CN106474312A - A kind of tonifying kidney and benefiting sperm capsule and preparation method thereof - Google Patents
A kind of tonifying kidney and benefiting sperm capsule and preparation method thereof Download PDFInfo
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Abstract
The invention provides a kind of tonifying kidney and benefiting sperm capsule and preparation method thereof, described capsule contains following material：Morinda officinalis water extract, raspberry water extract, pilose antler water extract, Chinese yam water extract, saline cistanche alcohol extracting thing, fructus schisandrae alcohol extracting thing, root of bidentate achyranthes alcohol extracting thing, prepared rhizome of rehmannia alcohol extracting thing, cornusol extract, hippocampus powder, lactose and soluble starch and 75% ethanol.Prior art is compared, preparation process is simple of the present invention.Obtained tonifying kidney and benefiting sperm capsule increases can oligoasthenospermia patient's semen volume, and sperm motility is improved, progressive sperm increasing number, and wherein shared by a+b class sperm, percentage is improved, and have preferably the soreness of waist of dispelling, and strengthening the muscles and bones is acted on.
Description
Technical field
The invention belongs to field of medicaments, more particularly to a kind of tonifying kidney and benefiting sperm capsule and preparation method thereof.
Background technology
Kidney deficiency refers to that kidney vital essence negative and positive are not enough, and the species of kidney deficiency has a lot, and most common of which is kidney-yin deficiency, kidney-yang deficiency.
The symptom of kidney deficiency：The symptom of kidney-yang deficiency is the soreness of waist, coldness of extremities, chilly, or even also oedema, is the symptom of " trembling with fear ", sexual function
Bad also result in kidney-yang deficiency；The symptom of kidney-yin deficiency is " heat ", mainly has the soreness of waist, scorching, night sweat, abnormal sweating, dizziness, tinnitus etc..
When people occurs kidney deficiency, no matter kidney-yin deficiency or kidney-yang deficiency, can all cause the reduction of the immunocompetence of people.
As kidney has the difference of the deficiency of Yin, the deficiency of yang, essence void, the deficiency of vital energy, kidney tonifying just has kidney tonifying, nourishing kidney-yin, kidney-nourishing gas, fills out kidney essense etc.
Etc. different approach and different medications.But currently but having a kind of mistake to tend to, i.e., in health products based on qi-restoratives, qi-restoratives
Based on kidney tonifying, kidney tonifying causes the product of tonifying kidney and strengthening yang to be abused again based on kidney-replenishing.
Therefore a kind of good medicine of effectively treatment kidney deficiency is the expectation of extensive patients.
Content of the invention
It is an object of the invention to provide a kind of tonifying kidney and benefiting sperm capsule, containing plurality of Chinese extract component, using secure side
Just, lasting medicine, medication are simple.
Another object of the present invention is to providing a kind of preparation method of tonifying kidney and benefiting sperm capsule.
A kind of tonifying kidney and benefiting sperm capsule of the offer of the present invention, containing following raw material：
The preparation method of the Morinda officinalis water extract：
Morinda officinalis meal is weighed, 0.25-0.75h is soaked, 90-100 DEG C is heated to, decoct and extract 3 times, add for the first time
10-18 times of water, extracts 0.5-2h, second plus 10-15 times of water, extracts 0.5-1.5h, third time plus 8-12 times of water, extracts
0.5-1.5h, uses filtered through gauze every time, and merging filtrate, filtrate be concentrated into viscous pasty state, then is placed on water-bath and steams to just not flowing
Dynamic state, be put in 40-80 DEG C of baking oven dry, be ground into 40-80 mesh sieve fine powder, obtain water extract be placed in standby in drier
With；
The preparation method of the raspberry water extract：
Raspberry meal is weighed, 0.25-0.75h is soaked, 90-100 DEG C is heated to, decoct and extract 2 times, add for the first time
12-18 times of water, extracts 1-2.5h, second plus 10-15 times of water, extracts 1-2.5h, every time with filtered through gauze, merging filtrate,
Filtrate is concentrated into viscous pasty state, then is placed on water-bath and steams to just not flow regime, is put in 40-80 DEG C of baking oven and dries, crushes
Became 40-80 mesh sieve fine powder, obtain water extract be placed in standby in drier；
The preparation method of the pilose antler water extract：
Pilose antler meal is weighed, 0.25-0.75h is soaked, 90-100 DEG C is heated to, heating decocts extraction 4 times, for the first time
Plus 18-25 times of water, 1-2.5h is extracted, second plus 15-18 times of water, extract 1-2h, third time plus 10-12 times of water, extract
0.5-1.5h, the 4th time plus 8-10 times of water, 0.5-1.5h is extracted, each suction filtration, merging filtrate, filtrate are concentrated into viscous pasty state,
It is placed on water-bath again and steams to firm not flow regime, is put in 40-80 DEG C of baking oven and dries, 40-80 mesh sieve fine powder was ground into, is obtained
Water extract is placed in standby in drier；
The preparation method of the Chinese yam water extract：
Chinese yam is weighed, 0.25-0.75h is soaked, 90-100 DEG C is heated to, heating is decocted extracts 3 times, adds for the first time
10-18 times of water, extracts 1-2.5h, second plus 10-12 times of water, extracts 0.5-1.5h, third time plus 8-10 times of water, extracts
0.5-1.5h, uses filtered through gauze every time, and merging filtrate, filtrate be concentrated into viscous pasty state, then is placed on water-bath and steams to just not flowing
Dynamic state, be put in 40-80 DEG C of baking oven dry, be ground into 40-80 mesh sieve fine powder, obtain water extract be placed in standby in drier
With.
The preparation method of the saline cistanche alcohol extracting thing：
Saline cistanche meal being weighed, 0.25-0.75h being soaked with 70% ethanol, then heating and refluxing extraction 3 times, first time add
10-18 times of 70% ethanol, extraction 1-2.5h, second plus 8-15 times of 70% ethanol, 0.5-1.5h is extracted, third time adds 8-12 times
70% ethanol, extraction 0.5-1.5h, each suction filtration, merging filtrate, filtrate reduced in volume is to viscous pasty state, then is placed on water-bath
Steam to not flow regime, be put in 40-80 DEG C of baking oven and dry, 40-80 mesh sieve fine powder was ground into, is obtained alcohol extracting thing and is placed in drying
Standby in device；
The preparation method of the fructus schisandrae alcohol extracting thing：
Weigh fructus schisandrae meal, with 70% ethanol soak 0.25-0.75h, then heating and refluxing extraction 2 times, for the first time
Plus 10-18 times of 70% ethanol, 1-2.5h is extracted, second plus 8-15 times of 70% ethanol, extract 0.5-1.5h, each suction filtration, conjunction
And filtrate, ethanol is reclaimed with Rotary Evaporators, be concentrated into viscous pasty state, then be placed on water-bath and steam to not flow regime, be put in
In 40-80 DEG C of baking oven dry, be ground into 40-80 mesh sieve fine powder, obtain alcohol extracting thing be placed in standby in drier；
The preparation method of the root of bidentate achyranthes alcohol extracting thing：
Root of bidentate achyranthes meal is weighed, and 0.25-0.75h is soaked with 10-15 times of 80% ethanol, then heating and refluxing extraction 3 times, every time
0.5-2.5h, filters every time, merging filtrate, reclaims ethanol with Rotary Evaporators, then is placed on water-bath and steams to not flow regime,
Be put in 40-80 DEG C of baking oven dry, be ground into 40-80 mesh sieve fine powder, obtain root of bidentate achyranthes alcohol extracting thing be placed in standby in drier；
The preparation method of the prepared rhizome of rehmannia alcohol extracting thing：
Prepared rhizome of rehmannia is weighed, and 0.25-0.75h, then heating and refluxing extraction 3 times, each use is soaked with 10-15 times of 20% ethanol
10-15 times of 20% ethanol, each 1-2.5h, filters every time, merging filtrate, reclaims ethanol with Rotary Evaporators, then be placed in water-bath
Steam to not flow regime on pot, be put in 40-80 DEG C of baking oven and dry, 40-80 mesh sieve fine powder was ground into, obtains prepared rhizome of rehmannia alcohol extracting
Thing is placed in standby in drier；
The preparation method of the cornusol extract：
Fructus Corni is weighed, and 0.25-0.75h, then heating and refluxing extraction 3 times, each use is soaked with 8-12 times of 80% ethanol
10-15 times of 20% ethanol, each 1-2.5h, filters every time, merging filtrate, reclaims ethanol with Rotary Evaporators, then be placed in water-bath
Steam to not flow regime on pot, be put in 40-80 DEG C of baking oven and dry, 40-80 mesh sieve fine powder was ground into, obtain cornusol extraction
Thing is placed in standby in drier.
The hippocampus powder is prepared by the following method：
Hippocampus is taken, and 40-80 mesh sieve is crossed after crushing, is obtained fine powder standby.
A kind of preparation method of tonifying kidney and benefiting sperm capsule that the present invention is provided, comprises the following steps：
A) claim the Morinda officinalis water extract of formula ratio, raspberry water extract, pilose antler water extract, Chinese yam water extract,
Saline cistanche alcohol extracting thing, fructus schisandrae alcohol extracting thing, root of bidentate achyranthes alcohol extracting thing, prepared rhizome of rehmannia alcohol extracting thing, cornusol extract, sea
Ma Fen, lactose and soluble starch, mix, obtain mixture；
B) mixture for preparing step a) is placed in pallet, sprays 75% ethanol 70-120 part, is rubbed and is touched to holding is agglomerating
Dissipate, cross 10-16 mesh sieve manual expression and sieve granulation, drying in 40-60 DEG C of baking oven is placed in, whole with 10-30 mesh, 40-80 mesh sieve
Grain, can pass through 10-30 mesh sieve, it is impossible to be wanted particle by the particle of 40-80 mesh sieve；
C) by pelleting capsule board fill capsule, obtain final product tonifying kidney and benefiting sperm capsule.
Various composition in the present invention is as follows：
Fructus Corni taste is sour, puckery, and slightly warm in nature returns liver and kidney channel, with tonifying the liver and kidney, puckery essence solid de-, only band only collapse, restrain and stop
Sweat, the effect for promoting the production of body fluid to quench thirst.Be mainly used in treat dizziness and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, uterine bleeding under band, greatly
Sweat is collapsed, the disease such as Heat Diabetes.Because it is the medicine of flat tonifying yin sun simply, no matter the deficiency of Yin or the deficiency of yang, can all use.
《Do not record》：" stomach ailment said due to cold or exposure, fever and chills hernia lump in the abdomen, head wind, general mood go to come, and nasal obstruction, mesh are yellow, deaf, pimples, middle benefit gas, and lower gas is perspired, by force
The moon, benefit essence, five viscera settling, lead to nine orifices, only little facility, improving eyesight, strongly.”
The ripe use filling liver kidney of the root of bidentate achyranthes, strengthening the bones and muscles, can kidney tonifying, essence replenishing, control control waist and knee ostalgia, spasm of limbs, impotence etc., for waist and knee
Ache, muscles and bones is powerless.《Do not record》：" few gas in curing the wound, male kidney yin disappear, and old man loses and drowns, and bowl spares is continuous to fill out marrow absolutely, except pain in brain and
Pain along spinal column, married woman's moon water are obstructed, and blood is tied, benefit essence, and Li Yin gas only turns white.Life scattered blood stasis, subduing inflammation.”
Morinda officinalis taste is pungent, sweet, slightly warm in nature, return kidney, Liver Channel.Can tonify the kidney and support yang, dispelling wind and eliminating dampness.Impotence due to deficiency of the kidney is cured mainly, is lost
Smart premature ejaculation, muscles and bones impotence, few abdomen crymodynia, arthralgia due to wind-dampness, kidney deficiency soreness and weakness of waist and knees and Xu Leiyang road are not lifted.《Book on Chinese herbal medicine justice》：" taste
Pungent, temperature, specially enter kidney man, for inspiring yang-energy to be used.Temperature supports Yuanyang, then perverse trend is removed certainly, an impotence, strengthening the bones and muscles, benefit essence, controls underbelly
Coupling pain, all effect of warming kidney for dispelling cold in the moon ".
Raspberry has liver-kidney tonifying, effect of astringent sperm contracting urine.Cure mainly impotence and premature ejaculation, emission and spermatorrhea and poliosis etc..
It is usually used in emission and spermatorrhea, enuresis frequent micturition, impotence and premature ejaculation, mesh are secretly dim-sighted.《Book on Chinese herbal medicine justice》：" raspberry is for nourishing Kidney-Yin medicine, taste
Micro- acid is carried, the cloudy gas and production of sperm liquid for taking the photograph dissipation can be received, specially enters kidney yin, the hard kidney qi of energy, strong will times power have son, all effect of benefiting kidney-YIN
?.”
Pilose antler has stronger antifatigue effect, can strengthen tolerance to cold, accelerated wound healing and stimulation adrenal cortex
Function.Therefore pilose antler is traditional tonic, for strong, kidney tonifying, Yiyang.To kidney-yang deficiency, asthenia of essence and blood card, darkish complexion,
The cold foot of foot is swollen, limbs shape is thin, and sufficient knee is weak, and difficult urination etc. has good curative effect.Cure mainly kidney deficiency, kidney-yang deficiency, asthenia of essence and blood,
The diseases such as dizzy mesh is dark, impotence and seminal emission and waist and knee crymodynia.
Saline cistanche is sweet, salty, warm in nature.Return kidney, large intestine channel.Energy kidney-replenishing, benefiting essence-blood.Main decline of kidney-YANG, asthenia of essence and blood it
Impotence, seminal emission, the frequent micturition heeltap, pain in the back flaccidity of lower limbs etc..《Bencao Jingshu》：" saline cistanche, the key medicine of nourshing kidney replenishing vital essence and blood.”
Prepared rhizome of rehmannia has functions that enrich blood moist and beneficial essence fill out marrow.Prepared rhizome of rehmannia be used for the hectic fever hectic fever due to yin of the deficiency of the kidney yin, night sweat,
Pass out semen, quench one's thirst.Can also be used for blood deficiency chlorosis, dizziness palpitaition, liver-kidney Yin deficiency, hectic fever night sweat, seminal emission impotence, soreness and weakness of waist and knees, palpus
Send out early bletilla syndrome characterized by dyspnea etc..
Hippocampus have physical fitness, tonifying kidney and strengthening yang, stimulate the circulation of the blood and cause the muscles and joints to relax, anti-inflammatory analgetic, tranquilizing and allaying excitement, warming kidney and enhancing body, dissipating bind disappear
The medicinal function such as swollen, can be used for impotence, the enuresis, kidney deficiency etc..The favor of people is enjoyed since ancient times, and men are even more feelings to be had solely
Clock.
Chinese yam is sweet, mild-natured；Return lung, spleen, kidney channel.Seminal emission, kidney deficiency frequent micturition can be treated.Have functions that reinforce the kidney beneficial essence, grow
The smart strong body of kidney benefit, the effect of nourishing kidney and replenishing pneuma.Generally the disease such as deficiency of the kidney seminal emission, frequent urination, can all take it.
Fructus schisandrae has restrains astringent or styptic treatment for spontaneous sweating, nourishing generate fluid, kidney calming.Can be used for emission, enuresis frequent micturition,
Spontaneous sweating, injury thirst, feeble pulse of losing heart, Heat Diabetes and palpitation and insomnia etc..
Capsule made by this product, in its capsule shells, content becomes brown granular shape, and granular size is moderate, and smell is dense
Strongly fragrant, good fluidity, good stability.
Compared with prior art, the capsule that the present invention is provided contains plurality of Chinese extract component, Fructus Corni tonifies the liver and kidney,
Puckery essence is solid de-；Root of bidentate achyranthes kidney tonifying, essence replenishing；Morinda officinalis cures mainly impotence due to deficiency of the kidney, premature ejaculation of passing out semen；Raspberry liver-kidney tonifying, astringent sperm contracting urine；Deer
Fine and soft kidney tonifying, Yiyang；Saline cistanche kidney-replenishing, benefiting essence-blood；Prepared rhizome of rehmannia benefit essence fills out marrow；Hippocampus tonifying kidney and strengthening yang；Chinese yam reinforce the kidney beneficial essence；North five
Taste is used for emission.Various both effectiveness compositions complement each other, and strengthen immunity, liver-kidney tonifying, warm liver establishing-Yang etc. with adjusting
Effect；Several Chinese medicines are mutually cooperateed with, and play a part of tonifying kidney and benefiting sperm.And, the tonifying kidney and benefiting sperm capsule that the application is provided is using peace
Full convenience, lasting medicine, medication are simple.Contain hormone with Western medicine, substantially, many patients take medicine all right, are discontinued for side effect
The features such as just recurring is compared, and the traditional Chinese medicine ingredients contained by the present invention have no side effect, and absorbs fast, markedly fast, good mouthfeel.?
Multiple conditionings can also be carried out to internal organ while treatment so as to the effects such as with more tonifying kidney and benefiting sperm, strengthen immunity, with very
Wide market prospects.
Specific embodiment
With reference to embodiment, the present invention will be further described.
Embodiment 1
A kind of tonifying kidney and benefiting sperm capsule, the raw material containing following weight：
1.1 each water extracts are extracted by the following method：
A) preparation of Morinda officinalis water extract
400g Morinda officinalis meal is weighed, 0.25h is soaked, 90 DEG C are heated to, decoct and extract 3 times, add 10 times for the first time
Water, extract 0.5h, second plus 10 times of water, extract 0.5h, third time plus 8 times of water, extract 0.5h, use filtered through gauze every time,
Merging filtrate, filtrate are concentrated into viscous pasty state, then are placed on water-bath and steam to just not flow regime, are put in 40 DEG C of baking ovens and dry
Dry, be ground into 40 mesh sieve fine powders, obtain water extract be placed in standby in drier；
B) preparation of raspberry water extract
400g raspberry meal is weighed, 0.25h is soaked, 90 DEG C are heated to, decoct and extract 2 times, add 12 times for the first time
Water, extract 1h, second plus 10 times of water, extract 2.5h, use filtered through gauze every time, merging filtrate, filtrate are concentrated into thick
State, then be placed on water-bath and steam to just not flow regime, it is put in 40 DEG C of baking ovens and dries, 40 mesh sieve fine powders was ground into, obtains water
Extract is placed in standby in drier；
C) preparation of pilose antler water extract
200g pilose antler meal is weighed, 0.25h is soaked, 90 DEG C are heated to, heating is decocted extracts 4 times, Jia 18 for the first time
Water again, extraction 1h, add 15 times of water second, 1h is extracted, adds 10 times of water for the third time, 0.5h is extracted, add 8 times of water the 4th time, carry
0.5h is taken, each suction filtration, merging filtrate, filtrate are concentrated into viscous pasty state, then be placed on water-bath and steam to just not flow regime, put
Dry in 40 DEG C of baking ovens, be ground into 40 mesh sieve fine powders, obtain water extract be placed in standby in drier；
D) preparation of Chinese yam water extract
400g Chinese yam is weighed, 0.25h is soaked, 90 DEG C are heated to, heating is decocted extracts 3 times, adds 10 times for the first time
Water, extracts 1h, second plus 10 times of water, extracts 0.5h, third time plus 8 times of water, extracts 0.5h, use filtered through gauze every time, merges
Filtrate, filtrate are concentrated into viscous pasty state, then are placed on water-bath and steam to just not flow regime, are put in 40 DEG C of baking ovens and dry, powder
Be broken into 40 mesh sieve fine powders, obtain water extract be placed in standby in drier.
1.2 each alcohol extracting things are extracted by the following method：
A) preparation of saline cistanche alcohol extracting thing
400g saline cistanche meal is weighed, is put in round-bottomed flask and 0.25h is soaked with 70% ethanol, be put in electric jacket and add
Heat, with refluxing extraction device refluxing extraction 3 times, for the first time plus 10 times of 70% ethanol, extracts 1h, and second plus 8 times of 70% ethanol are carried
Take 0.5h, third time plus 8 times of 70% ethanol, extract 0.5h, each suction filtration, merging filtrate, filtrate reduced in volume to viscous pasty state,
It is placed on water-bath again and steams to not flow regime, is put in 40 DEG C of baking ovens and dries, 40 mesh sieve fine powders were ground into, obtain alcohol extracting thing
It is placed in standby in drier；
B) preparation of fructus schisandrae alcohol extracting thing
300g fructus schisandrae meal is weighed, is put in round-bottomed flask and 0.25h is soaked with 70% ethanol, be put in electric jacket and add
Heat, with refluxing extraction device refluxing extraction 2 times, for the first time plus 10 times of 70% ethanol, extracts 1h, and second plus 8 times of 70% ethanol are carried
0.5h is taken, each suction filtration, merging filtrate, reclaims ethanol with Rotary Evaporators, is concentrated into viscous pasty state, then is placed in steaming on water-bath
To not flow regime, be put in 40 DEG C of baking ovens dry, be ground into 40 mesh sieve fine powders, obtain alcohol extracting thing be placed in standby in drier
With；
C) preparation of root of bidentate achyranthes alcohol extracting thing
300g root of bidentate achyranthes meal is weighed, 0.25h is soaked with 10 times of 80% ethanol, be put in electric jacket and heat, use refluxing extraction
Device refluxing extraction 3 times, each 0.5h, filters every time, merging filtrate, reclaims ethanol with Rotary Evaporators, then be placed on water-bath
Steam to not flow regime, be put in 40 DEG C of baking ovens and dry, 40 mesh sieve fine powders were ground into, are obtained root of bidentate achyranthes alcohol extracting thing and is placed in drier
In standby；
D) preparation of prepared rhizome of rehmannia alcohol extracting thing
300g prepared rhizome of rehmannia is weighed, 0.25h is soaked with 10 times of 20% ethanol, be put in electric jacket and heat, use refluxing extraction device
Refluxing extraction 3 times, every time with 10 times of 20% ethanol, each 1h, filter every time, merging filtrate, ethanol is reclaimed with Rotary Evaporators,
It is placed on water-bath again and steams to not flow regime, is put in 40 DEG C of baking ovens and dries, 40 mesh sieve fine powders were ground into, obtain cultivated land flavol
Extract is placed in standby in drier；
E) preparation of cornusol extract
300g Fructus Corni is weighed, 0.25h is soaked with 8 times of 80% ethanol, be put in electric jacket and heat, returned with refluxing extraction device
Stream is extracted 3 times, every time with 10 times of 20% ethanol, each 1h, and filter every time, merging filtrate, ethanol is reclaimed with Rotary Evaporators, then
It is placed on water-bath and steams to not flow regime, is put in 40 DEG C of baking ovens and dries, 40 mesh sieve fine powders were ground into, obtain Fructus Corni alcohol extracting
Take thing be placed in standby in drier.
The preparation of 1.3 hippocampus powder
Take 20 pairs of hippocampus, be placed in micromill be ground into 40 mesh sieves fine powder standby.
A kind of 1.4 preparations of tonifying kidney and benefiting sperm capsule：
The Morinda officinalis water extract of title formula ratio, raspberry water extract, pilose antler water extract, Chinese yam water extract, meat
Desert cistanche alcohol extracting thing, fructus schisandrae alcohol extracting thing, root of bidentate achyranthes alcohol extracting thing, prepared rhizome of rehmannia alcohol extracting thing, cornusol extract, hippocampus
Powder, lactose and soluble starch, mix, obtain mixture；
B) mixture is placed in pallet, 75% ethanol 90ml is sprayed, rubbed with hand and dissipate to agglomerating the touching of holding, cross 12 mesh sieves
Manual expression sieves granulation, is placed in 40 DEG C of baking ovens and dries, with 10 mesh, 80 mesh sieve whole grains, can pass through 10 mesh sieves, it is impossible to by 80
The particle of mesh sieve is wanted particle；
C) by pelleting capsule board fill capsule, obtain final product tonifying kidney and benefiting sperm capsule.
Embodiment 2
A kind of tonifying kidney and benefiting sperm capsule, the raw material containing following weight：
2.1 each water extracts are extracted by the following method：
A) preparation of Morinda officinalis water extract
500g Morinda officinalis meal is weighed, 0.5h is soaked, 95 DEG C are heated to, decoct and extract 3 times, add 15 times for the first time
Water, extracts 1h, second plus 12 times of water, extracts 1h, third time plus 10 times of water, extracts 1h, use filtered through gauze every time, merges filter
Liquid, filtrate are concentrated into viscous pasty state, then are placed on water-bath and steam to just not flow regime, are put in 60 DEG C of baking ovens and dry, crush
Became 60 mesh sieve fine powders, obtain water extract be placed in standby in drier；
B) preparation of raspberry water extract
500g raspberry meal is weighed, 0.5h is soaked, 95 DEG C are heated to, decoct and extract 2 times, add 15 times for the first time
Water, extracts 1.5h, second plus 12 times of water, extracts 2h, uses filtered through gauze every time, and merging filtrate, filtrate are concentrated into viscous pasty state,
It is placed on water-bath again and steams to firm not flow regime, be put in 60 DEG C of baking ovens and dry, 60 mesh sieve fine powders were ground into, obtains water extraction
Thing is placed in standby in drier；
C) preparation of pilose antler water extract
250g pilose antler meal is weighed, 0.5h is soaked, 95 DEG C are heated to, heating is decocted extracts 4 times, adds 18 times for the first time
Water, extract 1.5h, second plus 16 times of water, extract 1.5h, third time plus 10 times of water, extract 1h, the 4th time plus 10 times of water, carry
1h is taken, each suction filtration, merging filtrate, filtrate are concentrated into viscous pasty state, then be placed on water-bath and steam to just not flow regime, be put in
In 40-80 DEG C of baking oven dry, be ground into 60 mesh sieve fine powders, obtain water extract be placed in standby in drier；
D) preparation of Chinese yam water extract
500g Chinese yam is weighed, 0.5h is soaked, 95 DEG C are heated to, heating is decocted extracts 3 times, adds 16 times for the first time
Water, extracts 1.5h, second plus 10 times of water, extracts 1h, third time plus 10 times of water, extracts 1h, use filtered through gauze every time, merges filter
Liquid, filtrate are concentrated into viscous pasty state, then are placed on water-bath and steam to just not flow regime, are put in 60 DEG C of baking ovens and dry, crush
Became 60 mesh sieve fine powders, obtain water extract be placed in standby in drier.
2.2 each alcohol extracting things are extracted by the following method：
A) preparation of saline cistanche alcohol extracting thing
Saline cistanche meal 500g is weighed, is put in round-bottomed flask and 0.5h is soaked with 70% ethanol, be put in electric jacket and heat,
With refluxing extraction device refluxing extraction 3 times, for the first time plus 16 times of 70% ethanol, 1.5h is extracted, second plus 10 times of 70% ethanol, carry
Take 1h, third time plus 10 times of 70% ethanol, extract 1h, each suction filtration, merging filtrate, filtrate reduced in volume to viscous pasty state, then
It is placed on water-bath and steams to not flow regime, is put in 60 DEG C of baking ovens and dries, 60 mesh sieve fine powders were ground into, are obtained alcohol extracting thing and puts
Standby in drier；
B) preparation of fructus schisandrae alcohol extracting thing
Fructus schisandrae meal 400g is weighed, is put in round-bottomed flask and 0.5h is soaked with 70% ethanol, be put in electric jacket and add
Heat, with refluxing extraction device refluxing extraction 2 times, for the first time plus 16 times of 70% ethanol, extracts 1.5h, second plus 10 times of 70% second
Alcohol, extraction 1h, each suction filtration, merging filtrate, reclaims ethanol with Rotary Evaporators, is concentrated into viscous pasty state, then is placed in water-bath
On steam to not flow regime, be put in 60 DEG C of baking ovens dry, be ground into 60 mesh sieve fine powders, and obtained alcohol extracting thing and be placed in drier
Standby；
C) preparation of root of bidentate achyranthes alcohol extracting thing
400g root of bidentate achyranthes meal is weighed, 0.5h is soaked with 12 times of 80% ethanol, be put in electric jacket and heat, use refluxing extraction device
Refluxing extraction 3 times, each 1h, filter every time, merging filtrate, reclaim ethanol with Rotary Evaporators, then be placed on water-bath steam to
Not flow regime, is put in 60 DEG C of baking ovens and dries, be ground into 60 mesh sieve fine powders, obtain achyranthes bidentata extract be placed in standby in drier
With；
D) preparation of prepared rhizome of rehmannia alcohol extracting thing
400g prepared rhizome of rehmannia is weighed, 0.5h is soaked with 14 times of 20% ethanol, be put in electric jacket and heat, returned with refluxing extraction device
Stream is extracted 3 times, every time with 14 times of 20% ethanol, each 1.5h, and filter every time, merging filtrate, ethanol is reclaimed with Rotary Evaporators,
It is placed on water-bath again and steams to not flow regime, is put in 60 DEG C of baking ovens and dries, 60 mesh sieve fine powders were ground into, obtain cultivated land flavol
Extract is placed in standby in drier；
E) preparation of cornusol extract
500g Fructus Corni is weighed, 0.5h is soaked with 10 times of 80% ethanol, be put in electric jacket and heat, returned with refluxing extraction device
Stream is extracted 3 times, every time with 14 times of 20% ethanol, each 1.5h, and filter every time, merging filtrate, ethanol is reclaimed with Rotary Evaporators,
It is placed on water-bath again and steams to not flow regime, is put in 60 DEG C of baking ovens and dries, 60 mesh sieve fine powders were ground into, obtain cornusol
Extract is placed in standby in drier.
The preparation of 2.3 hippocampus powder
Take 25 pairs of hippocampus, be placed in micromill be ground into 60 mesh sieves fine powder standby.
A kind of 2.4 preparations of tonifying kidney and benefiting sperm capsule：
A) claim the Morinda officinalis water extract of formula ratio, raspberry water extract, pilose antler water extract, Chinese yam water extract,
Saline cistanche alcohol extracting thing, fructus schisandrae alcohol extracting thing, root of bidentate achyranthes alcohol extracting thing, prepared rhizome of rehmannia alcohol extracting thing, cornusol extract, sea
Ma Fen, lactose and soluble starch, mix, obtain mixture；
B) mixture is placed in pallet, 75% ethanol 120ml is sprayed, rubbed with hand and dissipate to agglomerating the touching of holding, cross 14 mesh
Sieve manual expression sieves granulation, is placed in drying in 50 DEG C of baking ovens, with 10 mesh, 80 mesh sieve whole grains, can pass through 10 mesh sieves, it is impossible to pass through
The particle of 80 mesh sieves is wanted particle；
C) by pelleting capsule board fill capsule, obtain final product tonifying kidney and benefiting sperm capsule.
Embodiment 3
A kind of tonifying kidney and benefiting sperm capsule, the raw material containing following weight：
3.1 each water extracts are extracted by the following method：
A) preparation of Morinda officinalis water extract
600g Morinda officinalis meal is weighed, 0.75h is soaked, 100 DEG C are heated to, decoct and extract 3 times, add 18 times for the first time
Water, extract 2h, second plus 15 times of water, extract 1.5h, third time plus 12 times of water, extract 1.5h, use filtered through gauze every time, close
And filtrate, filtrate is concentrated into viscous pasty state, then is placed on water-bath and steams to just not flow regime, is put in 80 DEG C of baking ovens and dries,
Be ground into 80 mesh sieve fine powders, obtain water extract be placed in standby in drier；
B) preparation of raspberry water extract
600g raspberry meal is weighed, 0.75h is soaked, 100 DEG C are heated to, decoct and extract 2 times, add 18 times for the first time
Water, extract 2.5h, second plus 15 times of water, extract 1h, use filtered through gauze every time, merging filtrate, filtrate are concentrated into thick
State, then be placed on water-bath and steam to just not flow regime, it is put in 80 DEG C of baking ovens and dries, 80 mesh sieve fine powders was ground into, obtains water
Extract is placed in standby in drier；
C) preparation of pilose antler water extract
300g pilose antler meal is weighed, 0.75h is soaked, 100 DEG C are heated to, heating is decocted extracts 4 times, Jia 25 for the first time
Water again, extraction 2.5h, add 18 times of water second, 2h is extracted, adds 12 times of water for the third time, 1.5h is extracted, add 10 times of water the 4th time,
1.5h is extracted, each suction filtration, merging filtrate, filtrate be concentrated into viscous pasty state, then is placed on water-bath and steams to just not flow regime,
Be put in 80 DEG C of baking ovens dry, be ground into 80 mesh sieve fine powders, obtain water extract be placed in standby in drier；
D) preparation of Chinese yam water extract
600g Chinese yam is weighed, 0.75h is soaked, 100 DEG C are heated to, heating is decocted extracts 3 times, adds 18 times for the first time
Water, extracts 2.5h, second plus 12 times of water, extracts 1.5h, third time plus 10 times of water, extracts 1.5h, use filtered through gauze every time, closes
And filtrate, filtrate is concentrated into viscous pasty state, then is placed on water-bath and steams to just not flow regime, is put in 80 DEG C of baking ovens and dries,
Be ground into 80 mesh sieve fine powders, obtain water extract be placed in standby in drier.
3.2 each alcohol extracting things are extracted by the following method：
A) preparation of saline cistanche alcohol extracting thing
600g saline cistanche meal is weighed, is put in round-bottomed flask and 0.75h is soaked with 70% ethanol, be put in electric jacket and add
Heat, with refluxing extraction device refluxing extraction 3 times, for the first time plus 18 times of 70% ethanol, extracts 2.5h, second plus 15 times of 70% second
Alcohol, extracts 1.5h, third time plus 12 times of 70% ethanol, extracts 1.5h, each suction filtration, merging filtrate, and filtrate reduced in volume is to viscous
Thick state, then be placed on water-bath and steam to not flow regime, it is put in 80 DEG C of baking ovens and dries, 80 mesh sieve fine powders was ground into, is obtained
Alcohol extracting thing is placed in standby in drier；
B) preparation of fructus schisandrae alcohol extracting thing
500g fructus schisandrae meal is weighed, and is put in round-bottomed flask and 0.25-0.75h is soaked with 70% ethanol, is put into electric heating
Heat in set, with refluxing extraction device refluxing extraction 2 times, for the first time plus 10-18 times 70% ethanol, 1-2.5h is extracted, is added for second
8-15 times of 70% ethanol, extraction 0.5-1.5h, each suction filtration, merging filtrate, reclaims ethanol with Rotary Evaporators, is concentrated into sticky
State, then be placed on water-bath and steam to not flow regime, it is put in 40-80 DEG C of baking oven and dries, was ground into 40-80 mesh sieve thin
Powder, obtain alcohol extracting thing be placed in standby in drier；
C) preparation of root of bidentate achyranthes alcohol extracting thing
500g root of bidentate achyranthes meal is weighed, 0.75h is soaked with 15 times of 80% ethanol, be put in electric jacket and heat, use refluxing extraction
Device refluxing extraction 3 times, each 2.5h, filters every time, merging filtrate, reclaims ethanol with Rotary Evaporators, then be placed on water-bath
Steam to not flow regime, be put in 80 DEG C of baking ovens and dry, 80 mesh sieve fine powders were ground into, are obtained achyranthes bidentata extract and is placed in drier
Standby；
D) preparation of prepared rhizome of rehmannia alcohol extracting thing
500g prepared rhizome of rehmannia is weighed, 0.75h is soaked with 15 times of 20% ethanol, be put in electric jacket and heat, use refluxing extraction device
Refluxing extraction 3 times, every time with 15 times of 20% ethanol, each 2.5h, filters every time, merging filtrate, reclaims second with Rotary Evaporators
Alcohol, then be placed on water-bath and steam to not flow regime, it is put in 80 DEG C of baking ovens and dries, 80 mesh sieve fine powders was ground into, obtains cultivated land
Flavol extract is placed in standby in drier；
E) preparation of cornusol extract
600g Fructus Corni is weighed, 0.75h is soaked with 12 times of 80% ethanol, be put in electric jacket and heat, use refluxing extraction device
Refluxing extraction 3 times, every time with 15 times of 20% ethanol, each 2.5h, filters every time, merging filtrate, reclaims second with Rotary Evaporators
Alcohol, then be placed on water-bath and steam to not flow regime, it is put in 80 DEG C of baking ovens and dries, 80 mesh sieve fine powders was ground into, obtains mountain Zhu
Cornel alcohol extracting thing is placed in standby in drier.
The preparation of 3.3 hippocampus powder
Take 30 pairs of hippocampus, be placed in micromill be ground into 60 mesh sieves fine powder standby.
A kind of 3.4 preparations of tonifying kidney and benefiting sperm capsule：
A) claim the Morinda officinalis water extract of formula ratio, raspberry water extract, pilose antler water extract, Chinese yam water extract,
Saline cistanche alcohol extracting thing, fructus schisandrae alcohol extracting thing, root of bidentate achyranthes alcohol extracting thing, prepared rhizome of rehmannia alcohol extracting thing, cornusol extract, sea
Ma Fen, lactose and soluble starch, mix, obtain mixture；
B) mixture is placed in pallet, 75% ethanol 150ml is sprayed, rubbed with hand and dissipate to agglomerating the touching of holding, cross 16 mesh
Sieve manual expression sieves granulation, is placed in drying in 60 DEG C of baking ovens, with 10 mesh, 80 mesh sieve whole grains, can pass through 10 mesh sieves, it is impossible to pass through
The particle of 80 mesh sieves is wanted particle；
C) by pelleting capsule board fill capsule, obtain final product tonifying kidney and benefiting sperm capsule.
Embodiment 4
The physical and chemical index of embodiment 1,2,3 is as follows：
4.1 proterties
This product content is particle, suitable size, strong flavor, the capsule that finished product is dressed up for brown yellow granule.
The inspection of 4.2 size distribution
The order that medicines different for screen size is sieved by mesh number from small to large is stacked up from high to low, by ready-made content
Particle is poured in uppermost sieve, is slowly shaken the medicine sieve for stacking up, is separated particle of different sizes, and gained is respectively sieved
Percentage such as table 1 in number.
Percentage shared by particle in each screen size of table 1
| Screen size | Percentage |
| 10 mesh | 0.4 |
| 20 mesh | 48.9 |
| 40 mesh | 35.2 |
| 50 mesh | 11.3 |
| 60 mesh | 0.7 |
| 70 mesh | 0.6 |
| 80 mesh | 1.1 |
| More than 80 mesh | 0.7 |
4.3 content mobility are checked
Using fixing conical bottom method, chassis is a culture dish, two glass funnels is overlapping up and down, is fixed on brandreth
On platform, lower hopper outlet is 1cm with chassis distance, takes sample and is slowly added into from upper funnel, makes sample through two funnels
Buffering is gradually deposited on chassis, forms cone, till obtaining highest cone.Cone height h is determined, every kind of sample is respectively surveyed
Three times, average, angle of repose a is measured by a=arctg (h/r).Income value is 0.46, tan0.46=24.7 °, and mobility is relatively
Good.
4.4 capsule content uniformities are checked
Test sample 20 is taken, after the accurately weighed every weight of difference, capsule cap is taken away, is poured out content and (capsule must not be lost
Shell), wiped inside and outside for softgel shell (including utricule and capsule cap) only with small brushes or other suitable apparatus, and accurately weighed each capsule successively
Shell weight, you can obtain the tolerant loading amount of every intragranular and average loading amount.The weighing of every capsule extremely itself softgel shell is recorded successively
Data.Every content weight of calculation is asked according to difference of the every capsules weight with softgel shell weight, retains three significant digits.Per intragranular
Tolerant weight sum obtains per average loading amount divided by 20, retains three significant digits.By the content uniformity limit of States Pharmacopoeia specifications,
Obtain permission loading amount scope.As a result content uniformity inspection meets States Pharmacopoeia specifications.
The 4.5 capsule resultant effects are investigated
The effect for the capsule that embodiment 1,2,3 is produced is evaluated following with trying out.Using opinion poll point system, select
Object is tried out in the conduct for taking 30 45-50 year age brackets, is arbitrarily divided into three groups, the capsule for being prepared with embodiment 1,2,3 respectively.
It is administered orally daily twice, every time 2 capsules, use time is two months.Every using effect total score is 5 points：5 are divided into best result,
Represent very well, very satisfied；4 are divided into preferably；3 are divided into and can receive；Less than 3 points is bad, it is impossible to receive.Hereinafter put down for every
Equal score.The results are shown in Table 1：
2 resultant effect of table is investigated
In sum, the capsule obtained by the present invention increases can oligoasthenospermia patient's semen volume, and sperm motility is improved,
Progressive sperm increasing number, wherein shared by a+b class sperm, percentage is improved, and has preferably the soreness of waist of dispelling, and strengthening the muscles and bones is acted on.
Claims (10)
1. a kind of tonifying kidney and benefiting sperm capsule, it is characterised in that the tonifying kidney and benefiting sperm capsule contains following raw material：
2. tonifying kidney and benefiting sperm capsule according to claim 1, it is characterised in that the preparation side of the Morinda officinalis water extract
Method：
Morinda officinalis meal is weighed, 0.25-0.75h is soaked, 90-100 DEG C is heated to, decoct and extract 3 times, add 10- for the first time
18 times of water, extracts 0.5-2h, second plus 10-15 times of water, extracts 0.5-1.5h, third time plus 8-12 times of water, extracts 0.5-
1.5h, uses filtered through gauze every time, and merging filtrate, filtrate be concentrated into viscous pasty state, then is placed on water-bath and steams to the shape that just do not flow
State, be put in 40-80 DEG C of baking oven dry, be ground into 40-80 mesh sieve fine powder, obtain water extract be placed in standby in drier.
3. tonifying kidney and benefiting sperm capsule according to claim 1, it is characterised in that the preparation side of the raspberry water extract
Method：
Raspberry meal is weighed, 0.25-0.75h is soaked, 90-100 DEG C is heated to, decoct and extract 2 times, add 12- for the first time
18 times of water, extracts 1-2.5h, second plus 10-15 times of water, extracts 1-2.5h, uses filtered through gauze, merging filtrate, filtrate every time
Viscous pasty state is concentrated into, then is placed on water-bath and steams to just not flow regime, be put in 40-80 DEG C of baking oven and dry, be ground into
40-80 mesh sieve fine powder, obtain water extract be placed in standby in drier.
4. tonifying kidney and benefiting sperm capsule according to claim 1, it is characterised in that the preparation method of the pilose antler water extract：
Pilose antler meal is weighed, 0.25-0.75h is soaked, 90-100 DEG C is heated to, heating is decocted extracts 4 times, adds for the first time
18-25 times of water, extracts 1-2.5h, second plus 15-18 times of water, extracts 1-2h, third time plus 10-12 times of water, extracts 0.5-
1.5h, the 4th time plus 8-10 times of water, 0.5-1.5h is extracted, each suction filtration, merging filtrate, filtrate are concentrated into viscous pasty state, then put
Steam on water-bath to firm not flow regime, be put in 40-80 DEG C of baking oven and dry, 40-80 mesh sieve fine powder was ground into, obtains water extraction
Take thing be placed in standby in drier.
5. tonifying kidney and benefiting sperm capsule according to claim 1, it is characterised in that the preparation method of the Chinese yam water extract：
Chinese yam is weighed, 0.25-0.75h is soaked, 90-100 DEG C is heated to, heating is decocted extracts 3 times, adds 10-18 for the first time
Water again, extraction 1-2.5h, second plus 10-12 times of water, extract 0.5-1.5h, add 8-10 times of water for the third time, extract 0.5-
1.5h, uses filtered through gauze every time, and merging filtrate, filtrate be concentrated into viscous pasty state, then is placed on water-bath and steams to the shape that just do not flow
State, be put in 40-80 DEG C of baking oven dry, be ground into 40-80 mesh sieve fine powder, obtain water extract be placed in standby in drier.
6. tonifying kidney and benefiting sperm capsule according to claim 1, it is characterised in that the preparation side of the saline cistanche alcohol extracting thing
Method：
Saline cistanche meal is weighed, and 0.25-0.75h is soaked with 70% ethanol, is then heated, with refluxing extraction device refluxing extraction 3 times,
Add 10-18 times of 70% ethanol for the first time, 1-2.5h is extracted, second plus 8-15 times of 70% ethanol, extract 0.5-1.5h, for the third time
Plus 8-12 times of 70% ethanol, extraction 0.5-1.5h, each suction filtration, merging filtrate, filtrate reduced in volume is to viscous pasty state, then is placed in
Steam on water-bath to not flow regime, be put in 40-80 DEG C of baking oven and dry, 40-80 mesh sieve fine powder was ground into, obtains alcohol extracting thing
It is placed in standby in drier.
7. tonifying kidney and benefiting sperm capsule according to claim 1, it is characterised in that the preparation side of the fructus schisandrae alcohol extracting thing
Method：
Fructus schisandrae meal is weighed, and 0.25-0.75h is soaked with 70% ethanol, is then heated, with refluxing extraction device refluxing extraction 2
Secondary, add 10-18 times of 70% ethanol for the first time, 1-2.5h is extracted, second plus 8-15 times of 70% ethanol, 0.5-1.5h is extracted, every
Secondary suction filtration, merging filtrate, reclaims ethanol with Rotary Evaporators, is concentrated into viscous pasty state, then be placed on water-bath and steam to not flowing
State, be put in 40-80 DEG C of baking oven dry, be ground into 40-80 mesh sieve fine powder, obtain alcohol extracting thing be placed in standby in drier.
8. tonifying kidney and benefiting sperm capsule according to claim 1, it is characterised in that the preparation method of the root of bidentate achyranthes alcohol extracting thing：
Root of bidentate achyranthes meal is weighed, 0.25-0.75h is soaked with 10-15 times of 80% ethanol, then heats, carried with the backflow of refluxing extraction device
Take 3 times, each 0.5-2.5h, filter every time, merging filtrate, reclaim ethanol with Rotary Evaporators, then be placed on water-bath steam to
Flow regime, is not put in 40-80 DEG C of baking oven and dries, be ground into 40-80 mesh sieve fine powder, and obtained root of bidentate achyranthes alcohol extracting thing and be placed in drying
Standby in device.
9. tonifying kidney and benefiting sperm capsule according to claim 1, it is characterised in that the preparation side of the prepared rhizome of rehmannia alcohol extracting thing
Method：
Prepared rhizome of rehmannia is weighed, and 0.25-0.75h is soaked with 10-15 times of 20% ethanol, is then heated, with refluxing extraction device refluxing extraction 3
Secondary, every time with 10-15 times of 20% ethanol, each 1-2.5h, filter every time, merging filtrate, ethanol is reclaimed with Rotary Evaporators, then
It is placed on water-bath and steams to not flow regime, is put in 40-80 DEG C of baking oven and dries, 40-80 mesh sieve fine powder was ground into, obtains cultivated land
Flavol extract is placed in standby in drier；
The preparation method of the cornusol extract：
Fructus Corni is weighed, and 0.25-0.75h is soaked with 8-12 times of 80% ethanol, is then heated, with refluxing extraction device refluxing extraction 3
Secondary, every time with 10-15 times of 20% ethanol, each 1-2.5h, filter every time, merging filtrate, ethanol is reclaimed with Rotary Evaporators, then
It is placed on water-bath and steams to not flow regime, is put in 40-80 DEG C of baking oven and dries, 40-80 mesh sieve fine powder was ground into, obtains mountain Zhu
Cornel alcohol extracting thing is placed in standby in drier.
10. a kind of preparation method of the tonifying kidney and benefiting sperm capsule described in any one of claim 1-9, it is characterised in that the preparation
Method is comprised the following steps：
A) the Morinda officinalis water extract of title formula ratio, raspberry water extract, pilose antler water extract, Chinese yam water extract, meat desert
Rong's alcohol extracting thing, fructus schisandrae alcohol extracting thing, root of bidentate achyranthes alcohol extracting thing, prepared rhizome of rehmannia alcohol extracting thing, cornusol extract, hippocampus
Powder, lactose and soluble starch, mix, obtain mixture；
B) mixture for preparing step a) is placed in pallet, sprays 75% ethanol 70-120 part, is rubbed and is dissipated to agglomerating the touching of holding,
Cross 10-16 mesh sieve manual expression to sieve granulation, be placed in 40-60 DEG C of baking oven and dry, with 10-30 mesh, 40-80 mesh sieve whole grain, energy
By 10-30 mesh sieve, it is impossible to be wanted particle by the particle of 40-80 mesh sieve；
C) by pelleting capsule board fill capsule, obtain final product tonifying kidney and benefiting sperm capsule.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108991576A (en) * | 2018-08-06 | 2018-12-14 | 陕西宏达植物化工有限公司 | A kind of preparation method of raspberry powder |
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| CN1583112A (en) * | 2004-06-04 | 2005-02-23 | 刘俊尧 | Capsules for nourishing kidney and strengthening yang |
| CN101904972A (en) * | 2010-07-21 | 2010-12-08 | 秦中文 | Traditional Chinese medicinal preparation for tonifying kidney and strengthening yang as well as benefiting sperm and nourishing development |
| CN103784754A (en) * | 2014-01-22 | 2014-05-14 | 安徽思康生物科技有限公司 | Capsules with effects of tonifying kidney and strengthening yang and preparation method thereof |
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| CN101904972A (en) * | 2010-07-21 | 2010-12-08 | 秦中文 | Traditional Chinese medicinal preparation for tonifying kidney and strengthening yang as well as benefiting sperm and nourishing development |
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Application publication date: 20170308 |