CN101195045A - Compound biological medical material of biological ceramic silicon rubber - Google Patents
Compound biological medical material of biological ceramic silicon rubber Download PDFInfo
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- CN101195045A CN101195045A CNA2006101193026A CN200610119302A CN101195045A CN 101195045 A CN101195045 A CN 101195045A CN A2006101193026 A CNA2006101193026 A CN A2006101193026A CN 200610119302 A CN200610119302 A CN 200610119302A CN 101195045 A CN101195045 A CN 101195045A
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- silicone rubber
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Abstract
The invention relates to biological medical material which is compounded by biological ceramics, namely, hydroxyapatite ceramics, calcium phosphate ceramics, and silicon rubber. The biological ceramics and silicon rubber compound biological medical material of the invention is used to choose corresponding dies for manufacturing artificial nose bridges, artificial mandibles, artificial temples, artificial malar bones, plastic plates, or other implanted supports. After being implanted in the body, the biological ceramics can gradually degrade peripheral tissues for gradually growing in, which can improve the growth of new bones. The surface has micro-pore type structures, which is favorable for adhesion and growth of cells. The invention provides a preparing process of the biological ceramics and silicon rubber compound biological medical material.
Description
Technical field:
The present invention relates to a kind of bio-medical material, be specifically related to by hydroxylapatite ceramic, calcium phosphate ceramic and the compound bio-medical material of silicone rubber and preparation method thereof.
Background technology:
Because various factors causes the deformity of human organ and damaged, need rebuild reparation with the means that tissue transplantation and tissue substitute are implanted.Therefore, the tissue substitute material of development a kind of " ideal " is the research emphasis of medical domain always.Hydroxylapatite ceramic, calcium phosphate ceramic and silicone rubber are clinical packing material commonly used.The inorganic constituents of its composition structure of hydroxylapatite ceramic and calcium phosphate ceramic and human body bone, dental tissue is close, and has good biocompatibility and biological activity.Degradation in vivo can absorb, and the growth of new bone also has the bone guided effect around promoting.Silicone rubber has good physical and chemical stability and physiology inertia, also has blood and tissue intersolubility preferably.And the favorable manufacturability energy, it is moulding with engraving to be easy to die forming, is one of at present good embedded material.But above material all has corresponding shortcoming: hydroxylapatite ceramic and calcium phosphate ceramic granule lack the integrity and the mechanical stability of structure, and material is difficult to remain on needed position, and block soft or hard is difficult to engraving and is shaped.And the silicone rubber tissue bond is relatively poor, easily forms peplos, and peplos contracture can take place under certain condition.
Biomaterial commonly used clinically at present such as silicone rubber, hydroxylapatite ceramic, calcium phosphate ceramic, expanded PTFE, high density polyethylene (HDPE) etc. can not have both favorable mechanical performance and biological property because of material composition is single.
Summary of the invention
Technical problem to be solved by this invention is the advantage of comprehensive hydroxylapatite ceramic, calcium phosphate ceramic and silicone rubber, by changing its compositely proportional, the composite biological material of synthesising biological pottery and silicone rubber.One aspect of the present invention has kept the biological characteristic of hydroxylapatite ceramic and calcium phosphate ceramic; The biological nature that has also had silicone rubber on the other hand is a kind of mechanical performance, biological property is good and random moulding bioceramic and the compound bio-medical material of silicone rubber of energy.
Bioceramic of the present invention and silicon rubber composite material are by hydroxylapatite ceramic or calcium phosphate ceramic and silicone rubber is compound forms, and wherein the part by weight of bioceramic and silicone rubber is 2/8-8/2, and hardness is 20-80 Shao Shi.
Another object of the present invention has provided the preparation method of preparation bioceramic and silicon rubber composite material, and its preparation process is as follows:
1, even bioceramic and mixing silicon rubber, obtain mixture.
2, with the metal die preheating, said mixture is placed in the metal die.
3, metal die is placed sulfidization molding in the vulcanizer.
4, the composite that sulfuration is finished takes out recure.
5, the composite sterilization that sulfuration is finished, packing.
According to the needs of filling sclerous tissues and soft tissue, the part by weight that only needs to change bioceramic and silicone rubber gets final product, because the biological calcium pottery can change the soft durometer of silicone rubber, because the difference of hardness can select to be used for the filling of sclerous tissues and soft tissue.When bioceramic weight be silicone rubber 20%～50% the time, be suitable for the filling of soft tissue, when bioceramic weight be silicone rubber 50%～80% the time, be applicable to the filling of sclerous tissues.Optional corresponding mould is made the artificial bridge of the nose, artificial lower jaw, artificial sun cave, artificial cheekbone, trim panel or other implant frame.
Use bioceramic of the present invention and silicone rubber composite biological medical materials, after implanting, the bioceramic surrounding tissue of can progressively degrading can progressively be grown into, and can promote the growth of new bone.Because there is micropore shape structure on its surface, is beneficial to the adhesion and the growth of cell.
The specific embodiment:
Example 1
1) chooses nanometer hydroxyapatite pottery 30 grams, silicone rubber 100 grams.Mixing even in exploitation formula rubber mixing machine, obtain mixture.
2), above-mentioned mixing mixture is placed in the metal nose prosthese mould with metal nose prosthese mould and die preheating.
3) metal nose prosthese mould is placed sulfidization molding in the vulcanizer.
4) nose prosthesis of sulfidization molding is taken out recure, curing temperature is between 150 ℃-200 ℃.
5) the nose valency height that sulfuration is finished is pressed steam sterilization or Co-60 sterilization, makes product aseptic.
Example 2
A) choose nano-calcium phosphate pottery 50 grams, silicone rubber 50 grams.Mixing even in exploitation formula rubber mixing machine, obtain mixture.
B) with the preheating of metal shaping board mold, above-mentioned mixing mixture is placed in the metal shaping board mold.
C) metal shaping board mold is placed sulfidization molding in the vulcanizer.
D) trim panel of sulfidization molding is taken out recure, curing temperature is between 150 ℃-200 ℃.
E) trim panel high pressure steam sterilization or the Co-60 sterilization that sulfuration is finished makes product aseptic.
Claims (6)
1. bioceramic and the compound bio-medical material of silicone rubber is characterized in that: it is by hydroxylapatite ceramic or calcium phosphate ceramic and silicone rubber is compound forms, and wherein the weight ratio of bioceramic and silicone rubber is 2/8-8/2, and hardness is 20-80 Shao Shi.
2. a kind of bioceramic according to claim 1 and the compound bio-medical material of silicone rubber is characterized in that described bioceramic is nano level hydroxylapatite ceramic or calcium phosphate ceramic.
3. a kind of bioceramic according to claim 1 and the compound bio-medical material of silicone rubber is characterized in that described silicone rubber is the medical grade high-temperature silicon disulfide rubber.
4. the preparation method of a kind of according to claim 1 bioceramic and the compound bio-medical material of silicone rubber is characterized in that this preparation process is as follows:
1. bioceramic and mixing silicon rubber is even, obtain mixture;
2. with the metal die preheating, said mixture is placed in the metal die;
3. metal die is placed sulfidization molding in the vulcanizer;
4. the composite that sulfuration is finished takes out recure;
5. the composite sterilization that sulfuration is finished, packing.
5. a kind of bioceramic according to claim 4 and the compound method for preparing biomedical material of silicone rubber, it is characterized in that step 3. or the curing temperature 4. be between 150 ℃-200 ℃.
6. according to described a kind of bioceramic of claim 4 and the compound method for preparing biomedical material of silicone rubber, in it is characterized in that step 2., can select the corresponding mould of making the artificial bridge of the nose, artificial lower jaw, artificial sun cave, artificial cheekbone, trim panel or other implant frame for use.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101193026A CN101195045A (en) | 2006-12-07 | 2006-12-07 | Compound biological medical material of biological ceramic silicon rubber |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101193026A CN101195045A (en) | 2006-12-07 | 2006-12-07 | Compound biological medical material of biological ceramic silicon rubber |
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| Publication Number | Publication Date |
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| CN101195045A true CN101195045A (en) | 2008-06-11 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006101193026A Pending CN101195045A (en) | 2006-12-07 | 2006-12-07 | Compound biological medical material of biological ceramic silicon rubber |
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| CN (1) | CN101195045A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105802232A (en) * | 2014-11-10 | 2016-07-27 | 吴杰 | Material for preparing artificial joint and preparation method thereof |
| CN106365629A (en) * | 2014-11-10 | 2017-02-01 | 蒋春花 | Preparation method of carbon nanotube composite bioceramic |
| CN111529130A (en) * | 2020-05-30 | 2020-08-14 | 周锋杰 | Method for manufacturing surface micropore composite lower jaw prosthesis |
| CN115105641A (en) * | 2022-06-20 | 2022-09-27 | 四川大学 | Subcutaneous implantation material capable of being connected in bone healing manner |
-
2006
- 2006-12-07 CN CNA2006101193026A patent/CN101195045A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105802232A (en) * | 2014-11-10 | 2016-07-27 | 吴杰 | Material for preparing artificial joint and preparation method thereof |
| CN106365629A (en) * | 2014-11-10 | 2017-02-01 | 蒋春花 | Preparation method of carbon nanotube composite bioceramic |
| CN105802232B (en) * | 2014-11-10 | 2018-06-15 | 青岛大学附属医院 | It is a kind of to prepare joint prosthesis material and preparation method thereof |
| CN111529130A (en) * | 2020-05-30 | 2020-08-14 | 周锋杰 | Method for manufacturing surface micropore composite lower jaw prosthesis |
| CN115105641A (en) * | 2022-06-20 | 2022-09-27 | 四川大学 | Subcutaneous implantation material capable of being connected in bone healing manner |
| CN115105641B (en) * | 2022-06-20 | 2023-06-02 | 四川大学 | Subcutaneous implantation material for ossifiable healing connection |
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Open date: 20080611 |