CN106421876A - Surgical operation suturing material and preparation method thereof - Google Patents
Surgical operation suturing material and preparation method thereof Download PDFInfo
- Publication number
- CN106421876A CN106421876A CN201610917581.4A CN201610917581A CN106421876A CN 106421876 A CN106421876 A CN 106421876A CN 201610917581 A CN201610917581 A CN 201610917581A CN 106421876 A CN106421876 A CN 106421876A
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- CN
- China
- Prior art keywords
- parts
- surgical operation
- suturing material
- operation suturing
- ossein
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
- A61L17/12—Homopolymers or copolymers of glycolic acid or lactic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/005—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/08—At least partially resorbable materials of animal origin, e.g. catgut, collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
Abstract
The invention discloses a surgical operation suturing material and a preparation method thereof. The surgical operation suturing material comprises the following raw materials in parts by weight: 15-23 parts of polyglycolic acid, 5-8 parts of ossein, 11-14 parts of polylactic acid, 0.5-0.9 part of tryptophan, 0.4-0.8 part of fish collagen protein, 2-4 parts of radix achyranthis bidentatae and 0.01-0.05 part of nisin. The surgical operation suturing material disclosed by the invention is free of toxin, harm and accumulation, easy to process and mold, high in strength, easy to tie and good in properties such as flexibility and sterilization and disinfection resistance, capable of promoting heal of a wound, and can be completely absorbed and degraded in biological tissue within 15-25 days.
Description
Technical field
The present invention relates to a kind of medical material field, specifically a kind of surgical operation suturing material and preparation method thereof.
Background technology
Suture is common bio-compatible textile, is widely used in all kinds of surgical operations, in order to suture wound
Mouthful, connection is organized and ligation blood vessel.Early in B.C. 3500, ancient Egyptian was just sewed up a wound with cotton fiber, Iuba Equi, in
In the history records in state's ancient times, also the record of stitching thread made by early useful flaxen fiber.With the development of high polymer and its fiber, medical sutures
The kind of line also gets more and more.
Stitching thread species is a lot, including absorbability and nonabsorbable stitching thread.The weaving of many common natural and synthesis
Be used successfully as medical not absorbable suture line with fiber, the not absorbable suture line species developed at present have cotton, silkworm silk,
Fiber crops, polyamide, polyester, polypropylene and metal suture line.Absorbable suture have casing, ossein, chitin, PGA,
The copolymer of Acetic acid, hydroxy-, bimol. cyclic ester and lactide, poly- to dioxane ethyl ketone stitching thread.
Suture must have following performance requirement：
(1) intensity of line is higher, is not affected by body fluid and deforms, and before wound healing, mechanical property does not have big change；(2)
The pliability of fiber is good, colludes with intensity height, passes through tissue easily during suture, easy to operate during ligation, holds knot after making knots
Property is good；(3) biocompatibility is good, and tissue reaction is little, does not affect the growth of tissue；(4) for absorbable sutures,
Should completely be absorbed after tissue repair, in human body, not left foreign body；(5) stable and reliable product quality, can preserve for a long time,
Easily sterilize and invariance；(6) there is no toxicity, anaphylaxis, electrolyte, septic, carcinogenecity and capillarity.
It can be seen that, the prescription of suture is very high, but currently most of sutures have that biocompatibility is low, suture is in tissue
Interior tensile strength is little and hinders the phenomenons such as normal wound healing, is badly in need of researching and developing a kind of new surgical operation suturing material.
Content of the invention
It is an object of the invention to provide a kind of surgical operation suturing material and preparation method thereof, to solve above-mentioned background
The problem proposing in technology.
For achieving the above object, the present invention provides following technical scheme：
A kind of surgical operation suturing material, in parts by weight, raw material is：Polyglycolic acid 15-23 part, ossein 5-8 part, poly-
Lactic acid 11-14 part, tryptophan 0.5-0.9 part, fish collagen 0.4-0.8 part, Radix Achyranthis Bidentatae 2-4 part, nisin 0.01-0.05 part.
As the further scheme of the present invention：In parts by weight, raw material is：Polyglycolic acid 18-21 part, ossein 6-7
Part, polylactic acid 12-13 part, tryptophan 0.6-0.8 part, fish collagen 0.5-0.7 part, Radix Achyranthis Bidentatae 2-4 part, nisin 0.02-
0.04 part.
As the further scheme of the present invention：In parts by weight, raw material is：20 parts of polyglycolic acid, 7 parts of ossein, poly-
13 parts of lactic acid, 0.7 part of tryptophan, 0.6 part of fish collagen, 3 parts of Radix Achyranthis Bidentatae, 0.03 part of nisin.
A kind of preparation method of surgical operation suturing material, concretely comprises the following steps：
（1）First, polyglycolic acid, polylactic acid and tryptophan are mixed, subsequently put in reactor, 2MPa pressure and nitrogen are protected
Reacted under shield, reaction passes through melt spinning after terminating, and obtains spinning mixture after cooling；
（2）Then, spinning mixture is mixed with ossein, fish collagen, Radix Achyranthis Bidentatae, nisin, control moisture to exist
45%-50%, is then used by sonic oscillation and processes, and the power that sonic oscillation is processed is 120W, and the time is 13 minutes, is placed in 4 DEG C of temperature
The lower oven drying at low temperature of degree, obtains surgical operation suturing material.
As the further scheme of the present invention：Step（2）Middle control moisture is 48%.
Compared with prior art, the invention has the beneficial effects as follows：
Suture new material that the present invention is obtained is nontoxic no to be accumulated, easy processing molding, and intensity is high, easily tie a knot, and has good
The premium properties such as good flexibility and resistant to the sterilising sterilizing, and the healing of wound can be promoted, can in biological tissue 15-25 days complete
Degraded by absorption.
Specific embodiment
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described,
Obviously, described embodiment is only a part of embodiment of the present invention, rather than whole embodiments.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under the premise of not making creative work, all
Belong to the scope of protection of the invention.
Embodiment 1
A kind of surgical operation suturing material, in parts by weight, raw material is：15 parts of polyglycolic acid, 5 parts of ossein, polylactic acid
11 parts, 0.5 part of tryptophan, 0.4 part of fish collagen, 2 parts of Radix Achyranthis Bidentatae, 0.01 part of nisin.
A kind of preparation method of surgical operation suturing material, concretely comprises the following steps：
（1）First, polyglycolic acid, polylactic acid and tryptophan are mixed, subsequently put in reactor, 2MPa pressure and nitrogen are protected
Reacted under shield, reaction passes through melt spinning after terminating, and obtains spinning mixture after cooling；
（2）Then, spinning mixture is mixed with ossein, fish collagen, Radix Achyranthis Bidentatae, nisin, control moisture to exist
45%, it is then used by sonic oscillation and processes, the power that sonic oscillation is processed is 120W, and the time is 13 minutes, at a temperature of being placed in 4 DEG C
Oven drying at low temperature, obtains surgical operation suturing material.
Embodiment 2
A kind of surgical operation suturing material, in parts by weight, raw material is：18 parts of polyglycolic acid, 6 parts of ossein, polylactic acid
12 parts, 0.6 part of tryptophan, 0.5 part of fish collagen, 2 parts of Radix Achyranthis Bidentatae, 0.02 part of nisin.
A kind of preparation method of surgical operation suturing material, concretely comprises the following steps：
（1）First, polyglycolic acid, polylactic acid and tryptophan are mixed, subsequently put in reactor, 2MPa pressure and nitrogen are protected
Reacted under shield, reaction passes through melt spinning after terminating, and obtains spinning mixture after cooling；
（2）Then, spinning mixture is mixed with ossein, fish collagen, Radix Achyranthis Bidentatae, nisin, control moisture to exist
45%, it is then used by sonic oscillation and processes, the power that sonic oscillation is processed is 120W, and the time is 13 minutes, at a temperature of being placed in 4 DEG C
Oven drying at low temperature, obtains surgical operation suturing material.
Embodiment 3
A kind of surgical operation suturing material, in parts by weight, raw material is：20 parts of polyglycolic acid, 7 parts of ossein, polylactic acid
13 parts, 0.7 part of tryptophan, 0.6 part of fish collagen, 3 parts of Radix Achyranthis Bidentatae, 0.03 part of nisin.
A kind of preparation method of surgical operation suturing material, concretely comprises the following steps：
（1）First, polyglycolic acid, polylactic acid and tryptophan are mixed, subsequently put in reactor, 2MPa pressure and nitrogen are protected
Reacted under shield, reaction passes through melt spinning after terminating, and obtains spinning mixture after cooling；
（2）Then, spinning mixture is mixed with ossein, fish collagen, Radix Achyranthis Bidentatae, nisin, control moisture to exist
48%, it is then used by sonic oscillation and processes, the power that sonic oscillation is processed is 120W, and the time is 13 minutes, at a temperature of being placed in 4 DEG C
Oven drying at low temperature, obtains surgical operation suturing material.
Embodiment 4
A kind of surgical operation suturing material, in parts by weight, raw material is：21 parts of polyglycolic acid, 7 parts of ossein, polylactic acid
13 parts, 0.8 part of tryptophan, 0.7 part of fish collagen, 4 parts of Radix Achyranthis Bidentatae, 0.04 part of nisin.
A kind of preparation method of surgical operation suturing material, concretely comprises the following steps：
（1）First, polyglycolic acid, polylactic acid and tryptophan are mixed, subsequently put in reactor, 2MPa pressure and nitrogen are protected
Reacted under shield, reaction passes through melt spinning after terminating, and obtains spinning mixture after cooling；
（2）Then, spinning mixture is mixed with ossein, fish collagen, Radix Achyranthis Bidentatae, nisin, control moisture to exist
50%, it is then used by sonic oscillation and processes, the power that sonic oscillation is processed is 120W, and the time is 13 minutes, at a temperature of being placed in 4 DEG C
Oven drying at low temperature, obtains surgical operation suturing material.
Embodiment 5
A kind of surgical operation suturing material, in parts by weight, raw material is：23 parts of polyglycolic acid, 8 parts of ossein, polylactic acid
14 parts, 0.9 part of tryptophan, 0.8 part of fish collagen, 4 parts of Radix Achyranthis Bidentatae, 0.05 part of nisin.
A kind of preparation method of surgical operation suturing material, concretely comprises the following steps：
（1）First, polyglycolic acid, polylactic acid and tryptophan are mixed, subsequently put in reactor, 2MPa pressure and nitrogen are protected
Reacted under shield, reaction passes through melt spinning after terminating, and obtains spinning mixture after cooling；
（2）Then, spinning mixture is mixed with ossein, fish collagen, Radix Achyranthis Bidentatae, nisin, control moisture to exist
50%, it is then used by sonic oscillation and processes, the power that sonic oscillation is processed is 120W, and the time is 13 minutes, at a temperature of being placed in 4 DEG C
Oven drying at low temperature, obtains surgical operation suturing material.
After tested, the surgical operation suture new material of embodiment of the present invention 1-5 preparation all meets YY1116-2010
Absorbability surgical suturess standard；The surgical operation of wherein specification 4-0 is more than 9.3N with suture new material tensile strength meansigma methodss,
Single value is more than 8.7N, and the surgical operation of specification 4-0 is more than 5.6N with suture new material bonding strength meansigma methodss, and single value is big
In 5.2N；Wherein chemical property testing result shows, surgical operation is excellent with the biological property of suture new material, and Intradermal test is no
Zest, no cytotoxicity, no sensitivity response, no pyrogen reaction, NIP reacts, and Salmonella reversion test is negative, average degraded week
Phase, the average healing cycle of wound was 4 days at 20 days（Taking mice cesarean as a example）.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of the spirit or essential attributes of the present invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit requires rather than described above limits, it is intended that all in the implication and scope of the equivalency of claim by falling
Change is included in the present invention.
Moreover, it will be appreciated that although this specification is been described by according to embodiment, not each embodiment only wraps
Containing an independent technical scheme, only for clarity, those skilled in the art should for this narrating mode of description
Using description as an entirety, the technical scheme in each embodiment can also form those skilled in the art through appropriately combined
Understandable other embodiment.
Claims (5)
1. it is characterised in that in parts by weight, raw material is a kind of surgical operation suturing material：Polyglycolic acid 15-23 part,
Ossein 5-8 part, polylactic acid 11-14 part, tryptophan 0.5-0.9 part, fish collagen 0.4-0.8 part, Radix Achyranthis Bidentatae 2-4 part, Buddhist nun's life
Plain 0.01-0.05 part.
2. it is characterised in that in parts by weight, raw material is surgical operation suturing material according to claim 1：Poly- hydroxyl
Guanidine-acetic acid 18-21 part, ossein 6-7 part, polylactic acid 12-13 part, tryptophan 0.6-0.8 part, fish collagen 0.5-0.7 part,
Radix Achyranthis Bidentatae 2-4 part, nisin 0.02-0.04 part.
3. it is characterised in that in parts by weight, raw material is surgical operation suturing material according to claim 1 and 2：
20 parts of polyglycolic acid, 7 parts of ossein, 13 parts of polylactic acid, 0.7 part of tryptophan, 0.6 part of fish collagen, 3 parts of Radix Achyranthis Bidentatae, Buddhist nun's life
0.03 part of element.
4. a kind of preparation method of described surgical operation suturing material as arbitrary in claim 1-3 is it is characterised in that concrete
Step is：
（1）First, polyglycolic acid, polylactic acid and tryptophan are mixed, subsequently put in reactor, 2MPa pressure and nitrogen are protected
Reacted under shield, reaction passes through melt spinning after terminating, and obtains spinning mixture after cooling；
（2）Then, spinning mixture is mixed with ossein, fish collagen, Radix Achyranthis Bidentatae, nisin, control moisture to exist
45%-50%, is then used by sonic oscillation and processes, and the power that sonic oscillation is processed is 120W, and the time is 13 minutes, is placed in 4 DEG C of temperature
The lower oven drying at low temperature of degree, obtains surgical operation suturing material.
5. the preparation method of surgical operation suturing material according to claim 4 is it is characterised in that step（2）Middle control
Moisture processed is 48%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610917581.4A CN106421876A (en) | 2016-10-21 | 2016-10-21 | Surgical operation suturing material and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610917581.4A CN106421876A (en) | 2016-10-21 | 2016-10-21 | Surgical operation suturing material and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106421876A true CN106421876A (en) | 2017-02-22 |
Family
ID=58176464
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610917581.4A Pending CN106421876A (en) | 2016-10-21 | 2016-10-21 | Surgical operation suturing material and preparation method thereof |
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| CN (1) | CN106421876A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU181548U1 (en) * | 2016-11-07 | 2018-07-19 | Татьяна Юрьевна Малинина | Absorbable surgical suture material for operations and manipulations on the muscles of the pelvis |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110251639A1 (en) * | 2010-04-08 | 2011-10-13 | Tyco Healthcare Group Lp | Coated Looped Suture |
| CN104474586A (en) * | 2014-11-25 | 2015-04-01 | 苏州市贝克生物科技有限公司 | Polyglycolic acid medical absorbable suture and preparation method thereof |
| CN105056294A (en) * | 2015-08-11 | 2015-11-18 | 安徽省康宁医疗用品有限公司 | Slow-release, antibacterial and absorbable medical suture and preparation method thereof |
| CN105251043A (en) * | 2015-10-28 | 2016-01-20 | 钊桂英 | Medical polylactic acid (PLA) suture line and manufacturing method |
-
2016
- 2016-10-21 CN CN201610917581.4A patent/CN106421876A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110251639A1 (en) * | 2010-04-08 | 2011-10-13 | Tyco Healthcare Group Lp | Coated Looped Suture |
| CN104474586A (en) * | 2014-11-25 | 2015-04-01 | 苏州市贝克生物科技有限公司 | Polyglycolic acid medical absorbable suture and preparation method thereof |
| CN105056294A (en) * | 2015-08-11 | 2015-11-18 | 安徽省康宁医疗用品有限公司 | Slow-release, antibacterial and absorbable medical suture and preparation method thereof |
| CN105251043A (en) * | 2015-10-28 | 2016-01-20 | 钊桂英 | Medical polylactic acid (PLA) suture line and manufacturing method |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU181548U1 (en) * | 2016-11-07 | 2018-07-19 | Татьяна Юрьевна Малинина | Absorbable surgical suture material for operations and manipulations on the muscles of the pelvis |
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