CN206621583U - A kind of structure for nose shaping filling autogenous bone joint silica gel particle - Google Patents
A kind of structure for nose shaping filling autogenous bone joint silica gel particle Download PDFInfo
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- CN206621583U CN206621583U CN201621342347.5U CN201621342347U CN206621583U CN 206621583 U CN206621583 U CN 206621583U CN 201621342347 U CN201621342347 U CN 201621342347U CN 206621583 U CN206621583 U CN 206621583U
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Abstract
It the utility model is related to a kind of structure for nose shaping filling autogenous bone joint silica gel particle, the structure includes the nasal bone matrix being made by silica gel particle, the nasal bone matrix includes nose, nose pillar, the bridge of the nose, and the bridge of the nose connects nose pillar by nose；The bottom of the bridge of the nose is made up of two shapes that are in the shape of the letter V bridge of the nose section arranged in a crossed manner, and the nasal bone of human body is located between two bridge of the nose sections, to ensure that prosthese will not displacement and abrasion；There is hollow out body on the nasal bone matrix, autogenous bone is filled with the hollow out body.Beneficial effect is：Pass through the design of bridge of the nose section so that prosthese is in close contact with nasal bone, will not displacement or abrasion；By the hole on the bridge of the nose body fluid can be allowed to flow into hole and grow tissue, nose is promoted to be merged with ose implant stable, prevent that ose implant is mobile, come off, fester, prevent the pain of postoperative patient, this method is applied to androgynous, allosome synostosis silica gel particle processing.
Description
Technical field
Shaping technique field is the utility model is related to, is used for nose shaping filling autogenous bone connection more particularly, to one kind
Close the structure of silica gel particle.
Background technology
Nasal plastic (lift face) operation be to change the height of nose and form by being implanted into suitable material, be allowed to face other
Position is mutually coordinated, and is a kind of most common operation of field of orthopedic surgery.
Medically, nasal plastic material has many kinds, such as medical grade silicon rubber, autologous cartilage, allogeneic cartilage, animal tendon
Or ligament, varicosity (polytetrafluoroethylene (PTFE)), sodium hyaluronate etc..The preparation method of bridge of the nose prosthese is also more, wherein, autologous cartilage is due to coming
From body, so be not in rejection, also not sensitization, but it is moulding relatively difficult in manufacturing process, increase patient suffering.
Using allogeneic cartilage animal tendon, ligament as raw material, because its composition and structure are similar to tissue, good biocompatibility,
Implantation does not cause immunological rejection, can induce regeneration, but need to be handled through a series of biochemical technologies, and manufacturing process is more multiple
It is miscellaneous.For firm silicone rubber hump nose material because nontoxic, histocompatbility is relatively stable, is main medical prosthesis augmentation rhinoplasty material
Material, be easy to moulding in manufacturing process, but silicon rubber implant implant after be easily shifted over and wear.
Therefore, a kind of appearance of structure for nose shaping filling autogenous bone joint silica gel particle is necessary
, its manufacturing process is convenient, Stability Analysis of Structures, is not susceptible to shift and wears.
Utility model content
The utility model provides a kind of structure for nose shaping filling autogenous bone joint silica gel particle, to solve
Manufacturing process is more complicated in the prior art, the problems such as being easily subjected to displacement and wear.
The technical problem that the utility model solves is realized using following technical scheme：
It is a kind of for nose shaping filling autogenous bone joint silica gel particle structure, including by silica gel particle make and
Into nasal bone matrix, the nasal bone matrix include nose, nose pillar, the bridge of the nose, the bridge of the nose pass through nose connect nose pillar；
The bottom of the bridge of the nose is made up of two shapes that are in the shape of the letter V bridge of the nose section arranged in a crossed manner, and the nasal bone of human body is located at two
Between the individual bridge of the nose section, to ensure that prosthese will not displacement and abrasion；
There is hollow out body on the nasal bone matrix, autogenous bone is filled with the hollow out body, to reduce this material
Weight.
As preferable technical scheme, the bridge of the nose section is replaced by autogenous bone.
As preferable technical scheme, the surface of the bridge of the nose is densely covered with numerous holes, passes through described hole prosthese
It is flexible, it can stretch, can be very good to be bonded nose, hole can allow body fluid to flow into hole to promote fusion, allow nose
It is connected with ose implant, prevents that ose implant is mobile, come off, fester, prevent the pain of postoperative patient.
As preferable technical scheme, described hole is through hole or non through hole.
As preferable technical scheme, described hole is non through hole, and the bottom of described hole is plane or arc surface.It is described
What hole can be typed it out with laser, laser equipment punched hole, its hole periphery is mellow and full, and bottom is one smooth, impulse- free robustness.
As preferable technical scheme, the surface for being arranged in the bridge of the nose of described hole rule, described hole and hole
Between spacing it is identical, it is overall very attractive in appearance.A diameter of 0.02mm-0.1mm of described hole.
A kind of preparation method of the structure of nose shaping filling autogenous bone joint silica gel particle, comprises the following steps：
A) matrix is made, and nasal bone matrix is made using silica gel particle material；
B bone) is taken, obtains autogenous bone in an aseptic environment；
C) handle, the autogenous bone of acquirement is subjected to degreasing, decalcification, de- albumen and sterilization treatment successively；
D) cultivate, the autogenous bone after the processing in step C be assembled on the nasal bone matrix, and cultivate 24h,
E) chisel and carve, by step D) in culture after the nasal bone matrix chisel and carve into shape in needs, you can.
As preferable technical scheme, the autogenous bone is autologous rib, Auricular cartilage.
As preferable technical scheme, the concrete processing procedure in step B includes：
(1) autogenous bone is immersed into 6-24 hours in chloroform and methyl alcohol mixed liquor body；
(2) autogenous bone after above-mentioned steps (1) processing is added in hydrochloric acid solution, it is small persistently stirs 8-12
When；
(3) autogenous bone after above-mentioned steps (2) processing is immersed in TritonX-100 and ammoniacal liquor mixed solution
Act on 2-72 hours；
(4) by the autogenous bone freeze-drying after above-mentioned steps (3) processing, sterilization treatment；
Wherein：The volume ratio of chloroform and methanol in the chloroform and methyl alcohol mixed liquor is 1：1；
The concentration of the hydrochloric acid solution is 0.5-0.6mol/L；
The volumn concentration of TritonX-100 in TritonX-100 and the ammoniacal liquor mixed solution is 0.1%-
2%, the weight/mass percentage composition of ammonia is 0.3%；
The freeze-drying refers to the autogenous bone being put into freeze-dried 24h in -72 DEG C~-80 DEG C of freeze dryer
~48h；
The sterilization treatment refers to the autogenous bone with being put into ethylene oxide sterilizer after plastic bag packaging seal
Interior sterilizing, the mass concentration control of oxirane are controlled at 38 DEG C~42 DEG C in 480mg/L~520mg/L, sterilising temp, sterilizing
Humidity is 45%~55%, and the sterilization functions time is 3h~4h, and sterilization intensity is in 1500mg/hL~2000mg/hL.
As preferable technical scheme, the process of chiseling and carving includes punching the autogenous bone by laser equipment.
As preferable technical scheme, the bore dia that laser equipment punches to the autogenous bone is 0.02mm-
0.1mm；Hole density is 3000-200000/cm2。
The utility model has an advantageous effect in that：Pass through the design of bridge of the nose section so that prosthese is in close contact with nasal bone, no
Can displacement or abrasion；By the hole on the bridge of the nose body fluid can be allowed to flow into hole to grow tissue, make nose false with nose
Body finally merges, and prevents that ose implant is mobile, comes off, festers, prevents the pain of postoperative patient.
Brief description of the drawings
, below will be to implementing in order to illustrate more clearly of the utility model embodiment or technical scheme of the prior art
The required accompanying drawing used is briefly described in scheme or description of the prior art, it should be apparent that, drawings in the following description
Only some embodiments of the present utility model, for those of ordinary skill in the art, do not paying creative work
Property on the premise of, other accompanying drawings can also be obtained according to these accompanying drawings.
Fig. 1 is the utility model：A kind of knot of structure for nose shaping filling autogenous bone joint silica gel particle
Structure schematic diagram；
Fig. 2 is the utility model：A kind of structure for nose shaping filling autogenous bone joint silica gel particle is bowed
View；
Fig. 3 is the utility model：A kind of system of structure for nose shaping filling autogenous bone joint silica gel particle
The schematic flow sheet of Preparation Method.
Embodiment
In order that technological means, creation characteristic, reached purpose and effect that the utility model is realized are easy to understand, under
Face combines and is specifically illustrating, and the utility model is expanded on further.
Shown in reference picture 1-2, a kind of structure for nose shaping filling autogenous bone joint silica gel particle, including by
The nasal bone matrix 100 that silica gel particle is made, silica gel particle material have the advantages that light weight, intensity are high, corrosion-resistant；Nasal bone
Matrix 100 includes nose 1, nose pillar 2, the bridge of the nose 3, and the bridge of the nose 3 connects nose pillar 2 by nose 1；The bottom of the bridge of the nose 3 is in V by two
Word shape bridge of the nose section 12 arranged in a crossed manner forms, and the nasal bone of human body is located between two bridge of the nose sections 12, to ensure that prosthese will not
Displacement and abrasion.There is hollow out body 101 on the nasal bone matrix 100, autogenous bone is filled with the hollow out body 101, with
The weight of this material is reduced, meanwhile, autogenous bone can be realized realizes fusion growth with itself nasal bone, Stability Analysis of Structures, prevents
Ose implant is mobile, comes off.Preferably, the bridge of the nose section 12 is also replaced by autogenous bone.
The surface of the bridge of the nose 3 of the present utility model is densely covered with numerous holes 11, flexible by the prosthese of hole 11, can
With stretching, can be very good to be bonded nose, hole 11 can allow body fluid to flow into and hole 11 and grow tissue, allow nose with
Ose implant is connected, and prevents that ose implant is mobile, comes off, festers, prevents the pain of postoperative patient.Preferably, hole 11 is
Through hole or non through hole.
Hole 11 of the present utility model is non through hole, and the bottom of hole 11 is plane or arc surface.Hole 11, which can be used, to swash
What light typed it out, laser equipment punched hole, its hole periphery is mellow and full, and bottom is one smooth, impulse- free robustness.
The surface for being arranged in the bridge of the nose 3 or bridge of the nose section 12 of the rule of hole of the present utility model 11, hole 11 and hole 11 it
Between spacing it is identical, it is overall very attractive in appearance.The bore dia of hole 11 is 0.02mm-0.1mm；Hole density be 3000-200000/
cm2。
Shown in reference picture 3, the utility model also proposed a kind of nose shaping filling autogenous bone that is used for and combine silica gel
The preparation method of the structure of particle, comprises the following steps：
A) matrix is made, and nasal bone matrix is made using silica gel particle material；
B bone) is taken, obtains autogenous bone in an aseptic environment；
C) handle, the autogenous bone of acquirement is subjected to degreasing, decalcification, de- albumen and sterilization treatment successively；
D) cultivate, the autogenous bone after the processing in step C be assembled on the nasal bone matrix, and cultivate 24h,
E) chisel and carve, by step D) in culture after the nasal bone matrix chisel and carve into shape in needs, you can.
Concrete processing procedure in the step C of the utility model includes：
(1) autogenous bone is immersed into 6-24 hours in chloroform and methyl alcohol mixed liquor body；Wherein：The chloroform and first
The volume ratio of chloroform and methanol in alcohol mixed liquor is 1：1；
(2) autogenous bone after above-mentioned steps (1) processing is added in hydrochloric acid solution, it is small persistently stirs 8-12
When；The concentration of the hydrochloric acid solution is 0.5-0.6mol/L；
(3) autogenous bone after above-mentioned steps (2) processing is immersed in TritonX-100 and ammoniacal liquor mixed solution
Act on 2-72 hours；The volumn concentration of TritonX-100 in TritonX-100 and the ammoniacal liquor mixed solution is
0.1%-2%, the weight/mass percentage composition of ammonia is 0.3%；
(4) by the autogenous bone freeze-drying after above-mentioned steps (3) processing, sterilization treatment；Wherein, the freezing
Drying refers to the autogenous bone being put into freeze-dried 24h~48h in -72 DEG C~-80 DEG C of freeze dryer；At the sterilizing
Reason refers to sterilize the autogenous bone with being put into ethylene oxide sterilizer after plastic bag packaging seal, the matter of oxirane
Measure concentration control to control at 38 DEG C~42 DEG C in 480mg/L~520mg/L, sterilising temp, sterilizing humidity is 45%~55%, is gone out
Bacterium action time is 3h~4h, and sterilization intensity is in 1500mg/hL~2000mg/hL.
The process of chiseling and carving in the step E of the utility model includes beating the autogenous bone by laser equipment
Hole, wherein, bore dia 0.02mm-0.1mm；Hole density is 3000-200000/cm2。
Embodiment 1
1st, nasal bone matrix is made using silica gel particle material, nasal bone matrix is provided with numerous hollow holes；
2nd, autologous rib cartilage is obtained in an aseptic environment；It is preferred that taking the 11st section or the 12nd section rib, distilled water is used
Clean up and soak；
3rd, the autogenous bone is immersed 24 hours in chloroform and methyl alcohol mixed liquor body and carries out degreasing；Wherein：The chlorine
The volume ratio of chloroform and methanol in imitative and methyl alcohol mixed liquor is 1：1, cleaned after taking-up with distilled water；
4th, the autogenous bone after degreasing is immersed in the hydrochloric acid solution that concentration is 0.5mol/L, and continues stirring 12 hours
Decalcification is carried out, is cleaned after taking-up with distilled water；
5th, the autogenous bone after decalcification is immersed in TritonX-100 and ammoniacal liquor mixed solution to act on 72 hours and taken off
Albumen；Wherein, the volumn concentration of the TritonX-100 in TritonX-100 and the ammoniacal liquor mixed solution is 1.5%,
The weight/mass percentage composition of ammonia is 0.3%, is cleaned after taking-up with distilled water；
6th, the autogenous bone after de- albumen is placed in -80 DEG C of freeze dryer after freeze-dried 24h, uses plastic bag packaging
It is put into ethylene oxide sterilizer and sterilizes after sealing, the mass concentration of oxirane is controlled in 500mg/L, sterilising temp 38
DEG C, sterilizing humidity is 45%, and the sterilization functions time is 3h, and sterilization intensity is in 1500mg/hL.
7th, the autogenous bone after above-mentioned processing is assembled in the hollow hole on the nasal bone matrix, and cultivated
24h。
The 8th, nasal bone matrix after above-mentioned processing is chiseled and carved into the shape of needs, you can implantation.In order to ensure nasal bone matrix
Stable, the nasal bone matrix is punched by laser equipment to its surface, wherein, bore dia 0.05mm；Hole density is 10000
Individual/cm2。
Embodiment 2
1st, nasal bone matrix is made using silica gel particle material, nasal bone matrix is provided with numerous hollow holes；
2nd, Auricular cartilage is obtained in an aseptic environment；Cleaned up and soaked with distilled water；
3rd, the autogenous bone is immersed 24 hours in chloroform and methyl alcohol mixed liquor body and carries out degreasing；Wherein：The chlorine
The volume ratio of chloroform and methanol in imitative and methyl alcohol mixed liquor is 1：1, cleaned after taking-up with distilled water；
4th, the autogenous bone after degreasing is immersed in the hydrochloric acid solution that concentration is 0.6mol/L, and continues stirring 12 hours
Decalcification is carried out, is cleaned after taking-up with distilled water；
5th, the autogenous bone after decalcification is immersed in TritonX-100 and ammoniacal liquor mixed solution to act on 72 hours and taken off
Albumen；Wherein, the volumn concentration of the TritonX-100 in TritonX-100 and the ammoniacal liquor mixed solution is 1%, ammonia
Weight/mass percentage composition be 0.3%, cleaned after taking-up with distilled water；
6th, the autogenous bone after de- albumen is placed in -80 DEG C of freeze dryer after freeze-dried 24h, uses plastic bag packaging
It is put into ethylene oxide sterilizer and sterilizes after sealing, the mass concentration of oxirane is controlled in 500mg/L, sterilising temp 40
DEG C, sterilizing humidity is 45%, and the sterilization functions time is 3h, and sterilization intensity is in 2000mg/hL.
7th, the autogenous bone after above-mentioned processing is assembled in the hollow hole on the nasal bone matrix, and cultivated
24h。
The 8th, nasal bone matrix after above-mentioned processing is chiseled and carved into the shape of needs, you can implantation.In order to ensure nasal bone matrix
Stable, the nasal bone matrix is punched by laser equipment to its surface, wherein, bore dia 0.05mm；Hole density is 15000
Individual/cm2。
Embodiment 3
1st, nasal bone matrix is made using silica gel particle material, nasal bone matrix is provided with numerous hollow holes；
2nd, autologous rib cartilage is obtained in an aseptic environment；It is preferred that taking the 11st section or the 12nd section rib, distilled water is used
Clean up and soak；
3rd, the autogenous bone is immersed 24 hours in chloroform and methyl alcohol mixed liquor body and carries out degreasing；Wherein：The chlorine
The volume ratio of chloroform and methanol in imitative and methyl alcohol mixed liquor is 1：1, cleaned after taking-up with distilled water；
4th, the autogenous bone after degreasing is immersed in the hydrochloric acid solution that concentration is 0.6mol/L, and continues stirring 12 hours
Decalcification is carried out, is cleaned after taking-up with distilled water；
5th, the autogenous bone after decalcification is immersed in TritonX-100 and ammoniacal liquor mixed solution to act on 72 hours and taken off
Albumen；Wherein, the volumn concentration of the TritonX-100 in TritonX-100 and the ammoniacal liquor mixed solution is 0.5%,
The weight/mass percentage composition of ammonia is 0.3%, is cleaned after taking-up with distilled water；
6th, the autogenous bone after de- albumen is placed in -80 DEG C of freeze dryer after freeze-dried 24h, uses plastic bag packaging
It is put into ethylene oxide sterilizer and sterilizes after sealing, the mass concentration of oxirane is controlled in 500mg/L, sterilising temp 38
DEG C, sterilizing humidity is 45%, and the sterilization functions time is 3h, and sterilization intensity is in 1500mg/hL.
7th, the autogenous bone after above-mentioned processing is assembled in the hollow hole on the nasal bone matrix, and cultivated
24h。
The 8th, nasal bone matrix after above-mentioned processing is chiseled and carved into the shape of needs, you can implantation.In order to ensure nasal bone matrix
Stable, the nasal bone matrix is punched by laser equipment to its surface, wherein, bore dia 0.08mm；Hole density be 8000/
cm2。
Comparing result
Nasal bone prosthese is made according to the preparation method of above-described embodiment 1,2,3 respectively, and is implanted into corresponding human body
It is tracked and observes, statistics is shown in Table lattice 1.
Form 1
Result surface prosthesis implantation effect is good, no rejection, and healing is good.
Because material of the present utility model uses autogenous bone of the same race, no rejection, and hole is provided with the surface of cartilage,
By hole can allow body fluid flow into hole grow tissue, allow nose to be connected with ose implant, prevent ose implant movement,
Come off, fester, prevent the pain of postoperative patient.
The advantages of general principle and principal character of the present utility model and the utility model has been shown and described above.One's own profession
The technical staff of industry is it should be appreciated that the utility model is not restricted to the described embodiments, described in above-described embodiment and specification
Simply illustrate principle of the present utility model, on the premise of the spirit and scope of the utility model is not departed from, the utility model is also
Various changes and modifications are had, these changes and improvements are both fallen within claimed the scope of the utility model.The utility model
Claimed scope is by appended claims and its equivalent thereof.
Claims (6)
1. a kind of structure for nose shaping filling autogenous bone joint silica gel particle, it is characterised in that including by silica gel
The nasal bone matrix that particle is made, the nasal bone matrix include nose, nose pillar, the bridge of the nose, and the bridge of the nose is connected by nose
Nose pillar；
The bottom of the bridge of the nose is made up of two shapes that are in the shape of the letter V bridge of the nose section arranged in a crossed manner, and the nasal bone of human body is located at two institutes
Between stating bridge of the nose section, to ensure that prosthese will not displacement and abrasion；
There is hollow out body on the nasal bone matrix, autogenous bone is filled with the hollow out body.
2. a kind of structure for nose shaping filling autogenous bone joint silica gel particle according to claim 1, its
It is characterised by, the bridge of the nose section is replaced by autogenous bone.
3. a kind of structure for nose shaping filling autogenous bone joint silica gel particle according to claim 1, its
It is characterised by, the surface of the bridge of the nose is densely covered with numerous holes.
4. a kind of structure for nose shaping filling autogenous bone joint silica gel particle according to claim 3, its
It is characterised by, described hole is through hole or non through hole.
5. a kind of structure for nose shaping filling autogenous bone joint silica gel particle according to claim 3, its
It is characterised by, described hole is non through hole, and the bottom of described hole is plane or arc surface.
6. a kind of structure for nose shaping filling autogenous bone joint silica gel particle according to claim 3, its
It is characterised by, the surface for being arranged in the bridge of the nose of described hole rule, the spacing between described hole and hole is identical.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621342347.5U CN206621583U (en) | 2016-12-08 | 2016-12-08 | A kind of structure for nose shaping filling autogenous bone joint silica gel particle |
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| CN201621342347.5U CN206621583U (en) | 2016-12-08 | 2016-12-08 | A kind of structure for nose shaping filling autogenous bone joint silica gel particle |
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| CN206621583U true CN206621583U (en) | 2017-11-10 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106421890A (en) * | 2016-12-08 | 2017-02-22 | 大连裕辰科技发展有限公司 | Material used for autologous cortical bone synostosis silica gel particle for nasal plasty and preparation method of material |
-
2016
- 2016-12-08 CN CN201621342347.5U patent/CN206621583U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106421890A (en) * | 2016-12-08 | 2017-02-22 | 大连裕辰科技发展有限公司 | Material used for autologous cortical bone synostosis silica gel particle for nasal plasty and preparation method of material |
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