CN106442954A - Thromboelastographic instrument and hemagglutination data correction method - Google Patents
Thromboelastographic instrument and hemagglutination data correction method Download PDFInfo
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- CN106442954A CN106442954A CN201610753656.XA CN201610753656A CN106442954A CN 106442954 A CN106442954 A CN 106442954A CN 201610753656 A CN201610753656 A CN 201610753656A CN 106442954 A CN106442954 A CN 106442954A
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- 238000000034 method Methods 0.000 title claims abstract description 38
- 230000035931 haemagglutination Effects 0.000 title abstract 5
- 239000008280 blood Substances 0.000 claims abstract description 76
- 210000004369 blood Anatomy 0.000 claims abstract description 76
- 238000001514 detection method Methods 0.000 claims abstract description 17
- 230000008569 process Effects 0.000 claims abstract description 13
- 208000007536 Thrombosis Diseases 0.000 claims description 229
- 230000023555 blood coagulation Effects 0.000 claims description 186
- 239000010453 quartz Substances 0.000 claims description 27
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 27
- 239000013078 crystal Substances 0.000 claims description 19
- 238000012360 testing method Methods 0.000 description 6
- 230000010355 oscillation Effects 0.000 description 5
- 230000008859 change Effects 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 238000013100 final test Methods 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 239000004575 stone Substances 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01H—MEASUREMENT OF MECHANICAL VIBRATIONS OR ULTRASONIC, SONIC OR INFRASONIC WAVES
- G01H11/00—Measuring mechanical vibrations or ultrasonic, sonic or infrasonic waves by detecting changes in electric or magnetic properties
- G01H11/06—Measuring mechanical vibrations or ultrasonic, sonic or infrasonic waves by detecting changes in electric or magnetic properties by electric means
- G01H11/08—Measuring mechanical vibrations or ultrasonic, sonic or infrasonic waves by detecting changes in electric or magnetic properties by electric means using piezoelectric devices
Abstract
The invention provides a thromboelastographic instrument and a hemagglutination data correction method. The thromboelastographic instrument comprises a thromboelastographic instrument body, at least one vibration sensor and a data correction unit; the thromboelastographic instrument body is used for detecting blood to be detected in order to obtain the hemagglutination data of the blood to be detected; the at least one vibration sensor is used for detecting the vibration condition of the thromboelastographic instrument body in the detection process of the blood to be tested by using the thromboelastographic instrument body in order to obtain the vibration data of the thromboelastographic instrument body; and the data correction unit is used for correcting the hemagglutination data obtained by the thromboelastographic instrument body according to the vibration data obtained by all vibration sensors in order to form first corrected hemagglutination data. An error in a thromboelastographic instrument detection result, caused by vibration of the thromboelastographic instrument, is reduced in the invention.
Description
Technical field
The present invention relates to technical field of medical instruments, particularly to a kind of thrombus elastometer and blood clotting data correcting method.
Background technology
Thrombus elastometer be a kind of for detecting the medicine equipment whether blood can normally condense, previous carrying out performing the operation
As be required for by thrombus elastometer, the blood clotting data of patient being detected, the blood clotting data according to detecting judges patient's
Whether blood clotting process is normal, only patient could be performed the operation in the case that blood can normally condense, if blood
Liquid condensation process exists abnormal, and in surgical procedure, the blood of patient will be unable to normally condense, and leads to anthemorrhagic difficulty it is likely that crisis
The life of patient.
At present when measuring blood clotting data by thrombus elastometer, blood drives the rotation of thrombus elastometer under external force driving
Axis of rotation, the rotational angle according to rotary shaft obtains blood clotting data and exports.
Because when measuring blood clotting data, the rotary shaft of thrombus elastometer turns to different directions under the drive of blood
Dynamic, because external cause or rotation rotational axis direction change and thrombus elastometer can be led to vibrate, vibration will lead to revolve
The rotational angle of rotating shaft is affected, and prior art directly obtains blood clotting data according to the rotational angle of rotary shaft and exports,
The error being introduced by the vibration of thrombus elastometer in the blood clotting data being obtained is larger, thus the surveyed blood clotting number of existing thrombus elastometer
According to accuracy relatively low.
Content of the invention
Embodiments provide a kind of thrombus elastometer and blood clotting data correcting method, can reduce in testing result
The error being introduced due to the vibration of thrombus elastometer.
Embodiments provide a kind of thrombus elastometer, including：Thrombus elastometer body, at least one vibrating sensing
Device and data correction unit；
Described thrombus elastometer body, for detecting, obtains the blood clotting data of described blood to be measured to blood to be measured；
Described vibrating sensor, for detecting described thrombus elastometer body in the mistake that described blood to be measured is detected
The Vibration Condition of the body of thrombus elastometer described in journey, obtains the vibration data of described thrombus elastometer body；
Described data correction unit, for the described vibration data being obtained according to each described vibrating sensor, to described
The described blood clotting data that thrombus elastometer body obtains is modified, and forms the first correction blood clotting data.
Preferably,
Described vibrating sensor includes：Quartz crystal resonant formula sensor；
Described Quartz crystal resonant formula sensor, positioned at fulcrum and the described thrombus bullet of support of described thrombus elastometer body
Between the support platform of power instrument body, for the intrinsic frequency according to its own and the pressure that bears, obtain described thrombus elastic force
The vibration amplitude of instrument body and vibration frequency.
Preferably,
Described data correction unit, for according to described vibration amplitude and described vibration frequency, being obtained by equation below one
Obtain correction factor, and by equation below two, described blood clotting data is modified, obtain described first correction blood clotting data；
Described formula one is：
Described formula two is：
A1=δ A0
Wherein, described δ is described correction factor, and described L is the vibration amplitude that each described vibrating sensor detects
Mean value, described γ is the mean value of the vibration frequency that each described vibrating sensor detects, described A0For described blood clotting number
According to described A1For the described first correction blood clotting data.
Preferably, this thrombus elastometer further includes：Horizon sensor；
Described horizon sensor, for detecting described thrombus elastometer body in the mistake that described blood to be measured is detected
The inclination conditions of the body of thrombus elastometer described in journey, obtain the angle of inclination of described thrombus elastometer body；
Described data correction unit, is further used for the angle of inclination getting according to described horizon sensor, to described
First correction blood clotting data is modified, and forms the second correction blood clotting data and exports.
Preferably,
Described data correction unit, for the angle of inclination according to described thrombus elastometer body, by equation below three
Described first correction blood clotting data is modified, obtains described second correction blood clotting data；
Described formula three is：
A2=A1·cosα
Wherein, described α is the angle of inclination of described thrombus elastometer body, described A1For the described first correction blood clotting number
According to described A2For the described second correction blood clotting data.
The embodiment of the present invention additionally provides a kind of side blood clotting data being modified using any of the above-described thrombus elastometer
Method, including：
By thrombus elastometer body, blood to be measured is detected, obtain the blood clotting data of described blood to be measured；
Detect that described thrombus elastometer body is detecting to described blood to be measured using vibrating sensor each described
During described thrombus elastometer body Vibration Condition, obtain described thrombus elastometer body vibration data；
The described vibration data being obtained according to each described vibrating sensor, is modified to described blood clotting data, is formed
First correction blood clotting data.
Preferably,
When described vibrating sensor includes Quartz crystal resonant formula sensor, the described thrombus elastometer body of described detection
In the Vibration Condition that described blood to be measured is carried out with thrombus elastometer body described in detection process, obtain described thrombus elastometer
The vibration data of body includes：
During described thrombus elastometer body detects to described blood to be measured, humorous according to described quartz crystal
The intrinsic frequency of formula of shaking sensor and the pressure bearing, obtain vibration amplitude and the vibration frequency of described thrombus elastometer body.
Preferably,
The described described vibration data being obtained according to each described vibrating sensor, is modified to described blood clotting data,
Form the first correction blood clotting data to include：
According to described vibration amplitude and described vibration frequency, correction factor is obtained by equation below one, and by as follows
Formula two is modified to described blood clotting data, obtains described first correction blood clotting data；
Described formula one is：
Described formula two is：
A1=δ A0
Wherein, described δ is described correction factor, and described L is the vibration amplitude that each described vibrating sensor detects
Mean value, described γ is the mean value of the vibration frequency that each described vibrating sensor detects, described A0For described blood clotting number
According to described A1For the described first correction blood clotting data.
Preferably, the method further includes：
Detect described thrombus elastometer body described thrombus elastometer during described blood to be measured is detected
The inclination conditions of body, obtain the angle of inclination of described thrombus elastometer body；
According to the angle of inclination of described thrombus elastometer body, the described first correction blood clotting data is modified, is formed
Second correction blood clotting data simultaneously exports.
Preferably,
The described angle of inclination according to thrombus elastometer body, is modified to the described first correction blood clotting data, is formed
Second correction blood clotting data includes：
According to the angle of inclination of described thrombus elastometer body, by equation below three to the described first correction blood clotting data
It is modified, obtain described second correction blood clotting data；
Described formula three is：
A2=A1·cosα
Wherein, described α is the angle of inclination of described thrombus elastometer body, described A1For the described first correction blood clotting number
According to described A2For the described second correction blood clotting data.
Embodiments provide a kind of thrombus elastometer and blood clotting data correcting method, thrombus elastometer body is right
During the blood clotting data of blood to be measured is detected, the vibration feelings to thrombus elastometer body at least one vibrating sensor
Condition is detected, obtains the vibration data of thrombus elastometer body, data correction unit is according to shaking that vibrating sensor gets
Dynamic data, the blood clotting data that thrombus elastometer body is detected is modified, and forms the first correction blood clotting data.With respect to blood
The blood clotting data that bolt elastometer body detects, the first correction blood clotting data is the Vibration Condition pair according to thrombus elastometer body
Blood clotting data be modified after result, therefore using first correction blood clotting data can reduce detection as final testing result
The error being introduced due to the vibration of thrombus elastometer in result.
Brief description
In order to be illustrated more clearly that the embodiment of the present invention or technical scheme of the prior art, below will be to embodiment or existing
Have technology description in required use accompanying drawing be briefly described it should be apparent that, drawings in the following description are the present invention
Some embodiments, for those of ordinary skill in the art, on the premise of not paying creative work, can also basis
These accompanying drawings obtain other accompanying drawings.
Fig. 1 is a kind of schematic diagram of thrombus elastometer that one embodiment of the invention provides；
Fig. 2 is a kind of schematic diagram of thrombus elastometer that another embodiment of the present invention provides；
Fig. 3 is a kind of schematic diagram of thrombus elastometer that another embodiment of the present invention provides；
Fig. 4 is a kind of flow chart of blood clotting data correcting method that one embodiment of the invention provides；
Fig. 5 is a kind of flow chart of blood clotting data correcting method that another embodiment of the present invention provides.
Specific embodiment
Purpose, technical scheme and advantage for making the embodiment of the present invention are clearer, below in conjunction with the embodiment of the present invention
In accompanying drawing, the technical scheme in the embodiment of the present invention is clearly and completely described it is clear that described embodiment is
The a part of embodiment of the present invention, rather than whole embodiments, based on the embodiment in the present invention, those of ordinary skill in the art
The every other embodiment being obtained on the premise of not making creative work, broadly falls into the scope of protection of the invention.
As shown in figure 1, embodiments providing a kind of thrombus elastometer, including：Thrombus elastometer body 101, extremely
A few vibrating sensor 102 and data correction unit 103；
Described thrombus elastometer body 101, for detecting, obtains the blood clotting number of described blood to be measured to blood to be measured
According to；
Described vibrating sensor 102, for detecting that described thrombus elastometer body 101 examining to described blood to be measured
The Vibration Condition of described thrombus elastometer body 101 during survey, obtains the vibration data of described thrombus elastometer body 101；
Described data correction unit 103, for the described vibration data being obtained according to each described vibrating sensor 102,
The described blood clotting data that described thrombus elastometer body 101 is obtained is modified, and forms the first correction blood clotting data.
Embodiments provide a kind of thrombus elastometer, thrombus elastometer body is in the blood clotting data to blood to be measured
During being detected, at least one vibrating sensor detects to the Vibration Condition of thrombus elastometer body, obtains blood
The vibration data of bolt elastometer body, the vibration data that data correction unit gets according to vibrating sensor, to thrombus elastic force
The blood clotting data that instrument body detects is modified, and forms the first correction blood clotting data.With respect to the detection of thrombus elastometer body
The blood clotting data going out, the first correction blood clotting data is according to the Vibration Condition of thrombus elastometer body, blood clotting data to be modified
Result afterwards, therefore can be reduced in testing result due to thrombus bullet using the first correction blood clotting data as final testing result
The error that the vibration of power instrument introduces.
In an embodiment of the invention, vibrating sensor can be Quartz crystal resonant formula sensor, and quartz crystal is humorous
Formula of shaking sensor is located between the fulcrum of thrombus elastometer body and the support platform supporting thrombus elastometer body, quartz crystal
Resonant transducer is according to the change of its own intrinsic frequency and the pressure bearing, it is possible to obtain the vibration of thrombus elastometer body
Amplitude and vibration frequency, the vibration amplitude acquiring and vibration frequency are the vibration data of thrombus elastometer body.Due to stone
English crystal-resonance sensor has higher sensitivity, can also be by stone when thrombus elastometer body occurs small vibration
English crystal-resonance sensor detects, and reduces the mistake introducing due to the vibration of thrombus elastometer body in testing result further
Difference, improves the accuracy that thrombus elastometer is detected to blood blood clotting.
As shown in Fig. 2 the lower end of thrombus elastometer body 101 is provided with three fulcrums 201, the lower end of each fulcrum 201
It is provided with a quartz resonance sensor 202, when thrombus elastometer is placed in support platform 203,3 quartz resonances pass
Sensor 202 is located between three fulcrums 201 and support platform 203.In thrombus elastometer body 101, blood to be measured is detected
During, fulcrum 201 is vibrated jointly with thrombus elastometer body 101, the intrinsic frequency of quartz resonance sensor 202 with
The vibration frequency of point 201 changes, and quartz resonance sensor 202 determines fulcrum 201 according to the intrinsic frequency of its own
Vibration frequency, simultaneously quartz resonance sensor 202 shaking of fulcrum 201 is determined to the pressure that it produces according to fulcrum 201
Dynamic amplitude, thus the vibration data including thrombus elastometer body 101 vibration amplitude and vibration frequency getting.
In an embodiment of the invention, data correction unit gets according to each vibrating sensor vibration amplitude and
Vibration frequency, obtains correction factor by equation below one, further according to the correction factor obtaining, right by equation below two
The blood clotting data that thrombus elastometer body detects is modified, and obtains the first correction blood clotting data, concrete formula one and formula
Two is as follows：
Formula one is：
Formula two is：
A1=δ A0
Wherein, δ is correction factor, and L is the mean value of the vibration amplitude that each vibrating sensor detects, γ shakes for each
The mean value of the vibration frequency that dynamic sensor detects, A0For blood clotting data, A1For the first correction blood clotting data.
Due to the vibration of thrombus elastometer body, there is disturbance in blood to be measured, and the liquid level of blood to be measured is not with respect to shaking
Raise when dynamic, the contact area of the rotary shaft on thrombus elastometer body and blood to be measured increases, lead to what rotary shaft was subject to revolve
Turning driving force increases, and finally makes the blood clotting data that thrombus elastometer body detects bigger than normal, by formula one and formula two to blood
The blood clotting data that bolt elastometer body detects is modified, and can eliminate partially due to thrombus elastometer body vibrates introducing
Error, thus improve the accuracy that thrombus elastometer body is detected to blood clotting data.
When thrombus elastometer includes multiple vibrating sensor, the vibration amplitude being detected according to each vibrating sensor
And vibration frequency, calculate Mean Oscillation amplitude and the average oscillation frequency of thrombus elastometer body, by the Mean Oscillation calculating
Amplitude and average oscillation frequency substitute into above-mentioned formula one and obtain correction factor.The mean value being detected according to multiple vibrating sensors
Vibration data obtains correction factor that blood clotting data is modified it is ensured that the reliability of correction result.Blood for example shown in Fig. 2
Bolt elastometer, the vibration amplitude according to 3 quartz resonance sensor 202 detections and vibration frequency, obtain 3 vibrations respectively and shake
The mean value of the mean value of width and 3 vibration frequencies, as the vibration amplitude of thrombus elastometer body 101 and vibration frequency, passes through
Formula one obtains the correction factor that the blood clotting data that thrombus elastometer body 101 is detected is modified.
In an embodiment of the invention, as shown in figure 3, thrombus elastometer further comprises：Horizon sensor 301；
Horizon sensor 301, for detecting thrombus elastometer body 101 blood during blood to be measured is detected
The inclination conditions of bolt elastometer body 101, obtain the angle of inclination of thrombus elastometer body 101；
Data correction unit 103, is further used for the angle of inclination getting according to horizon sensor 301, repaiies to first
Positive blood clotting data is modified, and forms the second correction blood clotting data and exports.
Can there is certain angle of inclination, thrombus elastometer after being placed in support platform due to thrombus elastometer body
Body tilts to make the rotary shaft on thrombus elastometer body change with the contact area of blood to be measured, leads to blood pair to be measured
The driving force of rotary shaft changes, and then leads to the rotational angle of rotary shaft to be affected, true according to rotary shaft rotational angle
The error producing due to thrombus elastometer body run-off the straight can be carried in the blood clotting data made.According to thrombus elastometer originally
The angle of inclination of body, to first correction blood clotting data revised further, can reduce in the first correction blood clotting data due to
The error that thrombus elastometer body tilts and introduces, further increase that thrombus elastometer body detected to blood is accurate
Property.
In an embodiment of the invention, after horizon sensor detects the angle of inclination of thrombus elastometer body, will examine
The angle of inclination measured is sent to data correction unit, data correction unit according to the angle of inclination receiving, by public as follows
Formula three is revised further to the first correction blood clotting data, obtains the second correction blood clotting data, and wherein formula three is as follows：
A2=A1·cosα
Wherein, α is the angle of inclination of thrombus elastometer body, A1For the first correction blood clotting data, A2For the second correction blood clotting
Data.
Because the rotary shaft on thrombus elastometer body is with thrombus elastometer body run-off the straight, leads to rotary shaft and treat
The contact area surveying blood increases, and the angle that rotary shaft rotates under the driving of blood to be measured correspondingly increases, and leads to thrombus bullet
The blood clotting data that power instrument body detects is bigger than normal, by formula 3, first correction blood clotting data is modified, reduces first and repair
The error introducing because thrombus elastometer body tilts in positive blood clotting data, improves thrombus elastometer and blood blood clotting data is entered
The accuracy of row detection.
In an embodiment of the invention, horizon sensor can be realized by gyroscope, and gyroscope size is little, integrated level
Higher, can be conveniently fixed in and on thrombus elastometer body, the angle of inclination of thrombus elastometer body be measured；And,
The sensitivity of gyroscope is higher, even if it is also possible to detect thrombus elastic force when less at the angle of inclination of thrombus elastometer body
The angle of inclination of instrument body, and then blood clotting data that thrombus elastometer body is detected is modified it is ensured that final output
The accuracy of blood clotting data.
It should be noted that the vibration amplitude that can be detected according to vibrating sensor first of data correction unit and vibration
The error being introduced due to vibration in frequency correction blood clotting data, is then revised further according to the angle of inclination that horizon sensor detects
Due to tilting the error introducing in blood clotting data；The inclination that data correction unit can also detect according to horizon sensor first
Due to tilting the error introducing in angle modification blood clotting data, the vibration amplitude then detecting further according to vibrating sensor and shaking
The error being introduced due to vibration in dynamic frequency correction blood clotting data.The correction order of data correction unit can be according to practical business
Realize needing, flexibly selected.
As shown in figure 4, one embodiment of the invention provides one kind utilizes any one blood provided in an embodiment of the present invention
The method that bolt elastometer is modified to blood clotting data, including：
Step 401：By thrombus elastometer body, blood to be measured is detected, obtain the blood clotting data of blood to be measured；
Step 402：Using each vibrating sensor detection thrombus elastometer body, detection process is being carried out to blood to be measured
The Vibration Condition of middle thrombus elastometer body, obtains the vibration data of thrombus elastometer body；
Step 403：The vibration data being obtained according to each vibrating sensor, is modified to blood clotting data, forms first
Revise blood clotting data.
Embodiments provide a kind of method of blood clotting data correction, in thrombus elastometer body, blood to be measured is entered
During row detection, the Vibration Condition of detection thrombus elastometer body, obtain the vibration data of thrombus elastometer body, according to
The blood clotting data that vibration data detects to thrombus elastometer body is modified.According to vibration data, blood clotting data is repaiied
After just, reduce in testing result due to the error of thrombus elastometer body vibration two introducing, improve to blood blood clotting to be measured
The accuracy that data is detected.
In an embodiment of the invention, when detecting the Vibration Condition of thrombus elastometer body, passed with quartz resonance
Sensor is as vibrating sensor, during thrombus elastometer body detects to blood to be measured, humorous according to each quartz
The intrinsic frequency of formula of shaking sensor and the pressure bearing, obtain the vibration amplitude of thrombus elastometer body and vibration frequency as shaking
Dynamic data.
In an embodiment of the invention, get thrombus elastometer body vibration amplitude and vibration frequency after,
The vibration amplitude being detected according to each vibrating sensor and vibration frequency, obtain correction factor by equation below one, and lead to
Cross the blood clotting data that equation below two detects to thrombus elastometer body to be modified, obtain the first correction blood clotting data, its
In,
Formula one is：
Formula two is：
A1=δ A0
Wherein, δ is correction factor, and L is the mean value of the vibration amplitude that each vibrating sensor detects, γ shakes for each
The mean value of the vibration frequency that dynamic sensor detects, A0For blood clotting data, A1For the first correction blood clotting data.
In an embodiment of the invention, also include：Process blood to be measured being detected in thrombus elastometer body
In, the inclination conditions of thrombus elastometer body are detected, obtains the angle of inclination of thrombus elastometer body, according to thrombus bullet
The angle of inclination of power instrument body, is revised again to the first correction blood clotting data getting, is formed the second correction blood clotting number
According to and export.Angle of inclination according to thrombus elastometer body is modified to the first correction blood clotting data, can reduce thrombus
The error being introduced due to thrombus elastometer body run-off the straight in the blood clotting data that elastometer body detects, is improved further
The accuracy that thrombus elastometer is detected to blood blood clotting.
In an embodiment of the invention, behind the angle of inclination getting thrombus elastometer body, by as follows
Formula three to first correction blood clotting data be modified, obtain second correction blood clotting data, wherein,
Formula three is：
A2=A1·cosα
Wherein, α is the angle of inclination of described thrombus elastometer body, A1For the first correction blood clotting data, A2For the second correction
Blood clotting data.
Below with the vibration data according to thrombus elastometer body successively and angle of inclination blood clotting data is modified for
Example, is described in further detail to blood clotting data correcting method provided in an embodiment of the present invention, as shown in figure 5, the method is permissible
Comprise the following steps：
Step 501：By thrombus elastometer body, blood to be measured is detected.
In an embodiment of the invention, blood to be measured is loaded after thrombus elastometer body, driving means drive to be measured
Blood rotates, and blood to be measured rotates and drives the rotary shaft of thrombus elastometer body to rotate, and starts the blood clotting of blood to be measured is carried out
Detection.
Step 502：The Vibration Condition of thrombus elastometer body is detected, obtains the vibration number of thrombus elastometer body
According to.
In an embodiment of the invention, during thrombus elastometer body detects to blood to be measured, due to
Support platform for supporting thrombus elastometer body is vibrated, and the impact producing when rotation rotational axis direction changes,
Lead to thrombus elastometer body to produce vibration, detect the vibration feelings of thrombus elastometer body by least one vibrating sensor
Condition, each vibrating sensor detects vibration amplitude and the vibration frequency of one group of thrombus elastometer body respectively.
For example, as shown in Fig. 2 arranging between three fulcrums 201 of thrombus elastometer body 101 and support platform 203
There are three Quartz crystal resonant formula sensors 202, when thrombus elastometer body 101 sends vibration, thrombus elastometer body 101
Vibration Quartz crystal resonant formula sensor 202 is passed to by fulcrum 201, Quartz crystal resonant formula sensor 202 being capable of root
Change the intrinsic frequency of its own according to the frequency of the vibration receiving, and be capable of detecting when the pressure that fulcrum 201 produces to it,
Quartz crystal resonant formula sensor 202 determines thrombus elastometer body according to its own intrinsic frequency and the pressure bearing
101 vibration amplitude LiAnd vibration frequency γi.The vibration amplitude that three Quartz crystal resonant formula sensors 202 detect is respectively
L1、L2And L3, the vibration frequency that three Quartz crystal resonant formula sensors 202 detect is respectively γ1、γ2And γ3.
Step 503：The inclination conditions of thrombus elastometer body are detected, obtains the inclination angle of thrombus elastometer body
Degree.
In an embodiment of the invention, during thrombus elastometer body detects to blood to be measured, thrombus
The inclination conditions of thrombus elastometer body are examined by the certain angle of inclination of elastometer ontological existence by horizon sensor
Survey, get the angle of inclination of thrombus elastometer body.
For example, a gyroscope is fixed on thrombus elastometer body, in thrombus elastometer body, blood to be measured is entered
During row detection, gyroscope detects to the inclined degree of thrombus elastometer body, obtains thrombus elastometer body
Tilt angle alpha.
Step 504：According to vibration data, blood clotting data is modified, obtains the first correction blood clotting data.
In an embodiment of the invention, after thrombus elastometer body detects the blood clotting data of blood to be measured, data is repaiied
Vibration amplitude and vibration frequency that original unit gets according to vibrating sensor in step 502, detect to thrombus elastometer body
The blood clotting data going out is modified, and obtains the first correction blood clotting data, to reduce in blood clotting data due to thrombus elastometer body
The error vibrated and introduce.
For example, thrombus elastometer body detect blood blood clotting when, with the rotary shaft on thrombus elastometer body turn
Dynamic angle is exported as blood clotting data, is directed to any time that thrombus elastometer body is detected to blood to be measured,
The anglec of rotation of this moment rotary shaft is A0；Calculate the vibration amplitude that three Quartz crystal resonant formula sensors of this moment detect
L1、L2And L3Mean value L, and calculate vibration frequency γ that three Quartz crystal resonant formula sensors of this moment detect1、γ2
And γ3Mean value γ, by L and γ calculating substitute into equation below one, calculate correction factor δ, wherein formula one is：
After calculating correction factor δ, by the rotational angle A of rotary shaft0And correction factor δ substitutes into equation below two, calculate
Go out the first rotational angle A1, wherein formula two is：
A1=δ A0
Now the first rotational angle A1It is the first correction blood clotting data after vibration error is modified.
Step 505：According to angle of inclination, the first correction blood clotting data is modified, obtains second and revise blood clotting data simultaneously
Output.
In an embodiment of the invention, data correction unit is modified to vibration error obtaining the first correction blood clotting number
According to angle of inclination that is rear, being got according to horizon sensor in step 503 further, the first correction blood clotting data is carried out again
Revise, obtain the second correction blood clotting data, drawn because thrombus elastometer body tilts with reducing in the first correction blood clotting data
The error entering, second revises blood clotting data as the testing result output of thrombus elastometer the most at last.
For example, when thrombus elastometer is using the rotational angle of rotary shaft as blood clotting data, due in thrombus elastometer body
The process that blood to be measured is detected, the angle of inclination of thrombus elastometer body is held essentially constant, and gyroscope detects bleeding
After the tilt angle alpha of bolt elastometer body, according to tilt angle alpha and by the first rotational angle to any time for the formula three
A1It is modified, obtain corresponding second rotational angle A2, wherein formula three is：
A2=A1·cosα
Now the second rotational angle A2It is the second correction blood clotting number after vibration error and heeling error are modified
According to by final the second correction blood clotting data output obtaining.
It should be noted that when being modified to the vibration error in blood clotting data in step 504, can according to any when
The vibration data carving thrombus elastometer body is modified it is also possible to according to entirely detecting to this moment corresponding blood clotting data
In journey, the Mean Oscillation data of thrombus elastometer body is modified to the blood clotting data in each moment, in concrete business realizing mistake
Can flexibly select in journey；Correspondingly, when the heeling error in blood clotting data being modified in step 505, can according to appoint
The angle of inclination of meaning moment thrombus elastometer body is modified to this moment corresponding blood clotting data it is also possible to be examined according to whole
During survey, the average tilt angle of thrombus elastometer body is modified to the blood clotting data in each moment, real in concrete business
Can flexibly select during existing.
Need further exist for illustrating, the blood clotting data correcting method shown in Fig. 5 is to clearly describe blood clotting
The process of data correction and multiple steps of splitting into, do not have strict elder generation between each step during concrete business realizing
Order afterwards, such as step 502 can be executed with step 503 simultaneously, can first carry out step 505 is modified to heeling error again
Execution step 504 is modified to vibration error.
Each embodiment that the present invention provides, at least has the advantages that：
1st, during the blood clotting data to blood to be measured detects, at least one vibration passes thrombus elastometer body
Sensor detects to the Vibration Condition of thrombus elastometer body, obtains the vibration data of thrombus elastometer body, data correction
The vibration data that unit gets according to vibrating sensor, the blood clotting data that thrombus elastometer body is detected is modified,
Form the first correction blood clotting data.The blood clotting data detecting with respect to thrombus elastometer body, first revises blood clotting data is
Result after blood clotting data being modified according to the Vibration Condition of thrombus elastometer body, therefore with the first correction blood clotting data
The error introducing due to the vibration of thrombus elastometer in testing result can be reduced as final testing result.
2nd, thrombus elastometer can also include horizon sensor, and horizon sensor can detect inclining of thrombus elastometer body
Rake angle, the angle of inclination that data correction unit detects according to horizon sensor can further in blood clotting data due to blood
The error that bolt elastometer body tilts and introduces is modified, thus reducing in blood clotting data because thrombus elastometer body tilts
And the error introducing, improve the accuracy that thrombus elastometer is detected to blood.
3rd, due to gyroscope high precision, be quick on the draw, can be improved to thrombus bullet using gyroscope as horizon sensor
The accuracy that power instrument body angle of inclination is detected, such that it is able to greatly reduce in blood clotting data due to thrombus elastic force
The error that instrument body tilts and introduces, further increases the accuracy that thrombus elastometer is detected to blood.
4th, by multiple vibrating sensors, the vibration data of thrombus elastometer body can be detected, be shaken according to each
The mean value of the vibration data that dynamic sensor detects is modified to blood clotting data, can be according to whole thrombus elastometer body
Vibration Condition blood clotting data is modified, improve vibration error correction reliability.
It should be noted that herein, such as first and second etc relational terms are used merely to an entity
Or operation is made a distinction with another entity or operation, and not necessarily requires or imply exist between these entities or operation
Any this actual relation or order.And, term " inclusion ", "comprising" or its any other variant are intended to non-
The comprising of exclusiveness, so that including a series of process of key elements, method, article or equipment not only include those key elements,
But also include other key elements being not expressly set out, or also include being consolidated by this process, method, article or equipment
Some key elements.In the absence of more restrictions, the key element being limited by sentence " including ", does not arrange
Remove and also there is other identical factor in the process including described key element, method, article or equipment.
One of ordinary skill in the art will appreciate that：The all or part of step realizing said method embodiment can be passed through
Completing, aforesaid program can be stored in the storage medium of embodied on computer readable the related hardware of programmed instruction, this program
Upon execution, execute the step including said method embodiment；And aforesaid storage medium includes：ROM, RAM, magnetic disc or light
Disk etc. is various can be with the medium of store program codes.
Last it should be noted that：The foregoing is only presently preferred embodiments of the present invention, be merely to illustrate the skill of the present invention
Art scheme, is not intended to limit protection scope of the present invention.All any modifications made within the spirit and principles in the present invention,
Equivalent, improvement etc., are all contained in protection scope of the present invention.
Claims (10)
1. a kind of thrombus elastometer is it is characterised in that include：Thrombus elastometer body, at least one vibrating sensor and data
Amending unit；
Described thrombus elastometer body, for detecting, obtains the blood clotting data of described blood to be measured to blood to be measured；
Described vibrating sensor, for detecting described thrombus elastometer body during described blood to be measured is detected
The Vibration Condition of described thrombus elastometer body, obtains the vibration data of described thrombus elastometer body；
Described data correction unit, for the described vibration data being obtained according to each described vibrating sensor, to described thrombus
The described blood clotting data that elastometer body obtains is modified, and forms the first correction blood clotting data.
2. thrombus elastometer according to claim 1 it is characterised in that
Described vibrating sensor includes：Quartz crystal resonant formula sensor；
Described Quartz crystal resonant formula sensor, positioned at fulcrum and the described thrombus elastometer of support of described thrombus elastometer body
Between the support platform of body, for the intrinsic frequency according to its own and the pressure that bears, obtain described thrombus elastometer this
The vibration amplitude of body and vibration frequency.
3. thrombus elastometer according to claim 2 it is characterised in that
Described data correction unit, for according to described vibration amplitude and described vibration frequency, being obtained by equation below one and repairing
Positive coefficient, and by equation below two, described blood clotting data is modified, obtain described first correction blood clotting data；
Described formula one is：
Described formula two is：
A1=δ A0
Wherein, described δ is described correction factor, and described L is the average of the vibration amplitude that each described vibrating sensor detects
Value, described γ is the mean value of the vibration frequency that each described vibrating sensor detects, described A0For described blood clotting data, institute
State A1For the described first correction blood clotting data.
4. according to described thrombus elastometer arbitrary in claims 1 to 3 it is characterised in that further including：Horizontal sensor
Device；
Described horizon sensor, for detecting described thrombus elastometer body during described blood to be measured is detected
The inclination conditions of described thrombus elastometer body, obtain the angle of inclination of described thrombus elastometer body；
Described data correction unit, is further used for the angle of inclination getting according to described horizon sensor, to described first
Revise blood clotting data to be modified, form the second correction blood clotting data and export.
5. thrombus elastometer according to claim 4 it is characterised in that
Described data correction unit, for the angle of inclination according to described thrombus elastometer body, by equation below three to institute
State the first correction blood clotting data to be modified, obtain described second correction blood clotting data；
Described formula three is：
A2=A1·cosα
Wherein, described α is the angle of inclination of described thrombus elastometer body, described A1Revise blood clotting data for described first, described
A2For the described second correction blood clotting data.
6. a kind of method to blood clotting data correction for arbitrary described thrombus elastometer in utilization claim 1 to 5, its feature exists
In, including：
By thrombus elastometer body, blood to be measured is detected, obtain the blood clotting data of described blood to be measured；
Detect that described thrombus elastometer body is carrying out detection process to described blood to be measured using vibrating sensor each described
Described in thrombus elastometer body Vibration Condition, obtain described thrombus elastometer body vibration data；
The described vibration data being obtained according to each described vibrating sensor, is modified to described blood clotting data, forms first
Revise blood clotting data.
7. method according to claim 6 it is characterised in that
When described vibrating sensor includes Quartz crystal resonant formula sensor, the described thrombus elastometer body of described detection is right
Described blood to be measured carries out the Vibration Condition of thrombus elastometer body described in detection process, obtains described thrombus elastometer body
Vibration data include：
During described thrombus elastometer body detects to described blood to be measured, according to described Quartz crystal resonant formula
The intrinsic frequency of sensor and the pressure bearing, obtain vibration amplitude and the vibration frequency of described thrombus elastometer body.
8. method according to claim 7 it is characterised in that
The described described vibration data being obtained according to each described vibrating sensor, is modified to described blood clotting data, is formed
First correction blood clotting data includes：
According to described vibration amplitude and described vibration frequency, correction factor is obtained by equation below one, and pass through equation below
Two pairs of described blood clotting data are modified, and obtain described first correction blood clotting data；
Described formula one is：
Described formula two is：
A1=δ A0
Wherein, described δ is described correction factor, and described L is the average of the vibration amplitude that each described vibrating sensor detects
Value, described γ is the mean value of the vibration frequency that each described vibrating sensor detects, described A0For described blood clotting data, institute
State A1For the described first correction blood clotting data.
9. according to described method arbitrary in claim 6 to 8 it is characterised in that further including：
Detect described thrombus elastometer body described thrombus elastometer body during described blood to be measured is detected
Inclination conditions, obtain described thrombus elastometer body angle of inclination；
According to the angle of inclination of described thrombus elastometer body, the described first correction blood clotting data is modified, forms second
Revise blood clotting data and export.
10. method according to claim 9 it is characterised in that
The described angle of inclination according to thrombus elastometer body, is modified to the described first correction blood clotting data, forms second
Revise blood clotting data to include：
According to the angle of inclination of described thrombus elastometer body, by equation below three, described first correction blood clotting data is carried out
Revise, obtain described second correction blood clotting data；
Described formula three is：
A2=A1·cosα
Wherein, described α is the angle of inclination of described thrombus elastometer body, described A1Revise blood clotting data for described first, described
A2For the described second correction blood clotting data.
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| CN201610753656.XA CN106442954B (en) | 2016-08-30 | 2016-08-30 | A kind of thrombus elastometer and blood clotting data correcting method |
| PCT/CN2017/082755 WO2017186184A1 (en) | 2016-04-29 | 2017-05-02 | Apparatus for measuring blood coagulation data |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2017186184A1 (en) * | 2016-04-29 | 2017-11-02 | 诺泰科生物科技（苏州）有限公司 | Apparatus for measuring blood coagulation data |
| CN113804284A (en) * | 2021-09-03 | 2021-12-17 | 中国科学院苏州生物医学工程技术研究所 | Vibration displacement measuring method of vibration type viscoelastic sensor |
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| CN105158450A (en) * | 2015-10-10 | 2015-12-16 | 嘉兴凯实生物科技有限公司 | Thromboela-stogram instrument |
| US20160091516A1 (en) * | 2014-09-29 | 2016-03-31 | C A Casyso Ag | Blood Testing System and Method |
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| CN101322643A (en) * | 2007-06-12 | 2008-12-17 | 株式会社来易特制作所 | Instrument for measuring a refractive power |
| CN104614539A (en) * | 2013-11-05 | 2015-05-13 | 北京乐普医疗科技有限责任公司 | Thrombelastogram instrument |
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| CN113804284A (en) * | 2021-09-03 | 2021-12-17 | 中国科学院苏州生物医学工程技术研究所 | Vibration displacement measuring method of vibration type viscoelastic sensor |
| CN113804284B (en) * | 2021-09-03 | 2022-04-15 | 中国科学院苏州生物医学工程技术研究所 | Vibration displacement measuring method of vibration type viscoelastic sensor |
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