CN106458892A - 用于制备倍癌霉素前药的改进方法 - Google Patents
用于制备倍癌霉素前药的改进方法 Download PDFInfo
- Publication number
- CN106458892A CN106458892A CN201480079537.XA CN201480079537A CN106458892A CN 106458892 A CN106458892 A CN 106458892A CN 201480079537 A CN201480079537 A CN 201480079537A CN 106458892 A CN106458892 A CN 106458892A
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- China
- Prior art keywords
- compound
- formula
- reagent
- independently
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC1CC(*2)C2CC1 Chemical compound CC1CC(*2)C2CC1 0.000 description 5
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Abstract
Description
Claims (15)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2014/061701 WO2015185142A1 (en) | 2014-06-05 | 2014-06-05 | Improved process for making duocarmycin prodrugs |
Publications (2)
Publication Number | Publication Date |
---|---|
CN106458892A true CN106458892A (zh) | 2017-02-22 |
CN106458892B CN106458892B (zh) | 2019-10-18 |
Family
ID=50896304
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201480079537.XA Active CN106458892B (zh) | 2014-06-05 | 2014-06-05 | 用于制备倍癌霉素前药的改进方法 |
Country Status (13)
Country | Link |
---|---|
US (1) | US9890159B2 (zh) |
EP (1) | EP3152191B1 (zh) |
JP (1) | JP6275881B2 (zh) |
CN (1) | CN106458892B (zh) |
CY (1) | CY1122025T1 (zh) |
DK (1) | DK3152191T3 (zh) |
ES (1) | ES2738211T3 (zh) |
HR (1) | HRP20191378T1 (zh) |
HU (1) | HUE045447T2 (zh) |
LT (1) | LT3152191T (zh) |
PL (1) | PL3152191T3 (zh) |
PT (1) | PT3152191T (zh) |
WO (1) | WO2015185142A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112969478A (zh) * | 2018-11-09 | 2021-06-15 | 拜奥迪斯私人有限公司 | 可滤过的含倍癌霉素抗体-药物缀合物组合物及相关方法 |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9901567B2 (en) | 2007-08-01 | 2018-02-27 | Syntarga B.V. | Substituted CC-1065 analogs and their conjugates |
AU2011243294C1 (en) | 2010-04-21 | 2015-12-03 | Syntarga B.V. | Novel conjugates of CC-1065 analogs and bifunctional linkers |
KR20220045075A (ko) | 2014-01-10 | 2022-04-12 | 비온디스 비.브이. | 자궁내막암의 치료에서 사용하기 위한 듀오카르마이신 adc |
RU2769700C2 (ru) | 2014-01-10 | 2022-04-05 | Байондис Б.В. | Дуокармициновые adc, демонстрирующие улучшенную противоопухолевую активность in vivo |
PL3151865T3 (pl) | 2014-05-22 | 2022-01-03 | Byondis B.V. | Koniugacja w określonym miejscu leków-łączników z przeciwciałami oraz powstałe w jej wyniku koniugaty przeciwciało-lek (ADCs) |
TWI781098B (zh) | 2016-04-15 | 2022-10-21 | 美商宏觀基因股份有限公司 | 新穎的b7-h3-結合分子、其抗體藥物綴合物及其使用方法 |
JP7279042B2 (ja) | 2017-11-24 | 2023-05-22 | ビョンディス・ビー.ブイ. | リンカー薬物化合物vc-seco-DUBA製造のための改善された方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2433379T3 (es) | 2007-08-01 | 2013-12-10 | Syntarga B.V. | Análogos de CC-1065 sustituidos y sus conjugados |
US9901567B2 (en) | 2007-08-01 | 2018-02-27 | Syntarga B.V. | Substituted CC-1065 analogs and their conjugates |
WO2010062171A2 (en) | 2008-11-03 | 2010-06-03 | Syntarga B.V. | Novel cc-1065 analogs and their conjugates |
AU2011243294C1 (en) * | 2010-04-21 | 2015-12-03 | Syntarga B.V. | Novel conjugates of CC-1065 analogs and bifunctional linkers |
SG11201605605SA (en) | 2014-01-10 | 2016-08-30 | Synthon Biopharmaceuticals Bv | Method for purifying cys-linked antibody-drug conjugates |
PL3151865T3 (pl) | 2014-05-22 | 2022-01-03 | Byondis B.V. | Koniugacja w określonym miejscu leków-łączników z przeciwciałami oraz powstałe w jej wyniku koniugaty przeciwciało-lek (ADCs) |
US20170320965A1 (en) | 2014-09-22 | 2017-11-09 | Synthon Biopharmaceuticals B.V. | Pan-reactive antibodies to duocarmycins |
-
2014
- 2014-06-05 CN CN201480079537.XA patent/CN106458892B/zh active Active
- 2014-06-05 JP JP2016570985A patent/JP6275881B2/ja active Active
- 2014-06-05 WO PCT/EP2014/061701 patent/WO2015185142A1/en active Application Filing
- 2014-06-05 PL PL14728565T patent/PL3152191T3/pl unknown
- 2014-06-05 EP EP14728565.4A patent/EP3152191B1/en active Active
- 2014-06-05 DK DK14728565.4T patent/DK3152191T3/da active
- 2014-06-05 US US15/316,444 patent/US9890159B2/en active Active
- 2014-06-05 HU HUE14728565A patent/HUE045447T2/hu unknown
- 2014-06-05 ES ES14728565T patent/ES2738211T3/es active Active
- 2014-06-05 PT PT14728565T patent/PT3152191T/pt unknown
- 2014-06-05 LT LTEP14728565.4T patent/LT3152191T/lt unknown
-
2019
- 2019-07-30 CY CY20191100815T patent/CY1122025T1/el unknown
- 2019-07-31 HR HRP20191378 patent/HRP20191378T1/hr unknown
Non-Patent Citations (3)
Title |
---|
LUTZ F. TIETZE ET AL.: "Atropisomerism of aromatic carbamates", 《CHEMISTRY-A EUROPEAN JOURNAL》 * |
LUTZ F. TIETZE ET AL.: "Enantio- and Diastereoselective synthesis of duocarmycine-based prodrugs for a selective treatment of cancer by epoxide opening", 《CHEMISTRY-A EUROPEAN JOURNAL》 * |
LUTZ F. TIETZE ET AL.: "Synthesis of Fluorescence-Labelled Glycosidic Prodrugs Based on the Cytotoxic Antibiotic Duocarmycin", 《EUR. J. ORG. CHEM.》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112969478A (zh) * | 2018-11-09 | 2021-06-15 | 拜奥迪斯私人有限公司 | 可滤过的含倍癌霉素抗体-药物缀合物组合物及相关方法 |
CN112969478B (zh) * | 2018-11-09 | 2023-10-27 | 拜奥迪斯私人有限公司 | 可滤过的含倍癌霉素抗体-药物缀合物组合物及相关方法 |
Also Published As
Publication number | Publication date |
---|---|
US20170145006A1 (en) | 2017-05-25 |
LT3152191T (lt) | 2019-08-26 |
PL3152191T3 (pl) | 2019-10-31 |
JP2017516822A (ja) | 2017-06-22 |
HRP20191378T1 (hr) | 2019-11-15 |
DK3152191T3 (da) | 2019-08-12 |
CN106458892B (zh) | 2019-10-18 |
EP3152191A1 (en) | 2017-04-12 |
PT3152191T (pt) | 2019-08-30 |
HUE045447T2 (hu) | 2019-12-30 |
JP6275881B2 (ja) | 2018-02-07 |
EP3152191B1 (en) | 2019-05-15 |
WO2015185142A1 (en) | 2015-12-10 |
US9890159B2 (en) | 2018-02-13 |
CY1122025T1 (el) | 2020-11-25 |
ES2738211T3 (es) | 2020-01-20 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
CB03 | Change of inventor or designer information | ||
CB03 | Change of inventor or designer information |
Inventor after: Tiil Huibretz Inventor after: Ronald Christian Elgsma Inventor after: Patrick Henry Bosquel Inventor after: Johannes Albertus Fredericks Osten Inventor after: Rudy Gerardus Elizabeth Kooimans Inventor after: Henry Johannes Spilker Inventor after: Vero Menge Inventor after: Franciscus Marinas Hendricks Groot Inventor before: Tiil Huibgts Inventor before: Ronald Christian Elgsma Inventor before: Patrick Henry Bosquel Inventor before: Johannes Albertus Fredericks Osten Inventor before: Rudy Gerardus Elizabeth Kooimans Inventor before: Henry Johannes Spilker Inventor before: Vero Menge Inventor before: Franciscus Mariens Hendricks Groot |
|
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CP01 | Change in the name or title of a patent holder | ||
CP01 | Change in the name or title of a patent holder |
Address after: Nijmegen Patentee after: Byodes Private Limited Address before: Nijmegen Patentee before: SYNTHON BIOPHARMACEUTICALS B.V. |