CN101209358A - Bone repairing material with marine organism as rough material and preparation technique thereof - Google Patents
Bone repairing material with marine organism as rough material and preparation technique thereof Download PDFInfo
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- CN101209358A CN101209358A CNA2006101707250A CN200610170725A CN101209358A CN 101209358 A CN101209358 A CN 101209358A CN A2006101707250 A CNA2006101707250 A CN A2006101707250A CN 200610170725 A CN200610170725 A CN 200610170725A CN 101209358 A CN101209358 A CN 101209358A
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- bone filling
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- filling renovation
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Abstract
The invention relates to a bone repair material which takes marine organisms as the raw materials and the preparation process. The invention provides a bone filling and repair material, and is characterized in that the bone filling and repair material contains the effective ingredients with the following weight mixing ratio: oyster shell powder: excipient is equal to 1 to 5: 1. The invention further provides the preparation method of the bone filling and repair material. The bone repair material which takes the marine organisms as the raw materials and is provided by the invention can be made into irregular shape, so the invention can meet the bone defects which have the different shapes and need to be filled.
Description
Technical field
The present invention relates to a kind of is the bone renovating material and the preparation technology thereof of raw material with marine organisms.
Background technology
Bone is implanted in the organ transplantation of carrying out the whole year in the world and occupies second; The desirable bone renovating material of generally acknowledging have advantages such as good biocompatibility, good osteoinductive, good bone conductibility, suitable degradation speed, corresponding to mechanical activation and profile.
Existingly be used for clinical bone filling renovation material and comprise natural material, synthetic material, composite three classes; Synthetic material building-up process complexity, composition are single, the use cost height; Composite machinery intensity is relatively poor, moulding process requires height, and the scope of application is narrow; The natural material source is single, and processing technology is simple, and price is lower, is that a class has the bone of better future to fill renovating bracket material; Natural material mainly comprises natural processing bone material, several classes such as collagen and Corallium Japonicum Kishinouye; Owing to the difficulty of drawing materials from the body bone, it is limited to originate; Allograph bone and xenogenesis bone have pathophorous possibility, have limited its application clinically; Collagen has shortcomings such as degraded is fast, and mechanical strength is little, is difficult to adapt to the damaged alternate requirement of bone; Corallium Japonicum Kishinouye has the microcellular structure similar to inorganic bone, has good organization's compatibility and biodegradability, but in using distinct issues to remain degraded too fast, under the incomplete situation of skeletonization, Corallium Japonicum Kishinouye absorbs fully during 8 weeks, loses the effect that mechanics is supported.
Therefore be necessary to develop new natural filling bone renovating material, with the filling repairing effect of better performance.
Summary of the invention
The invention provides a kind of method that can effectively prepare human body, to remedy the deficiency of existing filling material of bone with the bone filling renovation material.
The technical solution adopted in the present invention is as follows:
The invention provides a kind of bone filling renovation material, it is characterized in that, described bone filling renovation material contains the effective ingredient of following weight proportion:
Oyster shell powder: excipient=1-5: 1.
The present invention also provides the preparation method of above-mentioned bone filling renovation material, it is characterized in that, described preparation method comprises the steps:
(1) gets Concha Ostreae and be ground into 20-300 purpose powder through after the cleaning treatment, weak acid soaked overnight;
(2) step (1) is prepared powder mixes with excipient by described weight proportion, extrusion forming, sterilization.
Described cleaning treatment is meant and adopts that 20-80KMz, 20-200W/L are ultrasonic to be cleaned the back to Concha Ostreae and adopt a kind of or its combination in any in the hydrochloric acid of 1-10%, acetic acid, the citric acid to carry out surface treatment.
It is fluid that above-mentioned cleaning treatment process can adopt water or ethanol.
Concha Ostreae is produced in preferred nearly river of the Concha Ostreae that preparation method adopted of above-mentioned bone filling renovation material and coastal waters.
A kind of or its combination in any in the optional chitosan of the employed excipient of the preparation method of above-mentioned bone filling renovation material, lactose, citric acid, starch, the medical collagen.
The moulding pressure that preparation method is used of above-mentioned bone filling renovation material is 5-80KPa.
The sterilization that preparation method is used of above-mentioned bone filling renovation material is oxirane disinfection.
The invention has the beneficial effects as follows:
1) Concha Ostreae can obtain the active bone repair material that has good biocompatibility and can meet clinical needs by the processing of above-mentioned technical process program.Experiment in vitro studies show that: bone marrow stroma stem cell can show at material and stick, and along with the prolongation of the time differentiation of can rising in value, synthetic powder forms new hydroxyapatite class crystallization.
2) the biological bone filling of natural marine Concha Ostreae renovating bracket material has excellent biological compatibility, degradability and biomechanical property.Experimental results show that 100 orders-200 purpose oyster shell powder in the animal body through implanting the damaged model of animal body internal skeleton behind the tabletting, histological observation confirmation bone renovating material and surrounding tissue do not have tangible immunological rejection and inflammatory reaction.Begin degraded in 8 weeks of bone renovating material; New bone formation is arranged on every side, the most degraded of 16 weeks, 24 all materials are degraded fully and are all substituted by new bone, and its degradation speed is suitable as the conduction support of artificial bone, and biomechanics confirms that new bone is suitable with normal bone.
3) since its can be made into irregularly shaped, so it is damaged to satisfy the bone of difformity needs fillings.
4) confirm that after deliberation it has bone conductibility in vivo.Experimental results show that in the animal body that 100 orders-200 purpose oyster shell powder through implanting the damaged model of animal body internal skeleton behind the tabletting, begins degraded in 8 weeks of bone renovating material; New bone formation is arranged on every side, the most degraded of 16 weeks, 24 all materials are degraded fully and are all substituted by new bone, confirm that it has good bone conduction effect.
The specific embodiment
Embodiment 1:
The employing Concha Ostreae is a raw material, adopts flowing water and frequency 20KMz, the ultrasonic of 40W/L solution that Concha Ostreae is cleaned; The hydrochloric acid of employing 1% carries out surface treatment, soaks 6 hours; Adopt common medical pulverizer, the Concha Ostreae after cleaning is pulverized, make its granularity about 100 orders; Concha Ostreae after pulverizing is mixed mutually pressurization 20KPa molding, oxirane disinfection according to 1: 1 ratio with excipient.
The invention has the beneficial effects as follows:
1) Concha Ostreae can obtain the active bone repair material that has good biocompatibility and can meet clinical needs by the processing of above-mentioned technical process program.Experiment in vitro studies show that: bone marrow stroma stem cell can show at material and stick, and along with the prolongation of the time differentiation of can rising in value, synthetic powder forms new hydroxyapatite class crystallization.
2) the biological bone filling of natural marine Concha Ostreae renovating bracket material has excellent biological compatibility, degradability and biomechanical property.Experimental results show that 100 orders-200 purpose oyster shell powder in the animal body through implanting the damaged model of animal body internal skeleton behind the tabletting, histological observation confirmation bone renovating material and surrounding tissue do not have tangible immunological rejection and inflammatory reaction.Begin degraded in 8 weeks of bone renovating material; New bone formation is arranged on every side, the most degraded of 16 weeks, 24 all materials are degraded fully and are all substituted by new bone, and its degradation speed is suitable as the conduction support of artificial bone, and biomechanics confirms that new bone is suitable with normal bone.
3) since its can be made into irregularly shaped, so it is damaged to satisfy the bone of difformity needs fillings.
4) confirm that after deliberation it has bone conductibility in vivo.Experimental results show that in the animal body that 100 orders-200 purpose oyster shell powder through implanting the damaged model of animal body internal skeleton behind the tabletting, begins degraded in 8 weeks of bone renovating material; New bone formation is arranged on every side, the most degraded of 16 weeks, 24 all materials are degraded fully and are all substituted by new bone, confirm that it has good bone conduction effect.
Embodiment 2:
Adopting nearly river or coastal waters Concha Ostreae is raw material, adopts flowing water and 40KMz, the ultrasonic of 70W/L solution that Concha Ostreae is cleaned; Adopt 1% hydrochloric acid, 1% acetic acid, 1% citric acid mixed liquor to carry out surface treatment, soaked 24 hours; Adopt common medical pulverizer, the Concha Ostreae after cleaning is pulverized, make its granularity about 200 orders; Concha Ostreae after pulverizing is mixed mutually pressurization 50KPa molding, oxirane disinfection according to 3: 1 ratios with excipient.
The invention has the beneficial effects as follows:
1) Concha Ostreae can obtain the active bone repair material that has good biocompatibility and can meet clinical needs by the processing of above-mentioned technical process program.Experiment in vitro studies show that: bone marrow stroma stem cell can show at material and stick, and along with the prolongation of the time differentiation of can rising in value, synthetic powder forms new hydroxyapatite class crystallization.
2) the biological bone filling of natural marine Concha Ostreae renovating bracket material has excellent biological compatibility, degradability and biomechanical property.Experimental results show that 100 orders-200 purpose oyster shell powder in the animal body through implanting the damaged model of animal body internal skeleton behind the tabletting, histological observation confirmation bone renovating material and surrounding tissue do not have tangible immunological rejection and inflammatory reaction.Begin degraded in 8 weeks of bone renovating material; New bone formation is arranged on every side, the most degraded of 16 weeks, 24 all materials are degraded fully and are all substituted by new bone, and its degradation speed is suitable as the conduction support of artificial bone, and biomechanics confirms that new bone is suitable with normal bone.
3) since its can be made into irregularly shaped, so it is damaged to satisfy the bone of difformity needs fillings.
4) confirm that after deliberation it has bone conductibility in vivo.Experimental results show that in the animal body that 100 orders-200 purpose oyster shell powder through implanting the damaged model of animal body internal skeleton behind the tabletting, begins degraded in 8 weeks of bone renovating material; New bone formation is arranged on every side, the most degraded of 16 weeks, 24 all materials are degraded fully and are all substituted by new bone, confirm that it has good bone conduction effect.
Embodiment 3:
Adopting nearly river or coastal waters Concha Ostreae is raw material, adopts flowing water and 60KMz, the ultrasonic of 60W/L solution that Concha Ostreae is cleaned; The acetic acid of employing 2% carries out surface treatment, soaked overnight; Adopt common medical pulverizer, the Concha Ostreae after cleaning is pulverized, make its granularity about 300 orders; Concha Ostreae after pulverizing is mixed mutually pressurization 70KPa molding, oxirane disinfection according to 4: 1 ratios with excipient.
The invention has the beneficial effects as follows:
1) Concha Ostreae can obtain the active bone repair material that has good biocompatibility and can meet clinical needs by the processing of above-mentioned technical process program.
Experiment in vitro studies show that: bone marrow stroma stem cell can show at material and stick, and along with the time
Between the prolongation differentiation of can rising in value, synthetic powder forms new hydroxyapatite class crystallization.
2) the biological bone filling of natural marine Concha Ostreae renovating bracket material has excellent biological compatibility, degradability and biomechanical property.
Experimental results show that 100 orders-200 purpose oyster shell powder in the animal body through implanting the damaged model of animal body internal skeleton behind the tabletting, histological observation confirmation bone renovating material and surrounding tissue do not have tangible immunological rejection and inflammatory reaction.Begin degraded in 8 weeks of bone renovating material; New bone formation is arranged on every side, the most degraded of 16 weeks, 24 all materials are degraded fully and are all substituted by new bone, and its degradation speed is suitable as the conduction support of artificial bone, and biomechanics confirms that new bone is suitable with normal bone.
3) since its can be made into irregularly shaped, so it is damaged to satisfy the bone of difformity needs fillings.
4) confirm that after deliberation it has bone conductibility in vivo.
Experimental results show that in the animal body that 100 orders-200 purpose oyster shell powder through implanting the damaged model of animal body internal skeleton behind the tabletting, begins degraded in 8 weeks of bone renovating material; New bone formation is arranged on every side, the most degraded of 16 weeks, 24 all materials are degraded fully and are all substituted by new bone, confirm that it has good bone conduction effect.
Embodiment 4:
Adopting nearly river or coastal waters Concha Ostreae is raw material, adopts ethanol and 80KMz, 30W/L are ultrasonic that Concha Ostreae is cleaned; The acetic acid of employing 10% carries out surface treatment, soaked overnight; Adopt common medical pulverizer, the Concha Ostreae after cleaning is pulverized, make its granularity at 800 orders; Concha Ostreae after pulverizing is mixed mutually pressurization 30KPa molding, oxirane disinfection according to 3: 1 ratios with excipient.
The invention has the beneficial effects as follows:
1) Concha Ostreae can obtain the active bone repair material that has good biocompatibility and can meet clinical needs by the processing of above-mentioned technical process program.
Experiment in vitro studies show that: bone marrow stroma stem cell can show at material and stick, and along with the prolongation of the time differentiation of can rising in value, synthetic powder forms new hydroxyapatite class crystallization.
2) the biological bone filling of natural marine Concha Ostreae renovating bracket material has excellent biological compatibility, degradability and biomechanical property.
Experimental results show that 100 orders-200 purpose oyster shell powder in the animal body through implanting the damaged model of animal body internal skeleton behind the tabletting, histological observation confirmation bone renovating material and surrounding tissue do not have tangible immunological rejection and inflammatory reaction.Begin degraded in 8 weeks of bone renovating material; New bone formation is arranged on every side, the most degraded of 16 weeks, 24 all materials are degraded fully and are all substituted by new bone, and its degradation speed is suitable as the conduction support of artificial bone, and biomechanics confirms that new bone is suitable with normal bone.
3) because it is irregularly shaped, so it is damaged to satisfy the bone of difformity needs filling.
4) confirm that after deliberation it has bone conductibility in vivo.
Experimental results show that in the animal body that 100 orders-200 purpose oyster shell powder through implanting the damaged model of animal body internal skeleton behind the tabletting, begins degraded in 8 weeks of bone renovating material; New bone formation is arranged on every side, the most degraded of 16 weeks, 24 all materials are degraded fully and are all substituted by new bone, confirm that it has good bone conduction effect.
Embodiment 5:
Adopting nearly river or coastal waters Concha Ostreae is raw material, adopts flowing water and 30KMz, the ultrasonic of 120W/L solution that Concha Ostreae is cleaned; The citric acid of employing 1% carries out surface treatment, soaked overnight; Adopt common medical pulverizer, the Concha Ostreae after cleaning is pulverized, make its granularity about 200 orders; Concha Ostreae after pulverizing is mixed mutually pressurization 30KPa molding, oxirane disinfection according to 2: 1 ratios with excipient.
The invention has the beneficial effects as follows:
1) Concha Ostreae can obtain the active bone repair material that has good biocompatibility and can meet clinical needs by the processing of above-mentioned technical process program.
Experiment in vitro studies show that: bone marrow stroma stem cell can show at material and stick, and along with the prolongation of the time differentiation of can rising in value, synthetic powder forms new hydroxyapatite class crystallization.
2) the biological bone filling of natural marine Concha Ostreae renovating bracket material has excellent biological compatibility, degradability and biomechanical property.
Experimental results show that 100 orders-200 purpose oyster shell powder in the animal body through implanting the damaged model of animal body internal skeleton behind the tabletting, histological observation confirmation bone renovating material and surrounding tissue do not have tangible immunological rejection and inflammatory reaction.Begin degraded in 8 weeks of bone renovating material; New bone formation is arranged on every side, the most degraded of 16 weeks, 24 all materials are degraded fully and are all substituted by new bone, and its degradation speed is suitable as the conduction support of artificial bone, and biomechanics confirms that new bone is suitable with normal bone.
3) because it is irregularly shaped, so it is damaged to satisfy the bone of difformity needs filling.
4) confirm that after deliberation it has bone conductibility in vivo.
Experimental results show that in the animal body that 100 orders-200 purpose oyster shell powder through implanting the damaged model of animal body internal skeleton behind the tabletting, begins degraded in 8 weeks of bone renovating material; New bone formation is arranged on every side, the most degraded of 16 weeks, 24 all materials are degraded fully and are all substituted by new bone, confirm that it has good bone conduction effect.
Embodiment 6:
Adopting nearly river or coastal waters Concha Ostreae is raw material, adopts the pilgrimage of flowing water and 60KMz, 180W/L solution that Concha Ostreae is cleaned; The citric acid of employing 10% carries out surface treatment, soaks liquid; Adopt common medical pulverizer, the Concha Ostreae after cleaning is pulverized, its granularity is remained on about 500 orders; With the Concha Ostreae after pulverizing and excipient according to 5: 1 ratios to mixing, the 50KPa molding of pressurizeing, oxirane disinfection.
The invention has the beneficial effects as follows:
1) oyster shell is by the processing of above-mentioned technical process program, and it is compatible to obtain to have good biological The property and the active bone repair material that can meet clinical needs.
Experiment in vitro studies show that: bone marrow stroma stem cell can show at material and stick, and along with the time Between the prolongation differentiation of can rising in value, synthetic powder forms new hydroxyapatite class crystallization.
2) natural marine oyster shell biological bone filling renovating bracket material has good biocompatibility, falls Solution property and biomechanical property.
Experimental results show that in the animal body that 100 orders-200 purpose oyster shell powder is through implanting the animal body in-seam behind the compressing tablet Defect model, histological observation confirmation bone renovating material and surrounding tissue do not have obvious immunological rejection and inflammation The property reaction. Begin degraded in 8 weeks of bone renovating material; There is new bone to form on every side, the most degraded of 16 weeks, 24 Week, material was degradable and all alternative by new bone, and its degradation speed is suitable as the conduction support of artificial bone, Biomethanics confirms that new bone is suitable with normal bone.
3) because it is irregularly shaped, so it is damaged to satisfy the bone of difformity needs filling.
4) confirm that after deliberation it has osteoconductive in vivo.
Implant animal body after experimental results show that 100 orders-200 purpose oyster shell powder process compressing tablet in the animal body The in-seam defect model begins degraded in 8 weeks of bone renovating material; There is new bone to form on every side, the most degraded of 16 weeks, 24 all materials are degradable and all alternative by new bone, confirm that it has good bone conduction effect.
Claims (8)
1. a bone filling renovation material is characterized in that, described bone filling renovation material contains the effective ingredient of following weight proportion:
Oyster shell powder: excipient=1-5: 1.
2. the preparation method of the described bone filling renovation material of claim 1 is characterized in that, described preparation method comprises the steps:
(1) gets Concha Ostreae through cleaning treatment, be ground into 20-300 purpose powder after the weak acid soaked overnight;
(2) step (1) is prepared powder mixes with excipient by described weight proportion, extrusion forming, sterilization.
3. according to the preparation method of the described bone filling renovation material of claim 2, it is characterized in that described cleaning treatment is meant and adopts that 20-80KMz, 20-200W/L are ultrasonic to be cleaned the back to Concha Ostreae and adopt a kind of or its combination in any in the hydrochloric acid of 1-10%, acetic acid, the citric acid to carry out surface treatment.
4. according to the preparation method of the described bone filling renovation material of claim 2, it is characterized in that it is fluid that described cleaning treatment process can adopt water or ethanol.
5. according to the preparation method of the described bone filling renovation material of claim 2, it is characterized in that Concha Ostreae is produced in preferred nearly river of the Concha Ostreae that preparation method adopted of described bone filling renovation material and coastal waters.
6. according to the preparation method of claim 1 or 2 any described bone filling renovation materials, it is characterized in that a kind of or its combination in any in the optional chitosan of the employed excipient of the preparation method of described bone filling renovation material, lactose, citric acid, starch, the medical collagen.
7. according to the preparation method of the described bone filling renovation material of claim 2, it is characterized in that the moulding pressure that preparation method is used of described bone filling renovation material is 5-80KPa.
8. according to the preparation method of the described bone filling renovation material of claim 2, it is characterized in that the sterilization that preparation method is used of described bone filling renovation material is oxirane disinfection.
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| Application Number | Priority Date | Filing Date | Title |
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| CN200610170725A CN101209358B (en) | 2006-12-26 | 2006-12-26 | Bone repairing material with marine organism as rough material and preparation technique thereof |
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| CN200610170725A CN101209358B (en) | 2006-12-26 | 2006-12-26 | Bone repairing material with marine organism as rough material and preparation technique thereof |
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| CN101209358A true CN101209358A (en) | 2008-07-02 |
| CN101209358B CN101209358B (en) | 2010-05-19 |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102755668A (en) * | 2011-04-29 | 2012-10-31 | 天津市赛宁生物工程技术有限公司 | Medical plastic bone cement |
| CN102921036A (en) * | 2012-10-11 | 2013-02-13 | 海南医学院 | Method for preparing marine environment-friendly calcium citrate hard tissue repair material |
| CN105126176A (en) * | 2015-09-21 | 2015-12-09 | 高瑞杰 | Oyster shell biocompatible biomimetic material used for thigh-bone repair and preparation method |
| CN106360736A (en) * | 2016-08-22 | 2017-02-01 | 青岛食安生物工程有限公司 | Preparation technology of pure natural nanometer ultrafine calcium powder |
| CN106421926A (en) * | 2016-09-28 | 2017-02-22 | 范玉梅 | Pure natural traditional Chinese medicine and marine organism active immunization bone |
| CN106474555A (en) * | 2016-11-04 | 2017-03-08 | 暨南大学 | A kind of polycaprolactone of 3D printing/oyster shell powder composite and preparation and application and the bone tissue engineering scaffold based on which |
| CN107771087A (en) * | 2015-06-23 | 2018-03-06 | Mbp(毛里求斯)有限公司 | The semi-synthetic dusty material obtained by modified natural marine organism material composition, its preparation method and its application |
| CN109224125A (en) * | 2018-09-28 | 2019-01-18 | 福州大学 | A kind of syringeability shell/calcium sulfate bone cement and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1167581A (en) * | 1997-07-09 | 1997-12-17 | 张永新 | Nutrient calcium milk oatmeal |
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2006
- 2006-12-26 CN CN200610170725A patent/CN101209358B/en not_active Expired - Fee Related
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102755668A (en) * | 2011-04-29 | 2012-10-31 | 天津市赛宁生物工程技术有限公司 | Medical plastic bone cement |
| CN102921036A (en) * | 2012-10-11 | 2013-02-13 | 海南医学院 | Method for preparing marine environment-friendly calcium citrate hard tissue repair material |
| CN107771087A (en) * | 2015-06-23 | 2018-03-06 | Mbp(毛里求斯)有限公司 | The semi-synthetic dusty material obtained by modified natural marine organism material composition, its preparation method and its application |
| CN107771087B (en) * | 2015-06-23 | 2021-04-23 | Mbp(毛里求斯)有限公司 | Semi-synthetic powder material obtained by modifying natural marine biomaterial composition, process for its preparation and its use |
| CN105126176A (en) * | 2015-09-21 | 2015-12-09 | 高瑞杰 | Oyster shell biocompatible biomimetic material used for thigh-bone repair and preparation method |
| CN105126176B (en) * | 2015-09-21 | 2018-07-24 | 高瑞杰 | A kind of oyster shell bio-compatible biomimetic material and preparation method for femur reparation |
| CN106360736A (en) * | 2016-08-22 | 2017-02-01 | 青岛食安生物工程有限公司 | Preparation technology of pure natural nanometer ultrafine calcium powder |
| CN106421926A (en) * | 2016-09-28 | 2017-02-22 | 范玉梅 | Pure natural traditional Chinese medicine and marine organism active immunization bone |
| CN106474555A (en) * | 2016-11-04 | 2017-03-08 | 暨南大学 | A kind of polycaprolactone of 3D printing/oyster shell powder composite and preparation and application and the bone tissue engineering scaffold based on which |
| CN106474555B (en) * | 2016-11-04 | 2019-09-17 | 暨南大学 | A kind of polycaprolactone of 3D printing/oyster shell powder composite material and preparation and application and the bone tissue engineering scaffold based on it |
| CN109224125A (en) * | 2018-09-28 | 2019-01-18 | 福州大学 | A kind of syringeability shell/calcium sulfate bone cement and preparation method thereof |
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