HUE045447T2 - Javított eljárás a duokarmicin gyógyszer-elõanyagainak az elõállítására - Google Patents

Javított eljárás a duokarmicin gyógyszer-elõanyagainak az elõállítására

Info

Publication number
HUE045447T2
HUE045447T2 HUE14728565A HUE14728565A HUE045447T2 HU E045447 T2 HUE045447 T2 HU E045447T2 HU E14728565 A HUE14728565 A HU E14728565A HU E14728565 A HUE14728565 A HU E14728565A HU E045447 T2 HUE045447 T2 HU E045447T2
Authority
HU
Hungary
Prior art keywords
duocarmycin
prodrugs
making
improved process
improved
Prior art date
Application number
HUE14728565A
Other languages
English (en)
Inventor
Tijl Huijbrgts
Ronald Christiaan Elgersma
Patrick Henry Beusker
Johannes Albertus Frederikus Joosten
Rudy Gerardus Elisabeth Coumans
Henri Johannes Spijker
Wiro Menge
Groot Franciscus Mariuns Hendrikus De
Original Assignee
Synthon Biopharmaceuticals Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthon Biopharmaceuticals Bv filed Critical Synthon Biopharmaceuticals Bv
Publication of HUE045447T2 publication Critical patent/HUE045447T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
HUE14728565A 2014-06-05 2014-06-05 Javított eljárás a duokarmicin gyógyszer-elõanyagainak az elõállítására HUE045447T2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14728565.4A EP3152191B1 (en) 2014-06-05 2014-06-05 Improved process for making duocarmycin prodrugs
PCT/EP2014/061701 WO2015185142A1 (en) 2014-06-05 2014-06-05 Improved process for making duocarmycin prodrugs

Publications (1)

Publication Number Publication Date
HUE045447T2 true HUE045447T2 (hu) 2019-12-30

Family

ID=50896304

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE14728565A HUE045447T2 (hu) 2014-06-05 2014-06-05 Javított eljárás a duokarmicin gyógyszer-elõanyagainak az elõállítására

Country Status (13)

Country Link
US (1) US9890159B2 (hu)
EP (1) EP3152191B1 (hu)
JP (1) JP6275881B2 (hu)
CN (1) CN106458892B (hu)
CY (1) CY1122025T1 (hu)
DK (1) DK3152191T3 (hu)
ES (1) ES2738211T3 (hu)
HR (1) HRP20191378T1 (hu)
HU (1) HUE045447T2 (hu)
LT (1) LT3152191T (hu)
PL (1) PL3152191T3 (hu)
PT (1) PT3152191T (hu)
WO (1) WO2015185142A1 (hu)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
PT3108886T (pt) 2010-04-21 2020-08-27 Syntarga Bv Conjugados de analógicos cc-1065 e ligantes bifuncionais
CN105899237B (zh) 2014-01-10 2019-09-03 斯索恩生物制药有限公司 用于治疗子宫内膜癌的倍癌霉素adc
CA2935433C (en) 2014-01-10 2019-04-02 Synthon Biopharmaceuticals B.V. Duocarmycin anti-her2 antibody drug conjucates with activity against her2 expressing malignancies
LT3151865T (lt) 2014-05-22 2021-10-25 Byondis B.V. Prijungiamų vaistų vietai specifinis konjugavimas su antikūnais ir to pasekoje gaunami avk
BR112018071105A2 (pt) 2016-04-15 2019-02-26 Macrogenics, Inc. conjugado de droga e anticorpo, molécula de ligação, composição farmacêutica e uso
PT3713939T (pt) 2017-11-24 2021-09-16 Byondis Bv Processo melhorado para a síntese de fármaco ligante vcseco- duba
CN112969478B (zh) * 2018-11-09 2023-10-27 拜奥迪斯私人有限公司 可滤过的含倍癌霉素抗体-药物缀合物组合物及相关方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007357156B2 (en) 2007-08-01 2013-01-10 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
ES2647317T3 (es) 2008-11-03 2017-12-20 Syntarga B.V. Análogos de CC-1065 y sus conjugados
PT3108886T (pt) 2010-04-21 2020-08-27 Syntarga Bv Conjugados de analógicos cc-1065 e ligantes bifuncionais
LT3092010T (lt) 2014-01-10 2018-10-25 Synthon Biopharmaceuticals B.V. Metodas, skirtas gryninimui cys-sujungtų antikūno-vaisto konjugatų
LT3151865T (lt) 2014-05-22 2021-10-25 Byondis B.V. Prijungiamų vaistų vietai specifinis konjugavimas su antikūnais ir to pasekoje gaunami avk
US20170320965A1 (en) 2014-09-22 2017-11-09 Synthon Biopharmaceuticals B.V. Pan-reactive antibodies to duocarmycins

Also Published As

Publication number Publication date
WO2015185142A1 (en) 2015-12-10
ES2738211T3 (es) 2020-01-20
CN106458892A (zh) 2017-02-22
DK3152191T3 (da) 2019-08-12
JP6275881B2 (ja) 2018-02-07
US9890159B2 (en) 2018-02-13
US20170145006A1 (en) 2017-05-25
CY1122025T1 (el) 2020-11-25
EP3152191B1 (en) 2019-05-15
HRP20191378T1 (hr) 2019-11-15
LT3152191T (lt) 2019-08-26
PL3152191T3 (pl) 2019-10-31
EP3152191A1 (en) 2017-04-12
PT3152191T (pt) 2019-08-30
CN106458892B (zh) 2019-10-18
JP2017516822A (ja) 2017-06-22

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