CN106421926A - Pure natural traditional Chinese medicine and marine organism active immunization bone - Google Patents

Pure natural traditional Chinese medicine and marine organism active immunization bone Download PDF

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Publication number
CN106421926A
CN106421926A CN201610858372.7A CN201610858372A CN106421926A CN 106421926 A CN106421926 A CN 106421926A CN 201610858372 A CN201610858372 A CN 201610858372A CN 106421926 A CN106421926 A CN 106421926A
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parts
bone
radix
rhizoma
immunity
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CN201610858372.7A
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范玉梅
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention discloses a pure natural traditional Chinese medicine and marine organism active immunization bone. The active immunization bone provided by the invention is prepared from bone protein and a concentrated traditional Chinese medicinal solution. The pure natural traditional Chinese medicine and marine organism active immunization bone provided by the invention can rapidly stop bleeding in a part with fracture within a short time, prevent deformation, repair bone cells and promote rapid healing of a wound, enhance an antibacterial effect, nourish bones and muscles as well as tendons and periostea, and enhance a bone density. The pure natural traditional Chinese medicine and marine organism active immunization bone provided by the invention, when applied to osteosynthesis, can avoid pain in a patient who accepts a secondary operation to take out a steel body which is used for setting the fracture due to injury, atrophy and deformation on wound healing as well as complication infection, and can avoid the phenomenon that the patient becomes disabled due to a failed operation.

Description

Natural Chinese medicines marine bioactivity immunity bone
Technical field
The present invention relates to a kind of natural Chinese medicines marine bioactivity immunity bone.
Background technology
Fracture refers to cause bone parts or a kind of disease for rupturing completely due to reasons such as wound or pathology.Which mainly faces Bed shows as：Fractures have localized pain and a tenderness, local swelling and ecchymosis occur, limb function position or completely lose, Still there is cacomelia and abnormal movement in complete fracture.
In China, fracture has become as a kind of commonly encountered diseases, frequently-occurring disease.Except the fracture that contingency is caused, more common Be the fracture for causing because of osteoporosises.Osteoporosis are significantly reduced with bone amount, the micro-structure of bone is destroyed, make the fragility of bone Increase, fracture risk increase a kind of general disease.Preferably osteoporosises data medicine well should be able to improve bone mass and Bone density is raised, so as to increasing bone strength, reducing fracture risk.Due to the aging of population and the increasing of mankind's life expectancy Plus.Osteoporosis are increasingly becoming gerontal patient and disable and a kind of lethal common cause.Show according to investigations, China's osteoporosises Disease morbidity total number of persons has reached 100,000,000, also increases 7,000,000 sufferers of osteoporosis face newly every year, and corresponding medical expense is more than 15,000,000,000 yuan of people People's coin.Especially, the fracture that osteoporosis are caused has become as the stealthy killer of senior health and fitness's life.Because fracture causes Injury limits normal action and the life of patient, increased the pain of patient and the burden of household.
Content of the invention
In order to improve the problems referred to above, the present invention provides a kind of natural Chinese medicines marine bioactivity immunity bone.
To achieve these goals, the technical solution used in the present invention is as follows：
A kind of natural Chinese medicines marine bioactivity immunity bone, is prepared from the concentrated liquid of tradition Chinese medicine by bone protein.
Select as a kind of, the bone protein is prepared from the following materials：Hippocampus, pig, yak, sheep, donkey；The sea Horse, pig, yak, sheep, donkey consumption identical.
Alternatively, the bone protein is prepared from the following materials：Hippocampus, DABAI shark, squid, whale, Testudiniss, Trionyx sinensis Wiegmann, crocodile；The Hippocampus, DABAI shark, squid, whale, Testudiniss, Trionyx sinensis Wiegmann, crocodile consumption identical.
Specifically, the concentrated liquid of tradition Chinese medicine is concentrated by following raw material and is formed, by weight：
10～20 parts of Radix Notoginseng, 10～20 parts of Pyritum, 10～20 parts of ground beetle, 1～5 part of Formica fusca, 10～20 parts of teasel, Rhizoma Polygoni Cuspidati 10～20 parts, 10～15 parts of Radix Angelicae Pubescentiss, 10～15 parts of Radix Clematidis, 10～15 parts of Radix Angelicae Sinensis, 5～12 parts of Lignum Sappan, 5～12 parts of Rhizoma Curcumae Longae, thoroughly 5～15 parts of GUCAO, 5～15 parts of Ramulus Mori, 10～15 parts of Herba Saussureae Involueratae, 10～20 parts of Flos Carthami, 5～15 parts of Caulis Spatholobi, geranium 5～15 Part, 5～15 parts of Caulis Lonicerae, 5～15 parts of the Radix Polygoni Multiflori, 5～15 parts of Pterospermi Heterophylli, 5～15 parts of Ganoderma, 0.1～0.2 part of Moschus, Radix Salviae Miltiorrhizae 10 ～20 parts, 10～15 parts of Rhizoma Chuanxiong, 10～15 parts of Radix Paeoniae Rubra, 5～15 parts of Rhizoma Atractylodis, 5～15 parts of Rhizoma Corydalis, 5～12 parts of Semen Sinapis Albae, Herba Asari 5～12 parts, 5～12 parts of Radix Saposhnikoviae, 5～15 parts of Rhizoma Curcumae, 5～15 parts of Radix Et Caulis Acanthopanacis Senticosi, 10～15 parts of Cordyceps, 10～20 parts of Rhizoma Cibotii, 10～15 parts of the Radix Rehmanniae, 15～25 parts of Rhizoma Drynariae.
Specifically, the pig is one or more in Corii Sus domestica, Os Sus domestica or pig muscle, and the yak is yak skin, Os Bovis grunniens Or one or more in yak muscle, the sheep is one or more in Corii Caprae seu Oviss, Os Caprae seu Ovis or sheep tendon, and the donkey is donkey skin, donkey One or more in bone or donkey muscle.
Specifically, the DABAI shark is one or more in DABAI sharkskin, great white shark fish scale or DABAI shark bone, The squid is squid skin or/and sleeve-fish ear, and the whale is whale leather, one or more in whale bone, whale squama, described Testudiniss are Testudiniss first, and the Trionyx sinensis Wiegmann is Trionyx sinensis Wiegmann skin, and the crocodile is one or more in crocodile skin, crocodile bone or Crocodile scale.
Select as a kind of, the concentrated liquid of tradition Chinese medicine is concentrated by following raw material and formed, by weight：
15 parts of Radix Notoginseng, 15 parts of Pyritum, 15 parts of ground beetle, 3 parts of Formica fusca, 15 parts of teasel, 15 parts of Rhizoma Polygoni Cuspidati, 12 parts of Radix Angelicae Pubescentiss, Wheeling Celestial 12 parts, 12 parts of Radix Angelicae Sinensis, 9 parts of Lignum Sappan, 9 parts of Rhizoma Curcumae Longae, 10 parts of Herba speranskiae tuberculatae, 10 parts of Ramulus Mori, 12 parts of Herba Saussureae Involueratae, 15 parts of Flos Carthami, Sanguis Gallus domesticus 10 parts of rattan, 10 parts of geranium, 10 parts of Caulis Lonicerae, 10 parts of the Radix Polygoni Multiflori, 10 parts of Pterospermi Heterophylli, 10 parts of Ganoderma, 0.1 part of Moschus, 15 parts of Radix Salviae Miltiorrhizae, 12 parts of Rhizoma Chuanxiong, 12 parts of Radix Paeoniae Rubra, 10 parts of Rhizoma Atractylodis, 10 parts of Rhizoma Corydalis, 9 parts of Semen Sinapis Albae, 9 parts of Herba Asari, 9 parts of Radix Saposhnikoviae, 10 parts of Rhizoma Curcumae, thorn five Plus 10 parts, 12 parts of Cordyceps, 15 parts of Rhizoma Cibotii, 12 parts of the Radix Rehmanniae, 20 parts of Rhizoma Drynariae.
Specifically, powder is ground into by bone protein, after mixing homogeneously with the concentrated liquid of tradition Chinese medicine, then through high temperature sterilize, cooling, solidifying Admittedly make.
The present invention compared with prior art, with advantages below and beneficial effect：
The natural Chinese medicines marine bioactivity immunity bone of the present invention can make fracture stop blooding rapidly at short notice, prevent from becoming Shape, repairs osteocyte fast healing of wound, and antibacterial action is notable, nutrition skeleton and muscle, tendon periosteum, strengthens bone density.
After the natural Chinese medicines marine bioactivity immunity bone osteopathy of the present invention avoids steel body synthetism, secondary handss are needed Art takes steel body and causes wound healing to damage atrophy, deformation, and complication infection and causes patient to perform the operation for the second time pain, and operation Patient disabilities are unsuccessfully caused.
Specific embodiment
With reference to embodiment, the invention will be further described, and embodiments of the present invention include but is not limited to following reality Apply example.
Embodiment 1
A kind of natural Chinese medicines marine bioactivity immunity bone, is prepared from the concentrated liquid of tradition Chinese medicine by bone protein；Concrete preparation side Method is as follows：
（1）By the Hippocampus of same amount, pig, yak, sheep, donkey by salting out method obtain bone protein, then high temperature sterilize, cooling, It is ground into powder；
（2）By Radix Notoginseng 15g, Pyritum 15g, ground beetle 15g, Formica fusca 3g, teasel 15g, Rhizoma Polygoni Cuspidati 15g, Radix Angelicae Pubescentiss 12g, Radix Clematidis 12g, Radix Angelicae Sinensis 12g, Lignum Sappan 9g, Rhizoma Curcumae Longae 9g, Herba speranskiae tuberculatae 10g, Ramulus Mori 10g, Herba Saussureae Involueratae 12g, Flos Carthami 15g, Caulis Spatholobi 10g, old crane Careless 10g, Caulis Lonicerae 10g, Radix Polygoni Multiflori 10g, Pterospermi Heterophylli 10g, Ganoderma 10g, Moschus 0.1g, Radix Salviae Miltiorrhizae 15g, Rhizoma Chuanxiong 12g, Radix Paeoniae Rubra 12g, grey Art 10g, Rhizoma Corydalis 10g, Semen Sinapis Albae 9g, Herba Asari 9g, Radix Saposhnikoviae 9g, Rhizoma Curcumae 10g, Radix Et Caulis Acanthopanacis Senticosi 10g, Cordyceps 12g, Rhizoma Cibotii 15g, Radix Rehmanniae 12g, Rhizoma Drynariae 20g is extracted, refines, is condensed into the concentrated liquid of tradition Chinese medicine；
（3）Powder is mixed homogeneously with concentrated solution, powder is mixed homogeneously with concentrated solution, high temperature sterilize, cooling, solidification obtain final product pure day Right Chinese medicine marine bioactivity immunity bone.
Wherein, the pig be Corii Sus domestica, one or more in Os Sus domestica or pig muscle, the yak is yak skin, Os Bovis grunniens or One or more in yak muscle, the sheep is one or more in Corii Caprae seu Oviss, Os Caprae seu Ovis or sheep tendon, and the donkey is donkey skin, Os Equi Asini Or one or more in donkey muscle.
When actually used, as the case may be the pure-natural marine living-things active immne bone of the present invention can be prepared into The diaphysis of various models to meet the demand of patient, for example：Bone attachment screw, diaphysis template.
In addition, the present invention needs after making various diaphysis to carry out cold preservation, refrigerated storage temperature is that 15～20 DEG C, temperature is too low easily Broken, to scrap, temperature is too high soluble.The diaphysis allergy sufferers disabling of the present invention, Post operation taboo eats maror, Semen Viciae fabae, fish, acidity Food, the taboo phase is three months.
Additionally, carrying out operation consent in the natural Chinese medicines marine bioactivity immunity bone using the present invention, need to patient Carry out allergy test：Skin test is test 15 minutes, and discovery is red and swollen, itch, having smallpox disables natural Chinese medicines marine bioactivity immunity bone, Fracture reduction operation is carried out by not occurring.
In order to preferably reach surgical effect, carry out in the natural Chinese medicines marine bioactivity immunity bone using the present invention Post operation, yellow wine is taken after mixing it with water 15g Radix Notoginseng powder.
Embodiment 2
A kind of natural Chinese medicines marine bioactivity immunity bone, is prepared from the concentrated liquid of tradition Chinese medicine by bone protein；Concrete preparation side Method is as follows：
（1）By the Hippocampus of same amount, pig, yak, sheep, donkey by salting out method obtain bone protein, then high temperature sterilize, cooling, It is ground into powder；
（2）By Radix Notoginseng 10g, Pyritum 10g, ground beetle 10g, Formica fusca 1g, teasel 10g, Rhizoma Polygoni Cuspidati 10g, Radix Angelicae Pubescentiss 10g, Radix Clematidis 10g, Radix Angelicae Sinensis 10g, Lignum Sappan 5g, Rhizoma Curcumae Longae 5g, Herba speranskiae tuberculatae 5g, Ramulus Mori 5g, Herba Saussureae Involueratae 10g, Flos Carthami 10g, Caulis Spatholobi 5g, geranium 5g, Caulis Lonicerae 5g, Radix Polygoni Multiflori 5g, Pterospermi Heterophylli 5g, Ganoderma 5g, Moschus 0.15g, Radix Salviae Miltiorrhizae 10g, Rhizoma Chuanxiong 10g, Radix Paeoniae Rubra 10g, Rhizoma Atractylodis 5g, Rhizoma Corydalis 5g, Semen Sinapis Albae 5g, Herba Asari 5g, Radix Saposhnikoviae 5g, Rhizoma Curcumae 5g, Radix Et Caulis Acanthopanacis Senticosi 5g, Cordyceps 10g, Rhizoma Cibotii 10g, Radix Rehmanniae 10g, Rhizoma Drynariae 15g is extracted, refines, is condensed into the concentrated liquid of tradition Chinese medicine；
（3）Powder is mixed homogeneously with concentrated solution, powder is mixed homogeneously with concentrated solution, high temperature sterilize, cooling, solidification obtain final product pure day Right Chinese medicine marine bioactivity immunity bone.
Wherein, the pig be Corii Sus domestica, one or more in Os Sus domestica or pig muscle, the yak is yak skin, Os Bovis grunniens or One or more in yak muscle, the sheep is one or more in Corii Caprae seu Oviss, Os Caprae seu Ovis or sheep tendon, and the donkey is donkey skin, Os Equi Asini Or one or more in donkey muscle.
When actually used, as the case may be the pure-natural marine living-things active immne bone of the present invention can be prepared into The diaphysis of various models to meet the demand of patient, for example：Bone attachment screw, diaphysis template.
In addition, the present invention needs after making various diaphysis to carry out cold preservation, refrigerated storage temperature is that 15～20 DEG C, temperature is too low easily Broken, to scrap, temperature is too high soluble.The diaphysis allergy sufferers disabling of the present invention, Post operation taboo eats maror, Semen Viciae fabae, fish, acidity Food, the taboo phase is three months.
Additionally, carrying out operation consent in the natural Chinese medicines marine bioactivity immunity bone using the present invention, need to patient Carry out allergy test：Skin test is test 15 minutes, and discovery is red and swollen, itch, having smallpox disables natural Chinese medicines marine bioactivity immunity bone, Fracture reduction operation is carried out by not occurring.
In order to preferably reach surgical effect, carry out in the natural Chinese medicines marine bioactivity immunity bone using the present invention Post operation, yellow wine is taken after mixing it with water 15g Radix Notoginseng powder.
Embodiment 3
A kind of natural Chinese medicines marine bioactivity immunity bone, is prepared from the concentrated liquid of tradition Chinese medicine by bone protein；Concrete preparation side Method is as follows：
（1）By the Hippocampus of same amount, pig, yak, sheep, donkey by salting out method obtain bone protein, then high temperature sterilize, cooling, It is ground into powder；
（2）By Radix Notoginseng 20g, Pyritum 20g, ground beetle 20g, Formica fusca 5g, teasel 20g, Rhizoma Polygoni Cuspidati 20g, Radix Angelicae Pubescentiss 15g, Radix Clematidis 15g, Radix Angelicae Sinensis 15g, Lignum Sappan 12g, Rhizoma Curcumae Longae 12g, Herba speranskiae tuberculatae 15g, Ramulus Mori 15g, Herba Saussureae Involueratae 15g, Flos Carthami 20g, Caulis Spatholobi 15g, always Crane grass 15g, Caulis Lonicerae 15g, Radix Polygoni Multiflori 15g, Pterospermi Heterophylli 15g, Ganoderma 15g, Moschus 0.2g, Radix Salviae Miltiorrhizae 20g, Rhizoma Chuanxiong 15g, Radix Paeoniae Rubra 15g, Rhizoma Atractylodis 15g, Rhizoma Corydalis 15g, Semen Sinapis Albae 12g, Herba Asari 12g, Radix Saposhnikoviae 12g, Rhizoma Curcumae 15g, Radix Et Caulis Acanthopanacis Senticosi 15g, Cordyceps 15g, Canis familiaris L. Ridge 20g, Radix Rehmanniae 15g, Rhizoma Drynariae 25g is extracted, refines, is condensed into the concentrated liquid of tradition Chinese medicine；
（3）Powder is mixed homogeneously with concentrated solution, powder is mixed homogeneously with concentrated solution, high temperature sterilize, cooling, solidification obtain final product pure day Right Chinese medicine marine bioactivity immunity bone.
Wherein, the pig be Corii Sus domestica, one or more in Os Sus domestica or pig muscle, the yak is yak skin, Os Bovis grunniens or One or more in yak muscle, the sheep is one or more in Corii Caprae seu Oviss, Os Caprae seu Ovis or sheep tendon, and the donkey is donkey skin, Os Equi Asini Or one or more in donkey muscle.
When actually used, as the case may be the pure-natural marine living-things active immne bone of the present invention can be prepared into The diaphysis of various models to meet the demand of patient, for example：Bone attachment screw, diaphysis template.
In addition, the present invention needs after making various diaphysis to carry out cold preservation, refrigerated storage temperature is that 15～20 DEG C, temperature is too low easily Broken, to scrap, temperature is too high soluble.The diaphysis allergy sufferers disabling of the present invention, Post operation taboo eats maror, Semen Viciae fabae, fish, acidity Food, the taboo phase is three months.
Additionally, carrying out operation consent in the natural Chinese medicines marine bioactivity immunity bone using the present invention, need to patient Carry out allergy test：Skin test is test 15 minutes, and discovery is red and swollen, itch, having smallpox disables natural Chinese medicines marine bioactivity immunity bone, Fracture reduction operation is carried out by not occurring.
In order to preferably reach surgical effect, carry out in the natural Chinese medicines marine bioactivity immunity bone using the present invention Post operation, yellow wine is taken after mixing it with water 15g Radix Notoginseng powder.
Embodiment 4
A kind of natural Chinese medicines marine bioactivity immunity bone, is prepared from the concentrated liquid of tradition Chinese medicine by bone protein；Concrete preparation side Method is as follows：
（1）The Hippocampus of same amount, DABAI shark, squid, whale, Testudiniss, Trionyx sinensis Wiegmann, crocodile are obtained bone egg by salting out method In vain, then high temperature sterilize, cool down, be ground into powder；
（2）By Radix Notoginseng 15g, Pyritum 15g, ground beetle 15g, Formica fusca 3g, teasel 15g, Rhizoma Polygoni Cuspidati 15g, Radix Angelicae Pubescentiss 12g, Radix Clematidis 12g, Radix Angelicae Sinensis 12g, Lignum Sappan 9g, Rhizoma Curcumae Longae 9g, Herba speranskiae tuberculatae 10g, Ramulus Mori 10g, Herba Saussureae Involueratae 12g, Flos Carthami 15g, Caulis Spatholobi 10g, old crane Careless 10g, Caulis Lonicerae 10g, Radix Polygoni Multiflori 10g, Pterospermi Heterophylli 10g, Ganoderma 10g, Moschus 0.1g, Radix Salviae Miltiorrhizae 15g, Rhizoma Chuanxiong 12g, Radix Paeoniae Rubra 12g, grey Art 10g, Rhizoma Corydalis 10g, Semen Sinapis Albae 9g, Herba Asari 9g, Radix Saposhnikoviae 9g, Rhizoma Curcumae 10g, Radix Et Caulis Acanthopanacis Senticosi 10g, Cordyceps 12g, Rhizoma Cibotii 15g, Radix Rehmanniae 12g, Rhizoma Drynariae 20g is extracted, refines, is condensed into the concentrated liquid of tradition Chinese medicine；
（3）Powder is mixed homogeneously with concentrated solution, powder is mixed homogeneously with concentrated solution, high temperature sterilize, cooling, solidification obtain final product pure day Right Chinese medicine marine bioactivity immunity bone.
Wherein, the DABAI shark is one or more in DABAI sharkskin, great white shark fish scale or DABAI shark bone, institute Squid is stated for squid skin or/and sleeve-fish ear, the whale is whale leather, one or more in whale bone, whale squama, the crow Testudiniss are Testudiniss first, and the Trionyx sinensis Wiegmann is Trionyx sinensis Wiegmann skin, and the crocodile is one or more in crocodile skin, crocodile bone or Crocodile scale.
When actually used, as the case may be the pure-natural marine living-things active immne bone of the present invention can be prepared into The diaphysis of various models to meet the demand of patient, for example：Bone attachment screw, diaphysis template.
In addition, the present invention needs after making various diaphysis to carry out cold preservation, refrigerated storage temperature is that 15～20 DEG C, temperature is too low easily Broken, to scrap, temperature is too high soluble.The diaphysis allergy sufferers disabling of the present invention, Post operation taboo eats maror, Semen Viciae fabae, fish, acidity Food, the taboo phase is three months.
Additionally, carrying out operation consent in the natural Chinese medicines marine bioactivity immunity bone using the present invention, need to patient Carry out allergy test：Skin test is test 15 minutes, and discovery is red and swollen, itch, having smallpox disables natural Chinese medicines marine bioactivity immunity bone, Fracture reduction operation is carried out by not occurring.
In order to preferably reach surgical effect, carry out in the natural Chinese medicines marine bioactivity immunity bone using the present invention Post operation, yellow wine is taken after mixing it with water 15g Radix Notoginseng powder.
Embodiment 5
A kind of natural Chinese medicines marine bioactivity immunity bone, is prepared from the concentrated liquid of tradition Chinese medicine by bone protein；Concrete preparation side Method is as follows：
（1）The Hippocampus of same amount, DABAI shark, squid, whale, Testudiniss, Trionyx sinensis Wiegmann, crocodile are obtained bone egg by salting out method In vain, then high temperature sterilize, cool down, be ground into powder；
（2）By Radix Notoginseng 10g, Pyritum 10g, ground beetle 10g, Formica fusca 1g, teasel 10g, Rhizoma Polygoni Cuspidati 10g, Radix Angelicae Pubescentiss 10g, Radix Clematidis 10g, Radix Angelicae Sinensis 10g, Lignum Sappan 5g, Rhizoma Curcumae Longae 5g, Herba speranskiae tuberculatae 5g, Ramulus Mori 5g, Herba Saussureae Involueratae 10g, Flos Carthami 10g, Caulis Spatholobi 5g, geranium 5g, Caulis Lonicerae 5g, Radix Polygoni Multiflori 5g, Pterospermi Heterophylli 5g, Ganoderma 5g, Moschus 0.15g, Radix Salviae Miltiorrhizae 10g, Rhizoma Chuanxiong 10g, Radix Paeoniae Rubra 10g, Rhizoma Atractylodis 5g, Rhizoma Corydalis 5g, Semen Sinapis Albae 5g, Herba Asari 5g, Radix Saposhnikoviae 5g, Rhizoma Curcumae 5g, Radix Et Caulis Acanthopanacis Senticosi 5g, Cordyceps 10g, Rhizoma Cibotii 10g, Radix Rehmanniae 10g, Rhizoma Drynariae 15g is extracted, refines, is condensed into the concentrated liquid of tradition Chinese medicine；
（3）Powder is mixed homogeneously with concentrated solution, powder is mixed homogeneously with concentrated solution, high temperature sterilize, cooling, solidification obtain final product pure day Right Chinese medicine marine bioactivity immunity bone.
Wherein, the DABAI shark is one or more in DABAI sharkskin, great white shark fish scale or DABAI shark bone, institute Squid is stated for squid skin or/and sleeve-fish ear, the whale is whale leather, one or more in whale bone, whale squama, the crow Testudiniss are Testudiniss first, and the Trionyx sinensis Wiegmann is Trionyx sinensis Wiegmann skin, and the crocodile is one or more in crocodile skin, crocodile bone or Crocodile scale.
When actually used, as the case may be the pure-natural marine living-things active immne bone of the present invention can be prepared into The diaphysis of various models to meet the demand of patient, for example：Bone attachment screw, diaphysis template.
In addition, the present invention needs after making various diaphysis to carry out cold preservation, refrigerated storage temperature is that 15～20 DEG C, temperature is too low easily Broken, to scrap, temperature is too high soluble.The diaphysis allergy sufferers disabling of the present invention, Post operation taboo eats maror, Semen Viciae fabae, fish, acidity Food, the taboo phase is three months.
Additionally, carrying out operation consent in the natural Chinese medicines marine bioactivity immunity bone using the present invention, need to patient Carry out allergy test：Skin test is test 15 minutes, and discovery is red and swollen, itch, having smallpox disables natural Chinese medicines marine bioactivity immunity bone, Fracture reduction operation is carried out by not occurring.
In order to preferably reach surgical effect, carry out in the natural Chinese medicines marine bioactivity immunity bone using the present invention Post operation, yellow wine is taken after mixing it with water 15g Radix Notoginseng powder.
Embodiment 6
A kind of natural Chinese medicines marine bioactivity immunity bone, is prepared from the concentrated liquid of tradition Chinese medicine by bone protein；Concrete preparation side Method is as follows：
（1）The Hippocampus of same amount, DABAI shark, squid, whale, Testudiniss, Trionyx sinensis Wiegmann, crocodile are obtained bone egg by salting out method In vain, then high temperature sterilize, cool down, be ground into powder；
（2）By Radix Notoginseng 20g, Pyritum 20g, ground beetle 20g, Formica fusca 5g, teasel 20g, Rhizoma Polygoni Cuspidati 20g, Radix Angelicae Pubescentiss 15g, Radix Clematidis 15g, Radix Angelicae Sinensis 15g, Lignum Sappan 12g, Rhizoma Curcumae Longae 12g, Herba speranskiae tuberculatae 15g, Ramulus Mori 15g, Herba Saussureae Involueratae 15g, Flos Carthami 20g, Caulis Spatholobi 15g, always Crane grass 15g, Caulis Lonicerae 15g, Radix Polygoni Multiflori 15g, Pterospermi Heterophylli 15g, Ganoderma 15g, Moschus 0.2g, Radix Salviae Miltiorrhizae 20g, Rhizoma Chuanxiong 15g, Radix Paeoniae Rubra 15g, Rhizoma Atractylodis 15g, Rhizoma Corydalis 15g, Semen Sinapis Albae 12g, Herba Asari 12g, Radix Saposhnikoviae 12g, Rhizoma Curcumae 15g, Radix Et Caulis Acanthopanacis Senticosi 15g, Cordyceps 15g, Canis familiaris L. Ridge 20g, Radix Rehmanniae 15g, Rhizoma Drynariae 25g is extracted, refines, is condensed into the concentrated liquid of tradition Chinese medicine；
（3）Powder is mixed homogeneously with concentrated solution, powder is mixed homogeneously with concentrated solution, high temperature sterilize, cooling, solidification obtain final product pure day Right Chinese medicine marine bioactivity immunity bone.
Wherein, the DABAI shark is one or more in DABAI sharkskin, great white shark fish scale or DABAI shark bone, institute Squid is stated for squid skin or/and sleeve-fish ear, the whale is whale leather, one or more in whale bone, whale squama, the crow Testudiniss are Testudiniss first, and the Trionyx sinensis Wiegmann is Trionyx sinensis Wiegmann skin, and the crocodile is one or more in crocodile skin, crocodile bone or Crocodile scale.
When actually used, as the case may be the pure-natural marine living-things active immne bone of the present invention can be prepared into The diaphysis of various models to meet the demand of patient, for example：Bone attachment screw, diaphysis template.
In addition, the present invention needs after making various diaphysis to carry out cold preservation, refrigerated storage temperature is that 15～20 DEG C, temperature is too low easily Broken, to scrap, temperature is too high soluble.The diaphysis allergy sufferers disabling of the present invention, Post operation taboo eats maror, Semen Viciae fabae, fish, acidity Food, the taboo phase is three months.
Additionally, carrying out operation consent in the natural Chinese medicines marine bioactivity immunity bone using the present invention, need to patient Carry out allergy test：Skin test is test 15 minutes, and discovery is red and swollen, itch, having smallpox disables natural Chinese medicines marine bioactivity immunity bone, Fracture reduction operation is carried out by not occurring.
In order to preferably reach surgical effect, carry out in the natural Chinese medicines marine bioactivity immunity bone using the present invention Post operation, yellow wine is taken after mixing it with water 15g Radix Notoginseng powder.
What deserves to be explained is：
The immune natural rare Chinese medicine research fracture operation Therapeutic Method of macromolecule pure-natural marine living-things active immne bone intervention and Effect, fracture site of analyzing and researching, in art at the good reset of reasonable selection operation, fracture is repaired, and osteoarticular sites determine After carry out reliable fixing be implanted into pure-natural marine living-things active immne bone, repair and damage fracture and ligament and muscle, tendon, pars nervosa Position, the reason treatment of early postoperation functional complexes, and functional exercise, according to reduction of the fracture situation, healing state, functional rehabilitation is pre- Survey：3～10 months, select best opportunity and state to be performed the operation, recover contour structures in the significant points of B＆J as far as possible, Guarantee joint, and the steadiness of fracture, quick-acting, safety, health, avirulence, having no side effect property, aseptic, is operation Operation is avoided and reduces complication generation.
Open fracture and with hematoma, nerve injury, the patient that bone fascial bursa is damaged should take emergency operation, control to the ill Treat, operative treatment is carried out according to patient body situation and injury degree, Operative approch analysis classification of fracture position selects most Good otch is dissected bone grafting method and selects near-end to be connected as standard to fracture, and according to classification of fracture, position shifts degree, sclerite big Little, during block number selects special natural Chinese medicines marine bioactivity immunity bone intervention nutrition immune reunion of fractured tendons and bones pure natural famous and precious Medicine carries out operative treatment, immune all types of, the model of bone screw fixation of biological activity, position diaphysis model, after replacement and fixation, in conjunction with The scanning of preoperative x-ray, CT or MRI is checked, routinely detects fracture face, and ligament, tendon, wound face degree of injury, strengthen in fixing, Plus outer fixing Gypsum Fibrosum method for strengthening, Chinese medicine special formula treatment is carried out, wrapping, outer fixing Gypsum Fibrosum time, general surrounding removed Gypsum Fibrosum, In the adhesion of this when of knochenbruch end, limbs can be with light activity, but fracture, also in the protection period, discomfort is fit to do acutely Activity, the plaster fixing time is as far as possible more short better while ensureing safe, and the plaster fixing time is oversize to easily cause osteoarthrosis Adhesion, amyotrophy, osteoporosises, and deformation etc., the time is too short, removes Gypsum Fibrosum and easily caves in again, can coordinate after removing Gypsum Fibrosum Special prescription drug carries out systemic naturopathy flow process, can the next day naturopathy once, upper Gypsum Fibrosum consolidation time separately can enter Row prediction section repair time, adds Chinese medicine formula to coordinate naturopathy, preventing injuries property arthritis, osteoporosises, muscular atrophy Contracting, repairs ligament and applies tension force, reduce damaging hematoma, adhesion, the fast quick-recovery elasticity of muscle, reducing swelling and alleviating pain, blood circulation promoting and blood stasis dispelling, strong muscle Bone strengthening, reduces postoperative complication, and the steel body that takes for the second time after eliminating with front spring fracture reduction operation is performed the operation, and has indeformable work( Effect, wound healing is rapid, and haemostatic effect is rapid, is that patient palliates the agonizing sufferings, and reduces secondary taking steel operation and bring traumatic deformity.Fill Distribution wave new high-tech apply quick-acting, efficiently, safety, steadiness, no side effectses high science and technology curative effect.
After comprehensive health check-up is combined, conscientiously understand conditions of patients medical history, comprehensively the X piece of analysis and research patient injury, CT or MRI check, fully grasp classification of fracture, degree, shift situation, select pure-natural biological active immne periosteum type, treat into Pay attention to medical history in row, X, CT, MRI are noted at surgical anatomic reset to carry out therapeutic scheme being processed for the sufferer state of an illness, are strengthened interior Fixing, the functional exercise after enforcement surgery, shorten the outer fixing plasterboard time limit, reduce amyotrophy, blood circulation promoting, operation Functional exercise is to osteoarthrosis afterwards, and ligament peri-musculotendinous soft tissue, and god's essence week is significant.
Pure-natural marine living-things active immne bone compatibility antiphlogistic antibacterial, enhancing immunity, bone and muscle strengthening, blood circulation promoting and blood stasis dispelling, name Your Chinese medicine quintessence method of purification, by high temperature sterilization, manufactures diaphysis membranous type, purifies quintessence antibacterial, antiinflammatory, promoting blood circulation using high-tech Blood stasis dispelling, reuniting the fractured tendons and bones, the nutrition macromolecule intervention diaphysis model of periosteum immune drug is repaired, high temperature sterilize is frozen into synthetism after processing Membranous type.
Human body temperature is predicted using high-tech film tool freezing method, is determined within 24 hours, in human fracture affected part pure-natural biological The hybrid medicine of active immne bone dissolves in the time, and dissolves in human fracture affected part healing grade and the time difference, then internal skeleton between when Incrustation healing, the absorption of nutrition immune medicine, distribution and metabolism at folding, are discharged through body heat circulation, and pharmacokineticss conversion medicine divides Minor structure is crosslinked.Through affected part incrustation healing of fracturing, steadiness, health type, safety, quick-acting, the high-tech of no side effectses Skill molecule, the immune Chinese medicine solidification human fracture's osteopathy of pure-natural marine living-things active immne bone intervention, fully burst, in vivo Pharmacodynamicss → Pharmacodynamics in vitro → pharmacokineticss → body heat circulation science, pure-natural marine living-things active immne synosteosis model, Cone, screw, hone lamella, flintiness, stable degree, make of the identical freezing method invention of membranous type after the prediction of load-bearing degree mechanics.
After pure-natural marine living-things active immne bone osteopathy avoids steel body synthetism, need second operation to take steel body and cause Wound healing damages atrophy, deformation, and complication infection and causes patient to perform the operation for the second time pain, and operative failure causes patient Disabled.
Application pure-natural marine living-things active immne bone can make fracture stop blooding rapidly at short notice, prevent deformation, Osteocyte fast healing of wound is repaired, antibacterial action is notable, nutrition skeleton and muscle, tendon periosteum, strengthen bone density, when pure day After so marine bioactivity immunity bone is implanted into fracture, in healing time section, wound fracture load-bearing dynamics and tough and tensile is predicted Degree and healing time section produce bioconversion by extracorporeal circulation so as to which fracture is formed a scab rapidly, and as closely linked as flesh and blood, union bone fractures Become muscle tendon ligament forces after place is stable and strengthen skeletal muscle nutritional development, quick reparation osteocyte organized renewing elastic force.
Stop blooding after pure-natural marine living-things active immne bone synthetism rapid, circulated by body heat thin with periosteum kindred skin Born of the same parents' tissue crosslinking produces mechanical strength, rapid recovery tendon elasticity tension, and medicine macromolecule is produced, and enhancing immunity side chain is handed over Coproduction bone growth promoting meat is connected in cell connective tissue, and quick Psoralen pith knot crust is consolidated, pure-natural biological active immne bone secret recipe compatibility Macromolecule nutritional drugs diaphysis chain between pass through pharmacodynamicss, hot pressing mechanics, body heat circulation science side chain takes forms a hyperspace Net high-polymer formation cross-linked structure, synthetism crust dimension stable, after being heated, gene molecule cell mass is crosslinked and solidifies, due to crosslinking The particularity of reaction, the immune diaphysis of solid solidification dissolves post-crosslinking reaction and dissolves in 35～38 DEG C of human body temperature and will produce and fill The immunity side chain for dividing, produces quick incrustation, under heating with pressurized conditions, still has fluid ability, can be full of bone during beginning Membrane cavity, after crosslinked reaction, that is, being fixed on fracture makes its incrustation grow new periosteum and as closely linked as flesh and blood.Cell tissue and biology Tissue produces side chain pure-natural biological active immne bone becomes tension force of speeding, and intermolecular force increases hemostasis rapidly, blood clotting Gu good, antimicrobial and anti-inflammation efficacy increases, quick healing wounds, and immunity is notable.
Pure-natural marine living-things active immne bone macromolecule, be in marine mammal and land mammals connective tissue Primarily form, and the skeleton in marine organisms, due to the difference of the aspects such as aminoacid composition and the degree of cross linking, Aquatic product can be adopted The abundant bone protein of animal skins, bone, squama, muscle manufacture, says the natural activity bone not having with a lot of land existence animal bone protein Albumen, which has a low antigenicity, the characteristic of hypoallergenic, has good biocompatibility, biological degradability and biological activity, Therefore in food, medicine, cosmetics research and development application, very good useful effect is played.
Absorb after synthetism：Bone model is made to coordinate reunion of fractured tendons and bones immune substance, and pure day in human body by body heat circulating temperature So the quintessence synthetism immune substance of biological activity immunity bone dissolves in the absorption of fracture operation junction, plays rapid at synthetism, hemostasis, disappears Inflammation, the effect of antibacterial, produce as closely linked as flesh and blood continue muscle incrustation good effects and firm Absorption.
It is distributed after synthetism：Pure-natural marine living-things active immne bone reaches 35～38 DEG C of human body temperature in fracture and produces admittedly Change effect and the intermiscibility of its kindred, are distributed mainly on skin, tendon, periosteum, substrate microstructure, groups of cells and are made into polygon netted phase Molten immunity bone, is distributed in bone, muscle, periosteum, tendon, bone cavity, basement membrane, produces quick alimentation, and stop blooding, disappear during distribution Inflammation, antibacterial, blood circulation promoting and blood stasis dispelling, detumescence and promoting granulation are rapid.
Metabolism after synthetism：After synthetism using body circulation steadiness, promote cell, tissue, skeleton, bone marrow, skin, hair The metabolism of thin blood vessel so as to which blood concentration is circulated, diaphysis incrustation is connected, enhancing human body immunity, by Pharmacodynamics in vitro, in vivo Pharmacodynamics screening converts macromolecule, through thermodynamic cycle, pharmacokineticss scientific application, improves pure-natural marine living-things activity The science, reasonability of immune bone, safety, quick-acting, high efficiency, the high molecular crosslink biological activity immunity bone of steadiness.
Excretion after synthetism：By chamber membranous type, drain through kidney glandule, saliva, perspiration, tear, pore, urine, big Just drain, the pure-natural biological activity of no side effectses is served, conversion nutrition polymeric absorbent is comprehensive, stability, peace Quan Xing.
According to above-described embodiment, the present invention just can be realized well.

Claims (8)

1. a kind of natural Chinese medicines marine bioactivity immunity bone, it is characterised in that prepared by bone protein and the concentrated liquid of tradition Chinese medicine and Become.
2. natural Chinese medicines marine bioactivity according to claim 1 immunity bone, it is characterised in that the bone protein by Following raw material is prepared from：Hippocampus, pig, yak, sheep, donkey；The Hippocampus, pig, yak, sheep, donkey consumption identical.
3. natural Chinese medicines marine bioactivity according to claim 1 immunity bone, it is characterised in that the bone protein by Following raw material is prepared from：Hippocampus, DABAI shark, squid, whale, Testudiniss, Trionyx sinensis Wiegmann, crocodile；The Hippocampus, DABAI shark, squid Fish, whale, Testudiniss, Trionyx sinensis Wiegmann, crocodile consumption identical.
4. natural Chinese medicines marine bioactivity according to claim 1 immunity bone, it is characterised in that the traditional Chinese drug inspissation Liquid is concentrated by following raw material and is formed, by weight：
10～20 parts of Radix Notoginseng, 10～20 parts of Pyritum, 10～20 parts of ground beetle, 1～5 part of Formica fusca, 10～20 parts of teasel, Rhizoma Polygoni Cuspidati 10～20 parts, 10～15 parts of Radix Angelicae Pubescentiss, 10～15 parts of Radix Clematidis, 10～15 parts of Radix Angelicae Sinensis, 5～12 parts of Lignum Sappan, 5～12 parts of Rhizoma Curcumae Longae, thoroughly 5～15 parts of GUCAO, 5～15 parts of Ramulus Mori, 10～15 parts of Herba Saussureae Involueratae, 10～20 parts of Flos Carthami, 5～15 parts of Caulis Spatholobi, geranium 5～15 Part, 5～15 parts of Caulis Lonicerae, 5～15 parts of the Radix Polygoni Multiflori, 5～15 parts of Pterospermi Heterophylli, 5～15 parts of Ganoderma, 0.1～0.2 part of Moschus, Radix Salviae Miltiorrhizae 10 ～20 parts, 10～15 parts of Rhizoma Chuanxiong, 10～15 parts of Radix Paeoniae Rubra, 5～15 parts of Rhizoma Atractylodis, 5～15 parts of Rhizoma Corydalis, 5～12 parts of Semen Sinapis Albae, Herba Asari 5～12 parts, 5～12 parts of Radix Saposhnikoviae, 5～15 parts of Rhizoma Curcumae, 5～15 parts of Radix Et Caulis Acanthopanacis Senticosi, 10～15 parts of Cordyceps, 10～20 parts of Rhizoma Cibotii, 10～15 parts of the Radix Rehmanniae, 15～25 parts of Rhizoma Drynariae.
5. natural Chinese medicines marine bioactivity according to claim 2 immunity bone, it is characterised in that the pig be One or more in skin, Os Sus domestica or pig muscle, the yak is one or more in yak skin, Os Bovis grunniens or yak muscle, institute State sheep be Corii Caprae seu Oviss, one or more in Os Caprae seu Ovis or sheep tendon, the donkey is one or more in donkey skin, Os Equi Asini or donkey muscle.
6. natural Chinese medicines marine bioactivity according to claim 3 immunity bone, it is characterised in that the DABAI shark For one or more in DABAI sharkskin, great white shark fish scale or DABAI shark bone, the squid is squid skin or/and squid Ear, the whale is whale leather, whale bone, one or more in whale squama, and it is first that the Testudiniss are Testudiniss first, the Trionyx sinensis Wiegmann Fish skin, the crocodile is one or more in crocodile skin, crocodile bone or Crocodile scale.
7. natural Chinese medicines marine bioactivity according to claim 4 immunity bone, it is characterised in that the traditional Chinese drug inspissation Liquid is concentrated by following raw material and is formed, by weight：
15 parts of Radix Notoginseng, 15 parts of Pyritum, 15 parts of ground beetle, 3 parts of Formica fusca, 15 parts of teasel, 15 parts of Rhizoma Polygoni Cuspidati, 12 parts of Radix Angelicae Pubescentiss, Wheeling Celestial 12 parts, 12 parts of Radix Angelicae Sinensis, 9 parts of Lignum Sappan, 9 parts of Rhizoma Curcumae Longae, 10 parts of Herba speranskiae tuberculatae, 10 parts of Ramulus Mori, 12 parts of Herba Saussureae Involueratae, 15 parts of Flos Carthami, Sanguis Gallus domesticus 10 parts of rattan, 10 parts of geranium, 10 parts of Caulis Lonicerae, 10 parts of the Radix Polygoni Multiflori, 10 parts of Pterospermi Heterophylli, 10 parts of Ganoderma, 0.1 part of Moschus, 15 parts of Radix Salviae Miltiorrhizae, 12 parts of Rhizoma Chuanxiong, 12 parts of Radix Paeoniae Rubra, 10 parts of Rhizoma Atractylodis, 10 parts of Rhizoma Corydalis, 9 parts of Semen Sinapis Albae, 9 parts of Herba Asari, 9 parts of Radix Saposhnikoviae, 10 parts of Rhizoma Curcumae, thorn five Plus 10 parts, 12 parts of Cordyceps, 15 parts of Rhizoma Cibotii, 12 parts of the Radix Rehmanniae, 20 parts of Rhizoma Drynariae.
8. natural Chinese medicines marine bioactivity according to claim 1 immunity bone, it is characterised in that crushed by bone protein Become powder, after mixing homogeneously with the concentrated liquid of tradition Chinese medicine, then make through high temperature sterilize, cooling, solidification.
CN201610858372.7A 2016-09-28 2016-09-28 Pure natural traditional Chinese medicine and marine organism active immunization bone Pending CN106421926A (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110013566A (en) * 2019-05-24 2019-07-16 大连医科大学附属第一医院 A kind of preparation method of composite bone repairing material

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CN105288560A (en) * 2015-11-30 2016-02-03 山东卫康生物医药科技有限公司 Marine organism cream for treating osteoarticular disease
AU2015205476A1 (en) * 2014-01-10 2016-07-21 Mbp (Mauritius) Ltd Method for manufacturing osteosynthesis devices, osteosynthesis devices and implants made of semi-synthetic hybrid material obtained by structural modification of the components of a natural marine biomaterial

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Publication number Priority date Publication date Assignee Title
CN101209358A (en) * 2006-12-26 2008-07-02 温州医学院附属第二医院 Bone repairing material with marine organism as rough material and preparation technique thereof
AU2015205476A1 (en) * 2014-01-10 2016-07-21 Mbp (Mauritius) Ltd Method for manufacturing osteosynthesis devices, osteosynthesis devices and implants made of semi-synthetic hybrid material obtained by structural modification of the components of a natural marine biomaterial
CN105288560A (en) * 2015-11-30 2016-02-03 山东卫康生物医药科技有限公司 Marine organism cream for treating osteoarticular disease

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110013566A (en) * 2019-05-24 2019-07-16 大连医科大学附属第一医院 A kind of preparation method of composite bone repairing material
CN110013566B (en) * 2019-05-24 2021-09-14 大连医科大学附属第一医院 Preparation method of composite bone repair material

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Application publication date: 20170222