CN102363050A - Medical biological material and preparation method thereof - Google Patents
Medical biological material and preparation method thereof Download PDFInfo
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- CN102363050A CN102363050A CN2011101793401A CN201110179340A CN102363050A CN 102363050 A CN102363050 A CN 102363050A CN 2011101793401 A CN2011101793401 A CN 2011101793401A CN 201110179340 A CN201110179340 A CN 201110179340A CN 102363050 A CN102363050 A CN 102363050A
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- hydroxyapatite
- biological material
- silicon rubber
- biomaterial
- medical
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Abstract
The invention discloses a medical biological material which contains the following raw materials in mass fraction: 40-80 percent of hydroxyapatite and 20-60 percent of silicon rubber. The hydroxyapatite and the silicon rubber are respectively nano-grade powder and have the grain size of about 50-100nm. The preparation method of the medical biological material comprises the following steps of: firstly, mixing the hydroxyapatite and the silicon rubber according to the proportion; secondly, placing the mixture in a die and then taking the die in a vulcanizing machine for vulcanizing, wherein the vulcanizing temperature is controlled to be 120-180DEG C; and thirdly, sterilizing by using steam at high pressure to obtain the medical biological material. The invention has the benefits that a proper amount of silicon rubber is additionally arranged so as to successfully solve the problem of poor mechanical stability of a hydroxyapatite material; and after the biological material is transplanted into a human body, biological ceramics can be used for gradually degrading surrounding tissues and can be gradually grown so as to promote the growth of new bones.
Description
Technical field
The invention belongs to field of new, specifically is a kind of biomaterial for medical purpose and preparation method thereof.
Background technology
Bio-medical material be used for to organism repair or replace its sick decrease tissue, organ or promote its altogether more can novel high-tech material, generally be the bio-medical material implant that tooth and skeleton are repaired and replaced.What use was more at present is hydroxyapatite material, because therefore the composition of hydroxyapatite material and the skeleton imagination has superior bioactive and biocompatibility.But the particulate mechanical stability of hydroxylapatite ceramic is relatively poor, is difficult to carve molding.
Summary of the invention
The purpose of this invention is to provide all outstanding biomaterial for medical purpose of a kind of mechanical performance, biological activity and biocompatibility and preparation method thereof.
Technical scheme of the present invention is achieved in that a kind of biomaterial for medical purpose, in mass fraction, contains following raw material: hydroxyapatite 40-80%, silicone rubber 20-60%.
Said hydroxyapatite and silicone rubber are nanometer grade powder, and its particle diameter is all at 50-100nm.
The method for preparing of biomaterial for medical purpose, step is following:
1) hydroxyapatite and silicone rubber is mixing in proportion; 2) put into mould and be placed on vulcanizer and vulcanize, curing temperature is controlled at 120-180 ℃; 3) obtain product behind the high pressure steam sterilization.
The invention has the beneficial effects as follows: the present invention is through adding an amount of silicone rubber; Successfully solved the problem of hydroxyapatite material mechanical stability difference; Behind this biomaterial implant into body, the bioceramic surrounding tissue of can degrading gradually can progressively be grown into, and can promote the growth of new bone.
The specific embodiment
Embodiment 1
A kind of biomaterial for medical purpose in mass fraction, contains following raw material: hydroxyapatite 40%, silicone rubber 60%.Said hydroxyapatite and silicone rubber are nanometer grade powder, and its particle diameter is all at 50nm.
The method for preparing of biomaterial for medical purpose, step is following:
1) hydroxyapatite and silicone rubber is mixing in proportion; 2) put into mould and be placed on vulcanizer and vulcanize, curing temperature is controlled at 120 ℃; 3) obtain product behind the high pressure steam sterilization.
Embodiment 2
A kind of biomaterial for medical purpose in mass fraction, contains following raw material: hydroxyapatite 80%, silicone rubber 20%.Said hydroxyapatite and silicone rubber are nanometer grade powder, and its particle diameter is all at 100nm.
The method for preparing of biomaterial for medical purpose, step is following:
1) hydroxyapatite and silicone rubber is mixing in proportion; 2) put into mould and be placed on vulcanizer and vulcanize, curing temperature is controlled at 180 ℃; 3) obtain product behind the high pressure steam sterilization.
The above; Be merely the preferable specific embodiment of the present invention; But protection scope of the present invention is not limited thereto; Any technical staff who is familiar with the present technique field is equal to replacement or change according to technical scheme of the present invention and inventive concept thereof in the technical scope that the present invention discloses, all should be encompassed within protection scope of the present invention.
Claims (3)
1. a biomaterial for medical purpose is characterized in that, in mass fraction, contains following raw material: hydroxyapatite 40-80%, silicone rubber 20-60%.
2. biomaterial for medical purpose according to claim 1 is characterized in that said hydroxyapatite and silicone rubber are nanometer grade powder, and its particle diameter is all at 50-100nm.
3. according to claim 1 or claim 2 the method for preparing of biomaterial for medical purpose is characterized in that step is following:
1) hydroxyapatite and silicone rubber is mixing in proportion; 2) put into mould and be placed on vulcanizer and vulcanize, curing temperature is controlled at 120-180 ℃; 3) obtain product behind the high pressure steam sterilization.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101793401A CN102363050A (en) | 2011-06-29 | 2011-06-29 | Medical biological material and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101793401A CN102363050A (en) | 2011-06-29 | 2011-06-29 | Medical biological material and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102363050A true CN102363050A (en) | 2012-02-29 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011101793401A Pending CN102363050A (en) | 2011-06-29 | 2011-06-29 | Medical biological material and preparation method thereof |
Country Status (1)
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| CN (1) | CN102363050A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104399121A (en) * | 2014-11-10 | 2015-03-11 | 苏州维泰生物技术有限公司 | Material for preparing artificial bones and preparation method thereof |
| CN104399129A (en) * | 2014-11-10 | 2015-03-11 | 苏州维泰生物技术有限公司 | Material for preparing artificial joints and preparation method thereof |
| CN108434521A (en) * | 2018-06-14 | 2018-08-24 | 中国人民解放军陆军军医大学第附属医院 | A kind of implantation material and preparation method thereof promoting bone wound healing |
| CN108641367A (en) * | 2018-05-30 | 2018-10-12 | 谭亚 | A kind of preparation method of antibacterial medical silicon rubber |
| CN108686269A (en) * | 2018-06-06 | 2018-10-23 | 扬州大学 | The preparation method of hydroxyapatite/ABS composite material tooth-implanting |
| CN108938142A (en) * | 2018-05-28 | 2018-12-07 | 上海康宁医疗用品有限公司 | A kind of hollow type silicon rubber shaping implant and preparation method thereof |
-
2011
- 2011-06-29 CN CN2011101793401A patent/CN102363050A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104399121A (en) * | 2014-11-10 | 2015-03-11 | 苏州维泰生物技术有限公司 | Material for preparing artificial bones and preparation method thereof |
| CN104399129A (en) * | 2014-11-10 | 2015-03-11 | 苏州维泰生物技术有限公司 | Material for preparing artificial joints and preparation method thereof |
| CN104399121B (en) * | 2014-11-10 | 2016-04-13 | 中南大学湘雅医院 | Material for preparing artificial bone and preparation method thereof |
| CN105802232A (en) * | 2014-11-10 | 2016-07-27 | 吴杰 | Material for preparing artificial joint and preparation method thereof |
| CN104399129B (en) * | 2014-11-10 | 2016-08-24 | 荆门市第二人民医院 | One prepares joint prosthesis material and preparation method thereof |
| CN105802232B (en) * | 2014-11-10 | 2018-06-15 | 青岛大学附属医院 | It is a kind of to prepare joint prosthesis material and preparation method thereof |
| CN108938142A (en) * | 2018-05-28 | 2018-12-07 | 上海康宁医疗用品有限公司 | A kind of hollow type silicon rubber shaping implant and preparation method thereof |
| CN108641367A (en) * | 2018-05-30 | 2018-10-12 | 谭亚 | A kind of preparation method of antibacterial medical silicon rubber |
| CN108686269A (en) * | 2018-06-06 | 2018-10-23 | 扬州大学 | The preparation method of hydroxyapatite/ABS composite material tooth-implanting |
| CN108434521A (en) * | 2018-06-14 | 2018-08-24 | 中国人民解放军陆军军医大学第附属医院 | A kind of implantation material and preparation method thereof promoting bone wound healing |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20120229 |