CN106413728A - Tablet containing sake yeast - Google Patents
Tablet containing sake yeast Download PDFInfo
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- CN106413728A CN106413728A CN201580028973.9A CN201580028973A CN106413728A CN 106413728 A CN106413728 A CN 106413728A CN 201580028973 A CN201580028973 A CN 201580028973A CN 106413728 A CN106413728 A CN 106413728A
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- tablet
- saccharomyces sake
- mass
- silicon dioxide
- content
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/064—Saccharomycetales, e.g. baker's yeast
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
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- General Health & Medical Sciences (AREA)
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- Natural Medicines & Medicinal Plants (AREA)
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- Alternative & Traditional Medicine (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The present invention provides a tablet that contains a sake yeast and silicon dioxide; that contains, per tablet, at least 15 mass% of sake yeast cells (A); and that has a mass ratio (B/A), of the silicon dioxide (B) content to the sake yeast cells (A) content, of at least 0.7/100 and at most 38/100. This tablet is preferably produced by premixing the sake yeast and the silicon dioxide, and then mixing other ingredients therewith.
Description
Technical field
The present invention relates to the tablet containing saccharomyces sake.
Background technology
The nutritional labelings such as abundant vitaminss, amino acidses, dietary fiber, mineralogical composition are contained in saccharomyces sake.Cause
This, can expect to reach nutritional supplementation, prevention disease and other effects by absorbing saccharomyces sake.
Tablet containing saccharomyces sake and saccharomyces sake in itself compared with, can more easily take.Therefore, containing rice wine ferment
Female tablet is as being useful for obtaining the nutritional supplementation effect that saccharomyces sake is played.But, in order to obtain above-mentioned battalion
Support and supplement or other effects, need to absorb the saccharomyces sake of more amount.Therefore, if the content of saccharomyces sake is less in tablet,
The number of tablets then absorbed can become excessive, goes wrong in taking.Therefore, in order to improve the tablet containing saccharomyces sake
Taking, needs to improve the yeast concentration in tablet.
Record in patent documentation 1 after medicine is mixed with rheology modifiers such as light anhydrous silicic acid, by this mixed powder
Body is mixed with other additives, can accelerate the mixing velocity of medicine and additive, improves the content uniformity of medicine.Patent literary composition
Offer and recorded in 2 in the manufacture method containing chlorination meat poisoning alkali preparation that chlorination carnitine is mixed with dry yeast phase, permissible
Using binding agents such as light anhydrous silicic acid.
Prior art literature
Patent documentation
Patent documentation 1：Japanese Unexamined Patent Publication 2003-81876 publication
Patent documentation 2：Japanese Unexamined Patent Publication 10-45580 publication
Content of the invention
Invent problem to be solved
But, the technology of patent documentation 1 is to be related to the preparation technique of the compound as medicine, does not suppose that it is fitted completely
For yeast.Additionally, the technology described in patent documentation 2 is the technology alleviating chlorination carnitine hygroscopy, for yeast preparation
Tablet physical property do not carry out any research.
It is an object of the invention to provide a kind of tablet, no matter the content of saccharomyces sake is how many, and it all has sufficiently
The tablet physical property such as hardness, disintegrative.
The technical scheme of solve problem
The present invention provides (1)～(3).
(1) a kind of tablet, it contains saccharomyces sake and silicon dioxide, containing saccharomyces sakes more than 15 mass % in every tablet
Thalline (A), the quality ratio (B/A) of the content of silicon dioxide (B) content with respect to saccharomyces sake thalline (A) is 0.7/100
Above and less than 38/100.
(2) according to the tablet described in (1), it is by being pre-mixed saccharomyces sake and silicon dioxide (B), then adds and mix it
His material is manufacturing.
(3) manufacture method of the tablet according to described in (1) or (2), it includes being pre-mixed saccharomyces sake and silicon dioxide
, then the step adding and mix other materials (B).
Invention effect
According to the present invention it is possible to provide the good tablets of tablet physical property such as hardness, disintegrative.
Specific embodiment
Saccharomyces sake is contained in the tablet of the present invention.Saccharomyces sake is yeast used in rice wine is brewageed.When brewageing rice wine
The yeast using principally falls into saccharomyces cerevisiae (S.cerevisiae).As saccharomyces sake, No. 6 yeast (K- of association can be enumerated
6), No. 7 yeast (K-7) of association, No. 9 yeast (K-9) of association, No. 601 yeast (K-601) of association, No. 701 yeast (K- of association
701), No. 901 yeast (K-901) of association, No. 1001 yeast (K-1001) of association, No. 1501 yeast (K-1501) of association (are
Public good juridical person Japan brewages association and promulgates).Saccharomyces sake can be any one of raw thalline and dead thalline.
Saccharomyces sake is usually dried thalline.Part warp that thalline be the thalline such as the fragment of thalline and/or thalline is dried
The product of dried gained.As reason is dried, lyophilization, drying under reduced pressure can be enumerated, ventilating is dried, is spray-dried.
Thalline is dried and is usually powder.
The content of the saccharomyces sake thalline (A) (dry mass) in the tablet of the present invention, as rice wine ferment in every tablet
Female content, usually more than 15 mass %, more than preferably 20 mass %, more than more preferably 23 mass %.Thus, can will absorb
Piece numerical control system, in proper range, therefore can improve taking.Below the upper limit preferably 70 mass %, more preferably 60 mass % with
Under, below further preferred 50 mass %.Thus, can get sufficient hardness and the good disintegrative as tablet.Every
In tablet, content preferably 15 mass %～70 mass % of saccharomyces sake thalline (A), more preferably 20 mass %～60 mass %, enter
One step preferably 23 mass %～50 mass %.
Saccharomyces sake thalline (A) in the tablet of the present invention is contained in saccharomyces sake.Saccharomyces sake and saccharomyces sake bacterium
Body (A) is sometimes identical.Additionally, the composition beyond saccharomyces sake thalline (A) can also be contained in saccharomyces sake.As this rice wine ferment
Composition beyond female thalline (A), for example, can enumerate：Fermentation liquid, culture supernatant etc..
Silicon dioxide (another name is contained in the tablet of the present invention：Anhydrous silicic acid, silica particle, SiO2)(B).Titanium dioxide
The content of silicon (B) is not particularly limited.But, the content of silicon dioxide (B) in every tablet, usually more than 0.1 mass %,
More than preferably 0.3 mass %.Below the upper limit preferably 24 mass %, below more preferably 12 mass %.The content of silicon dioxide (B) is excellent
Select 0.1 mass %～24 mass %, more preferably 0.3 mass %～12 mass %.
By the content of silicon dioxide (B) more than preferred lower limit, tablet hardness change is readily obtained greatly good one-tenth
Shape.Below preferred higher limit, the better tablet of disintegrative can be obtained.
In the tablet of the present invention, the content of silicon dioxide (B) is with respect to the content of saccharomyces sake thalline (A) (dry mass)
Quality ratio (B/A), preferably more than 0.7/100, more preferably more than 1/100, the upper limit preferably less than 38/100, more preferably 25/
Less than 100.Thus, it is possible to more improve tablet physical property.(B/A) preferably more than 0.7/100 and less than 38/100, more preferably 1/
More than 100 and less than 25/100.
(B/A) more than preferred lower limit, tablet hardness becomes big, is readily obtained good formability.By preferred
Higher limit below, the better tablet of disintegrative can be obtained.
As long as bringing bad influence to effect of the present invention, can also be contained at it with not damaging the amount of effect degree of the present invention
Any condition used in the manufacture of his tablet such as pharmaceuticals, medicine part outer article, food.As any condition, for example, figuration
Agent, binding agent, disintegrating agent, enteric polymer, insoluble polymer, lubricant, surfactant, coloring agent, flavoring agent,
Adsorbent, antistatic additive, disintegrate extend agent, foaming agent etc..
As excipient, for example, can enumerate：Starch, corn starch, Saccharum Sinensis Roxb., Mannitol, crystalline cellulose, low-substituted hydroxypropyl
Base cellulose, magnesium carbonate, Calcium Carbonate, castor sugar, glucose, dextrose hydrate, Lactose etc..The content of excipient is not especially
Limit, preferably 0.1 mass %～80 mass %, further preferred 10 mass %～70 mass %.
As binding agent, for example, can enumerate：Sucrose, gelatin, gummi arabicum pulveratum, methylcellulose, hydroxypropyl cellulose, hydroxyl
Propyl methocel, carboxymethyl cellulose, sodium carboxymethyl cellulose, Polyvinylpyrrolidone, pulullan polysaccharide, dextrin, pre-
Gelatinized starch etc..The content of binding agent is not particularly limited, preferably 0.1～10 mass %, further preferred 1～5 mass %.
As disintegrating agent, for example, can enumerate：Cross-linked carboxymethyl sodium, insoluble crospolyvinylpyrrolidone, partial gelatinization
Starch, Crospovidone, carboxymethylcellulose calcium (another name：Carmellose Calcium, CMC-Ca), carboxymethyl starch sodium,
Corn starch etc..The content of disintegrating agent is not particularly limited, and preferably amounts to 0.1～30 mass %, further preferred 1～20 matter
Amount %.
As enteric polymer, for example, can enumerate：Hydroxypropyl methyl cellulose phthalic acid, acetate propionate fiber
Element, carboxymethylethylcellulose etc..
As insoluble polymer, for example, can enumerate：Eudragit E100 is (for example,
Eudragit E, Eudragit RS etc.), methacrylic acid copolymer (for example, Eudragit L30-55 etc.) etc..
As lubricant, for example, can enumerate：Polyethylene Glycol, Talcum, stearic acid or its salt (for example, calcium stearate), sucrose
Fatty acid ester etc..The content of lubricant is not particularly limited, preferably 0.001～5 mass %, further preferred 0.01～3 matter
Amount %.As this sucrose fatty acid ester, for example, can enumerate：Surfhope SE Cosme C 1216, Sucrose myristate, sucrose palmitate,
Sucrose stearate etc..As Surfhope SE Cosme C 1216, can enumerate：Sucrose monolaurate, sucrose dilaurate, sucrose March
Cinnamic acid ester etc.；As Sucrose myristate, can enumerate：Sucrose monomyristate, sucrose two myristinate, sucrose three meat
Myristate etc.；As sucrose palmitate, can enumerate：Sucrose palmitic acid ester, sucrose dipalmitate, sucrose three Palmic acid
Ester etc.；As sucrose stearate, can enumerate：Sucrose monostearate, sucrose distearate, sucrose tristearate etc..
As surfactant, for example, can enumerate：The anionic surfactanies such as alkyl sodium sulfate, polyoxyethylene
Nonionic surfactant such as Span, polyoxyethylene fatty acid ester and castor oil derivatives etc..
As coloring agent, for example, can enumerate：Tar pigment, caramel, iron oxide red, titanium oxide, riboflavin class, green tea extract
Food coloring, the edible color lake pigment etc. such as thing, chlorophyll copper sodium, edible Sunset Yellow FCF, edible Amaranth, edible blueness 2.
As flavoring agent, for example, can enumerate：Sweeting agent (for example, saccharin sodium, glycyrrhizic acid dipotassium, aspartame, stevioside,
Artificial sweetening agents such as Talin etc.), spice (for example, Fructus Citri Limoniae, Fructus Citri Limoniae Citrus aurantium Linn., orange, L- Mentholum, Oleum menthae, Herba Menthae MICRON
X-8277-T, Dry Coat matcha #421 etc.), acidic flavoring agent (for example, citric acid, tartaric acid, malic acid etc.), green tea powder etc..
As adsorbent, for example, can enumerate：Special calcium silicates (fluorite) etc..
As antistatic additive, for example, can enumerate：Light anhydrous silicic acid (AEROSIL) etc..
As foaming agent, for example, can enumerate：Sodium bicarbonate etc..
The manufacture method of tablet is not particularly limited, and by adding and can mix containing saccharomyces sake, silicon dioxide, appoint
The meaning raw material such as composition is manufacturing.Add and mixed material can be together add after mixing or first add a part
Mixing, then add remaining part and mix, preferably first add and mix saccharomyces sake and silicon dioxide, add again afterwards and mix
Close other materials.Thus, it is possible to improve the hardness of tablet.Other materials refers to, removes outside saccharomyces sake and silicon dioxide
Constitute all material (composition) of tablet.
For manufacture, pelletize can be carried out using methods such as wet type pelletize, dry type pelletizes as needed, can be following method：
The direct compression process of tabletting after saccharomyces sake, silicon dioxide and above-mentioned additives mixed；After dry type granule is made in compressed molding,
Or by add the mixed solvent carrying out of water knead/pelletize/drying make wet granulate after and person by making additive molten
Solution in the water equal solvent after carry out after spray drying makes wet granulate, making the indirect pressed disc method of compressed tablets；Or by this
The method of a little combinations.Wherein, preferred direct compression process.
Tablet can be coated process by coating materials.As coating materials, carboxymethyl cellulose, hydroxypropyl can be enumerated
The cellulose families such as cellulose, hydroxypropyl methyl cellulose, methylcellulose, ethyl cellulose；Polyvinyl alcohol, polyvinylpyrrolidine
Ketone etc. synthesizes macromolecule；The polyhydric alcohol such as Polyethylene Glycol, propylene glycol, glycerol；Triacetyl glycerine, triethyl citrate, glyceride
The synthesizing esters such as fat acid esters；The natural materials such as Lac, pulullan polysaccharide；Or these combination.Additionally, can be added as needed on
The pigment such as titanium oxide, ferrum oxide；Any conditions such as Mannitol, spermol, sodium lauryl sulfate.Additionally, after film coating, can
To add the polishing materials such as Brazil wax.
According to the present invention it is possible to provide a kind of taking excellent, the tablet of the tablet physical properties excellent such as hardness, disintegrative.
The hardness of tablet can be measured using durometer (for example, Fushan Mountain Industry Co., Ltd system, TH-203CP).If
Hardness in more than 5kgf, then can suppress the generation of the problems such as tablet cracking, sliver.Tablet is implemented with the situation of Cotton seeds
Under, if hardness, in more than 6kgf, can improve operability during this process.
Disintegrative can measure disintegration time according to the method described in Japanese Pharmacopoeia ordinary test method and be evaluated.Collapse
Preferably smaller than 60 minutes solution time, more preferably less than 40 minutes.Disintegration time is shorter, then can be evaluated as quick-acting more excellent
Tablet.
[embodiment]
Below, with reference to embodiment, the present invention is described in more detail, but embodiments of the present invention are not limited to
These embodiments
[embodiment 1～5]
Add and mix saccharomyces sake (in the dry yeast containing SAMe, Mitsubishi Gas Chemical Co., Ltd's system, yeast powder
Biomass 70%), silica particle (Carplex FPS-500, DSL Amada Co., Ltd. system), crystalline cellulose (CEOLUS
(registered trade mark) UF-F711, Asahi Chemical Corp's system) and carboxymethylcellulose calcium (E.C.G-FA, sun chemical industry
Co. Ltd. system) after, add and mix calcium stearate (calcium stearate, peaceful Chemical Industries Co. Ltd. system), by direct
Pressed disc method carries out tabletting under 12kN.Tabletting uses rotary tablet machine (LIBRA2, Kikusui Seisakusho Ltd.'s system).
[embodiment 6]
Mixing saccharomyces sake (the biomass in the dry yeast containing SAMe, Mitsubishi Gas Chemical Co., Ltd's system, yeast powder
70%), and after silica particle (Carplex FPS-500, DSL Amada Co., Ltd. system), add and mixed crystallization fiber
Plain (CEOLUS (registered trade mark) UF-F711, Asahi Chemical Corp's system) and carboxymethylcellulose calcium (E.C.G-FA, day
Wheel chemical industry Co. Ltd. system), then add and mix calcium stearate (calcium stearate, peaceful Chemical Industries Co., Ltd.
System), by direct compression process come tabletting.Tabletting is using rotary tablet machine (LIBRA2, Co., Ltd. similarly to Example 1
Chrysanthemum water makes made).
[embodiment 7]
Except replacing crystallization fine using low-substituted hydroxypropyl cellulose (L-HPC LH-21, Shin-Etsu Chemial Co., Ltd's system)
Dimension element, using Mannitol (PEARLITOL50C, ROQUETTE FRERES system) replace carboxymethylcellulose calcium beyond, according to
The same adding method of embodiment 1, each composition in mixture table 3 composition, tabletting is carried out by direct compression process.Tabletting using with
The same rotary tablet machine of embodiment 1 (LIBRA2, Kikusui Seisakusho Ltd.'s system).
[comparative example 1～3, embodiment 8～11]
Add and mix saccharomyces sake (in the dry yeast containing SAMe, Mitsubishi Gas Chemical Co., Ltd's system, yeast powder
Biomass 70%) and silicon dioxide (Carplex FPS-500, DSL.JAPAN system), corn starch (Japanese corn starch strain formula
Commercial firm's system), then add calcium stearate (calcium stearate, peaceful Chemical Industries Co. Ltd. system), mix 1 minute.By obtain
Mixed powder is pushed in 12kN by direct compression process in rotary tablet machine (LIBRA2, Kikusui Seisakusho Ltd.)
Piece, makes tablet.
Measure the hardness of each tablet obtaining and disintegration time.Using durometer (TH-203CP, Fushan Mountain Industry Co., Ltd
System) measure hardness, and judged according to following standard.The mensure of disintegration time is the Japanese Pharmacopoeia institute according to the 16th revision
The disintegration of tablet laboratory method included carries out disintegrate experiment, measures disintegration time (minute).Slaking test liquid uses ion exchange water,
Bath temperature is 37 DEG C.Calculate the meansigma methodss measuring 6 times, and judged according to following standard.
[criterion of hardness]
If hardness is in more than 5kgf then it is assumed that can accept.
☆：More than 8kgf
◎：6kgf is less than 8kgf
○：5kgf is less than 6kgf
×：Less than 5kgf
[criterion of disintegrative]
Disintegration time is if less than 60 minutes then it is assumed that can accept.
◎：Disintegration time is less than 40 minutes
○：Disintegration time was 40 minutes less than 60 minutes
×：Disintegration time is more than 60 minutes
Mixing in each embodiment when result as shown in table 1～table 4.
[table 1]
Combined amount (mg/ piece)
[table 2]
Combined amount (mg/ piece)
[table 3]
Combined amount (mg/ piece)
[table 4]
Combined amount (mg/ piece)
(footnote of table)
(saccharomyces sake thalline (A) amount=saccharomyces sake amount × 0.7 [is dried the amount of the saccharomyces sake thalline (A) in ※ saccharomyces sake
Quality]
The content unit of each composition：Mg/ piece
As clearly shown in table 1～table 4, the hardness of the tablet of embodiment 1～11 and disintegrative two aspect are all good.Its
In, the tablet of the embodiment 6 in advance saccharomyces sake being mixed with silicon dioxide, hardness aspect is very excellent.On the other hand, (B/
A) it is less than the collapsing of the tablet of comparative example 3 more than 38/100 of the hardness of tablet and (B/A) of 0.7/100 comparative example 1 and 2
Xie Xing, poor compared with embodiment.These results show the tablet of the present invention no matter how yeast concentration is respectively provided with sufficient piece
Agent physical property.
(Formulation Example)
<Tablet 1>
Manufacture plain piece using raw material same as Example 6 and same method, by hydroxypropyl methyl cellulose (METOLOSE
SE-06, Shin-Etsu Chemial Co., Ltd's system) and glycerol (food additive glycerol, slope this pharmaceutical industries Co. Ltd. system) molten
In Xie Yushui, it is configured to the coating solution of concentration 5%.In addition, plain piece is loaded in seed-coating machine, spray coating liquid.After spraying terminates,
It is dried and obtain tablet.
(coating materials)
Hydroxypropyl methyl cellulose 5
Glycerol 0.8
(B/A) 2.4/100
<Tablet 2>
Except using Lactose (Pharmatose 100M, DEF Pharma system) replace crystalline cellulose in addition to, using with embodiment
6 identical raw materials and same method are obtaining tablet.
Claims (3)
1. a kind of tablet it is characterised in that contain saccharomyces sake and silicon dioxide,
Containing saccharomyces sake thalline (A) more than 15 mass % in every tablet,
The mass ratio B/A of the content with respect to saccharomyces sake thalline (A) for the content of silicon dioxide (B) is more than 0.7/100 and is
Less than 38/100.
2. tablet according to claim 1, it is by being pre-mixed saccharomyces sake and silicon dioxide (B), then adds and mix
Close other materials to manufacture.
3. the manufacture method of the tablet described in a kind of claim 1 or 2, it includes being pre-mixed saccharomyces sake and silicon dioxide
, then the step adding and mix other materials (B).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014119948 | 2014-06-10 | ||
| JP2014-119948 | 2014-06-10 | ||
| PCT/JP2015/066558 WO2015190455A1 (en) | 2014-06-10 | 2015-06-09 | Tablet containing sake yeast |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106413728A true CN106413728A (en) | 2017-02-15 |
Family
ID=54833545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580028973.9A Pending CN106413728A (en) | 2014-06-10 | 2015-06-09 | Tablet containing sake yeast |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPWO2015190455A1 (en) |
| KR (1) | KR20170015277A (en) |
| CN (1) | CN106413728A (en) |
| WO (1) | WO2015190455A1 (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3743641A1 (en) * | 1987-12-22 | 1989-07-06 | Gerhard Dipl Chem Dr Ludwig | Use of riboflavin (vitamin B2) in foodstuffs |
| JPH1045580A (en) * | 1996-07-31 | 1998-02-17 | Asahi Breweries Ltd | Production of carnitine chloride-containing pharmaceutical preparation |
| WO2009081833A1 (en) * | 2007-12-20 | 2009-07-02 | Kaneka Corporation | Dried microorganism cell or microorganism extract containing stabilized (ss)-s-adenosyl-l-methionine, and method for production of the dried microorganism cell or microorganism extract |
| JP2012167131A (en) * | 2012-06-13 | 2012-09-06 | Kimura Sangyo Kk | Tablet containing probiotic agent, digestive enzyme agent, or both of them |
| CN103284164A (en) * | 2013-06-08 | 2013-09-11 | 哈尔滨珍宝制药有限公司 | Composition comprising a plurality of vitamins and mineral substances |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55162984A (en) * | 1979-06-06 | 1980-12-18 | Ebiosu Yakuhin Kogyo Kk | Direct tableting of dried beer yeast |
| JPS5735952A (en) * | 1980-08-12 | 1982-02-26 | Hitachi Plant Eng & Constr Co Ltd | Electric dust collector |
| JPH1014533A (en) * | 1996-06-27 | 1998-01-20 | Asahi Breweries Ltd | Lactobacillus-containing composition |
| JP4925526B2 (en) | 2001-09-10 | 2012-04-25 | 旭化成ケミカルズ株式会社 | Drug mixing method |
-
2015
- 2015-06-09 WO PCT/JP2015/066558 patent/WO2015190455A1/en active Application Filing
- 2015-06-09 JP JP2016527804A patent/JPWO2015190455A1/en active Pending
- 2015-06-09 KR KR1020167024717A patent/KR20170015277A/en unknown
- 2015-06-09 CN CN201580028973.9A patent/CN106413728A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3743641A1 (en) * | 1987-12-22 | 1989-07-06 | Gerhard Dipl Chem Dr Ludwig | Use of riboflavin (vitamin B2) in foodstuffs |
| JPH1045580A (en) * | 1996-07-31 | 1998-02-17 | Asahi Breweries Ltd | Production of carnitine chloride-containing pharmaceutical preparation |
| WO2009081833A1 (en) * | 2007-12-20 | 2009-07-02 | Kaneka Corporation | Dried microorganism cell or microorganism extract containing stabilized (ss)-s-adenosyl-l-methionine, and method for production of the dried microorganism cell or microorganism extract |
| JP2012167131A (en) * | 2012-06-13 | 2012-09-06 | Kimura Sangyo Kk | Tablet containing probiotic agent, digestive enzyme agent, or both of them |
| CN103284164A (en) * | 2013-06-08 | 2013-09-11 | 哈尔滨珍宝制药有限公司 | Composition comprising a plurality of vitamins and mineral substances |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20170015277A (en) | 2017-02-08 |
| WO2015190455A1 (en) | 2015-12-17 |
| JPWO2015190455A1 (en) | 2017-04-20 |
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| TW202038918A (en) | Pharmaceutical composition |
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