CN106474139A - One kind is for paracmastic tablet of pulmonary heart disease and preparation method thereof - Google Patents
One kind is for paracmastic tablet of pulmonary heart disease and preparation method thereof Download PDFInfo
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- CN106474139A CN106474139A CN201610741538.7A CN201610741538A CN106474139A CN 106474139 A CN106474139 A CN 106474139A CN 201610741538 A CN201610741538 A CN 201610741538A CN 106474139 A CN106474139 A CN 106474139A
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A61K31/37—Coumarins, e.g. psoralen
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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Abstract
The invention discloses a kind of be used for paracmastic tablet of pulmonary heart disease and preparation method thereof, described tablet is mainly to be composed of the following components in parts by weight：Phellopterin, zaluzanin C, TANSHINONES, Coixol, hyperin, Bergeninum, puerarin, glycyrrhizin, cryptoxanthine, rutin, pachyman, fucose, N acetylglucosamine, catechin；Described tablet also includes adjuvant：Filler, disintegrating agent, binding agent, lubricant.The tablet of the present invention is by multiple western the effective elements of the medicines and natural bioactivity substance rational proportion, prevention infection can be played, control arrhythmia and the effect of heart failure for the paracmastic treatment of pulmonary heart disease, risk factor can be resisted simultaneously, strengthen the immunocompetence of patient's human body, prevention of recurrence, accelerates patient's cardio-pulmonary function and recovers to slow down mental burden, Tablets preparation process is simple, easy to use, evident in efficacy.
Description
Technical field
The present invention relates to Digestive System Department practical technique field, it is specifically related to a kind of paracmastic for pulmonary heart disease
Tablet and preparation method thereof.
Background technology
Pulmonary heart disease, abbreviation pulmonary heart disease, mainly due to lung caused by bronchus, lung tissue or pulmonary artery pathological changes
The heart disease that arterial hypertension causes.According to onset emergency and course of disease length, acute and chronic two classes can be divided into.Clinically chronic relatively
For common, morbidity is slow, and clinical symptoms, in addition to original lung, the various symptoms of breast disease and sign, lung, the heart mainly progressively
Nonfunction and the sign of other organ injuries.This sick Etiological includes：The concurrent obstructive emphysema of chronic bronchitis, bronchus
Asthma, bronchiectasis, serious pulmonary tuberculosis, pneumoconiosis, chronic diffusivity interstitial pulmonary fibrosis, sarcoidosises, sequoiosises, thermophilic
Acid granuloma etc.；Movement of thorax obstacle disease, after such as serious vertebra, side is convex, spondylocace, rheumatoid arthritiss,
The extensive adhesion of pleura and thorax form the postoperative serious thorax causing or spine malformation, and neuromuscular illness such as gray nucleus
Scorching；Pulmonary vascular disease is more rare, involves Pulmonic allergic granulomatosis, extensively or the multiple pulmonary petty action that repeated
Arteries and veins thromboembolism and lung arteriolitises, and the primary pulmonary hypertension that reason is failed to understand, develop into pulmonary heart disease.The chronic pulmonary heart
Disease of ZANG-organs is because the pulmonary vascular resistance increase of chronic bronchial, lung, thorax or pulmonary artery chronic disease, pulmonary artery are high
Press and then make Right ventricular hypertrophy, expansion, companion or the not heart disease with right heart function exhaustion.Acute pulmonary heart disease mainly by
Main pulmonary artery or the unexpected thromboembolism of its Main Branches, be obstructed in the big portion of pulmonary circulation so that pulmonary artery pressure drastically increase, acute right ventricles
Expansion and the heart disease of right ventricular function exhaustion.Clinical symptoms are mainly shown as chronic cough, expectoration, out of breath, cardiopalmus after activity,
Dyspnea, weak and work tolerance decline, slight edema of lower limb etc., if treatment occurs multiple complications, such as not in time
Pulmonary encephalopathy, acid base imbalance and electrolyte disturbance, arrhythmia, digestive tract hemorrhage, disseminated inravascular coagulation (DIC) etc..
At present, clinically generally pass through infection control, oxygen therapy, control heart failure (diuretic, inotropic agent and blood vessel
Dilator), control arrhythmia and anticoagulant therapy to treat the pulmonary heart disease of acute stage.Although stabilizing surface disease
Shape, but there is the danger of recurrence at any time, and therefore paracmastic treatment is also very important, not only needs itself to strengthen forging
Refining, such as positive smoking cessation, preventing and treating respiratory tract infection, various anaphylactogen, the suction of harmful gass, suitable physical training etc., also need
To strengthen the immunologic function of patient using medicine evident in efficacy, remove risk factor, Acute Exacerbation Period is reduced or avoided
Occur, gradually make lung, cardiac function obtain part and recover.
Content of the invention
Present invention solves the technical problem that being to provide one kind to be used for the paracmastic tablet of pulmonary heart disease and its preparation side
Method.
The technical scheme is that, a kind of be used for the paracmastic tablet of pulmonary heart disease, described tablet be main by
The one-tenth of following weight portion is grouped into：Phellopterin 18-36 part, zaluzanin C 5-8 part, TANSHINONES 3-5 part, Coixol 6-12
Part, hyperin 4-8 part, Bergeninum 5-9 part；Described tablet also includes adjuvant：Filler 120-160 part, disintegrating agent 6-10
Part, binding agent 35-55 part, lubricant 5-8 part.
Further, described tablet also includes the composition of following weight portion：Puerarin 9-15 part, glycyrrhizin 6-10 part,
Cryptoxanthine 2-4 part, rutin 1-3 part, described medication combined onset can strengthen myocardial contraction, protecting myocardial cell moreover it is possible to
Expansion of blood vessels, reduce blood pressure, improve microcirculation, adjusting immunologic function, have additional nutrients supply.
Further, described tablet also includes the composition of following weight portion：Pachyman 6-12 part, fucose 3-6 part, N-
Acetylglucosamine 3-5 part, catechin 2-5 part, described medication combined for antiviral, antitumor, strengthen human immunity system
The function of system.
Further, the preparation method of described pachyman is：Weigh Poria grind into powder, cross 40 mesh sieves, add
The pure water of Poria weight 5-8 times amount, is heated to seething with excitement, decocts 2-3h, extracting solution is collected by filtration, add 3-5 times in filtering residue
The pure water of amount, is heated to seething with excitement, decocts 1-2h, extracting solution is collected by filtration, and extracting solution twice is merged, be evaporated to
All 1/5th of extracting liquid volume obtain concentrated solution, the second being 95% to the mass concentration adding 2-4 times amount in concentrated solution
Alcoholic solution, is placed in 8-12h in 5 DEG C of environment, fully precipitates, collects precipitate with macroporous adsorbent resin, and by precipitate with anhydrous
After ethanol, acetone, ether wash respectively, vacuum spray drying, that is, obtain pachyman, it has good antitumor action,
The immunoreation of cell can also be strengthened and activate the immune surveillance system to tumor for the body, there is immune-enhancing activity, can be used for
Antiviral, antiinflammatory, strengthen immunocompetence.
Further, described filler is any one in Pregelatinized Starch, Mannitol or betacyclodextrin or two
Plant above combination in any, strong to the adhesion of medicine, saturation is big.
Further, described disintegrating agent is carboxymethylcellulose calcium, low-substituted hydroxypropyl cellulose or cross-linked carboxymethyl
Any one in sodium cellulosate or two or more combination in any, the granule after disintegrate is tiny, is easy to human body effective to medicine
The absorption of composition, disintegrating property is superior.
Further, described binding agent is any one in Microcrystalline Cellulose, arabic gum or hydroxypropyl cellulose
Or two or more combination in any, viscosity is strong, is easy to pelletize.
Further, described lubricant is any one in magnesium stearate, micropowder silica gel or silicon dioxide or two kinds
Above combination in any, good fluidity, can improve the structural homogenity of medicine.
A kind of preparation method for the paracmastic tablet of pulmonary heart disease is：
Step one：Weigh Poria grind into powder, cross 40 mesh sieves, add the pure water of Poria weight 5-8 times amount, be heated to
Boiling, decocts 2-3h, extracting solution is collected by filtration, and to the pure water adding 3-5 times amount in filtering residue, is heated to seething with excitement, decocts 1-2h,
Extracting solution be collected by filtration, and extracting solution twice merged, be evaporated to 1/5th of whole extracting liquid volumes obtain dense
Contracting liquid, the ethanol solution being 95% to the mass concentration adding 2-4 times amount in concentrated solution, it is placed in 8-12h in 5 DEG C of environment, fully
Precipitation, collects precipitate with macroporous adsorbent resin, and after precipitate dehydrated alcohol, acetone, ether are washed respectively, vacuum is sprayed
Mist is dried, that is, obtain pachyman；
Step 2：Will be white to the phellopterin of described composition by weight, zaluzanin C, TANSHINONES, Coixol, hyperin, rock
Dish element, puerarin, glycyrrhizin, cryptoxanthine, rutin, pachyman, fucose, 2-Acetamido-2-deoxy-D-glucose, catechin make
With mechanical agitation, using Agravicmixer, driving material to reach parabolical peak when Agravicmixer runs makes thing
Material instantaneous weight loss, makes different-grain diameter, the material of different densities is realized uniformly mixing, the material of both sides is adverse movement, material phase
Mutually fall in opposing regions, central part forms convection current, so that it is guaranteed that material radial direction, ring, axial three-dimensional shed motion, formed
Combined-circulation, is rapidly reached uniform mixing, and incorporation time is short, and the medicaments uniformity blending is good, is mixed after stirring 3-5min
Close medicated powder, then mixed powder is ground, cross 300-400 mesh sieve, make hybrid medicine fine powder, standby；
Step 3：By the binding agent of described composition by weight and purified water according to 1:The weight of 3-5 is configured to than mixed dissolution
Binder solution, the hybrid medicine fine powder that prepare step 2 and the filler mix homogeneously of described composition by weight, add step
In the binder solutions of three preparations, it is prepared into wet granular, then by wet grain drying and granulate obtains dry particl, baking temperature 35-
45 DEG C, to the disintegrating agent, the lubricant that add described composition by weight in dry particl, tabletted after mix homogeneously, that is, prepare use
In the paracmastic tablet of pulmonary heart disease.
Beneficial effects of the present invention are embodied in：By multiple western the effective elements of the medicines and natural bioactivity substance Reasonable
Than, phellopterin, zaluzanin C, TANSHINONES, Coixol, hyperin, Bergeninum synergy, there is anti-inflammation, clear
Lung cough-relieving, suppression virus infection, effect that is calm, improving heart abnormality, can effectively suppress the recurrence of pulmonary heart disease；
Puerarin, glycyrrhizin, cryptoxanthine, rutin joint onset can strengthen myocardial contraction, and protecting myocardial cell is moreover it is possible to expand
Blood vessel, reduce blood pressure, improve microcirculation, adjusting immunologic function, have additional nutrients supply；Pachyman, fucose, N- acetylamino
Glucose, catechin combine the function of strengthening human immune system for antiviral, antitumor.Delay for pulmonary heart disease
The treatment of solution phase can be played prevention infection, control arrhythmia and the effect of heart failure, can resist risk factor simultaneously, increase
The immunocompetence of strong patient's human body, prevention of recurrence, accelerate patient's cardio-pulmonary function and recover to slow down mental burden, Tablets system
Standby process is simple, easy to use, evident in efficacy.
Specific embodiment
Embodiment 1：
One kind is used for the paracmastic tablet of pulmonary heart disease, and described tablet is the main packet of the one-tenth by following weight portion
Become：18 parts of phellopterin, 5 parts of zaluzanin C, 3 parts of TANSHINONES, 6 parts of Coixol, 4 parts of hyperin, 5 parts of Bergeninum；Institute
State tablet and also include adjuvant：120 parts of filler, 6 parts of disintegrating agent, 35 parts of binding agent, 5 parts of lubricant.
Wherein, described filler is Pregelatinized Starch, strong to the adhesion of medicine, and saturation is big.Described disintegrating agent
For carboxymethylcellulose calcium, the granule after disintegrate is tiny, is easy to the absorption to effective ingredient for the human body, disintegrating property is superior.
Described binding agent is Microcrystalline Cellulose, and viscosity is strong, is easy to pelletize.Described lubricant is magnesium stearate, and good fluidity is permissible
Improve the structural homogenity of medicine.
A kind of preparation method for the paracmastic tablet of pulmonary heart disease is：
Step one：Will be white to the phellopterin of described composition by weight, zaluzanin C, TANSHINONES, Coixol, hyperin, rock
Dish element uses mechanical agitation, using Agravicmixer, drives material to reach parabolical highest when Agravicmixer runs
Point makes material instantaneous weight loss, makes different-grain diameter, the material of different densities is realized uniformly mixing, the material of both sides is adverse movement,
Material mutually falls in opposing regions, and central part forms convection current, so that it is guaranteed that material radial direction, ring, axial three-dimensional shed fortune
Dynamic, form combined-circulation, be rapidly reached uniform mixing, incorporation time is short, and the medicaments uniformity blending is good, after stirring 3min
To mixed powder, then mixed powder is ground, cross 300 mesh sieves, make hybrid medicine fine powder, standby；
Step 2：By the binding agent of described composition by weight and purified water according to 1:3 weight is configured to glue than mixed dissolution
Mixture solution, the hybrid medicine fine powder that prepare step 2 and the filler mix homogeneously of described composition by weight, add step 3
In the binder solution of preparation, it is prepared into wet granular, then by wet grain drying and granulate obtains dry particl, 35 DEG C of baking temperature,
To the disintegrating agent, the lubricant that add described composition by weight in dry particl, tabletted after mix homogeneously, that is, prepare for lung source
The property paracmastic tablet of heart disease.
Embodiment 2：One kind is used for the paracmastic tablet of pulmonary heart disease, and described tablet is main by following weight portion
One-tenth is grouped into：27 parts of phellopterin, 6.5 parts of zaluzanin C, 4 parts of TANSHINONES, 9 parts of Coixol, 6 parts of hyperin, Rhizoma Seu Herba Bergeniae
7 parts of element；Described tablet also includes adjuvant：140 parts of filler, 8 parts of disintegrating agent, 45 parts of binding agent, 6.5 parts of lubricant.
Wherein, described filler is Mannitol, strong to the adhesion of medicine, and saturation is big.Described disintegrating agent is low
Replace hydroxypropyl cellulose, the granule after disintegrate is tiny, is easy to the absorption to effective ingredient for the human body, disintegrating property is superior.
Described binding agent is arabic gum, and viscosity is strong, is easy to pelletize.Described lubricant is micropowder silica gel, good fluidity, Ke Yigai
The structural homogenity of kind medicine.
A kind of preparation method for the paracmastic tablet of pulmonary heart disease is：
Step one：Will be white to the phellopterin of described composition by weight, zaluzanin C, TANSHINONES, Coixol, hyperin, rock
Dish element uses mechanical agitation, using Agravicmixer, drives material to reach parabolical highest when Agravicmixer runs
Point makes material instantaneous weight loss, makes different-grain diameter, the material of different densities is realized uniformly mixing, the material of both sides is adverse movement,
Material mutually falls in opposing regions, and central part forms convection current, so that it is guaranteed that material radial direction, ring, axial three-dimensional shed fortune
Dynamic, form combined-circulation, be rapidly reached uniform mixing, incorporation time is short, and the medicaments uniformity blending is good, after stirring 4min
To mixed powder, then mixed powder is ground, cross 350 mesh sieves, make hybrid medicine fine powder, standby；
Step 2：By the binding agent of described composition by weight and purified water according to 1:4 weight is configured to glue than mixed dissolution
Mixture solution, the hybrid medicine fine powder that prepare step 2 and the filler mix homogeneously of described composition by weight, add step 3
In the binder solution of preparation, it is prepared into wet granular, then by wet grain drying and granulate obtains dry particl, 40 DEG C of baking temperature,
To the disintegrating agent, the lubricant that add described composition by weight in dry particl, tabletted after mix homogeneously, that is, prepare for lung source
The property paracmastic tablet of heart disease.
Embodiment 3：One kind is used for the paracmastic tablet of pulmonary heart disease, and described tablet is main by following weight portion
One-tenth is grouped into：36 parts of phellopterin, 8 parts of zaluzanin C, 5 parts of TANSHINONES, 12 parts of Coixol, 8 parts of hyperin, Bergeninum
9 parts；Described tablet also includes adjuvant：160 parts of filler, 10 parts of disintegrating agent, 55 parts of binding agent, 8 parts of lubricant.
Wherein, described filler is betacyclodextrin, strong to the adhesion of medicine, and saturation is big.Described disintegrating agent
For cross-linking sodium carboxymethyl cellulose, the granule after disintegrate is tiny, is easy to the absorption to effective ingredient for the human body, disintegrating property is excellent
More.Described binding agent is hydroxypropyl cellulose, and viscosity is strong, is easy to pelletize.Described lubricant is silicon dioxide, mobility
Good, the structural homogenity of medicine can be improved.
A kind of preparation method for the paracmastic tablet of pulmonary heart disease is：
Step one：Will be white to the phellopterin of described composition by weight, zaluzanin C, TANSHINONES, Coixol, hyperin, rock
Dish element uses mechanical agitation, using Agravicmixer, drives material to reach parabolical highest when Agravicmixer runs
Point makes material instantaneous weight loss, makes different-grain diameter, the material of different densities is realized uniformly mixing, the material of both sides is adverse movement,
Material mutually falls in opposing regions, and central part forms convection current, so that it is guaranteed that material radial direction, ring, axial three-dimensional shed fortune
Dynamic, form combined-circulation, be rapidly reached uniform mixing, incorporation time is short, and the medicaments uniformity blending is good, after stirring 5min
To mixed powder, then mixed powder is ground, cross 400 mesh sieves, make hybrid medicine fine powder, standby；
Step 2：By the binding agent of described composition by weight and purified water according to 1:5 weight is configured to glue than mixed dissolution
Mixture solution, the hybrid medicine fine powder that prepare step 2 and the filler mix homogeneously of described composition by weight, add step 3
In the binder solution of preparation, it is prepared into wet granular, then by wet grain drying and granulate obtains dry particl, 45 DEG C of baking temperature,
To the disintegrating agent, the lubricant that add described composition by weight in dry particl, tabletted after mix homogeneously, that is, prepare for lung source
The property paracmastic tablet of heart disease.
Embodiment 4：One kind is used for the paracmastic tablet of pulmonary heart disease, and described tablet is main by following weight portion
One-tenth is grouped into：18 parts of phellopterin, 5 parts of zaluzanin C, 3 parts of TANSHINONES, 6 parts of Coixol, 4 parts of hyperin, Bergeninum 5
Part, 9 parts of puerarin, 6 parts of glycyrrhizin, 2 parts of cryptoxanthine, 1 part of rutin；Described tablet also includes adjuvant：120 parts of filler,
6 parts of disintegrating agent, 35 parts of binding agent, 5 parts of lubricant.
Wherein, described filler is Pregelatinized Starch, strong to the adhesion of medicine, and saturation is big.Described disintegrating agent
For carboxymethylcellulose calcium, the granule after disintegrate is tiny, is easy to the absorption to effective ingredient for the human body, disintegrating property is superior.
Described binding agent is Microcrystalline Cellulose, and viscosity is strong, is easy to pelletize.Described lubricant is magnesium stearate, and good fluidity is permissible
Improve the structural homogenity of medicine.
A kind of preparation method for the paracmastic tablet of pulmonary heart disease is：
Step one：Will be white to the phellopterin of described composition by weight, zaluzanin C, TANSHINONES, Coixol, hyperin, rock
Dish element, puerarin, glycyrrhizin, cryptoxanthine, rutin use mechanical agitation, using Agravicmixer, Agravicmixer
Driving material to reach parabolical peak during operation makes material instantaneous weight loss, so that the material of different-grain diameter, different densities is realized
Uniformly mix, the material of both sides is adverse movement, and material mutually falls in opposing regions, central part forms convection current, thus really
Guarantor's material radial direction, ring, axial three-dimensional shed motion, form combined-circulation, are rapidly reached uniform mixing, and incorporation time is short, mixed
The medicaments uniformity closing out is good, obtains mixed powder, then mixed powder is ground, cross 300 mesh sieves, make after stirring 3min
Hybrid medicine fine powder, standby；
Step 2：By the binding agent of described composition by weight and purified water according to 1:3 weight is configured to glue than mixed dissolution
Mixture solution, the hybrid medicine fine powder that prepare step 2 and the filler mix homogeneously of described composition by weight, add step 3
In the binder solution of preparation, it is prepared into wet granular, then by wet grain drying and granulate obtains dry particl, 35 DEG C of baking temperature,
To the disintegrating agent, the lubricant that add described composition by weight in dry particl, tabletted after mix homogeneously, that is, prepare for lung source
The property paracmastic tablet of heart disease.
Embodiment 5：One kind is used for the paracmastic tablet of pulmonary heart disease, and described tablet is main by following weight portion
One-tenth is grouped into：27 parts of phellopterin, 6.5 parts of zaluzanin C, 4 parts of TANSHINONES, 9 parts of Coixol, 6 parts of hyperin, Rhizoma Seu Herba Bergeniae
7 parts of element, 12 parts of puerarin, 8 parts of glycyrrhizin, 3 parts of cryptoxanthine, 2 parts of rutin；Described tablet also includes adjuvant：Filler 140
Part, 8 parts of disintegrating agent, 45 parts of binding agent, 6.5 parts of lubricant.
Wherein, described filler is Mannitol, strong to the adhesion of medicine, and saturation is big.Described disintegrating agent is low
Replace hydroxypropyl cellulose, the granule after disintegrate is tiny, is easy to the absorption to effective ingredient for the human body, disintegrating property is superior.
Described binding agent is arabic gum, and viscosity is strong, is easy to pelletize.Described lubricant is micropowder silica gel, good fluidity, Ke Yigai
The structural homogenity of kind medicine.
A kind of preparation method for the paracmastic tablet of pulmonary heart disease is：
Step one：Will be white to the phellopterin of described composition by weight, zaluzanin C, TANSHINONES, Coixol, hyperin, rock
Dish element, puerarin, glycyrrhizin, cryptoxanthine, rutin use mechanical agitation, using Agravicmixer, Agravicmixer
Driving material to reach parabolical peak during operation makes material instantaneous weight loss, so that the material of different-grain diameter, different densities is realized
Uniformly mix, the material of both sides is adverse movement, and material mutually falls in opposing regions, central part forms convection current, thus really
Guarantor's material radial direction, ring, axial three-dimensional shed motion, form combined-circulation, are rapidly reached uniform mixing, and incorporation time is short, mixed
The medicaments uniformity closing out is good, obtains mixed powder, then mixed powder is ground, cross 350 mesh sieves, make after stirring 4min
Hybrid medicine fine powder, standby；
Step 2：By the binding agent of described composition by weight and purified water according to 1:4 weight is configured to glue than mixed dissolution
Mixture solution, the hybrid medicine fine powder that prepare step 2 and the filler mix homogeneously of described composition by weight, add step 3
In the binder solution of preparation, it is prepared into wet granular, then by wet grain drying and granulate obtains dry particl, 40 DEG C of baking temperature,
To the disintegrating agent, the lubricant that add described composition by weight in dry particl, tabletted after mix homogeneously, that is, prepare for lung source
The property paracmastic tablet of heart disease.
Embodiment 6：One kind is used for the paracmastic tablet of pulmonary heart disease, and described tablet is main by following weight portion
One-tenth is grouped into：36 parts of phellopterin, 8 parts of zaluzanin C, 5 parts of TANSHINONES, 12 parts of Coixol, 8 parts of hyperin, Bergeninum
9 parts, 15 parts of puerarin, 10 parts of glycyrrhizin, 4 parts of cryptoxanthine, 3 parts of rutin；Described tablet also includes adjuvant：Filler 160
Part, 10 parts of disintegrating agent, 55 parts of binding agent, 8 parts of lubricant.
Wherein, described filler is betacyclodextrin, strong to the adhesion of medicine, and saturation is big.Described disintegrating agent
For cross-linking sodium carboxymethyl cellulose, the granule after disintegrate is tiny, is easy to the absorption to effective ingredient for the human body, disintegrating property is excellent
More.Described binding agent is hydroxypropyl cellulose, and viscosity is strong, is easy to pelletize.Described lubricant is silicon dioxide, mobility
Good, the structural homogenity of medicine can be improved.
A kind of preparation method for the paracmastic tablet of pulmonary heart disease is：
Step one：Will be white to the phellopterin of described composition by weight, zaluzanin C, TANSHINONES, Coixol, hyperin, rock
Dish element, puerarin, glycyrrhizin, cryptoxanthine, rutin use mechanical agitation, using Agravicmixer, Agravicmixer
Driving material to reach parabolical peak during operation makes material instantaneous weight loss, so that the material of different-grain diameter, different densities is realized
Uniformly mix, the material of both sides is adverse movement, and material mutually falls in opposing regions, central part forms convection current, thus really
Guarantor's material radial direction, ring, axial three-dimensional shed motion, form combined-circulation, are rapidly reached uniform mixing, and incorporation time is short, mixed
The medicaments uniformity closing out is good, obtains mixed powder, then mixed powder is ground, cross 400 mesh sieves, make after stirring 5min
Hybrid medicine fine powder, standby；
Step 2：By the binding agent of described composition by weight and purified water according to 1:5 weight is configured to glue than mixed dissolution
Mixture solution, the hybrid medicine fine powder that prepare step 2 and the filler mix homogeneously of described composition by weight, add step 3
In the binder solution of preparation, it is prepared into wet granular, then by wet grain drying and granulate obtains dry particl, 45 DEG C of baking temperature,
To the disintegrating agent, the lubricant that add described composition by weight in dry particl, tabletted after mix homogeneously, that is, prepare for lung source
The property paracmastic tablet of heart disease.
Embodiment 7：One kind is used for the paracmastic tablet of pulmonary heart disease, and described tablet is main by following weight portion
One-tenth is grouped into：18 parts of phellopterin, 5 parts of zaluzanin C, 3 parts of TANSHINONES, 6 parts of Coixol, 4 parts of hyperin, Bergeninum 5
Part, 6 parts of pachyman, 3 parts of fucose, 3 parts of 2-Acetamido-2-deoxy-D-glucose, 2 parts of catechin；Described tablet also includes adjuvant：Fill out
Fill 120 parts of agent, 6 parts of disintegrating agent, 35 parts of binding agent, 5 parts of lubricant.
Wherein, the preparation method of described pachyman is：Weigh Poria grind into powder, cross 40 mesh sieves, add Poria
The pure water of weight 5 times amount, is heated to seething with excitement, decocts 2h, extracting solution is collected by filtration, to the pure water adding 3 times amount in filtering residue,
It is heated to seething with excitement, decocts 1h, extracting solution is collected by filtration, and extracting solution twice is merged, be evaporated to whole extracting liqs
Long-pending 1/5th obtain concentrated solution, the ethanol solution being 95% to the mass concentration adding 2 times amount in concentrated solution, are placed in 5 DEG C
8h in environment, fully precipitates, collects precipitate with macroporous adsorbent resin, and by precipitate dehydrated alcohol, acetone, ether respectively
After washing, vacuum spray drying, that is, obtain pachyman, it has good antitumor action moreover it is possible to strengthen the immunity of cell
React and activate the immune surveillance system to tumor for the body, there is immune-enhancing activity, can be used for antiviral, antiinflammatory, enhancing is exempted from
Epidemic disease ability.Described filler is Pregelatinized Starch, strong to the adhesion of medicine, and saturation is big.Described disintegrating agent is carboxylic first
Base cellulose calcium, the granule after disintegrate is tiny, is easy to the absorption to effective ingredient for the human body, and disintegrating property is superior.Described
Binding agent is Microcrystalline Cellulose, and viscosity is strong, is easy to pelletize.Described lubricant is magnesium stearate, and good fluidity can improve medicine
The structural homogenity of thing.
A kind of preparation method for the paracmastic tablet of pulmonary heart disease is：
Step one：Weigh Poria grind into powder, cross 40 mesh sieves, add the pure water of Poria weight 5 times amount, be heated to boiling
Rise, decoct 2h, extracting solution is collected by filtration, to the pure water adding 3 times amount in filtering residue, be heated to seething with excitement, decoct 1h, be collected by filtration
Extracting solution, and extracting solution twice is merged, be evaporated to whole extracting liquid volumes 1/5th obtain concentrated solution, to dense
Add in contracting liquid 2 times amount mass concentration be 95% ethanol solution, be placed in 8h in 5 DEG C of environment, fully precipitate, use macroporous absorption
Resin trap precipitate, and after precipitate dehydrated alcohol, acetone, ether are washed respectively, vacuum spray drying, that is, obtain Fu
Siberian cocklebur polysaccharide；
Step 2：Will be white to the phellopterin of described composition by weight, zaluzanin C, TANSHINONES, Coixol, hyperin, rock
Dish element, pachyman, fucose, 2-Acetamido-2-deoxy-D-glucose, catechin use mechanical agitation, using Agravicmixer, no
Driving material to reach parabolical peak when gravity mixer runs makes material instantaneous weight loss, makes different-grain diameter, different densities
Material realize uniformly mixing, the material of both sides is adverse movement, and material mutually falls in opposing regions, and central part forms right
Stream, so that it is guaranteed that material radial direction, ring, axial three-dimensional shed motion, forms combined-circulation, is rapidly reached uniform mixing, mixing
Time is short, and the medicaments uniformity blending is good, obtains mixed powder, then mixed powder is ground, cross 300 after stirring 3min
Mesh sieve, makes hybrid medicine fine powder, standby；
Step 3：By the binding agent of described composition by weight and purified water according to 1:3 weight is configured to glue than mixed dissolution
Mixture solution, the hybrid medicine fine powder that prepare step 2 and the filler mix homogeneously of described composition by weight, add step 3
In the binder solution of preparation, it is prepared into wet granular, then by wet grain drying and granulate obtains dry particl, 35 DEG C of baking temperature,
To the disintegrating agent, the lubricant that add described composition by weight in dry particl, tabletted after mix homogeneously, that is, prepare for lung source
The property paracmastic tablet of heart disease.
Embodiment 8：One kind is used for the paracmastic tablet of pulmonary heart disease, and described tablet is main by following weight portion
One-tenth is grouped into：27 parts of phellopterin, 6.5 parts of zaluzanin C, 4 parts of TANSHINONES, 9 parts of Coixol, 6 parts of hyperin, Rhizoma Seu Herba Bergeniae
7 parts of element, 9 parts of pachyman, 4.5 parts of fucose, 4 parts of 2-Acetamido-2-deoxy-D-glucose, 3.5 parts of catechin；Described tablet also includes
Adjuvant：140 parts of filler, 8 parts of disintegrating agent, 45 parts of binding agent, 6.5 parts of lubricant.
Wherein, the preparation method of described pachyman is：Weigh Poria grind into powder, cross 40 mesh sieves, add Poria
The pure water of weight 6.5 times amount, is heated to seething with excitement, decocts 2.5h, extracting solution is collected by filtration, to adding the pure of 4 times amount in filtering residue
Water purification, is heated to seething with excitement, decocts 1.5h, extracting solution is collected by filtration, and extracting solution twice is merged, be evaporated to and all carry
Take liquid long-pending 1/5th obtain concentrated solution, and the ethanol solution being 95% to the mass concentration adding 3 times amount in concentrated solution is put
10h in 5 DEG C of environment, fully precipitates, collects precipitate with macroporous adsorbent resin, and by precipitate dehydrated alcohol, acetone, second
After ether washs respectively, vacuum spray drying, that is, obtain pachyman, it has good antitumor action moreover it is possible to strengthen cell
Immunoreation and activate the immune surveillance system to tumor for the body, there is immune-enhancing activity, can be used for antiviral, antiinflammatory,
Strengthen immunocompetence.Described filler is Mannitol, strong to the adhesion of medicine, and saturation is big.Described disintegrating agent is low
Replace hydroxypropyl cellulose, the granule after disintegrate is tiny, is easy to the absorption to effective ingredient for the human body, disintegrating property is superior.
Described binding agent is arabic gum, and viscosity is strong, is easy to pelletize.Described lubricant is micropowder silica gel, good fluidity, Ke Yigai
The structural homogenity of kind medicine.
A kind of preparation method for the paracmastic tablet of pulmonary heart disease is：
Step one：Weigh Poria grind into powder, cross 40 mesh sieves, add the pure water of Poria weight 6.5 times amount, be heated to
Boiling, decocts 2.5h, extracting solution is collected by filtration, and to the pure water adding 4 times amount in filtering residue, is heated to seething with excitement, decocts 1.5h, mistake
Extracting solution is collected in filter, and extracting solution twice is merged, and be evaporated to whole extracting liquid volumes 1/5th are concentrated
Liquid, the ethanol solution being 95% to the mass concentration adding 3 times amount in concentrated solution, it is placed in 10h in 5 DEG C of environment, fully precipitates, use
Macroporous adsorbent resin collects precipitate, and after precipitate dehydrated alcohol, acetone, ether are washed respectively, vacuum spray drying,
Obtain pachyman；
Step 2：Will be white to the phellopterin of described composition by weight, zaluzanin C, TANSHINONES, Coixol, hyperin, rock
Dish element, pachyman, fucose, 2-Acetamido-2-deoxy-D-glucose, catechin use mechanical agitation, using Agravicmixer, no
Driving material to reach parabolical peak when gravity mixer runs makes material instantaneous weight loss, makes different-grain diameter, different densities
Material realize uniformly mixing, the material of both sides is adverse movement, and material mutually falls in opposing regions, and central part forms right
Stream, so that it is guaranteed that material radial direction, ring, axial three-dimensional shed motion, forms combined-circulation, is rapidly reached uniform mixing, mixing
Time is short, and the medicaments uniformity blending is good, obtains mixed powder, then mixed powder is ground, cross 350 after stirring 4min
Mesh sieve, makes hybrid medicine fine powder, standby；
Step 3：By the binding agent of described composition by weight and purified water according to 1:4 weight is configured to glue than mixed dissolution
Mixture solution, the hybrid medicine fine powder that prepare step 2 and the filler mix homogeneously of described composition by weight, add step 3
In the binder solution of preparation, it is prepared into wet granular, then by wet grain drying and granulate obtains dry particl, 40 DEG C of baking temperature,
To the disintegrating agent, the lubricant that add described composition by weight in dry particl, tabletted after mix homogeneously, that is, prepare for lung source
The property paracmastic tablet of heart disease.
Embodiment 9：One kind is used for the paracmastic tablet of pulmonary heart disease, and described tablet is main by following weight portion
One-tenth is grouped into：36 parts of phellopterin, 8 parts of zaluzanin C, 5 parts of TANSHINONES, 12 parts of Coixol, 8 parts of hyperin, Bergeninum
9 parts, 12 parts of pachyman, 6 parts of fucose, 5 parts of 2-Acetamido-2-deoxy-D-glucose, 5 parts of catechin；Described tablet also includes adjuvant：
160 parts of filler, 10 parts of disintegrating agent, 55 parts of binding agent, 8 parts of lubricant.
Wherein, the preparation method of described pachyman is：Weigh Poria grind into powder, cross 40 mesh sieves, add Poria
The pure water of weight 8 times amount, is heated to seething with excitement, decocts 3h, extracting solution is collected by filtration, to the pure water adding 5 times amount in filtering residue,
It is heated to seething with excitement, decocts 2h, extracting solution is collected by filtration, and extracting solution twice is merged, be evaporated to whole extracting liqs
Long-pending 1/5th obtain concentrated solution, the ethanol solution being 95% to the mass concentration adding 4 times amount in concentrated solution, are placed in 5 DEG C
12h in environment, fully precipitates, collects precipitate with macroporous adsorbent resin, and precipitate dehydrated alcohol, acetone, ether are divided
Not Xi Di after, vacuum spray drying, that is, obtain pachyman, it has good antitumor action moreover it is possible to strengthen the exempting from of cell
Epidemic disease is reacted and is activated the immune surveillance system to tumor for the body, has immune-enhancing activity, can be used for antiviral, antiinflammatory, strengthens
Immunocompetence.Described filler is Pregelatinized Starch, strong to the adhesion of medicine, and saturation is big.Described disintegrating agent is carboxylic
Methylcellulose calcium, the granule after disintegrate is tiny, is easy to the absorption to effective ingredient for the human body, and disintegrating property is superior.Described
Binding agent be Microcrystalline Cellulose, viscosity is strong, is easy to pelletize.Described lubricant is magnesium stearate, and good fluidity can improve
The structural homogenity of medicine.
A kind of preparation method for the paracmastic tablet of pulmonary heart disease is：
Step one：Weigh Poria grind into powder, cross 40 mesh sieves, add the pure water of Poria weight 5 times amount, be heated to boiling
Rise, decoct 2h, extracting solution is collected by filtration, to the pure water adding 3 times amount in filtering residue, be heated to seething with excitement, decoct 1h, be collected by filtration
Extracting solution, and extracting solution twice is merged, be evaporated to whole extracting liquid volumes 1/5th obtain concentrated solution, to dense
Add in contracting liquid 2 times amount mass concentration be 95% ethanol solution, be placed in 8h in 5 DEG C of environment, fully precipitate, use macroporous absorption
Resin trap precipitate, and after precipitate dehydrated alcohol, acetone, ether are washed respectively, vacuum spray drying, that is, obtain Fu
Siberian cocklebur polysaccharide；
Step 2：Will be white to the phellopterin of described composition by weight, zaluzanin C, TANSHINONES, Coixol, hyperin, rock
Dish element, pachyman, fucose, 2-Acetamido-2-deoxy-D-glucose, catechin use mechanical agitation, using Agravicmixer, no
Driving material to reach parabolical peak when gravity mixer runs makes material instantaneous weight loss, makes different-grain diameter, different densities
Material realize uniformly mixing, the material of both sides is adverse movement, and material mutually falls in opposing regions, and central part forms right
Stream, so that it is guaranteed that material radial direction, ring, axial three-dimensional shed motion, forms combined-circulation, is rapidly reached uniform mixing, mixing
Time is short, and the medicaments uniformity blending is good, obtains mixed powder, then mixed powder is ground, cross 300 after stirring 3min
Mesh sieve, makes hybrid medicine fine powder, standby；
Step 3：By the binding agent of described composition by weight and purified water according to 1:3 weight is configured to glue than mixed dissolution
Mixture solution, the hybrid medicine fine powder that prepare step 2 and the filler mix homogeneously of described composition by weight, add step 3
In the binder solution of preparation, it is prepared into wet granular, then by wet grain drying and granulate obtains dry particl, 35 DEG C of baking temperature,
To the disintegrating agent, the lubricant that add described composition by weight in dry particl, tabletted after mix homogeneously, that is, prepare for lung source
The property paracmastic tablet of heart disease.
Embodiment 10：One kind is used for the paracmastic tablet of pulmonary heart disease, and described tablet is main by following weight portion
One-tenth be grouped into：18 parts of phellopterin, 5 parts of zaluzanin C, 3 parts of TANSHINONES, 6 parts of Coixol, 4 parts of hyperin, Rhizoma Seu Herba Bergeniae
5 parts of element, 9 parts of puerarin, 6 parts of glycyrrhizin, 2 parts of cryptoxanthine, 1 part of rutin, 6 parts of pachyman, 3 parts of fucose, N- acetyl
3 parts of glucosamine, 2 parts of catechin；Described tablet also includes adjuvant：120 parts of filler, 6 parts of disintegrating agent, 35 parts of binding agent,
5 parts of lubricant.
Wherein, the preparation method of described pachyman is：Weigh Poria grind into powder, cross 40 mesh sieves, add Poria
The pure water of weight 5 times amount, is heated to seething with excitement, decocts 2h, extracting solution is collected by filtration, to the pure water adding 3 times amount in filtering residue,
It is heated to seething with excitement, decocts 1h, extracting solution is collected by filtration, and extracting solution twice is merged, be evaporated to whole extracting liqs
Long-pending 1/5th obtain concentrated solution, the ethanol solution being 95% to the mass concentration adding 2 times amount in concentrated solution, are placed in 5 DEG C
8h in environment, fully precipitates, collects precipitate with macroporous adsorbent resin, and by precipitate dehydrated alcohol, acetone, ether respectively
After washing, vacuum spray drying, that is, obtain pachyman, it has good antitumor action moreover it is possible to strengthen the immunity of cell
React and activate the immune surveillance system to tumor for the body, there is immune-enhancing activity, can be used for antiviral, antiinflammatory, enhancing is exempted from
Epidemic disease ability.Described filler is Pregelatinized Starch, strong to the adhesion of medicine, and saturation is big.Described disintegrating agent is carboxylic first
Base cellulose calcium, the granule after disintegrate is tiny, is easy to the absorption to effective ingredient for the human body, and disintegrating property is superior.Described
Binding agent is Microcrystalline Cellulose, and viscosity is strong, is easy to pelletize.Described lubricant is magnesium stearate, and good fluidity can improve medicine
The structural homogenity of thing.
A kind of preparation method for the paracmastic tablet of pulmonary heart disease is：
Step one：Weigh Poria grind into powder, cross 40 mesh sieves, add the pure water of Poria weight 5 times amount, be heated to boiling
Rise, decoct 2h, extracting solution is collected by filtration, to the pure water adding 3 times amount in filtering residue, be heated to seething with excitement, decoct 1h, be collected by filtration
Extracting solution, and extracting solution twice is merged, be evaporated to whole extracting liquid volumes 1/5th obtain concentrated solution, to dense
Add in contracting liquid 2 times amount mass concentration be 95% ethanol solution, be placed in 8h in 5 DEG C of environment, fully precipitate, use macroporous absorption
Resin trap precipitate, and after precipitate dehydrated alcohol, acetone, ether are washed respectively, vacuum spray drying, that is, obtain Fu
Siberian cocklebur polysaccharide；
Step 2：Will be white to the phellopterin of described composition by weight, zaluzanin C, TANSHINONES, Coixol, hyperin, rock
Dish element, puerarin, glycyrrhizin, cryptoxanthine, rutin, pachyman, fucose, 2-Acetamido-2-deoxy-D-glucose, catechin make
With mechanical agitation, using Agravicmixer, driving material to reach parabolical peak when Agravicmixer runs makes thing
Material instantaneous weight loss, makes different-grain diameter, the material of different densities is realized uniformly mixing, the material of both sides is adverse movement, material phase
Mutually fall in opposing regions, central part forms convection current, so that it is guaranteed that material radial direction, ring, axial three-dimensional shed motion, formed
Combined-circulation, is rapidly reached uniform mixing, and incorporation time is short, and the medicaments uniformity blending is good, is mixed after stirring 3min
Medicated powder, then mixed powder is ground, cross 300 mesh sieves, make hybrid medicine fine powder, standby；
Step 3：By the binding agent of described composition by weight and purified water according to 1:3 weight is configured to glue than mixed dissolution
Mixture solution, the hybrid medicine fine powder that prepare step 2 and the filler mix homogeneously of described composition by weight, add step 3
In the binder solution of preparation, it is prepared into wet granular, then by wet grain drying and granulate obtains dry particl, 35 DEG C of baking temperature,
To the disintegrating agent, the lubricant that add described composition by weight in dry particl, tabletted after mix homogeneously, that is, prepare for lung source
The property paracmastic tablet of heart disease.
Embodiment 11：One kind is used for the paracmastic tablet of pulmonary heart disease, and described tablet is main by following weight portion
One-tenth be grouped into：27 parts of phellopterin, 6.5 parts of zaluzanin C, 4 parts of TANSHINONES, 9 parts of Coixol, 6 parts of hyperin, rock are white
7 parts of dish element, 12 parts of puerarin, 8 parts of glycyrrhizin, 3 parts of cryptoxanthine, 2 parts of rutin, 9 parts of pachyman, 4.5 parts of fucose, N-
4 parts of acetylglucosamine, 3.5 parts of catechin；Described tablet also includes adjuvant：140 parts of filler, 8 parts of disintegrating agent, binding agent
45 parts, 6.5 parts of lubricant.
Wherein, the preparation method of described pachyman is：Weigh Poria grind into powder, cross 40 mesh sieves, add Poria
The pure water of weight 6.5 times amount, is heated to seething with excitement, decocts 2.5h, extracting solution is collected by filtration, to adding the pure of 4 times amount in filtering residue
Water purification, is heated to seething with excitement, decocts 1.5h, extracting solution is collected by filtration, and extracting solution twice is merged, be evaporated to and all carry
Take liquid long-pending 1/5th obtain concentrated solution, and the ethanol solution being 95% to the mass concentration adding 3 times amount in concentrated solution is put
10h in 5 DEG C of environment, fully precipitates, collects precipitate with macroporous adsorbent resin, and by precipitate dehydrated alcohol, acetone, second
After ether washs respectively, vacuum spray drying, that is, obtain pachyman, it has good antitumor action moreover it is possible to strengthen cell
Immunoreation and activate the immune surveillance system to tumor for the body, there is immune-enhancing activity, can be used for antiviral, antiinflammatory,
Strengthen immunocompetence.Described filler is Mannitol, strong to the adhesion of medicine, and saturation is big.Described disintegrating agent is low
Replace hydroxypropyl cellulose, the granule after disintegrate is tiny, is easy to the absorption to effective ingredient for the human body, disintegrating property is superior.
Described binding agent is arabic gum, and viscosity is strong, is easy to pelletize.Described lubricant is micropowder silica gel, good fluidity, Ke Yigai
The structural homogenity of kind medicine.
A kind of preparation method for the paracmastic tablet of pulmonary heart disease is：
Step one：Weigh Poria grind into powder, cross 40 mesh sieves, add the pure water of Poria weight 6.5 times amount, be heated to
Boiling, decocts 2.5h, extracting solution is collected by filtration, and to the pure water adding 4 times amount in filtering residue, is heated to seething with excitement, decocts 1.5h, mistake
Extracting solution is collected in filter, and extracting solution twice is merged, and be evaporated to whole extracting liquid volumes 1/5th are concentrated
Liquid, the ethanol solution being 95% to the mass concentration adding 3 times amount in concentrated solution, it is placed in 10h in 5 DEG C of environment, fully precipitates, use
Macroporous adsorbent resin collects precipitate, and after precipitate dehydrated alcohol, acetone, ether are washed respectively, vacuum spray drying,
Obtain pachyman；
Step 2：Will be white to the phellopterin of described composition by weight, zaluzanin C, TANSHINONES, Coixol, hyperin, rock
Dish element, puerarin, glycyrrhizin, cryptoxanthine, rutin, pachyman, fucose, 2-Acetamido-2-deoxy-D-glucose, catechin make
With mechanical agitation, using Agravicmixer, driving material to reach parabolical peak when Agravicmixer runs makes thing
Material instantaneous weight loss, makes different-grain diameter, the material of different densities is realized uniformly mixing, the material of both sides is adverse movement, material phase
Mutually fall in opposing regions, central part forms convection current, so that it is guaranteed that material radial direction, ring, axial three-dimensional shed motion, formed
Combined-circulation, is rapidly reached uniform mixing, and incorporation time is short, and the medicaments uniformity blending is good, is mixed after stirring 4min
Medicated powder, then mixed powder is ground, cross 350 mesh sieves, make hybrid medicine fine powder, standby；
Step 3：By the binding agent of described composition by weight and purified water according to 1:4 weight is configured to glue than mixed dissolution
Mixture solution, the hybrid medicine fine powder that prepare step 2 and the filler mix homogeneously of described composition by weight, add step 3
In the binder solution of preparation, it is prepared into wet granular, then by wet grain drying and granulate obtains dry particl, 40 DEG C of baking temperature,
To the disintegrating agent, the lubricant that add described composition by weight in dry particl, tabletted after mix homogeneously, that is, prepare for lung source
The property paracmastic tablet of heart disease.
Embodiment 12：One kind is used for the paracmastic tablet of pulmonary heart disease, and described tablet is main by following weight portion
One-tenth be grouped into：36 parts of phellopterin, 8 parts of zaluzanin C, 5 parts of TANSHINONES, 12 parts of Coixol, 8 parts of hyperin, Rhizoma Seu Herba Bergeniae
9 parts of element, 15 parts of puerarin, 10 parts of glycyrrhizin, 4 parts of cryptoxanthine, 3 parts of rutin, 12 parts of pachyman, 6 parts of fucose, N- second
5 parts of acylamino- glucose, 5 parts of catechin；Described tablet also includes adjuvant：160 parts of filler, 10 parts of disintegrating agent, binding agent 55
Part, 8 parts of lubricant.
Wherein, the preparation method of described pachyman is：Weigh Poria grind into powder, cross 40 mesh sieves, add Poria
The pure water of weight 8 times amount, is heated to seething with excitement, decocts 3h, extracting solution is collected by filtration, to the pure water adding 5 times amount in filtering residue,
It is heated to seething with excitement, decocts 2h, extracting solution is collected by filtration, and extracting solution twice is merged, be evaporated to whole extracting liqs
Long-pending 1/5th obtain concentrated solution, the ethanol solution being 95% to the mass concentration adding 4 times amount in concentrated solution, are placed in 5 DEG C
12h in environment, fully precipitates, collects precipitate with macroporous adsorbent resin, and precipitate dehydrated alcohol, acetone, ether are divided
Not Xi Di after, vacuum spray drying, that is, obtain pachyman, it has good antitumor action moreover it is possible to strengthen the exempting from of cell
Epidemic disease is reacted and is activated the immune surveillance system to tumor for the body, has immune-enhancing activity, can be used for antiviral, antiinflammatory, strengthens
Immunocompetence.Described filler is betacyclodextrin, strong to the adhesion of medicine, and saturation is big.Described disintegrating agent is to hand over
Connection sodium carboxymethyl cellulose, the granule after disintegrate is tiny, is easy to the absorption to effective ingredient for the human body, disintegrating property is superior.
Described binding agent is hydroxypropyl cellulose, and viscosity is strong, is easy to pelletize.Described lubricant is silicon dioxide, and good fluidity can
To improve the structural homogenity of medicine.
A kind of preparation method for the paracmastic tablet of pulmonary heart disease is：
Step one：Weigh Poria grind into powder, cross 40 mesh sieves, add the pure water of Poria weight 8 times amount, be heated to boiling
Rise, decoct 3h, extracting solution is collected by filtration, to the pure water adding 5 times amount in filtering residue, be heated to seething with excitement, decoct 2h, be collected by filtration
Extracting solution, and extracting solution twice is merged, be evaporated to whole extracting liquid volumes 1/5th obtain concentrated solution, to dense
Add in contracting liquid 4 times amount mass concentration be 95% ethanol solution, be placed in 12h in 5 DEG C of environment, fully precipitate, inhaled with macropore
Attached resin trap precipitate, and after precipitate dehydrated alcohol, acetone, ether are washed respectively, vacuum spray drying, that is, obtain
Pachyman；
Step 2：Will be white to the phellopterin of described composition by weight, zaluzanin C, TANSHINONES, Coixol, hyperin, rock
Dish element, puerarin, glycyrrhizin, cryptoxanthine, rutin, pachyman, fucose, 2-Acetamido-2-deoxy-D-glucose, catechin make
With mechanical agitation, using Agravicmixer, driving material to reach parabolical peak when Agravicmixer runs makes thing
Material instantaneous weight loss, makes different-grain diameter, the material of different densities is realized uniformly mixing, the material of both sides is adverse movement, material phase
Mutually fall in opposing regions, central part forms convection current, so that it is guaranteed that material radial direction, ring, axial three-dimensional shed motion, formed
Combined-circulation, is rapidly reached uniform mixing, and incorporation time is short, and the medicaments uniformity blending is good, is mixed after stirring 5min
Medicated powder, then mixed powder is ground, cross 400 mesh sieves, make hybrid medicine fine powder, standby；
Step 3：By the binding agent of described composition by weight and purified water according to 1:5 weight is configured to glue than mixed dissolution
Mixture solution, the hybrid medicine fine powder that prepare step 2 and the filler mix homogeneously of described composition by weight, add step 3
In the binder solution of preparation, it is prepared into wet granular, then by wet grain drying and granulate obtains dry particl, 45 DEG C of baking temperature,
To the disintegrating agent, the lubricant that add described composition by weight in dry particl, tabletted after mix homogeneously, that is, prepare for lung source
The property paracmastic tablet of heart disease.
The animal toxicity test of medicine of the present invention
Choose experiment mice 120, male and female dual-purpose, body weight 120-150g, be divided into 12 groups, every group 10, by embodiment
Tablet prepared by 1-12 uses to 12 groups of mices difference gavages according to the weight ratio of 0.5g/kg, and administering mode is by tablet
Add the pure water of fine powder 5 times amount to carry out gastric infusion after grinding to form fine powder, three times a day, serve on 15 days, observe little after being administered
The reaction of Mus, result shows that 12 groups of mice activities, diet are normal, after dissection, the major organs such as liver, stomach in mice body is carried out
Inspection, all shows normal, does not find any damage, therefore concludes that the tablet of present invention preparation does not temporarily find that any bad poison is secondary
Effect.
Clinical trial：
1. clinical case selects and is grouped：Inventor collects 120 pulmonary heart disease catabasises patients making a definite diagnosis altogether, with
Machine is divided into four groups, every group of 30 people, the data such as four groups of sexes, age, state of an illness there are no significant difference, has comparability.
2. diagnostic criteria：Clinical manifestation is chronic cough, expectoration, out of breath, cardiopalmus, dyspnea, weak and labor after activity
Dynamic endurance declines, and health check-up can have obvious emphysema to levy, and auscultation diminished breath sound occasionally has dry, moist sound, the slight edema of lower limb
Deng no acute exacerbation trend.
3. test method：Respectively to test group patient take embodiment 2, embodiment 5, embodiment 8, embodiment 11 preparation
Tablet, takes 3 times, each 0.5g daily, is within 7 days a course for the treatment of, and experimental period is three courses for the treatment of.
4. criterion of therapeutical effect and therapeutic outcome
4.1 criterion of therapeutical effect
Effective：Clinical symptom disappearance, every sign recovers normal, observes half a year no recidivist；
Take a turn for the better：Clinical symptoms are clearly better, and every sign makes moderate progress, and body constitution is progressively recovered；
Invalid：Clinical symptoms are not alleviated or increase.
4.2 treatment statistics
1 three groups of comparitive study of table
| The medicine taken | Case number | Effective | Take a turn for the better | Invalid | Untoward reaction | Total effective rate % |
| Embodiment 2 | 30 | 13 | 14 | 3 | 0 | 90.0 |
| Embodiment 5 | 30 | 18 | 11 | 1 | 0 | 96.7 |
| Embodiment 8 | 30 | 16 | 13 | 1 | 0 | 96.7 |
| Embodiment 11 | 30 | 22 | 8 | 0 | 0 | 100.0 |
5. conclusion：During clinical trial, the patient accepting Tablets treatment finds no any untoward reaction, by
Table 1 data is visible, and Tablets reach more than 90.0% to for the paracmastic total effective rate of pulmonary heart disease, are for lung
The paracmastic safe and effective medicine of source property heart disease, has good clinical meaning.
6. clinical individual case
Case 1：Huang, man, 52 years old, morning get up after happen suddenly agitation uncomfortable in chest, fever of the body is thirsty, cough, increased heart rate, goes out void
Antiperspirant, is pulmonary heart disease through hospital diagnosis, and after 5 days, symptom is obviously improved the tablet prepared using the embodiment of the present invention 5, coughs
Cough, uncomfortable in chest, irritated symptom slows down, after being continuing with 20, all symptoms all disappear, for recurrence in half a year.
Case 2：Section so-and-so, female, 65 years old, suffer from chronic obstructive pulmonary disease, bronchiectasis, chronic pulmonary heart disease companion
Cough, expectorant, breathe heavily and suppress 5 years, gradually increase in half a year, using the tablet of the embodiment of the present invention 8 preparation, continuously take 30 days, lower limb water
Swollen disappearance, remission, after continuing to take 30 days, former exception is all improved on inspection, does not recur within 1 year.
Case 3：Beam, man, 43 years old, patient was uncomfortable in chest, and cough is coughed up phlegm, shortness of breath and palpitation, xerostomia, and back is ice-cold, abdominal part distension
Discomfort, inappetence, through being diagnosed as pulmonary heart disease, the tablet prepared using the embodiment of the present invention 11 15 days, symptom takes a turn for the better,
Patient mental's state is obviously improved, and continues to take 30 days, cures, does not recur in 1 year.
Although the present invention is described and illustrated with reference to its specific embodiments, it will be appreciated by those skilled in the art that
Without departing from the spirit and scope of the present invention it can be variously modified, change and replace.For example, due to quilt
The change of the responding ability of people for the treatment of particular condition, the effective dose beyond the preferred dose being explained as above may be suitable for.With
Sample ground it was observed that pharmacology's response may basis and particular active compounds selected by relying on or with the presence or absence of pharmaceutical carrier and
Preparation type and mode of administration used and become, according to the purpose of the present invention and practice be contemplated to this kind of performance of expected change in result or
Difference.Therefore, the invention is intended to only being limited by the scope of following claims and these claim should be in rational degree
Explain as broadly as possible.
Claims (9)
1. one kind is used for the paracmastic tablet of pulmonary heart disease it is characterised in that described tablet is main by following weight portion
One-tenth be grouped into：Phellopterin 18-36 part, zaluzanin C 5-8 part, TANSHINONES 3-5 part, Coixol 6-12 part, hyperin
4-8 part, Bergeninum 5-9 part；Described tablet also includes adjuvant：Filler 120-160 part, disintegrating agent 6-10 part, binding agent 35-
55 parts, lubricant 5-8 part.
2. as claimed in claim 1 a kind of for the paracmastic tablet of pulmonary heart disease it is characterised in that described tablet also
Composition including following weight portion：Puerarin 9-15 part, glycyrrhizin 6-10 part, cryptoxanthine 2-4 part, rutin 1-3 part.
3. as claimed in claim 1 a kind of for the paracmastic tablet of pulmonary heart disease it is characterised in that described tablet also
Composition including following weight portion：Pachyman 6-12 part, fucose 3-6 part, 2-Acetamido-2-deoxy-D-glucose 3-5 part, catechin
2-5 part.
4. as claimed in claim 3 a kind of for the paracmastic tablet of pulmonary heart disease it is characterised in that described Poria
The preparation method of polysaccharide is：Weigh Poria grind into powder, cross 40 mesh sieves, add the pure water of Poria weight 5-8 times amount, heating
To seething with excitement, decoct 2-3h, extracting solution is collected by filtration, to the pure water adding 3-5 times amount in filtering residue, be heated to seething with excitement, decoct 1-
2h, is collected by filtration extracting solution, and extracting solution twice is merged, be evaporated to whole extracting liquid volumes 1/5th obtain
Concentrated solution, the ethanol solution being 95% to the mass concentration adding 2-4 times amount in concentrated solution, it is placed in 8-12h in 5 DEG C of environment, fill
Fractional precipitation, collects precipitate with macroporous adsorbent resin, and after precipitate dehydrated alcohol, acetone, ether are washed respectively, vacuum
It is spray-dried, that is, obtain pachyman.
5. as claimed in claim 1 a kind of for the paracmastic tablet of pulmonary heart disease it is characterised in that described filling
Agent is any one or two or more combination in any in Pregelatinized Starch, Mannitol or betacyclodextrin.
6. as claimed in claim 1 a kind of for the paracmastic tablet of pulmonary heart disease it is characterised in that described disintegrate
Agent is carboxymethylcellulose calcium, any one or two kinds in low-substituted hydroxypropyl cellulose or cross-linking sodium carboxymethyl cellulose with
On combination in any.
7. as claimed in claim 1 a kind of for the paracmastic tablet of pulmonary heart disease it is characterised in that described bonding
Agent is any one or two or more combination in any in Microcrystalline Cellulose, arabic gum or hydroxypropyl cellulose.
8. as claimed in claim 1 a kind of for the paracmastic tablet of pulmonary heart disease it is characterised in that described lubrication
Agent is any one or two or more combination in any in magnesium stearate, micropowder silica gel or silicon dioxide.
9. the one kind as described in claim 1-6 any one be used for the paracmastic tablet of pulmonary heart disease it is characterised in that
Preparation method is：
Step one：Weigh Poria grind into powder, cross 40 mesh sieves, add the pure water of Poria weight 5-8 times amount, be heated to boiling
Rise, decoct 2-3h, extracting solution is collected by filtration, to the pure water adding 3-5 times amount in filtering residue, be heated to seething with excitement, decoct 1-2h, mistake
Extracting solution is collected in filter, and extracting solution twice is merged, and be evaporated to whole extracting liquid volumes 1/5th are concentrated
Liquid, the ethanol solution being 95% to the mass concentration adding 2-4 times amount in concentrated solution, it is placed in 8-12h in 5 DEG C of environment, fully heavy
Form sediment, collect precipitate with macroporous adsorbent resin, and after precipitate dehydrated alcohol, acetone, ether are washed respectively, vacuum spraying
It is dried, that is, obtain pachyman；
Step 2：By the phellopterin of described composition by weight, zaluzanin C, TANSHINONES, Coixol, hyperin, Rhizoma Seu Herba Bergeniae
Element, puerarin, glycyrrhizin, cryptoxanthine, rutin, pachyman, fucose, 2-Acetamido-2-deoxy-D-glucose, catechin use
Mechanical agitation, using Agravicmixer, obtains mixed powder after stirring 3-5min, then mixed powder is ground, mistake
300-400 mesh sieve, makes hybrid medicine fine powder, standby；
Step 3：By the binding agent of described composition by weight and purified water according to 1:The weight of 3-5 is configured to bond than mixed dissolution
Agent solution, the hybrid medicine fine powder that prepare step 2 and the filler mix homogeneously of described composition by weight, add step 3 system
In standby binder solution, it is prepared into wet granular, then by wet grain drying and granulate obtains dry particl, 35-45 DEG C of baking temperature,
To the disintegrating agent, the lubricant that add described composition by weight in dry particl, tabletted after mix homogeneously, that is, prepare for lung source
The property paracmastic tablet of heart disease.
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Cited By (1)
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Application publication date: 20170308 |