepared from by the bulk drug of following weight parts:39 parts of dried orange peel, 36 parts of the banksia rose, 20 30 parts of coix seed, 9 15 parts of Poria cocos, 39 parts of the bark of official magnolia, 36 parts of cardamom, 6 12 parts of radix glehniae, 6 12 parts of the tuber of dwarf lilyturf, 36 parts of ginger, 24 parts of the coptis, 39 parts of caulis bambusae in taenian.Chinese medicine composition compatibility of the present invention is reasonable, all medicines share, and playing altogether improves the effect of damp heat in the spleen and the stomach caused halitosis.

Description

For improving Chinese medicine composition and the preparation method and applications of halitosis
Technical field
The present invention relates to the field of Chinese medicines, more particularly to a kind of Chinese medicine composition for improving halitosis and preparation method and Its application.
Background technology
Halitosis refers to give out a kind of illness of dirty smelly smell in oral cavity, shows as having obvious stink when exhaling more.Typically Be apt to occur in the elderly, usually affect people's social interaction, had even causes mental handicape, especially in modern society with The contacts of people are more frequent, therefore halitosis brings many worries and inconvenience to its work and life, and these patients are often to gargle, brush Tooth is eaten chewing gum to alleviate oral cavity smell, however, these are all cured the symptoms, not the disease, it is difficult to reach the purpose of radical cure.
Content of the invention
Based on this, one of the object of the invention is to provide a kind of Chinese medicine composition for improving halitosis.
The concrete technical scheme for solving above-mentioned technical problem is as follows:
A kind of Chinese medicine composition for improving halitosis, the active ingredient of the Chinese medicine composition is by the original of following weight parts Material medicine is prepared from:Dried orange peel 3-9 part, banksia rose 3-6 part, coix seed 20-30 part, Poria cocos 9-15 part, bark of official magnolia 3-9 part, cardamom 3-6 Part, radix glehniae 6-12 part, tuber of dwarf lilyturf 6-12 part, ginger 3-6 part, coptis 2-4 part, caulis bambusae in taenian 3-9 part.
Preferably, the active ingredient of the Chinese medicine composition is prepared from by the bulk drug of following weight parts:Dried orange peel 4-8 Part, banksia rose 4-6 part, coix seed 20-25 part, Poria cocos 10-14 part, bark of official magnolia 4-8 part, cardamom 4-6 part, radix glehniae 8-11 part, the tuber of dwarf lilyturf 8-11 part, ginger 4-6 part, coptis 2-3 part, caulis bambusae in taenian 4-8 part.
Preferably, the active ingredient of the Chinese medicine composition is prepared from by the bulk drug of following weight parts:Dried orange peel 5-6 Part, banksia rose 5-6 part, coix seed 20-22 part, Poria cocos 12-13 part, bark of official magnolia 5-6 part, cardamom 5-6 part, radix glehniae 8-9 part, tuber of dwarf lilyturf 8- 9 parts, ginger 5-6 part, coptis 2-3 part, caulis bambusae in taenian 5-6 part.
Another object of the present invention is to a kind of above-mentioned preparation method for improving the Chinese medicine composition of halitosis is provided, bag Include following steps:
1) dried orange peel, coix seed, Poria cocos, the bark of official magnolia, cardamom, radix glehniae, the tuber of dwarf lilyturf, ginger, the coptis and caulis bambusae in taenian are first decocted;
2) descend the banksia rose afterwards, filter, you can.
Preferably, step 1) decoction time be 10-30min.
Preferably, step 2) banksia rose decocting time be 5-10min.
Another object of the present invention is to it is damp heat in the spleen and the stomach caused for improving in preparation to provide a kind of above-mentioned Chinese medicine composition The medicine of halitosis or health products in application.
The pharmacological property of each bulk drug of Chinese medicine composition of the present invention and effect as follows:
Dried orange peel:Bitter, pungent, temperature.Return lung, the spleen channel.Regulating qi-flowing for strengthening spleen is eliminating dampness and eliminating phlegm.For abdominal fullness and distention, deficiency of food is spitted blood, cough Abundant expectoration.
The banksia rose:Pungent, bitter, temperature.Returns spleen, stomach, large intestine, three burnt, gallbladder channels.Promoting qi circulation and relieving pain, reinforcing spleen to promote digestion.For chest side of body, gastral cavity abdomen Distending pain, weight after rush down dysentery, dyspepsia, do not feel like eating.Roasted RADIX AUCKLANDIAE reality intestines antidiarrheal.For stomachache of having loose bowels.
Coix seed:Sweet, light, cool.Returns spleen, stomach, lung channel.Clearing damp and promoting diuresis, invigorating the spleen to arrest diarrhea, except numbness, apocenosis, detoxicating and resolving a mass.With In oedema, tinea pedis, difficult urination, splenasthenic diarrhea, arthritis with fixed pain caused by dampness contraction, lung carbuncle, acute appendicitis, wart, cancerous swelling.
Poria cocos:Sweet, light, put down.The thoughts of returning home, lung, spleen, kidney channel.Clearing damp and promoting diuresis, invigorating the spleen, calming heart.For oedema oliguria, phlegm and retained fluid is dizzy Throb with fear, spleen eating less, loose stool are had loose bowels, confused and worried, insomnia of palpitating with fear.
The bark of official magnolia:Bitter, pungent, temperature.Returns spleen, stomach, lung, large intestine channel.Eliminating dampness dissolving phlegm, lower gas removes full.For in humidity hysteresis wound, gastral cavity ruffian is told Rush down, stagnation of QI due to dyspepsia, abdominal distention constipation, phlegm and retained fluid is breathed with cough.
Cardamom:Pungent, temperature.Return lung, spleen, stomach.Dampness elimination promoting the circulation of qi, warming middle energizer to arrest vomiting, appetite-stimulating indigestion-relieving.For turbi damp obstructing in middle-JIAO, do not think Diet, damp-warm syndrome is from the beginning of uncomfortable in chest not hungry, cold-dampness is vomitted inverse, chest and abdomen swelling and pain, dyspepsia.
Radix glehniae:Sweet, slight bitter, is slightly cold.Attach to the lung and stomach meridians.Nourishiing yin to clear away the lung-heat, reinforcing stomach reg fluid.For lung-heat type cough, labor is coughed phlegm Blood, deficiency of stomach-Yin, pyreticosis Tianjin are hindered, dry throat and mouth.
The tuber of dwarf lilyturf:Sweet, slight bitter, is slightly cold.The thoughts of returning home, lung, stomach.Nourishing Yin and promoting production of body fluid, moistening lung clears away heart-fire.For dryness of the lung dry cough, deficiency of Yin labor Cough, larynx numbness pharyngalgia, injury thirst, Heat Diabetes, vexed insomnia, dry constipation of intestines.
Ginger:Pungent, tepor.Return lung, spleen, stomach.Relieving exterior syndrome and dispelling cold, warming middle energizer to arrest vomiting, preventing phlegm from forming and stopping coughing, solving toxin of fish and crab.For wind Cold flu, gastrofrigid vomiting, cold productive cough are coughed, fish and crab poisoning.
The coptis:Hardship, trembles with fear.The thoughts of returning home, spleen, stomach, liver, courage, large intestine channel.Heat-clearing and damp-drying drug, purging intense heat and detonicating.For damp and hot feeling of fullness, vomit Tell acid regurgitation, rush down dysentery, jaundice, unconsciousness due to high fever, heart-fire hyperactivity, dysphoria and insomnia, palpitation and uneasiness, blood-head tells nosebleed, hot eyes, toothache, quench one's thirst, Carbuncle swells furunculosis;Eczema is controlled outward, and wet sore, duct are suppurated.It is burning hot that prepared RHIZOMA COPTIDIS with vino is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For hot eyes, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach and Stomach preventing or arresting vomiting.Mutually tie for fever and chills, damp and hot middle resistance, feeling of fullness is vomitted.Cornel coptis are relaxed liver anti-vomiting.For liver-stomach disharmony, vomiting is gulped down Acid.
Caulis bambusae in taenian:Sweet, it is slightly cold.Return lung, stomach, the heart, gallbladder channel.Clearing heat and eliminating phlegm, relieving restlessness, preventing or arresting vomiting.For phlegm-heat cough, courage fire is held under the arm Phlegm, palpitation with fear is not peaceful, vexed insomnia, middle wind phlegm vomiting, pernicious vomiting, fetal irritability.
Of the present invention a kind of for improving Chinese medicine composition of halitosis and its preparation method and application with following excellent Point and beneficial effect:
1) Chinese medicine composition compatibility of the present invention is reasonable, and all medicines share is significantly improved because of taste by invigorating the spleen and stomach Damp and hot caused halitosis.
2) preparation method of the present invention is simple, convenient.
Specific embodiment
Below with reference to specific embodiment, the present invention will be further described, clearer so as to those skilled in the art The solution present invention, but and it is not so limited the present invention.
Embodiment 1
The present embodiment is related to a kind of Chinese medicine composition for improving halitosis, and its active ingredient is by the bulk drug of following weight It is prepared from:Dried orange peel 6g, banksia rose 6g, coix seed 22g, Poria cocos 12g, bark of official magnolia 6g, cardamom 6g, radix glehniae 9g, tuber of dwarf lilyturf 9g, ginger 6g, coptis 3g, caulis bambusae in taenian 6g.
The above-mentioned preparation method for improving the Chinese medicine composition of halitosis, step are as follows:
First take dried orange peel, coix seed, Poria cocos, the bark of official magnolia, cardamom, radix glehniae, the tuber of dwarf lilyturf, ginger, the coptis and caulis bambusae in taenian and decoct 10- 30min, then the lower banksia rose, decoct 5-10min, filter, and take filter residue and continue to decoct, filter, merge filtrate twice, you can.
Embodiment 2
The present embodiment is related to a kind of Chinese medicine composition for improving halitosis, and its active ingredient is by the bulk drug of following weight It is prepared from:Dried orange peel 3g, banksia rose 3g, coix seed 20g, Poria cocos 9g, bark of official magnolia 3g, cardamom 3g, radix glehniae 6g, tuber of dwarf lilyturf 6g, ginger 3g, Coptis 2g, caulis bambusae in taenian 3g.
The above-mentioned preparation method reference embodiment 1 for improving the Chinese medicine composition of halitosis.
Embodiment 3
The present embodiment is related to a kind of Chinese medicine composition for improving halitosis, and its active ingredient is by the bulk drug of following weight It is prepared from:Dried orange peel 8g, banksia rose 6g, coix seed 25g, Poria cocos 14g, bark of official magnolia 8g, cardamom 6g, radix glehniae 10g, tuber of dwarf lilyturf 10g, ginger 6g, coptis 3g, caulis bambusae in taenian 8g.
The above-mentioned preparation method reference embodiment 1 for improving the Chinese medicine composition of halitosis.
Beneficial effects of the present invention are described further below in conjunction with model case in practice.
First, diagnostic criteria
1st, Western medicine diagnostic criteria
The Rosenberg scoring scheme that recommends by the symposium of international halitosis in 1999 is divided into three degree
Slight halitosis:Slight halitosis, has peculiar smell certainly, but very slight;
Severe halitosis:Obvious halitosis;
Severe halitosis:Serious halitosis but examiner still bear hard, notably fetor, and examiner cannot stand.
2nd, tcm diagnosis standard
Syndrome of dampness-heat of spleen and stomach:Primary symptom:A, gastral cavilty ruffian is swollen or pain;B, red tongue body, yellow and greasy fur is yellow thick.Secondary disease:A, gastral cavilty burn Heat;B, bitter taste halitosis;C, n and V;D, stool are viscid;E, slippery and rapid pulse moisten number.Card type determines:Possess primary symptom 2 plus time disease 1, or primary symptom the 1st plus time disease 2.
2nd, exclusion standard
A, gastroscope or barium check the alimentary canal structural disease change person such as Diagnosis of Peptic Ulcer, cancer of the stomach thoroughly;
B, the department of stomatology check periodontitis, the suffering from oral disease such as gingivitis;
C, there is smoking history person in the recent period, in the recent period the food of feed tanginess, or the person that takes some drugses;
D, with internal organs serious disease or other systems disease, the observation that such as cirrhosis, uremia etc. may affect the treatment Person;
E, women's pregnancy, menstrual period, nursing period person.
3rd, inclusive criteria
A, all while meet traditional Chinese and western medicine diagnostic criteria, and there is no any one person in exclusion standard;
B, 18-60 year person of age;
The experimenter of test is participated in c, voluntarily cooperation.
4th, clinical data
According to case selection standard, Eligibility 100, be divided into treatment group 1 (25, man 11, female 14, average year Age 30-52 year, the average course of disease 3-10 month, slight halitosis 12, moderate halitosis 11, severe halitosis 2), treatment group 2 (25, Man 10, female 15, average age 32-53 year, the average course of disease 4-12 month, slight halitosis 9, moderate halitosis 14, severe mouth Smelly 2), treatment group 3 (25, man 12, female 13, average age 31-52 year, the average course of disease 3-11 month, slight halitosis 11 Example, moderate halitosis 13, severe halitosis 1), control group (25, man 14, female 11, average age 35-55 year, average disease The journey 3-12 month, slight halitosis 10, moderate halitosis 14, severe halitosis 1), four groups in the side such as sex, the course of disease and pathology weight Noodles part nothing significant difference, with comparativity.
5th, treatment method
Treatment group 1-3 takes the Chinese medicine composition obtained by embodiment 1-3 respectively, 2 times/day.Control group is taken:Dried orange peel 6g, banksia rose 6g, coix seed 22g, Poria cocos 12g, bark of official magnolia 6g, ginger 6g, coptis 3g, caulis bambusae in taenian 6g, preparation method is with reference to embodiment 1,2 Times/day.The course for the treatment of is 2 weeks, disables other drugs, it is to avoid pungent cold and cool food during treatment.
6th, criterion of therapeutical effect
It is almost recovered:Halitosis symptom disappears;
Effectively:Halitosis symptom mitigation, degree reduce;
Invalid:It is not improved.
7th, treatment results
Four groups of comparitive study the results are shown in Table 1.As it can be seen from table 1 total effective rate treatment group 1>Treatment group 3>Treatment group 2> Control group.Illustrate that the Chinese medicine composition obtained by embodiment can significantly improve damp heat in the spleen and the stomach caused halitosis symptom.Four groups of treatments Obvious adverse reaction is had no in front and back, and blood, routine urinalysis and biochemical indicator have no abnormal changes.
Table 1
Group Example Recovery from illness Effectively Invalid Total effective rate
Control group 25 10 9 6 76%
Treatment group 1 25 16 7 2 92%
Treatment group 2 25 13 8 4 84%
Treatment group 3 25 15 7 3 88%

Claims (7)

1. a kind of Chinese medicine composition for improving halitosis, it is characterised in that the active ingredient of the Chinese medicine composition is by following The bulk drug of weight portion is prepared from:Dried orange peel 3-9 part, banksia rose 3-6 part, coix seed 20-30 part, Poria cocos 9-15 part, bark of official magnolia 3-9 Part, cardamom 3-6 part, radix glehniae 6-12 part, tuber of dwarf lilyturf 6-12 part, ginger 3-6 part, coptis 2-4 part, caulis bambusae in taenian 3-9 part.
2. the Chinese medicine composition for improving halitosis according to claim 1, it is characterised in that the Chinese medicine composition Active ingredient is prepared from by the bulk drug of following weight parts:Dried orange peel 4-8 part, banksia rose 4-6 part, coix seed 20-25 part, Poria cocos 10-14 part, bark of official magnolia 4-8 part, cardamom 4-6 part, radix glehniae 8-11 part, tuber of dwarf lilyturf 8-11 part, ginger 4-6 part, coptis 2-3 part, caulis bambusae in taenian 4-8 part.
3. the Chinese medicine composition for improving halitosis according to claim 2, it is characterised in that the Chinese medicine composition Active ingredient is prepared from by the bulk drug of following weight parts:Dried orange peel 5-6 part, banksia rose 5-6 part, coix seed 20-22 part, Poria cocos 12-13 part, bark of official magnolia 5-6 part, cardamom 5-6 part, radix glehniae 8-9 part, tuber of dwarf lilyturf 8-9 part, ginger 5-6 part, coptis 2-3 part, caulis bambusae in taenian 5-6 Part.
4. a kind of preparation method for improving the Chinese medicine composition of halitosis as described in above-mentioned any one of claim 1-3, its It is characterised by, comprises the steps:
1) dried orange peel, coix seed, Poria cocos, the bark of official magnolia, cardamom, radix glehniae, the tuber of dwarf lilyturf, ginger, the coptis and caulis bambusae in taenian are first decocted;
2) descend the banksia rose afterwards, filter, you can.
5. the preparation method for improving the Chinese medicine composition of halitosis according to claim 4, it is characterised in that step 1) The time of the decoction is 10-30min.
6. the preparation method for improving the Chinese medicine composition of halitosis according to claim 4, it is characterised in that step 2) The decocting time of the banksia rose is 5-10min.
7. damp heat in the spleen and the stomach for improving in preparation for improving the Chinese medicine composition of halitosis as described in any one of claim 1-3 Application in the medicine of caused halitosis or health products.
CN201611268834.6A 2016-12-31 2016-12-31 For improving Chinese medicine composition and the preparation method and applications of halitosis Pending CN106474452A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101259263A (en) * 2008-04-21 2008-09-10 北京中科仁和科技有限公司 Medicaments assembly for treating stomach-heat moisture resistance type obesity and preparation thereof
CN102441134A (en) * 2011-12-08 2012-05-09 张学忠 Chinese herbal medicinal composition, preparation, and preparation method and application thereof
CN103610986A (en) * 2013-12-06 2014-03-05 山东省立医院 Medicine for treating ozostomia

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101259263A (en) * 2008-04-21 2008-09-10 北京中科仁和科技有限公司 Medicaments assembly for treating stomach-heat moisture resistance type obesity and preparation thereof
CN102441134A (en) * 2011-12-08 2012-05-09 张学忠 Chinese herbal medicinal composition, preparation, and preparation method and application thereof
CN103610986A (en) * 2013-12-06 2014-03-05 山东省立医院 Medicine for treating ozostomia

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