CN2737357Y - Porous high polymer composite implant for surgery - Google Patents
Porous high polymer composite implant for surgery Download PDFInfo
- Publication number
- CN2737357Y CN2737357Y CN 200420096179 CN200420096179U CN2737357Y CN 2737357 Y CN2737357 Y CN 2737357Y CN 200420096179 CN200420096179 CN 200420096179 CN 200420096179 U CN200420096179 U CN 200420096179U CN 2737357 Y CN2737357 Y CN 2737357Y
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- Prior art keywords
- surgery
- polymer composite
- implant
- porous polymer
- composite implant
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- Expired - Fee Related
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- 239000007943 implant Substances 0.000 title claims abstract description 57
- 239000002131 composite material Substances 0.000 title claims abstract description 24
- 238000001356 surgical procedure Methods 0.000 title claims abstract description 19
- 229920000642 polymer Polymers 0.000 title claims abstract description 14
- 239000000463 material Substances 0.000 claims abstract description 52
- 239000001506 calcium phosphate Substances 0.000 claims description 12
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 12
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 11
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 11
- -1 polyethylene Polymers 0.000 claims description 11
- 230000000975 bioactive effect Effects 0.000 claims description 10
- 229920000573 polyethylene Polymers 0.000 claims description 9
- 239000004698 Polyethylene Substances 0.000 claims description 8
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 claims description 8
- 102000008186 Collagen Human genes 0.000 claims description 6
- 108010035532 Collagen Proteins 0.000 claims description 6
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 claims description 6
- 239000004952 Polyamide Substances 0.000 claims description 6
- 229920000954 Polyglycolide Polymers 0.000 claims description 6
- 239000002639 bone cement Substances 0.000 claims description 6
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 6
- 235000011010 calcium phosphates Nutrition 0.000 claims description 6
- 229920001436 collagen Polymers 0.000 claims description 6
- 229910052587 fluorapatite Inorganic materials 0.000 claims description 6
- 229940077441 fluorapatite Drugs 0.000 claims description 6
- 239000011521 glass Substances 0.000 claims description 6
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 6
- 229920002647 polyamide Polymers 0.000 claims description 6
- 239000004633 polyglycolic acid Substances 0.000 claims description 6
- 239000004626 polylactic acid Substances 0.000 claims description 6
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 6
- 235000019731 tricalcium phosphate Nutrition 0.000 claims description 6
- 229940078499 tricalcium phosphate Drugs 0.000 claims description 6
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims description 4
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 claims description 4
- 229940112869 bone morphogenetic protein Drugs 0.000 claims description 4
- 229950000845 politef Drugs 0.000 claims description 4
- 229920002101 Chitin Polymers 0.000 claims description 3
- 239000004743 Polypropylene Substances 0.000 claims description 3
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 3
- 229920003232 aliphatic polyester Polymers 0.000 claims description 3
- 125000003118 aryl group Chemical group 0.000 claims description 3
- 229920002678 cellulose Polymers 0.000 claims description 3
- 239000001913 cellulose Substances 0.000 claims description 3
- 239000003822 epoxy resin Substances 0.000 claims description 3
- OBNCKNCVKJNDBV-UHFFFAOYSA-N ethyl butyrate Chemical compound CCCC(=O)OCC OBNCKNCVKJNDBV-UHFFFAOYSA-N 0.000 claims description 3
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 3
- 229920000058 polyacrylate Polymers 0.000 claims description 3
- 229920001610 polycaprolactone Polymers 0.000 claims description 3
- 239000004632 polycaprolactone Substances 0.000 claims description 3
- 229920000647 polyepoxide Polymers 0.000 claims description 3
- 229920000728 polyester Polymers 0.000 claims description 3
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 3
- 229920006324 polyoxymethylene Polymers 0.000 claims description 3
- 229920001155 polypropylene Polymers 0.000 claims description 3
- 229920001296 polysiloxane Polymers 0.000 claims description 3
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 3
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 3
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 3
- 229920002379 silicone rubber Polymers 0.000 claims description 3
- 229920002521 macromolecule Polymers 0.000 claims description 2
- 230000006798 recombination Effects 0.000 claims description 2
- 238000005215 recombination Methods 0.000 claims description 2
- 238000002513 implantation Methods 0.000 abstract description 10
- 239000011148 porous material Substances 0.000 abstract description 7
- 230000004071 biological effect Effects 0.000 abstract description 4
- 230000008901 benefit Effects 0.000 abstract description 3
- 238000002316 cosmetic surgery Methods 0.000 abstract description 3
- 210000004556 brain Anatomy 0.000 abstract 1
- 239000002861 polymer material Substances 0.000 abstract 1
- 238000009966 trimming Methods 0.000 abstract 1
- 210000001508 eye Anatomy 0.000 description 11
- 238000000034 method Methods 0.000 description 10
- 230000008569 process Effects 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- 230000008439 repair process Effects 0.000 description 5
- 210000004204 blood vessel Anatomy 0.000 description 4
- 238000007493 shaping process Methods 0.000 description 4
- 210000004872 soft tissue Anatomy 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 238000000465 moulding Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 229910052586 apatite Inorganic materials 0.000 description 2
- 238000005452 bending Methods 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 230000002490 cerebral effect Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 229920001903 high density polyethylene Polymers 0.000 description 2
- 239000004700 high-density polyethylene Substances 0.000 description 2
- 201000010260 leiomyoma Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 210000003625 skull Anatomy 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 206010003694 Atrophy Diseases 0.000 description 1
- 241000150100 Margo Species 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 239000000607 artificial tear Substances 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 239000003462 bioceramic Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 238000005137 deposition process Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 210000003027 ear inner Anatomy 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 210000004373 mandible Anatomy 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 102000006240 membrane receptors Human genes 0.000 description 1
- 108020004084 membrane receptors Proteins 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000004279 orbit Anatomy 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 238000013138 pruning Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000003980 solgel method Methods 0.000 description 1
- 238000004544 sputter deposition Methods 0.000 description 1
- 210000000216 zygoma Anatomy 0.000 description 1
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- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
The utility model relates to a porous high polymer composite material implant for the surgery, belonging to the apparatus field of inputting the medium into the person's body. The utility model comprises a high polymer material basic skeleton with a pore; the surface of the basic skeleton and the pore are compounded with a biological activity material layer. The utility model has the advantages of high intensity, good toughness, easy forming, easy trimming, and easy implantation. The utility model can be make into various complex shapes and structures, and uses for different implantation parts. The porous high polymer composite material implant for the surgery is widely suitable for the repairing surgery and the reconstruction surgery of the brain surgery, the plastic surgery, the ophthalmology, and the stomatology.
Description
Technical field
This utility model belongs to imports the intravital instrument field of people with medium, relates to a kind of reparation of department of cerebral surgery, plastic surgery, ophthalmology, the department of stomatology and surgery porous polymer composite implant of reconstructive operation of being applicable to.
Background technology
External existing commodity MEDPOR's by name be the implant of raw material manufacturing with polyethylene (PE), and pore shape is similar to the present invention, but it is made by single polythene material, is bio-inert material, does not possess biological activity.
Hydroxyapatite/polyethylene (HA/PE) composite implant of external existing commodity HAPEX by name is used in the middle of clinical, but it is non-porous structure, the tissue of the organism implant inside of can't growing into.
Domestic and international prior biological pottery or bio-vitric polyporous materials implant, hole and the present invention of part material are similar, but its toughness and pruning property are poor, and hardness is too high, and fragility is big, is difficult to be shaped, and is difficult to repair in operation process.
Summary of the invention
The purpose of this utility model is to solve above-mentioned prior art problem and a kind of intensity height is provided, and good toughness is easy to be shaped, the surgery that is easy to implant porous polymer composite implant.
The technical solution adopted in the utility model: a kind of surgery comprises the macromolecule material basic framework that has hole with porous polymer composite implant, and its basic framework and pore surface are compounded with one deck bioactive materials layer.
Described hole connects fully.
Described pore diameter is 50-1000 μ m, and apparent porosity is 10-80%.
Described basic framework material is selected from polyethylene, polypropylene, polyacrylate, aromatic polyester, polysiloxanes, polyformaldehyde, politef, expanded PTFE, acrylic acid methyl ester., polymethyl methacrylate, epoxy resin, medical organic silicon rubber, collagen, aliphatic polyester, chitin, cellulose, polyamino acid, polyvinyl alcohol, polycaprolactone, polylactic acid, polyamide, polyglycolic acid, poly butyric ester, one or more composites in the polyglycolic acid.
Described basic framework material is macromolecular material and hydroxyapatite, tricalcium phosphate, calcium phosphate bone cement, fluor-apatite, bioactivity glass any or several composite, and wherein macromolecular material content is greater than 50wt%.
Described bioactive materials layer material is hydroxyapatite, tricalcium phosphate, calcium phosphate bone cement, fluor-apatite, bioactivity glass, bone morphogenetic protein, polylactic acid, polyamide, collagen or wherein several composite.
This utility model is compared with existing implant, has following actively useful effect:
A. have certain intensity, toughness is better, can make the implant of various complicated shapes with comparalive ease, can be used for different implant sites in surgical operation, reaches the purpose that the human body different parts is carried out shaping, repairs and reproduces;
B. in operation process, can use simple operation tool, promptly implant be pruned, implant is trimmed to the needed shape of doctor according to patient's practical situation;
C. in operation process, can carry out bending and moulding to implant with comparalive ease, to be fit to the curve form of patient's implant site;
D. have loose structure, hole connects fully, and apparent porosity can be regulated in the 10-80% scope, and pore diameter distributes and can regulate in the 50-1000 mu m range as required, can make the portions of implanting of growing into such as soft tissue, blood vessel of organism;
E. can be according to clinician's needs, the distribution of control apparent porosity and pore diameter in the implant manufacture process;
F. implant material surface biologically active material layer, the advantage that possesses high bioactivity, suitable with the biocompatibility and the biological activity of biomaterials such as hydroxyapatite, and can form chemical bonding between tissue, the bond strength height, vascularization speed is fast, rather than is only surrounded by the fibroid film as bio-inert material;
G. have the toughness height of macromolecular material, easily repair advantage, can make the shape and the structure of various complexity, be used for different implant sites, the effect of playing shaping, repair and reproducing, biocompatibility and biological activity are far above macromolecular material.
This utility model is applicable to the reparation and the reconstructive operation of department of cerebral surgery, plastic surgery, ophthalmology, the department of stomatology.As the shaping that in surgical operation, is mainly used in human body cranium face, ear, eye, nose, repair and reproduce, comprise that the surgical operation of multiple shapes such as 2/3 implant, atrophy of eyeball wedge shape implant, margo orbitalis implant, artificial tear duct implant under skull implant, calvarium implant, temples implant, round end bolt, eye socket implant, cheekbone implant, nasal side implant, nose arch, Nose implant, ear implant, chin portion implant, angle of mandible implant, ocular implant (artificial eye platform), the lamellar implant that passage is arranged, palpebra inferior inserted sheet, full socket of the eye and the socket of the eye is implanted.
Description of drawings
Fig. 1 is this utility model structure partial cutaway view Amplified image.
The specific embodiment
Consult shown in Figure 1, a kind of surgery mainly is made of basic framework 1, bioactive materials layer 2, hole 3 with porous polymer composite implant, and its basic framework 1 adopts macromolecular material to make, be loose structure, have the hole 3 of 50-1000 μ m, hole connects fully, and apparent porosity is 10-80%, behind the implantable bioartificial body, the soft tissue of organism, blood vessel etc. can enter hole, the material internal of growing into, and it is chimeric to form physics; The surface recombination of basic framework 1 has one deck bioactive materials layer 2, can adopt technologies such as heat seal, vapour deposition process, thermal chemical reaction method, sputtering method, laser method, bonding method, sol-gel process or bionical solution growth method to be composited.
Described basic framework 1 material is a macromolecular material, optional one or more composites in polyethylene, polypropylene, polyacrylate, aromatic polyester, polysiloxanes, polyformaldehyde, politef, expanded PTFE, acrylic acid methyl ester., polymethyl methacrylate, epoxy resin, medical organic silicon rubber, collagen, aliphatic polyester, chitin, cellulose, polyamino acid, polyvinyl alcohol, polycaprolactone, polylactic acid, polyamide, polyglycolic acid, poly butyric ester, polyglycolic acid etc.Or select macromolecular material and other material for use, as with hydroxyapatite, tricalcium phosphate, calcium phosphate bone cement, fluor-apatite, any or several composites such as bioactivity glass, wherein macromolecular material content is greater than 50wt%, because macromolecular material plays skeleton function in whole implant, so intensity of embedded material, physical properties such as toughness are mainly determined by the performance of macromolecular material, thereby more traditional bioceramic or the bio-vitric class material of toughness of the present utility model is far better, can be made into the implant of various labyrinths easily, the implant of making also can be used simple operation tool in operation process, as scalpel, operating scissors, deep cutter, electric drills etc. are further pruned this utility model implant, according to patient's practical situation, implant is trimmed to the needed shape of doctor; Because the macromolecular material ratio is easier to mouldingly, therefore, this utility model also can be easier to carry out bending and moulding, with the curve form of suitable patient's implant site.
Described bioactive materials layer 2 can be selected hydroxyapatite, tricalcium phosphate, calcium phosphate bone cement, fluor-apatite, bioactivity glass, bone morphogenetic protein (BMP), polylactic acid, polyamide, collagen etc. or several composites in the middle of them for use.
Mechanism of the present utility model: in physiological environment, mutual molecular recognition and specificity that the interaction of cell and implant is actually between the respective ligand that surface of cell membrane receptor and extracellular biomaterial can provide interact.Macromolecular material, as polyethylene, politef etc. belong to bio-inert material, can do not admitted, can be taken as foreign body, in the implantable bioartificial body, be surrounded by the fibroid film by organism, and isolated with osseous tissue on every side, this is one of tissue defense reaction of avoiding foreign body infringement.Implant of the present utility model is compound one deck bioactive materials layer 2 on basic framework 1 surface of macromolecular material, in implanted organism, implant surfaces of the present utility model can form the new apatite layer of one deck again, formed chemical bonding between implant and tissue, formed firm combining with tissue by this layer apatite layer.
Enumerate embodiment 1
Adopt high-density polyethylene material as basic framework 1, hydroxyapatite material is prepared into spherical artificial eye platform as surface bioactive material layer 2, the about 300 μ m of its hole 3 diameters, apparent porosity about 50%.Blood vessel and soft tissue around the loose structure of this artificial eye platform makes can promptly grow into artificial eye holder inside, and eye muscle can drive artificial eye holder and rotate to reach the cosmetic purpose of mixing the spurious with the genuine.
Adopt high-density polyethylene material as basic framework 1, hydroxyapatite material is prepared into lamellar implantation body as surface bioactive material layer 2, the about 100-400 μ of its hole 3 diameters m, apparent porosity about 50%.This lamellar implantation body can be used for the reparation at the bottom of socket of the eye wall and the socket of the eye, also can be used for the reparation and the shaping of cranium face, in operation process, the doctor can be trimmed to needed shape with implantation body with low weight the changing places of operating scissors, after soaking several minutes with 90 ℃ normal saline, can be with the needed curved surface of the crooked moulding one-tenth of implantation body, and, obtain the implantation body that adapts with implant site shape and curved surface with the cold saline typing.After the implantation, blood vessel on every side and soft tissue can promptly grow into implantation body inside, and be chimeric with planting material formation physics, simultaneously because the hydroxyapatite effect of implant surface, form chemical bonding between planting material and tissue, on the bone around implantation body is fixed on.
Claims (6)
1, a kind of surgery comprises the macromolecule material basic framework that has hole with porous polymer composite implant, it is characterized in that basic framework (1) and hole (3) surface recombination have one deck bioactive materials layer (2).
2, surgery according to claim 1 is characterized in that with porous polymer composite implant described hole (3) connects fully.
3, surgery according to claim 1 is characterized in that with porous polymer composite implant described hole (3) diameter is 50-1000 μ m, and apparent porosity is 10-80%.
4, surgery according to claim 1 is characterized in that with porous polymer composite implant described basic framework (1) material is selected from polyethylene, polypropylene, polyacrylate, aromatic polyester, polysiloxanes, polyformaldehyde, politef, expanded PTFE, acrylic acid methyl ester., polymethyl methacrylate, epoxy resin, medical organic silicon rubber, collagen, aliphatic polyester, chitin, cellulose, polyamino acid, polyvinyl alcohol, polycaprolactone, polylactic acid, polyamide, polyglycolic acid, poly butyric ester, one or more composites in the polyglycolic acid.
5, according to claim 1 or 4 described surgeries porous polymer composite implant, it is characterized in that described basic framework (1) material is macromolecular material and hydroxyapatite, tricalcium phosphate, calcium phosphate bone cement, fluor-apatite, bioactivity glass any or several composite, wherein macromolecular material content is greater than 50wt%.
6, surgery according to claim 1 is characterized in that with porous polymer composite implant described bioactive materials layer (2) material is hydroxyapatite, tricalcium phosphate, calcium phosphate bone cement, fluor-apatite, bioactivity glass, bone morphogenetic protein, polylactic acid, polyamide, collagen or wherein several composite.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200420096179 CN2737357Y (en) | 2004-09-28 | 2004-09-28 | Porous high polymer composite implant for surgery |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200420096179 CN2737357Y (en) | 2004-09-28 | 2004-09-28 | Porous high polymer composite implant for surgery |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN2737357Y true CN2737357Y (en) | 2005-11-02 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200420096179 Expired - Fee Related CN2737357Y (en) | 2004-09-28 | 2004-09-28 | Porous high polymer composite implant for surgery |
Country Status (1)
| Country | Link |
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| CN (1) | CN2737357Y (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102746433A (en) * | 2012-06-28 | 2012-10-24 | 东华大学 | Preparation method of medical implanted gel and application |
| TWI411595B (en) * | 2010-04-07 | 2013-10-11 | Univ Kaohsiung Medical | Process for preparing composition comprising porous ceramic with thermo-response hydrogel |
| CN103566411A (en) * | 2013-11-11 | 2014-02-12 | 浙江大学 | Mesoporous bioactive glass-modified porous ceramic ball prosthetic eye holder and preparation method thereof |
| CN104945685A (en) * | 2015-06-30 | 2015-09-30 | 苏州佑君环境科技有限公司 | Preparation method of polyethylene material used for bone cement |
-
2004
- 2004-09-28 CN CN 200420096179 patent/CN2737357Y/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI411595B (en) * | 2010-04-07 | 2013-10-11 | Univ Kaohsiung Medical | Process for preparing composition comprising porous ceramic with thermo-response hydrogel |
| CN102746433A (en) * | 2012-06-28 | 2012-10-24 | 东华大学 | Preparation method of medical implanted gel and application |
| CN102746433B (en) * | 2012-06-28 | 2014-04-02 | 东华大学 | Preparation method of medical implanted gel and application |
| CN103566411A (en) * | 2013-11-11 | 2014-02-12 | 浙江大学 | Mesoporous bioactive glass-modified porous ceramic ball prosthetic eye holder and preparation method thereof |
| CN104945685A (en) * | 2015-06-30 | 2015-09-30 | 苏州佑君环境科技有限公司 | Preparation method of polyethylene material used for bone cement |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: BEIJING HAISEN BIOLOGY SCIENCE CO., LTD. Free format text: FORMER OWNER: ZHANG LIN; PATENTEE Effective date: 20060127 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20060127 Address after: 102200 No. 18 Fukang Road, Changping District science and Technology Park, Beijing Patentee after: Beijing Haisen Biotechnology Co. Ltd. Address before: 102208 Beijing City, Changping District Huilongguan Longzeyuan West No. 28 -1-2101 Co-patentee before: Yao Jianzhong Patentee before: Zhang Lin |
|
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20051102 Termination date: 20110928 |