CN106421890A - Material used for autologous cortical bone synostosis silica gel particle for nasal plasty and preparation method of material - Google Patents
Material used for autologous cortical bone synostosis silica gel particle for nasal plasty and preparation method of material Download PDFInfo
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- CN106421890A CN106421890A CN201611123420.4A CN201611123420A CN106421890A CN 106421890 A CN106421890 A CN 106421890A CN 201611123420 A CN201611123420 A CN 201611123420A CN 106421890 A CN106421890 A CN 106421890A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/025—Other specific inorganic materials not covered by A61L27/04 - A61L27/12
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/18—Internal ear or nose parts, e.g. ear-drums
- A61F2/186—Nose parts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/40—Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking
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Abstract
The invention relates to a material used for an autologous cortical bone synostosis silica gel particle for nasal plasty and a preparation method of the material. The material structurally comprises a nasal bone base body made of the silica gel particle, the nasal bone base body comprises an apex nasi, a columella nasi and a nose ridge, the nose ridge is connected with the columella nasi through the apex nasi; the lower part of the nose ridge comprises two nose ridge sections arranged in a V shape in a crossing manner, a nasal bone of a human body is located between the two nose ridge sections to ensure that a prosthesis does not displace or abrade, the nasal bone base body is provided with a hollow body, and the hollow body is filled with an autologous cortical bone. The material and the preparation method have the beneficial effects that due to the design of the nose ridge section, the prosthesis is tightly in contact with the nose bone and does not displace or abrade; and a body fluid flows into a hole in the nose ridge to grow a human tissue, so that the stable fusion of the nose and the nose prosthesis is promoted, the nose prosthesis is prevented from moving, falling off or festering, and the pain of a patient is prevented after the operation. The method is suitable for treating the autologous or allogeneic bone synostosis silica gel particles.
Description
Technical field
The present invention relates to shaping technique field, especially relate to a kind of nose shaping filling autogenous bone that is used for and combine silicon
Material of glue granule and preparation method thereof.
Background technology
Nasal plastic (face-lifting) operation is to change height and the form of nose by implanting suitable material, be allowed to face other
Position phase is coordinated, and is a kind of modal operation of field of orthopedic surgery.
Medically, nasal plastic material has many kinds, such as medical grade silicon rubber, autologous cartilage, allogeneic cartilage, animal tendon
Or ligament, varicosity (politef), hyaluronic acid etc..The preparation method of bridge of the nose prosthese is also more, and wherein, autologous cartilage is due to coming
From body, so being not in rejection, also not sensitization, but moulding relatively difficult in manufacturing process, increase patient suffering.
With allogeneic cartilage animal tendon, ligament as raw material, because its composition and structure are similar to tissue, good biocompatibility,
Implantation does not cause immunological rejection, inducible tissue regeneration, but need to process through a series of biochemical technologies, and manufacturing process is more multiple
Miscellaneous., because nontoxic, histocompatibility is relatively stable, is main medical prosthesis augmentation rhinoplasty material for firm silicone rubber hump nose material
Material, is easy to moulding in manufacturing process, but silicone rubber implant is susceptible to after implanting shift and weares and teares.
Therefore, the going out of a kind of material and preparation method thereof filling autogenous bone joint silica gel particle for nose shaping
Existing necessary, its manufacturing process is convenient, Stability Analysis of Structures, is not susceptible to shift and weares and teares.
Content of the invention
The present invention provides a kind of material and its preparation side filling autogenous bone joint silica gel particle for nose shaping
Method, more complicated to solve manufacturing process in prior art, it is susceptible to the problems such as displacement and abrasion.
Technical problem solved by the invention employs the following technical solutions to realize：
A kind of material filling autogenous bone joint silica gel particle for nose shaping, including by silica gel particle making
The nasal bone matrix becoming, described nasal bone matrix includes nose, nose pillar, the bridge of the nose, and the described bridge of the nose connects nose pillar by nose；
The bottom of the described bridge of the nose is made up of two shape that is in the shape of the letter V bridge of the nose sections arranged in a crossed manner, and the nasal bone of human body is located at two
Between individual described bridge of the nose section, to ensure that prosthese will not displacement and abrasion；
Hollow out body is had on described nasal bone matrix, described hollow out body is filled with autogenous bone, to reduce this material
Weight.
As preferred technical scheme, described bridge of the nose section is replaced by autogenous bone.
As preferred technical scheme, the surface of the described bridge of the nose is densely covered with numerous holes, makes prosthese by described hole
There is elasticity, can stretch, can be very good nose of fitting, hole can allow body fluid flow into hole to promote to merge, allow nose
It is connected with nose prosthesiss, prevent nose prosthesiss from moving, come off, festering, prevent the pain of postoperative patient.
As preferred technical scheme, described hole is through hole or non through hole.
As preferred technical scheme, described hole is non through hole, and the bottom of described hole is plane or arc surface.Described
Hole can be typed it out with laser, laser equipment punched hole, and its hole periphery is mellow and full, and bottom is one and smooths, impulse- free robustness.
As preferred technical scheme, the surface being arranged in the described bridge of the nose, described hole and the hole of described hole rule
Between spacing identical, overall very attractive in appearance.A diameter of 0.02mm-0.1mm of described hole.
The preparation method of the material of autogenous bone joint silica gel particle is filled in a kind of nose shaping, comprises the following steps：
A) matrix makes, and makes nasal bone matrix using silica gel particle material；
B) take bone, obtain autogenous bone in an aseptic environment；
C) process, the described autogenous bone obtaining is carried out defat, decalcification, deproteinization and sterilization treatment successively；
D) cultivate, the autogenous bone after the process in step C be assembled on described nasal bone matrix, and cultivate 24h,
E) chisel and carve, by step D) in culture after described nasal bone matrix chisel and carve in need shape, you can.
As preferred technical scheme, described autogenous bone is autologous rib, Auricular cartilage.
As preferred technical scheme, the concrete processing procedure in step B includes：
(1) described autogenous bone is immersed 6-24 hour in chloroform and methanol mixed liquid；
(2) the described autogenous bone after above-mentioned steps (1) process is added in hydrochloric acid solution, continuously stirred 8-12 is little
When；
(3) by the described autogenous bone immersion TritonX-100 and ammonia mixed solution after above-mentioned steps (2) process
Effect 2-72 hour；
(4) by the described autogenous bone lyophilization after above-mentioned steps (3) process, sterilization treatment；
Wherein：The volume ratio of the chloroform in described chloroform and methyl alcohol mixed liquor and methanol is 1：1；
The concentration of described hydrochloric acid solution is 0.5-0.6mol/L；
The volumn concentration of the TritonX-100 in described TritonX-100 and ammonia mixed solution is 0.1%-
2%, the weight/mass percentage composition of ammonia is 0.3%；
Freeze-dried 24h in the freeze dryer that described lyophilization refers to put into described autogenous bone -72 DEG C～-80 DEG C
～48h；
Described sterilization treatment refers to put into ethylene oxide sterilizer by after described autogenous bone plastic bag packaging seal
Interior sterilizing, the mass concentration of oxirane controls in 480mg/L～520mg/L, and sterilising temp controls at 38 DEG C～42 DEG C, sterilizing
Humidity is 45%～55%, and the sterilization functions time is 3h～4h, and sterilization intensity is in 1500mg/h L～2000mg/h L.
As preferred technical scheme, the described process of chiseling and carving includes by laser equipment, described autogenous bone being punched.
As preferred technical scheme, the bore dia that laser equipment punches to described autogenous bone is 0.02mm-
0.1mm；Hole density is 3000-200000/cm2.
The invention has the advantages that：By the design of bridge of the nose section so that prosthese is in close contact with nasal bone, Bu Huiwei
Move or wear and tear；Body fluid can be allowed to flow into hole by the hole on the described bridge of the nose to grow tissue, allow nose with nose prosthesiss
Merge eventually, prevent nose prosthesiss from moving, come off, festering, prevent the pain of postoperative patient.
Brief description
In order to be illustrated more clearly that embodiment of the present invention or technical scheme of the prior art, below will be to embodiment
Or in description of the prior art the accompanying drawing of required use be briefly described it should be apparent that, drawings in the following description are only
It is some embodiments of the present invention, for those of ordinary skill in the art, in the premise not paying creative labor
Under, other accompanying drawings can also be obtained according to these accompanying drawings.
Fig. 1 is the present invention：A kind of structure of the material filling autogenous bone joint silica gel particle for nose shaping is shown
It is intended to；
Fig. 2 is the present invention：A kind of top view of the material filling autogenous bone joint silica gel particle for nose shaping；
Fig. 3 is the present invention：A kind of preparation side of the material filling autogenous bone joint silica gel particle for nose shaping
The schematic flow sheet of method.
Specific embodiment
In order that technological means, creation characteristic, reached purpose and effect that the present invention realizes are easy to understand, tie below
Conjunction is specifically illustrating, and the present invention is expanded on further.
With reference to shown in Fig. 1-2, a kind of material filling autogenous bone joint silica gel particle for nose shaping, including by
The nasal bone matrix 100 that silica gel particle is made, silica gel particle material has the advantages that light weight, intensity are high, corrosion-resistant；Nasal bone
Matrix 100 includes nose 1, nose pillar 2, the bridge of the nose 3, and the bridge of the nose 3 connects nose pillar 2 by nose 1；The bottom of the bridge of the nose 3 is in V by two
Word shape bridge of the nose section 12 arranged in a crossed manner forms, and the nasal bone of human body is located between two bridge of the nose sections 12, to ensure that prosthese will not
Displacement and abrasion.Hollow out body 101 is had on described nasal bone matrix 100, described hollow out body 101 is filled with autogenous bone, with
Reduce the weight of this material, meanwhile, autogenous bone is capable of realizing fusion growth, Stability Analysis of Structures with itself nasal bone, prevents
Nose prosthesiss move, come off.Preferably, described bridge of the nose section 12 is also replaced by autogenous bone.
The surface of the bridge of the nose 3 of the present invention is densely covered with numerous holes 11, makes prosthese have elasticity, Ke Yila by hole 11
Stretch, can be very good nose of fitting, hole 11 can allow body fluid flow into hole 11 and grow tissue, make nose false with nose
Body is connected, and prevents nose prosthesiss from moving, come off, festering, prevents the pain of postoperative patient.Preferably, hole 11 is through hole
Or non through hole.
The hole 11 of the present invention is non through hole, and the bottom of hole 11 is plane or arc surface.Hole 11 can be beaten with laser
Out, laser equipment punched hole, its hole periphery is mellow and full, and bottom is one and smooths, impulse- free robustness.
The surface being arranged in the bridge of the nose 3 or bridge of the nose section 12 of hole 11 rule of the present invention, between hole 11 and hole 11
Spacing is identical, overall very attractive in appearance.The bore dia of hole 11 is 0.02mm-0.1mm；Hole density is 3000-200000/cm2.
With reference to shown in Fig. 3, the invention allows for a kind of combine silica gel particle for nose shaping filling autogenous bone
Material preparation method, comprise the following steps：
A) matrix makes, and makes nasal bone matrix using silica gel particle material；
B) take bone, obtain autogenous bone in an aseptic environment；
C) process, the described autogenous bone obtaining is carried out defat, decalcification, deproteinization and sterilization treatment successively；
D) cultivate, the autogenous bone after the process in step C be assembled on described nasal bone matrix, and cultivate 24h,
E) chisel and carve, by step D) in culture after described nasal bone matrix chisel and carve in need shape, you can.
Concrete processing procedure in step C of the present invention includes：
(1) described autogenous bone is immersed 6-24 hour in chloroform and methanol mixed liquid；Wherein：Described chloroform and first
The volume ratio of the chloroform in alcohol mixed liquor and methanol is 1：1；
(2) the described autogenous bone after above-mentioned steps (1) process is added in hydrochloric acid solution, continuously stirred 8-12 is little
When；The concentration of described hydrochloric acid solution is 0.5-0.6mol/L；
(3) by the described autogenous bone immersion TritonX-100 and ammonia mixed solution after above-mentioned steps (2) process
Effect 2-72 hour；The volumn concentration of the TritonX-100 in described TritonX-100 and ammonia mixed solution is
0.1%-2%, the weight/mass percentage composition of ammonia is 0.3%；
(4) by the described autogenous bone lyophilization after above-mentioned steps (3) process, sterilization treatment；Wherein, described freezing
Freeze-dried 24h～48h in the dry freeze dryer referring to put into described autogenous bone -72 DEG C～-80 DEG C；At described sterilizing
Reason refers to put into sterilizing, the matter of oxirane in ethylene oxide sterilizer after described autogenous bone plastic bag packaging seal
Amount concentration controls in 480mg/L～520mg/L, and sterilising temp controls at 38 DEG C～42 DEG C, and sterilizing humidity is 45%～55%, goes out
Bacterium action time is 3h～4h, and sterilization intensity is in 1500mg/h L～2000mg/h L.
The process of chiseling and carving described in step E of the present invention includes by laser equipment, described autogenous bone being punched, its
In, bore dia is 0.02mm-0.1mm；Hole density is 3000-200000/cm2.
Embodiment 1
1st, silica gel particle material is adopted to make nasal bone matrix, nasal bone matrix is provided with numerous hollow holes；
2nd, obtain autologous rib cartilage in an aseptic environment；Preferably take the 11st section or the 12nd section rib, use distilled water
Clean up and soak；
3rd, described autogenous bone is immersed in chloroform and methanol mixed liquid and carry out defat in 24 hours；Wherein：Described chlorine
The volume ratio of the chloroform in imitative and methyl alcohol mixed liquor and methanol is 1：1, it is carried out with distilled water after taking-up；
4th, the autogenous bone after defat is immersed in the hydrochloric acid solution that concentration is 0.5mol/L, and continuously stirred 12 hours
Carry out decalcification, be carried out with distilled water after taking-up；
5th, the autogenous bone after decalcification is immersed to act in TritonX-100 and ammonia mixed solution and taken off for 72 hours
Albumen；Wherein, the volumn concentration of the TritonX-100 in described TritonX-100 and ammonia mixed solution is 1.5%,
The weight/mass percentage composition of ammonia is 0.3%, is carried out with distilled water after taking-up；
6th, the autogenous bone after deproteinization is placed in after freeze-dried 24h in -80 DEG C of freeze dryer, uses plastic bag packaging
Sterilizing in ethylene oxide sterilizer is put into, the mass concentration of oxirane controls in 500mg/L, sterilising temp is 38 after sealing
DEG C, sterilizing humidity is 45%, and the sterilization functions time is 3h, and sterilization intensity is in 1500mg/h L.
7th, the autogenous bone after above-mentioned process is assembled to the hollow out in the hole on described nasal bone matrix, and cultivates
24h.
8th, the nasal bone matrix after above-mentioned process is chiseled and carved into the shape of needs, you can implantation.In order to ensure nasal bone matrix
Stable, described nasal bone matrix passes through laser equipment and is punched in its surface, and wherein, bore dia is 0.05mm；Hole density is 10000
Individual/cm2.
Embodiment 2
1st, silica gel particle material is adopted to make nasal bone matrix, nasal bone matrix is provided with numerous hollow holes；
2nd, obtain Auricular cartilage in an aseptic environment；Cleaned up with distilled water and soak；
3rd, described autogenous bone is immersed in chloroform and methanol mixed liquid and carry out defat in 24 hours；Wherein：Described chlorine
The volume ratio of the chloroform in imitative and methyl alcohol mixed liquor and methanol is 1：1, it is carried out with distilled water after taking-up；
4th, the autogenous bone after defat is immersed in the hydrochloric acid solution that concentration is 0.6mol/L, and continuously stirred 12 hours
Carry out decalcification, be carried out with distilled water after taking-up；
5th, the autogenous bone after decalcification is immersed to act in TritonX-100 and ammonia mixed solution and taken off for 72 hours
Albumen；Wherein, the volumn concentration of the TritonX-100 in described TritonX-100 and ammonia mixed solution is 1%, ammonia
Weight/mass percentage composition be 0.3%, be carried out with distilled water after taking-up；
6th, the autogenous bone after deproteinization is placed in after freeze-dried 24h in -80 DEG C of freeze dryer, uses plastic bag packaging
Sterilizing in ethylene oxide sterilizer is put into, the mass concentration of oxirane controls in 500mg/L, sterilising temp is 40 after sealing
DEG C, sterilizing humidity is 45%, and the sterilization functions time is 3h, and sterilization intensity is in 2000mg/h L.
7th, the autogenous bone after above-mentioned process is assembled to the hollow out in the hole on described nasal bone matrix, and cultivates
24h.
8th, the nasal bone matrix after above-mentioned process is chiseled and carved into the shape of needs, you can implantation.In order to ensure nasal bone matrix
Stable, described nasal bone matrix passes through laser equipment and is punched in its surface, and wherein, bore dia is 0.05mm；Hole density is 15000
Individual/cm2.
Embodiment 3
1st, silica gel particle material is adopted to make nasal bone matrix, nasal bone matrix is provided with numerous hollow holes；
2nd, obtain autologous rib cartilage in an aseptic environment；Preferably take the 11st section or the 12nd section rib, use distilled water
Clean up and soak；
3rd, described autogenous bone is immersed in chloroform and methanol mixed liquid and carry out defat in 24 hours；Wherein：Described chlorine
The volume ratio of the chloroform in imitative and methyl alcohol mixed liquor and methanol is 1：1, it is carried out with distilled water after taking-up；
4th, the autogenous bone after defat is immersed in the hydrochloric acid solution that concentration is 0.6mol/L, and continuously stirred 12 hours
Carry out decalcification, be carried out with distilled water after taking-up；
5th, the autogenous bone after decalcification is immersed to act in TritonX-100 and ammonia mixed solution and taken off for 72 hours
Albumen；Wherein, the volumn concentration of the TritonX-100 in described TritonX-100 and ammonia mixed solution is 0.5%,
The weight/mass percentage composition of ammonia is 0.3%, is carried out with distilled water after taking-up；
6th, the autogenous bone after deproteinization is placed in after freeze-dried 24h in -80 DEG C of freeze dryer, uses plastic bag packaging
Sterilizing in ethylene oxide sterilizer is put into, the mass concentration of oxirane controls in 500mg/L, sterilising temp is 38 after sealing
DEG C, sterilizing humidity is 45%, and the sterilization functions time is 3h, and sterilization intensity is in 1500mg/h L.
7th, the autogenous bone after above-mentioned process is assembled to the hollow out in the hole on described nasal bone matrix, and cultivates
24h.
8th, the nasal bone matrix after above-mentioned process is chiseled and carved into the shape of needs, you can implantation.In order to ensure nasal bone matrix
Stable, described nasal bone matrix passes through laser equipment and is punched in its surface, and wherein, bore dia is 0.08mm；Hole density be 8000/
cm2.
Comparing result
Make nasal bone prosthese according to the preparation method of above-described embodiment 1,2,3 respectively, and be implanted in corresponding human body
It is tracked and observes, statistical data is shown in Table lattice 1.
Form 1
This result surface prosthesis implantation effect is good, no rejects, and healing is good.
Material due to the present invention adopts autogenous bone of the same race, no rejects, and is provided with hole on the surface of cartilage, passes through
Hole can allow body fluid flow into hole and grow tissue, allow nose to be connected with nose prosthesiss, prevent nose prosthesiss mobile, de-
Fall, fester, prevent the pain of postoperative patient.
Ultimate principle and principal character and the advantages of the present invention of the present invention have been shown and described above.The technology of the industry
, it should be appreciated that the present invention is not restricted to the described embodiments, the simply explanation described in above-described embodiment and description is originally for personnel
The principle of invention, without departing from the spirit and scope of the present invention, the present invention also has various changes and modifications, these changes
Change and improvement both falls within scope of the claimed invention.Claimed scope by appending claims and its
Equivalent thereof.
Claims (10)
1. a kind of material for nose shaping filling autogenous bone joint silica gel particle is it is characterised in that include by silica gel
The nasal bone matrix that granule is made, described nasal bone matrix includes nose, nose pillar, the bridge of the nose, and the described bridge of the nose is connected by nose
Nose pillar；
The bottom of the described bridge of the nose is made up of two shape that is in the shape of the letter V bridge of the nose sections arranged in a crossed manner, and the nasal bone of human body is located at two institutes
State between bridge of the nose section, to ensure that prosthese will not displacement and abrasion；
Hollow out body is had on described nasal bone matrix, described hollow out body is filled with autogenous bone.
2. a kind of material filling autogenous bone joint silica gel particle for nose shaping according to claim 1, its
It is characterised by, described bridge of the nose section is replaced by autogenous bone.
3. a kind of material filling autogenous bone joint silica gel particle for nose shaping according to claim 1, its
It is characterised by, the surface of the described bridge of the nose is densely covered with numerous holes.
4. a kind of material filling autogenous bone joint silica gel particle for nose shaping according to claim 3, its
It is characterised by, described hole is through hole or non through hole.
5. a kind of material filling autogenous bone joint silica gel particle for nose shaping according to claim 3, its
It is characterised by, described hole is non through hole, the bottom of described hole is plane or arc surface.
6. a kind of material filling autogenous bone joint silica gel particle for nose shaping according to claim 3, its
It is characterised by, the surface being arranged in the described bridge of the nose of described hole rule, the spacing between described hole and hole is identical.
7. a kind of for nose shaping fill autogenous bone joint silica gel particle material preparation method it is characterised in that
Comprise the following steps：
A) matrix makes, and makes nasal bone matrix using silica gel particle material；
B) take bone, obtain autogenous bone in an aseptic environment；
C) process, the described autogenous bone obtaining is carried out defat, decalcification, deproteinization and sterilization treatment successively；
D) cultivate, the autogenous bone after the process in step C be assembled on described nasal bone matrix, and cultivate 24h,
E) chisel and carve, by step D) in culture after described nasal bone matrix chisel and carve in such as claim 1-6 any claim institute
A kind of shape of the material filling autogenous bone joint silica gel particle for nose shaping stated, you can.
8. the system of a kind of material filling autogenous bone joint silica gel particle for nose shaping according to claim 7
Preparation Method is it is characterised in that the concrete processing procedure in step C includes：
(1) described autogenous bone is immersed 6-24 hour in chloroform and methanol mixed liquid；
(2) the described autogenous bone after above-mentioned steps (1) process is added in hydrochloric acid solution, continuously stirred 8-12 hour；
(3) will act in the described autogenous bone immersion TritonX-100 after above-mentioned steps (2) process and ammonia mixed solution
2-72 hour；
(4) by the described autogenous bone lyophilization after above-mentioned steps (3) process, sterilization treatment；
Wherein：The volume ratio of the chloroform in described chloroform and methyl alcohol mixed liquor and methanol is 1：1；
The concentration of described hydrochloric acid solution is 0.5-0.6mol/L；
The volumn concentration of the TritonX-100 in described TritonX-100 and ammonia mixed solution is 0.1%-2%, ammonia
Weight/mass percentage composition be 0.3%；
Freeze-dried 24h in the freeze dryer that described lyophilization refers to put into described autogenous bone -72 DEG C～-80 DEG C～
48h；
Described sterilization treatment refers to go out putting in ethylene oxide sterilizer after described autogenous bone plastic bag packaging seal
Bacterium, the mass concentration of oxirane controls in 480mg/L～520mg/L, and sterilising temp controls at 38 DEG C～42 DEG C, and sterilize humidity
For 45%～55%, the sterilization functions time is 3h～4h, and sterilization intensity is in 1500mg/h L～2000mg/h L；Or
Described sterilization treatment is irradiation sterilization, and the ultraviolet light of irradiation is 265-266nm, and the sterilization functions time is 3h～4h.
9. the system of a kind of material filling autogenous bone joint silica gel particle for nose shaping according to claim 7
Preparation Method is it is characterised in that described autogenous bone is autologous rib, Auricular cartilage.
10. a kind of material filling autogenous bone joint silica gel particle for nose shaping according to claim 7
Preparation method it is characterised in that the described process of chiseling and carving includes by laser equipment, described autogenous bone being punched, wherein, hole
A diameter of 0.02mm-0.1mm；Hole density is 3000-200000/cm2.
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| CN201611123420.4A CN106421890A (en) | 2016-12-08 | 2016-12-08 | Material used for autologous cortical bone synostosis silica gel particle for nasal plasty and preparation method of material |
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| CN201611123420.4A CN106421890A (en) | 2016-12-08 | 2016-12-08 | Material used for autologous cortical bone synostosis silica gel particle for nasal plasty and preparation method of material |
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| CN110075356A (en) * | 2019-03-28 | 2019-08-02 | 中国辐射防护研究院 | A kind of plasticity packing material and preparation method thereof for surgical intervention bone defect |
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