CN106456681A - Tablet containing sake yeast - Google Patents

Tablet containing sake yeast Download PDF

Info

Publication number
CN106456681A
CN106456681A CN201580028888.2A CN201580028888A CN106456681A CN 106456681 A CN106456681 A CN 106456681A CN 201580028888 A CN201580028888 A CN 201580028888A CN 106456681 A CN106456681 A CN 106456681A
Authority
CN
China
Prior art keywords
coating
tablet
saccharomyces sake
mass
glycerine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201580028888.2A
Other languages
Chinese (zh)
Other versions
CN106456681B (en
Inventor
金岛大辅
五木田智夫
南埜秀明
松野步
菅藤寿裕
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lion Corp
Original Assignee
Lion Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lion Corp filed Critical Lion Corp
Publication of CN106456681A publication Critical patent/CN106456681A/en
Application granted granted Critical
Publication of CN106456681B publication Critical patent/CN106456681B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A61K36/064—Saccharomycetales, e.g. baker's yeast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The purpose of the present invention is to obtain a coating agent that has excellent coating characteristics and is problem-free in terms of appearance, odor and flavor. The present invention provides a tablet containing sake yeast, said tablet being coated with a coating agent containing hydroxypropyl methylcellulose and glycerol. The ratio (A/B) of the coating percentage (A) of the hydroxypropyl methylcellulose to the coating percentage (B) of the glycerol is 2 to 20, and the content of sake yeast cells (C) is 15 mass% with respect to an uncoated tablet.

Description

Tablet containing saccharomyces sake
Technical field
The present invention relates to the tablet containing saccharomyces sake.
Background technology
The nutrient contents such as abundant vitamins, amino acids, food fiber, mineralogical composition are contained in saccharomyces sake.Cause This, can expect to reach nutritional supplementation, prevention disease and other effects by absorbing saccharomyces sake.
Tablet containing saccharomyces sake and saccharomyces sake in itself compared with, can more easily take.Therefore, containing saccharomyces sake Tablet is as being useful for obtaining the nutritional supplementation effect that saccharomyces sake is played.But, mend to obtain above-mentioned nutrition Fill or other effects, need to absorb the saccharomyces sake of more amount.Therefore, if the content of saccharomyces sake is few in tablet, absorb Tablet can become excessive, taking goes wrong.Therefore, in order to improve the taking of the tablet containing saccharomyces sake, Need to improve the yeast concentration in tablet.But, if improving the yeast concentration in tablet, produce the hardship from saccharomyces sake Taste, the problem of distinctive smell.
As the technology suppressing such bitter taste, smell, there is technology tablet being coated by coating agent.Patent literary composition Offer the tablet recorded in 1 with cellulose derivative is dried thalline to the microorganism containing SAM (SAMe) to enter Row coating, and describe preparation example hydroxypropyl methyl cellulose being used as cellulose derivative.
Prior art literature
Patent document
Patent document 1：International Publication No. 2009/081833
Content of the invention
Invent problem to be solved
But, the method described in patent document 1, its object is to make contained stable components in yeast it is difficult to prevent The only decortication of generation, wrinkling, the coating property variation such as sliver, sticking.
It is an object of the invention to, obtain a kind of excellent, the bag of equal no problem in terms of outward appearance, aroma and flavor of coating property Clothing agent.
The technical scheme of solve problem
The present inventor has carried out deep discussion to solve above-mentioned problem.During find will be fine for hydroxypropyl methyl Dimension element uses as coating agent with glycerine is combined, can keep good coating.Further, by adjusting hydroxypropyl methyl The balance of cellulose and glycerine coating rate, can keep good outward appearance, aroma and flavor.
The present invention provides (1)～(3).
(1) a kind of tablet, it is the plain piece containing saccharomyces sake, and this plain piece is by the bag containing hydroxypropyl methyl cellulose and glycerine Clothing agent coating forms, wherein,
The coating rate (A) of hydroxypropyl methyl cellulose is 2～20 with respect to the ratio (A/B) of the coating rate (B) of glycerine,
The content of saccharomyces sake thalline (C) is with respect to plain piece more than 15 mass %.
(2) tablet according to (1), wherein, the coating rate (B) of glycerine is 0.025%～2.5%.
(3) tablet according to (1) or (2), wherein, the coating rate (A) of hydroxypropyl methyl cellulose is more than 0.5%.
Invention effect
A kind of coating property can be provided excellent according to the present invention, in containing of the aspect no problem such as outward appearance, aroma and flavor The coated tablet of saccharomyces sake.
Specific embodiment
Saccharomyces sake is contained in the tablet of the present invention.Saccharomyces sake is the yeast using when brewageing pure mellow wine.When brewageing pure mellow wine The yeast using principally falls into saccharomyces cerevisiae (S.cerevisiae).As saccharomyces sake, No. 6 yeast (K- of association can be enumerated 6), No. 7 yeast (K-7) of association, No. 9 yeast (K-9) of association, No. 601 yeast (K-601) of association, No. 701 yeast (K- of association 701), No. 901 yeast (K-901) of association, No. 1001 yeast (K-1001) of association, No. 1501 yeast (K-1501) of association (are Public good juridical person Japan brewages association and promulgates).Saccharomyces sake can be any one of raw thalline and dead thalline.
Saccharomyces sake is usually dried thalline.Part warp that thalline be the thalline such as the fragment of thalline and/or thalline is dried The product of dried process gained.As dried process, freeze-drying, drying under reduced pressure can be enumerated, ventilating is dried, is spray-dried. Thalline is dried and is usually powder.
With respect to the quality of plain piece of the present invention, the content of saccharomyces sake thalline (C) (dry mass) is as in every tablet The content of saccharomyces sake, more than plain piece usually 15 mass %, more than preferably 20 mass %, more preferably 23 mass % with On.Thus, it is possible to piece numerical control system will be absorbed in proper range, taking therefore can be improved.The upper limit preferably 70 mass % with Under, below more preferably 60 mass %, below further preferred 50 mass %.Thus, it is possible to prevent from saccharomyces sake Bitter taste, distinctive smell, can keep taste and smell.In every tablet, the content of saccharomyces sake thalline (C) is with respect to plain piece, Preferably 15 mass %～70 mass %, more preferably 20 mass %～60 mass %, further preferred 23 mass %～50 mass %.
Saccharomyces sake thalline (C) in the tablet of the present invention is contained in saccharomyces sake.Saccharomyces sake and saccharomyces sake bacterium Body (C) is sometimes identical.Additionally, the composition beyond saccharomyces sake thalline (C) can also be contained in saccharomyces sake.As this pure mellow wine ferment Composition beyond female thalline (C), for example, can enumerate：Zymotic fluid, culture supernatant etc..
The tablet of the present invention, can be coated to the plain piece containing saccharomyces sake by coating agent.Coating agent contains hydroxyl Propyl methocel and glycerine.
Hydroxypropyl methyl cellulose (another name：HPMC the viscosity in 20 DEG C of the 2 mass % aqueous solution), preferably 2mm2/ s with On, more preferably 4mm2/ more than s.The preferred 10mm of the upper limit2/ below s, more preferably 8mm2/ below s.Thus, it is possible to realize film formability Good coating.
The substitution value of hydroxypropyl methyl cellulose, methoxyl content preferably more than 15%, more preferably more than 20%.The upper limit is excellent Select less than 40%, more preferably less than 30%.Additionally, hydroxypropoxy content preferably more than 2%, more preferably more than 5%.The upper limit is excellent Select less than 15%, more preferably less than 12%.Thus, it is possible to realize the good coating of film formability.
As hydroxypropyl methyl cellulose, can enumerate：The METOLOSE60SH-03 of Shin-Etsu Chemial Co., Ltd, 60SH-06, SE-06, MCE-4, SB-4, SM-4, TC-5E, TC-5M, TC-5R etc..Wherein, particularly preferred SE-06, TC-5R.
The coating rate (A) of hydroxypropyl methyl cellulose, preferably more than 0.5%, more preferably more than 1%.The upper limit preferably 10% Hereinafter, more preferably less than 5%, further preferred less than 3%.This coating rate preferably 0.5%～10%, more preferably 0.5%～ 5%, further preferred 1%～3%.
If the coating rate (A) of hydroxypropyl methyl cellulose, more than preferred lower limit, can more reduce from pure mellow wine ferment The bitter taste of mother, distinctive smell, if below preferred higher limit, can get the better tablet of disintegrative.
As glycerine, it is possible to use Japanese Pharmacopoeia or glycerine specified in food additives statutory document.
The coating rate (B) of glycerine, preferably more than 0.025%, more preferably more than 0.1%.The upper limit preferably less than 2.5%, more Preferably less than 0.8%.This coating rate preferably 0.025%～2.5%, more preferably 0.1%～0.8%.
If the coating rate (B) of glycerine, more than preferred lower limit, can keep better coating, if preferred Higher limit below, then be more difficult to over time through generation cosmetic variation.
Coating rate in the present invention is the numerical value being calculated by following formula.
(formula)
Coating rate=(quality of the content/plain piece of coating constituents) × 100
In tablet the coating rate (A) of hydroxypropyl methyl cellulose with respect to the ratio (A/B) of the coating rate (B) of glycerine 2 More than, preferably more than 4.The upper limit preferably less than 20, preferably less than 10.This ratio is 2～20, preferably 4～10.
If (A/B) more than preferred lower limit and below higher limit, better coating can be kept.
Coating agent can contain the composition in addition to ylmethyl cellulose and glycerine.As this composition, can enumerate poly- Vinyl alcohol, polyvinylpyrrolidone etc. synthesize macromolecule；The polyalcohols such as polyethylene glycol, propane diols, glycerine；Triacetyl glycerine, The synthesizing esters such as triethyl citrate, fatty acid glyceride；Carboxymethylcellulose calcium, hydroxypropyl cellulose, methylcellulose, ethyl The cellulose families such as cellulose；The natural materials such as shellac, pulullan polysaccharide, gum arabic；Or these combination.Additionally, can To be added as needed on the pigment such as titanium oxide, iron oxide；Any conditions such as mannitol, cetanol, NaLS.Additionally, After film coating, Brazil wax as polishing material etc. can be added.
As long as the effect not giving the present invention does not bring bad influence, in the amount of the degree of the effect not damaging the present invention, can With any condition used in the manufacture containing tablets such as other pharmaceuticals, the outer product of medicine, food.As any condition, for example Can enumerate：Excipient, adhesive, disintegrant, enteric polymer, insoluble polymer, lubricant, surfactant, Toner, flavor enhancement, adsorbent, antistatic additive, disintegration extend agent, foaming agent etc..
As excipient, for example, can enumerate：Starch, cornstarch, granulated sugar, mannitol, avicel cellulose, magnesium carbonate, carbon Sour calcium, castor sugar, glucose, dextrose hydrate, lactose, silica (another name：Silicic acid anhydride, silica particle), low Replace hydroxypropyl cellulose etc..The content of excipient is not particularly limited, preferably 0.1～80 mass % in terms of amounting to, further Preferably 10～70 mass %.
As adhesive, for example, can enumerate：Sucrose, gelatin, gummi arabicum pulveratum, methylcellulose, hydroxypropyl cellulose, hydroxyl Propyl methocel, carboxymethylcellulose calcium, calcium carboxymethylcellulose, polyvinylpyrrolidone, pulullan polysaccharide, dextrin, pre- Gelatinized starch etc..The content of adhesive is not particularly limited, preferably 0.1～10 mass %, further preferred 1～5 mass %.
As disintegrant, for example, can enumerate：Cross-linked carboxymethyl sodium, insoluble PVPP, partial gelatinization Starch, PVPP, calcium carboxymethylcellulose (another name：Carmellose Calcium, CMC-Ca), sodium carboxymethyl starch, Cornstarch etc..The content of disintegrant is not particularly limited, preferably 0.1～30 mass %, further preferred 1～20 mass %.
As enteric polymer, for example, can enumerate：Hydroxypropyl methyl cellulose phthalic acid, acetate propionate fiber Element, carboxymethylethylcellulose etc..
As insoluble polymer, for example, can enumerate：Eudragit E100 is (for example, Eudragit E, Eudragit RS etc.), methacrylic acid copolymer (for example, Eudragit L30-55 etc.) etc..
As lubricant, for example, can enumerate：Polyethylene glycol, talcum, stearic acid or its salt (for example, calcium stearate), sucrose Fatty acid ester etc..The content of lubricant is not particularly limited, preferably 0.001～5 mass %, further preferred 0.01～3 matter Amount %.As this sucrose fatty ester, for example, can enumerate：Surfhope SE Cosme C 1216, Sucrose myristate, sucrose palmitate, Sucrose stearate etc..As Surfhope SE Cosme C 1216, can enumerate：Sucrose monolaurate, sucrose dilaurate, sucrose March Cinnamic acid ester etc.；As Sucrose myristate, can enumerate：Sucrose monomyristate, sucrose two myristinate, sucrose three meat Myristate etc.；As sucrose palmitate, can enumerate：Sucrose palmitic acid ester, sucrose dipalmitate, sucrose three palmitic acid Ester etc.；As sucrose stearate, can enumerate：Sucrose monostearate, sucrose distearate, sucrose tristearate etc..
As surfactant, for example, can enumerate：The anionic surfactant such as sodium alkyl sulfate, polyoxyethylene Nonionic surface active agent such as Span, polyoxyethylene fatty acid ester and castor oil derivatives etc..
As colouring agent, for example, can enumerate：Tar pigment, caramel, kermes, titanium oxide, riboflavin class, green-tea extract, Chlorophyll copper sodium, edible Sunset Yellow FCF, edible Amaranth, eat blue No. 2 and wait food coloring, edible color lake pigment etc..
As flavor enhancement, for example, can enumerate：Sweetener (for example, saccharin sodium, dipotassium glycyrrhizinate, Aspartame, stevioside, Artificial sweetening agents such as Talin etc.), spices (for example, lemon, lemon bitter orange, orange, L- menthol, peppermint oil, peppermint MICRON X-8277-T, Dry Coat smears tea #421 etc.), acid (for example, citric acid, tartaric acid, malic acid etc.), green tea powder etc..
As adsorbent, for example, can enumerate：Special calcium silicates (fluorite) etc..
Extend agent as antistatic additive, disintegration, for example, can enumerate：Light anhydrous silicic acid etc..
As foaming agent, for example, can enumerate：Sodium bicarbonate etc..
The manufacture method of the tablet of the present invention is not particularly limited, and is exemplified below one and illustrates.First, obtain element Piece.Plain piece can be granulated using methods such as wet type granulation, dry type granulations as needed.Additionally, can obtain by the following method Plain piece：Mix plain piece raw material and carry out the direct compression method of compressing tablet；After dry type particle is made in compressed shaping, or add water Carry out after mixed solvent kneading/granulate/drying make wet granulate after and or by after making additive and being dissolved in water equal solvent Carry out after spray drying makes wet granulate, making the indirect pressed disc method of compressed tablets；Or the method that these are combined.Connect , mixing hydroxypropyl methyl cellulose, glycerine and desired any condition simultaneously prepare coating solution, by coating solution Direct spraying or The Coating Solution adding water is sprayed in plain piece, defines coating membrane by being dried on plain piece surface, it is hereby achieved that The tablet of the present invention.
[embodiment]
Below, with reference to embodiment, the present invention is described in more detail, but embodiments of the present invention are not limited to These embodiments
Embodiment 1～14 and comparative example 1 and 2
(plain piece 1 and 2)
When manufacturing the saccharomyces sake tablet in each embodiment, make the plain piece 1 and 2 of coating object.The composition of plain piece such as table 1 institute Show.
[table 1]
(footnote in table 1)
The amount (saccharomyces sake thalline (C) amount=saccharomyces sake amount × 0.7) of the saccharomyces sake thalline (C) in ※ saccharomyces sake is [dry Drying quality]
The content unit of each composition：Mg/ piece
The manufacture method of plain piece is as follows.By saccharomyces sake (dry yeast containing SAMe, Mitsubishi's gas chemistry strain formula Biomass 70% in commercial firm's system, yeast powder) and silica particle (Carplex FPS-500, DSL Amada Co., Ltd. System) mixing after, add and mixed crystallization cellulose (CEOLUS (registration mark) UF-F711, Asahi Chemical Corp's system) With calcium carboxymethylcellulose (E.C.G-FA, sun chemical industry Co. Ltd. system), then add and mix calcium stearate (stearic Sour calcium, peaceful Chemical Industries Co. Ltd. system), compressing tablet is carried out under 12kgN by direct compression method.Compressing tablet uses rotary pressure Piece machine (LIBRA2, Kikusui Seisakusho Ltd.'s system).
Coating agent in table 2～4 is dissolved in the water, is configured to the coating solution of concentration 5%.On the other hand, by 200Kg element Piece loads in seed-coating machine (DRC-14000S, P Co., Ltd.'s owrex system), with 65 DEG C of feed air temperature, revolution 1rpm, the row of being preheated to After temperature degree is 45 DEG C, spray coating liquid under conditions of revolution 5rpm/ spray liquid speed 300mL/min.After spraying terminates, do Dry to delivery temperature be 50 DEG C, terminate coating.It is explained, the hydroxypropyl methyl cellulose (commodity used in each embodiment Name：METOLOSE SE-06, manufacturer's name：Shin-Etsu Chemial Co., Ltd) have the following properties that：2 mass % when 20 DEG C The viscosity of the aqueous solution is 5.9mm2/s；Methoxyl content is 28.9%；Hydroxypropoxy content is 9.0%.Additionally, glycerine uses Food additives glycerine, it is by slope this pharmaceutical industries Co. Ltd. system.
The coating of each tablet obtaining, outward appearance, aroma and flavor are evaluated.Coating property be evaluated as：Range estimation is seen Examine the decortication of coating, wrinkling, sliver situation in the tablet just having produced, and evaluated according to standard shown below.Piece The ocular estimate of agent is the changing condition that visual observations save outside color in the tablet of 4 months in 40 DEG C of thermostats, and Evaluated according to standard shown below.The evaluation of aroma and flavor is one group of 5 people smell/taste to the tablet just having produced Road is evaluated, and is evaluated according to standard shown below.
[criterion of coating property]
Appreciable coating decortication, wrinkling, sliver tablet, if be less than 2 in 100 then it is assumed that can accept.
◎：It can be seen that decortication, wrinkling, sliver tablet, in 100, it is 0
○：It can be seen that decortication, wrinkling, sliver tablet, in 100, it is more than 1 and less than 2
Δ：It can be seen that decortication, wrinkling, sliver tablet, in 100, it is more than 3 and less than 5
×：It can be seen that decortication, wrinkling, sliver tablet, in 100, it is more than 6
[criterion of outward appearance]
The preservation product of 4 months and the preservation condition ratio of shady place (5 DEG C) is saved, if appearance color is almost without change at 40 DEG C Change then it is assumed that can accept.
◎：Appearance color is unchanged
○：Appearance color is almost unchanged
Δ：It can be seen that appearance color change is less
×：It can be seen that appearance color change is more
[criterion of aroma and flavor]
The average mark of one group of 5 people is if above 4 points then it is assumed that can accept.
5 points：Do not feel smell/taste
4 points：Feel smell/taste slightly
3 points：Feel smell/taste
2 points：Feel apparent smell/taste
1 point：Feel very big smell/taste
<Evaluate>
◎：Average mark is higher than 4.5 points
○：Average mark is higher than 4 points and less than 4.5 points
△：Average mark is higher than 3 points and less than 4 points
×：Average mark is less than 3 points
In each embodiment and comparative example, the species of plain piece, coating conditions and evaluation result are as shown in table 2～4.
[table 2]
[table 3]
[table 4]
As clearly shown in table 2～4, the tablet of embodiment 1～14 is all evaluated as well in coating property and outward appearance, smell and taste Road is also within the acceptable range.On the other hand, A/B be less than 2 comparative example 1 coating agent coating property, outward appearance, smell and Taste is all poor, and, in coating agent, coating property, aroma and flavor are all poor for the comparative example 2 more than 20 for the A/B.This result shows this The coating of bright tablet is excellent, outward appearance aspect also no problem, in terms of smell, taste also without a doubt.
(Formulation Example)
<Tablet>
In addition to the combined amount of each composition, tablet is obtained by method similarly to Example 1.The composition of tablet such as table 5 institute Show.
[table 5]
(A)：Coating rate (%)/(B) of (a)：Coating rate (the %)=1.333/0.167=8 of (b).

Claims (3)

1. a kind of tablet, it is the plain piece containing saccharomyces sake, and this plain piece is by the bag containing hydroxypropyl methyl cellulose and glycerine Clothing agent coating forms,
Wherein, the coating rate (A) of hydroxypropyl methyl cellulose is 2～20 with respect to the ratio A/B of the coating rate (B) of glycerine,
The content of saccharomyces sake thalline (C) is more than 15 mass % with respect to plain piece.
2. tablet according to claim 1, wherein, the coating rate (B) of glycerine is 0.025%～2.5%.
3. tablet according to claim 1 and 2, wherein, the coating rate (A) of hydroxypropyl methyl cellulose is more than 0.5%.
CN201580028888.2A 2014-06-10 2015-06-09 Tablet containing saccharomyces sake Active CN106456681B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2014-119949 2014-06-10
JP2014119949 2014-06-10
PCT/JP2015/066559 WO2015190456A1 (en) 2014-06-10 2015-06-09 Tablet containing sake yeast

Publications (2)

Publication Number Publication Date
CN106456681A true CN106456681A (en) 2017-02-22
CN106456681B CN106456681B (en) 2019-11-22

Family

ID=54833546

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580028888.2A Active CN106456681B (en) 2014-06-10 2015-06-09 Tablet containing saccharomyces sake

Country Status (4)

Country Link
JP (1) JP6456377B2 (en)
KR (1) KR20170015315A (en)
CN (1) CN106456681B (en)
WO (1) WO2015190456A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106119009A (en) * 2016-08-31 2016-11-16 广东省九江酒厂有限公司 A kind of fruital pure rice wine and brewing method thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003506481A (en) * 1999-08-12 2003-02-18 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング Oral dosage form
JP2007031407A (en) * 2005-07-29 2007-02-08 Shin Etsu Chem Co Ltd Coating composition containing cellulose ether with low substitution degree, and film-coated preparation with concealed unpleasant taste
WO2009081833A1 (en) * 2007-12-20 2009-07-02 Kaneka Corporation Dried microorganism cell or microorganism extract containing stabilized (ss)-s-adenosyl-l-methionine, and method for production of the dried microorganism cell or microorganism extract
JP2010037326A (en) * 2008-07-10 2010-02-18 Taisho Pharmaceutical Co Ltd Drug particle for carrying medicine having unpleasant taste
CN101795676A (en) * 2007-09-01 2010-08-04 Lts罗曼治疗方法有限公司 Comprise zymic drug products
CN103458709A (en) * 2011-01-21 2013-12-18 凡赛尔医药股份有限公司 Microencapsulated probiotic substance and process of manufacture

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL72381A (en) * 1983-07-20 1988-03-31 Sanofi Sa Pharmaceutical composition based on valproic acid
ZA881301B (en) * 1987-02-27 1989-10-25 Lilly Co Eli Sustained release matrix formulations

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003506481A (en) * 1999-08-12 2003-02-18 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング Oral dosage form
JP2007031407A (en) * 2005-07-29 2007-02-08 Shin Etsu Chem Co Ltd Coating composition containing cellulose ether with low substitution degree, and film-coated preparation with concealed unpleasant taste
CN101795676A (en) * 2007-09-01 2010-08-04 Lts罗曼治疗方法有限公司 Comprise zymic drug products
WO2009081833A1 (en) * 2007-12-20 2009-07-02 Kaneka Corporation Dried microorganism cell or microorganism extract containing stabilized (ss)-s-adenosyl-l-methionine, and method for production of the dried microorganism cell or microorganism extract
JP2010037326A (en) * 2008-07-10 2010-02-18 Taisho Pharmaceutical Co Ltd Drug particle for carrying medicine having unpleasant taste
CN103458709A (en) * 2011-01-21 2013-12-18 凡赛尔医药股份有限公司 Microencapsulated probiotic substance and process of manufacture

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106119009A (en) * 2016-08-31 2016-11-16 广东省九江酒厂有限公司 A kind of fruital pure rice wine and brewing method thereof
CN106119009B (en) * 2016-08-31 2019-11-08 广东省九江酒厂有限公司 A kind of fruity pure rice wine and its brewing method

Also Published As

Publication number Publication date
CN106456681B (en) 2019-11-22
KR20170015315A (en) 2017-02-08
JPWO2015190456A1 (en) 2017-04-20
WO2015190456A1 (en) 2015-12-17
JP6456377B2 (en) 2019-01-23

Similar Documents

Publication Publication Date Title
JP4890260B2 (en) Film-forming starch composition
CN102791271B (en) Method for improving dissolvability of anticoagulant
TW201625309A (en) Disintegrating particle composition including microfibrous cellulose
JP6940600B2 (en) Composition for disintegrating tablets containing microfibrous cellulose and active ingredient
JP2016174616A (en) Disintegrable composition, and easily disintegrable compression molding
CN101239044A (en) Solid composition
CN106456681B (en) Tablet containing saccharomyces sake
JP6800596B2 (en) tablet
JP2008127350A (en) Deodorizing solid composition
CN104490790B (en) Cefuroxime axetil solid dispersion coated composition and preparation method thereof
JP2001039863A (en) Production of soft capsule and coating agent or lubricant
CN106456682B (en) Tablet containing sake yeast
JP7486258B2 (en) Granules for orally disintegrating tablets, their manufacturing method and orally disintegrating tablets
JP7545204B2 (en) tablet
JP2018108116A (en) Method for producing royal jelly stock, royal jelly stock, royal jelly-containing food and drink, and royal jelly-containing cosmetic
JP2001103918A (en) Method for improving gustatoriness and gustatoriness- improved persimmon juice preparation
TWI392505B (en) Solid composition
JP2001199886A (en) Taste-improving method and proanthocyanidin preparation for improving taste
CN106413728A (en) Tablet containing sake yeast
WO2015190453A1 (en) Sake-yeast-containing tablet
KR20240012091A (en) Tablet film coating composition comprising partially hydrolyzed guar gum as a film coating base materials
CN101637443A (en) Solid preparation containing cysteine with reduced smell
JP2008148647A (en) Milk constituent-containing composition

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant