CN108641367A - A kind of preparation method of antibacterial medical silicon rubber - Google Patents
A kind of preparation method of antibacterial medical silicon rubber Download PDFInfo
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- CN108641367A CN108641367A CN201810537219.3A CN201810537219A CN108641367A CN 108641367 A CN108641367 A CN 108641367A CN 201810537219 A CN201810537219 A CN 201810537219A CN 108641367 A CN108641367 A CN 108641367A
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
- C08L83/04—Polysiloxanes
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/32—Phosphorus-containing compounds
- C08K2003/321—Phosphates
- C08K2003/325—Calcium, strontium or barium phosphate
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/02—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group
- C08L2205/025—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group containing two or more polymers of the same hierarchy C08L, and differing only in parameters such as density, comonomer content, molecular weight, structure
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Abstract
The present invention relates to a kind of preparation methods of antibacterial medical silicon rubber, belong to antibacterial silicon rubber technical field.The present invention has α ﹣ tricalcium phosphates crystal forms and high degradability by high-temperature calcination ox bone generation high intensity, the native hydroxyl apatite of high bioactivity, and using it as carrier, antimicrobial natural hydroxyapatite is made, again mill is mixed with silicon rubber, being formed under the action of peroxide for silicon rubber is strong bonded, on the one hand its hydroxyl apatite can form synostosis with bone tissue, material is set to fix, on the other hand then has the performance of silicon rubber completely, such as in jaw face beauty and shaping art, when packing material is close to skin, it is required that packing material is colourless, to keep consistent with skin colour, silicon rubber is colourless, transparent characteristic can reach this requirement；Antibacterial medical silicon rubber of the present invention shows preferable anti-microbial property, and antimicrobial component will not be precipitated and generate cytotoxicity into intracellular, have good biocompatibility.
Description
Technical field
The present invention relates to a kind of preparation methods of antibacterial medical silicon rubber, belong to antibacterial silicon rubber technical field.
Background technology
Medical grade silicon rubber is relatively broad in the application of field of medical materials, and remarkable tribute is made that for the medical industry of the mankind
It offers, certainly, thereupon there are also negative effect, silicon rubber is implanted into material meeting Adherent bacteria during intervening human body,
So as to cause wound infection, it is used for making troubles.Domestic product in this respect relies primarily on import, improves patient's
Treatment cost.In addition, silicon catheter can cause thrombus as long-term interposing catheter implantation human body, to need to be intubated again,
And antithrombotic reagent is constantly injected during intubation, it is more likely that cause blood coagulation obstacle, pole is brought to patient
Big pain, and therefore cost that patient brings is higher.
Since silastic material product has great inertia to biological vital tissue so that used by the medical instrument that it is constituted
The type of product is on the increase and the field applied is more and more extensive.Also, with the development of the society, medical level constantly carries
The medical supplies difference of height, different classifications and function increasingly refines, and the product whether intervened in short term or is chronically implanted
Product, Varieties are all constantly increasing, and silicone rubber products are applied in medical treatment, service, health, healthy every field,
Form complete product chain.
Medical grade silicon rubber object form is various, various in style, and wherein primary articles form has three categories：Medical catheter, bottle
Plug and its product.Because silastic structure is special, play the role of in medical field incomparable, and dosage is increasingly
Increase.Such as to the sealing bottle stopper that elasticity requires, after needle adopts medicine, the hole of appearance remains able to self-closed,
Air-tightness is kept, and is generated because of breakage and falls disintegrating slag.
Sealing bottle stopper must have good drug resistance, adverse environment resistant sterilization treatment, and so just can guarantee makes
With stability in the process.If bottle stopper is to also need to ask bottle stopper will not react and draw with blood for sealed storage blood
Play that blood is rotten and Coagulation test, and silicon rubber is implanted into material and understands Adherent bacteria during intervene human body, so as to cause wound
Mouthfeel contaminates, and is used for making troubles, in fact, silicon rubber is difficult to meet clinical needs under conditions of without modification.
Generally reach practical application request by carrying out surface modification or blending and modifying to silicon rubber.Silicon rubber is in clinical application
It is constantly studied exploitation, there has been the product of many maturations in market.Medical grade silicon rubber material is as medical macromolecular materials
It uses, multifunction is presented in product, notable in clinical application effect, receives experts and scholars' concern.
Invention content
The technical problems to be solved by the invention：It can be adhered to during intervening human body carefully for silicon rubber implantation material
Bacterium the problem of being used for making troubles, provides a kind of preparation side of antibacterial medical silicon rubber so as to cause wound infection
Method.
In order to solve the above technical problems, the technical solution adopted by the present invention is：
A kind of preparation method of antibacterial medical silicon rubber, specific preparation process are：
（1）After taking fresh ox bone to wash with deionized water in mass ratio 1：1 is fitted into pressure cooker and boils 3~5h, is scraped off after cooling
The meat and fascia and drying and crushing on surface cross 60 mesh sieve, obtain ox bone particle；
（2）Ox bone particle is fitted into Muffle furnace and is calcined, rear ball milling is cooled to room temperature, crosses 200 mesh sieve, obtains native hydroxyl phosphorus ash
Stone；
（3）Silver nitrate, zinc nitrate is taken to be added in deionized water and stir evenly, then it is that 3% trisodium citrate is molten that mass fraction, which is added dropwise,
Liquid is stirred to obtain compound silver-colored zinc antiseptic；
（4）It takes native hydroxyl apatite, octamethylcy-clotetrasiloxane that ultrasonic disperse in deionized water is added, adds hydrochloric acid DOPA
Amine, sodium peroxide, compound silver-colored zinc antiseptic, mass fraction are 10% formalin, and it is that 20% ammonium hydroxide adjusts pH that mass fraction, which is used in combination,
It is 8.0~9.0, the filtration drying after the place of being protected from light is reacted 2~3 days obtains antimicrobial natural hydroxyapatite；
（5）It takes liquid silastic A to be placed in mill on open mill and adds liquid silastic B, antimicrobial natural hydroxy-apatite at strip
Stone, Silane coupling reagent KH-570 discharge after continuing 8~10min of plastics, obtain antibacterial medical silicon rubber.
Step（2）The calcination process is to be warming up to 500~600 DEG C with 5~10 DEG C/min rates, after calcining 1~2h, after
It is continuous to be warming up to 1350~1400 DEG C of 6~8h of calcining, then stand and be cooled to 1000~1100 DEG C of 1~2h of calcining.
Step（3）The compound silver-colored zinc antiseptic constitutive material parts by weight be 0.02~0.03 part of silver nitrate, 0.02~
150~200 parts of deionized waters, 20~30 parts of citric acid three sodium solutions are added in 0.04 part of zinc nitrate.
Step（4）Described weight of material part be 10~30 parts of native hydroxyl apatite, 1~2 part of octamethylcy-clotetrasiloxane,
300~500 parts of deionized waters, 1~2 part of Dopamine hydrochloride, 0.6~0.8 part of sodium peroxide, 100~150 parts of compound silver-colored zinc antibacterials
Agent, 20~30 parts of formalins.
Step（5）The mill parameter is that roll spacing is 3~4mm, speed ratio 1：1~1：1.2, preceding roll temperature is 55~60
DEG C, rear roll temperature is 50~55 DEG C.
Step（5）The liquid silastic A, liquid silastic B, antimicrobial natural hydroxyapatite, silane coupling agent KH-
570 parts by weight are 30~40 parts of liquid silastic A, 30~40 parts of liquid silastic B, 10~30 parts of antimicrobial natural hydroxy-apatites
Stone, 2~3 parts of Silane coupling reagent KH-570s.
Step（5）The liquid silastic is Bi-component liquid silicone rubber K-LIM1006A.
Compared with other methods, advantageous effects are the present invention：
（1）The present invention has α ﹣ tricalcium phosphates crystal forms and high degradability, Gao Sheng by high-temperature calcination ox bone generation high intensity
The active native hydroxyl apatite of object, and using it as carrier, hydroxyapatite surface is adhered to by dopamine polymerisation, and
By poly-dopamine to silver, the reduction of zinc ion and chelation, the method using in-situ reducing silver, zinc ion is equal by silver, zinc
Antimicrobial natural hydroxyapatite is made in the even native hydroxyl apatite surface that is supported on, then mixes mill with silicon rubber, silicon rubber
Vinyl is set to become free radical under the action of peroxide, to form chemical bond between vinyl, interface when vulcanization
Vinyl between form chemical bonds under the action of vulcanizing agent, form strong bonded, one side of hydroxyl apatite
Face can form synostosis with bone tissue, so that material is fixed, on the other hand then have the performance of silicon rubber completely, such as in jaw
In face beauty and shaping art, when packing material is close to skin, it is desirable that packing material is colourless, to keep, silicon consistent with skin colour
Colourless, the transparent characteristic of rubber can reach this requirement；
（2）Antibacterial medical silicon rubber of the present invention shows preferable anti-microbial property, and antimicrobial component will not be precipitated and enter cell
Interior generation cytotoxicity has good biocompatibility.
Specific implementation mode
It takes fresh ox bone and is washed with deionized 3~5 times, then by ox bone and the deionized water in mass ratio 1 after washing：
1 is fitted into pressure cooker and boils 3~5h, takes out ox bone after being cooled to room temperature, steel knife is used in combination to scrape off the meat and fascia on ox bone surface
After be transferred in drying box, dried to constant weight at 105~110 DEG C, then the ox bone after drying be fitted into pulverizer and is crushed, mistake 60
Mesh sieves, and obtains ox bone particle, ox bone particle is fitted into Muffle furnace, is warming up to 500~600 DEG C with 5~10 DEG C/min rates, calcining
After 1~2h, be continuously heating to 1350~1400 DEG C calcining 6~8h, then stand be cooled to 1000~1100 DEG C calcining 1~2h, it is cold
But to after room temperature, calcined product is transferred in ball mill, with 300~400r/min rotating speed 30~40min of ball milling, crosses 200 mesh sieve,
Native hydroxyl apatite is obtained, takes 0.02~0.03g silver nitrates, 0.02~0.04g zinc nitrates that 150~200mL deionized waters are added
In, 20~30min is stirred with 300~400r/min, then 20~30g mass fractions are added dropwise as 3% citric acid three with 1~2g/min
Sodium solution continues 20~30min of stirring, obtains compound silver-colored zinc antiseptic, takes 10~30g native hydroxyl apatite, 1~2g prestoxs
Cyclotetrasiloxane is added in 300~500mL deionized waters, disperses 20~30min with 300W ultrasonic echographies, adds 1~2g
Dopamine hydrochloride, 0.6~0.8g sodium peroxides, the compound silver-colored zinc antiseptics of 100~150g, 20~30g mass fractions are 10% formaldehyde
Solution, be used in combination mass fraction be 20% ammonium hydroxide adjust pH be 8.0~9.0, the place of being protected from light reaction 2~3 days, filtration drying obtains antibacterial
Native hydroxyl apatite takes 30~40g liquid silastics A to be placed on open mill and practices into strip, and roll spacing is 3~4mm, speed ratio 1：
1~1：1.2, preceding roll temperature is 55~60 DEG C, and rear roll temperature is 50~55 DEG C, and plasticate 5~8min, adds 30~40g liquid
Silicon rubber B, 10~30g antimicrobial natural hydroxyapatite, 2~3g Silane coupling reagent KH-570s go out after continuing 8~10min of plastics
Material, obtains antibacterial medical silicon rubber.
It takes fresh ox bone and is washed with deionized 3 times, then by ox bone and the deionized water in mass ratio 1 after washing：1 dress
Enter and boil 3h in pressure cooker, ox bone is taken out after being cooled to room temperature, is transferred to after being used in combination steel knife to scrape off the meat and fascia on ox bone surface
It in drying box, is dried to constant weight at 105 DEG C, then the ox bone after drying is fitted into pulverizer and is crushed, crosses 60 mesh sieve, obtain ox bone
Ox bone particle is fitted into Muffle furnace by particle, is warming up to 500 DEG C with 5 DEG C/min rates, after calcining 1h, is continuously heating to 1350
DEG C calcining 6h, then stand be cooled to 1000 DEG C calcining 1h, after being cooled to room temperature, calcined product is transferred in ball mill, with 300r/
Min rotating speed ball milling 30min cross 200 mesh sieve, obtain native hydroxyl apatite, and 0.02g silver nitrates, 0.02g zinc nitrates is taken to be added
In 150mL deionized waters, 20min is stirred with 300r/min, then it is that 3% trisodium citrate is molten that 20g mass fractions, which are added dropwise, with 1g/min
Liquid continues to stir 20min, obtains compound silver-colored zinc antiseptic, and 10g native hydroxyl apatite, 1g octamethylcy-clotetrasiloxanes is taken to be added
In 300mL deionized waters, 20min is disperseed with 300W ultrasonic echographies, adds 1g Dopamine hydrochlorides, 0.6g sodium peroxides,
The compound silver-colored zinc antiseptics of 100g, 20g mass fractions be 10% formalin, be used in combination mass fraction be 20% ammonium hydroxide adjust pH be 8.0,
The place of being protected from light react 2 days, filtration drying obtains antimicrobial natural hydroxyapatite, take 30g liquid silastics A be placed on open mill practice at
Strip, roll spacing 3mm, speed ratio 1：1, preceding roll temperature is 55 DEG C, and rear roll temperature is 50 DEG C, and plasticate 5min, adds 30g liquid
Silicon rubber B, 10g antimicrobial natural hydroxyapatite, 2g Silane coupling reagent KH-570s discharge after continuing plastics 8min, obtain antibacterial doctor
Use silicon rubber.
It takes fresh ox bone and is washed with deionized 4 times, then by ox bone and the deionized water in mass ratio 1 after washing：1 dress
Enter and boil 4h in pressure cooker, ox bone is taken out after being cooled to room temperature, is transferred to after being used in combination steel knife to scrape off the meat and fascia on ox bone surface
It in drying box, is dried to constant weight at 108 DEG C, then the ox bone after drying is fitted into pulverizer and is crushed, crosses 60 mesh sieve, obtain ox bone
Ox bone particle is fitted into Muffle furnace by particle, is warming up to 550 DEG C with 8 DEG C/min rates, after calcining 1h, is continuously heating to 1375
DEG C calcining 7h, then stand be cooled to 1050 DEG C calcining 1h, after being cooled to room temperature, calcined product is transferred in ball mill, with 350r/
Min rotating speed ball milling 35min cross 200 mesh sieve, obtain native hydroxyl apatite, and 0.02g silver nitrates, 0.03g zinc nitrates is taken to be added
In 180mL deionized waters, 25min is stirred with 350r/min, then it is that 3% trisodium citrate is molten that 25g mass fractions, which are added dropwise, with 1g/min
Liquid continues to stir 25min, obtains compound silver-colored zinc antiseptic, and 20g native hydroxyl apatite, 1g octamethylcy-clotetrasiloxanes is taken to be added
In 400mL deionized waters, 25min is disperseed with 300W ultrasonic echographies, adds 1g Dopamine hydrochlorides, 0.7g sodium peroxides,
The compound silver-colored zinc antiseptics of 120g, 25g mass fractions be 10% formalin, be used in combination mass fraction be 20% ammonium hydroxide adjust pH be 8.5,
The place of being protected from light react 2 days, filtration drying obtains antimicrobial natural hydroxyapatite, take 35g liquid silastics A be placed on open mill practice at
Strip, roll spacing 3mm, speed ratio 1：1.1, preceding roll temperature is 58 DEG C, and rear roll temperature is 53 DEG C, and plasticate 7min, adds 35g liquid
Body silicon rubber B, 20g antimicrobial natural hydroxyapatite, 2g Silane coupling reagent KH-570s discharge after continuing plastics 9min, obtain antibacterial
Medical grade silicon rubber.
It takes fresh ox bone and is washed with deionized 5 times, then by ox bone and the deionized water in mass ratio 1 after washing：1 dress
Enter and boil 5h in pressure cooker, ox bone is taken out after being cooled to room temperature, is transferred to after being used in combination steel knife to scrape off the meat and fascia on ox bone surface
It in drying box, is dried to constant weight at 110 DEG C, then the ox bone after drying is fitted into pulverizer and is crushed, crosses 60 mesh sieve, obtain ox bone
Ox bone particle is fitted into Muffle furnace by particle, is warming up to 600 DEG C with 10 DEG C/min rates, after calcining 2h, is continuously heating to 1400
DEG C calcining 8h, then stand be cooled to 1100 DEG C calcining 2h, after being cooled to room temperature, calcined product is transferred in ball mill, with 400r/
Min rotating speed ball milling 40min cross 200 mesh sieve, obtain native hydroxyl apatite, and 0.03g silver nitrates, 0.04g zinc nitrates is taken to be added
In 200mL deionized waters, 30min is stirred with 400r/min, then it is that 3% trisodium citrate is molten that 30g mass fractions, which are added dropwise, with 2g/min
Liquid continues to stir 30min, obtains compound silver-colored zinc antiseptic, and 30g native hydroxyl apatite, 2g octamethylcy-clotetrasiloxanes is taken to be added
In 500mL deionized waters, 30min is disperseed with 300W ultrasonic echographies, adds 2g Dopamine hydrochlorides, 0.8g sodium peroxides,
The compound silver-colored zinc antiseptics of 150g, 30g mass fractions be 10% formalin, be used in combination mass fraction be 20% ammonium hydroxide adjust pH be 9.0,
The place of being protected from light react 3 days, filtration drying obtains antimicrobial natural hydroxyapatite, take 40g liquid silastics A be placed on open mill practice at
Strip, roll spacing 4mm, speed ratio 1：1.2, preceding roll temperature is 60 DEG C, and rear roll temperature is 55 DEG C, and plasticate 8min, adds 40g liquid
Body silicon rubber B, 30g antimicrobial natural hydroxyapatite, 3g Silane coupling reagent KH-570s discharge after continuing plastics 10min, obtain antibacterial
Medical grade silicon rubber.
Reference examples：The antibacterial medical silicon rubber of Dongguan company production.
The antibacterial medical silicon rubber of example and reference examples is detected, specific detection is as follows：
Mechanics Performance Testing：Tensile strength, the elongation at break of composite material are measured according to national standard GB/T528-2009.
Static water contact angles are tested：It after silastic surface to be measured is cleaned out, is placed on sample stage, it is big to adjust drop
Small is 0.5ul, is connect down drop by moving up and down sample stage, is read after stablizing 10s, is surveyed in the different location of the same sample
It measures five times and is averaged.
Anti-microbial property test：（1）Sheet rubber is cut into the print of 1cm × 1lcm, it is for use after being cleaned with ethyl alcohol.（2）It will
Staphylococcus aureus actication of culture is configured to a concentration of 1 × 104Cfu/ml~5 × 104The bacteria suspension of cfu/ml.Then it will cut out
The sheet rubber sheared is put into.（3）Conical flask equipped with bacteria suspension and sheet rubber is fixed on oscillation shaking table, at 20 DEG C -25
2min is shaken with 300r/min at a temperature of DEG C.Then the bacteria suspension of 1.0ml is taken to be diluted to 100 times.（4）Draw sample liquid after vibrating
L.0ml, it is inoculated on agar base, under natural light, 37 DEG C of culture 48h.Then method carries out bacterium colony meter in GB15979-2003
Number.（5）The blank control group and negative control group of the experiment are operated as stated above.（6）Experiment is repeated 3 times, by public affairs
Formula calculates bacteriostasis rate
Specific testing result such as table 1.
1 performance characterization contrast table of table
| Detection project | Example 1 | Example 2 | Example 3 | Reference examples |
| Tensile strength/MPa | 11 | 12 | 10 | 5 |
| Elongation at break/% | 550 | 555 | 560 | 210 |
| Contact angle/° | 52.3 | 51.0 | 50.9 | 26.1 |
| Bacteriostasis rate/% | 100 | 95 | 97 | 51 |
As shown in Table 1, the antibacterial medical silicon rubber that prepared by the present invention has good mechanical property, contact angle and bacteriostasis rate.
Claims (7)
1. a kind of preparation method of antibacterial medical silicon rubber, which is characterized in that specifically preparation process is：
（1）After taking fresh ox bone to wash with deionized water in mass ratio 1：1 is fitted into pressure cooker and boils 3~5h, is scraped off after cooling
The meat and fascia and drying and crushing on surface cross 60 mesh sieve, obtain ox bone particle；
（2）Ox bone particle is fitted into Muffle furnace and is calcined, rear ball milling is cooled to room temperature, crosses 200 mesh sieve, obtains native hydroxyl phosphorus ash
Stone；
（3）Silver nitrate, zinc nitrate is taken to be added in deionized water and stir evenly, then it is that 3% trisodium citrate is molten that mass fraction, which is added dropwise,
Liquid is stirred to obtain compound silver-colored zinc antiseptic；
（4）It takes native hydroxyl apatite, octamethylcy-clotetrasiloxane that ultrasonic disperse in deionized water is added, adds hydrochloric acid DOPA
Amine, sodium peroxide, compound silver-colored zinc antiseptic, mass fraction are 10% formalin, and it is that 20% ammonium hydroxide adjusts pH that mass fraction, which is used in combination,
It is 8.0~9.0, the filtration drying after the place of being protected from light is reacted 2~3 days obtains antimicrobial natural hydroxyapatite；
（5）It takes liquid silastic A to be placed in mill on open mill and adds liquid silastic B, antimicrobial natural hydroxy-apatite at strip
Stone, Silane coupling reagent KH-570 discharge after continuing 8~10min of plastics, obtain antibacterial medical silicon rubber.
2. a kind of preparation method of antibacterial medical silicon rubber as described in claim 1, which is characterized in that step（2）It is described to forge
Burning process is to be warming up to 500~600 DEG C with 5~10 DEG C/min rates, after calcining 1~2h, is continuously heating to 1350~1400 DEG C
6~8h is calcined, then stands and is cooled to 1000~1100 DEG C of 1~2h of calcining.
3. a kind of preparation method of antibacterial medical silicon rubber as described in claim 1, which is characterized in that step（3）It is described multiple
Conjunction silver-colored zinc antiseptic constitutive material parts by weight be 0.02~0.03 part of silver nitrate, 0.02~0.04 part of zinc nitrate, be added 150~
200 parts of deionized waters, 20~30 parts of citric acid three sodium solutions.
4. a kind of preparation method of antibacterial medical silicon rubber as described in claim 1, which is characterized in that step（4）The object
Material parts by weight be 10~30 parts of native hydroxyl apatite, 1~2 part of octamethylcy-clotetrasiloxane, 300~500 parts of deionized waters, 1
~2 parts of Dopamine hydrochlorides, 0.6~0.8 part of sodium peroxide, 100~150 parts of compound silver-colored zinc antiseptics, 20~30 parts of formalins.
5. a kind of preparation method of antibacterial medical silicon rubber as described in claim 1, which is characterized in that step（5）It is described to open
It is 3~4mm, speed ratio 1 that refining parameter, which is roll spacing,：1~1：1.2, preceding roll temperature is 55~60 DEG C, and rear roll temperature is 50~55 DEG C.
6. a kind of preparation method of antibacterial medical silicon rubber as described in claim 1, which is characterized in that step（5）The liquid
Body silicon rubber A, liquid silastic B, antimicrobial natural hydroxyapatite, Silane coupling reagent KH-570 parts by weight are 30~40 parts of liquid
Silicon rubber A, 30~40 parts of liquid silastic B, 10~30 parts of antimicrobial natural hydroxyapatites, 2~3 parts of silane coupling agent KH-
570。
7. a kind of preparation method of antibacterial medical silicon rubber as described in claim 1, which is characterized in that step（5）The liquid
Body silicon rubber is Bi-component liquid silicone rubber K-LIM1006A.
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| CN109912982A (en) * | 2019-03-21 | 2019-06-21 | 山西大医院（山西医学科学院） | A kind of bio-medical silicon rubber with antibiotic property |
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| CN109912982A (en) * | 2019-03-21 | 2019-06-21 | 山西大医院（山西医学科学院） | A kind of bio-medical silicon rubber with antibiotic property |
| CN109912982B (en) * | 2019-03-21 | 2021-06-29 | 山西大医院（山西医学科学院） | Antibacterial biomedical silicone rubber |
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Application publication date: 20181012 |