CN109276751A - A kind of surgical operation suturing new material - Google Patents
A kind of surgical operation suturing new material Download PDFInfo
- Publication number
- CN109276751A CN109276751A CN201710636857.6A CN201710636857A CN109276751A CN 109276751 A CN109276751 A CN 109276751A CN 201710636857 A CN201710636857 A CN 201710636857A CN 109276751 A CN109276751 A CN 109276751A
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- CN
- China
- Prior art keywords
- parts
- surgical operation
- new material
- operation suturing
- ossein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/005—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
Abstract
The invention discloses a kind of surgical operation suturing new materials, the surgical operation suturing new material, in parts by weight, raw material are as follows: 15-23 parts of hydroxy methyl acetate, 5-8 parts of ossein, 11-14 parts of polyamide, 0.5-0.9 parts of indoles, 0.4-0.8 parts of Herba Duchesneae Indicae extract, 2-4 parts of Radix Notoginseng powder, 0.01-0.05 parts of nisin.The nontoxic no accumulation of suture new material produced by the present invention, easy processing forms, and intensity is high, easily knots, and has the excellent performances such as good flexibility and resistant to the sterilising sterilizing, and can promote the healing of wound, degradation can be absorbed completely within 15-25 days in biological tissue.
Description
Technical field
The present invention relates to a kind of medical material field, specifically a kind of surgical operation suturing new material.
Background technique
Suture is common bio-compatible textile, is widely used in all kinds of surgical operations, to suture wound
Mouthful, it is coupled tissue and ligation blood vessel.Early in B.C. 3500, ancient Egyptian was just sewed up a wound with cotton fiber, horse-hair, in
Also early useful flaxen fiber makees the record of suture in the history records in state's ancient times.With the development of high polymer and its fiber, medical sutures
The kind of line is also more and more.
There are many suture type, including absorbability and nonabsorbable suture.Many common natural and synthesis weavings
Be used successfully as medical not absorbable suture line with fiber, the not absorbable suture line type developed at present have cotton, silk,
Fiber crops, polyamide, polyester, polypropylene and metal suture line.Absorbable suture have casing, ossein, chitin, polyglycolide,
The copolymer of glycolide and lactide gathers to dioxane ethyl ketone suture.
Suture must have the following performance requirement:
(1) intensity of line is higher, is not influenced and is deformed by body fluid, the not big change of mechanical property before wound healing
Change;(2) flexibility of fiber is good, colludes with intensity height, is easy when suture by tissue, and when ligation is easy to operate, makes knots
After hold knot property it is good;(3) biocompatibility is good, and tissue reaction is small, does not influence the growth of tissue;(4) for absorbability
Suture should be absorbed completely after tissue repair, foreign matter is not left in human body;(5) stable and reliable product quality, Neng Gouchang
Phase saves, and is easy to sterilize and invariance;(6) there is no toxicity, anaphylaxis, electrolyte, septic, carcinogenicity and capillarity.
As it can be seen that the quality requirement of suture is very high, but there are biocompatibilities that low, suture is being organized for current most of sutures
Phenomena such as interior tensile strength is small and interferes normal wound healing is badly in need of researching and developing a kind of novel surgical operation suturing green wood
Material.
Summary of the invention
The purpose of the present invention is to provide a kind of surgical operation suturing new materials, to solve to propose in above-mentioned background technique
The problem of.
To achieve the above object, the invention provides the following technical scheme:
A kind of surgical operation suturing new material, in parts by weight, raw material are as follows: 15-23 parts of hydroxy methyl acetate, ossein
5-8 parts, 11-14 parts of polyamide, 0.5-0.9 parts of indoles, 0.4-0.8 parts of Herba Duchesneae Indicae extract, 2-4 parts of Radix Notoginseng powder, nisin 0.01-
0.05 part.
As a further solution of the present invention: in parts by weight, raw material are as follows: 18-21 parts of hydroxy methyl acetate, ossein 6-
7 parts, 12-13 parts of polyamide, 0.6-0.8 parts of indoles, 0.5-0.7 parts of Herba Duchesneae Indicae extract, 2-4 parts of Radix Notoginseng powder, nisin 0.02-
0.04 part.
As a further solution of the present invention: in parts by weight, raw material are as follows: 20 parts of hydroxy methyl acetate, 7 parts of ossein,
13 parts of polyamide, 0.7 part of indoles, 0.6 part of Herba Duchesneae Indicae extract, 3 parts of Radix Notoginseng powder, 0.03 part of nisin.
A kind of preparation method of surgical operation suturing new material, specific steps are as follows:
(1) it firstly, hydroxy methyl acetate, polyamide and indoles are mixed, then puts into reaction kettle, 2MPa pressure and nitrogen
It is reacted under gas shielded, after reaction by melt spinning, obtains spinning mixture after cooling;
(2) then, spinning mixture is mixed with ossein, Herba Duchesneae Indicae extract, Radix Notoginseng powder, nisin, control moisture contains
Amount is then handled using sonic oscillation in 45%-50%, and the power of sonic oscillation processing is 120W, and the time is 13 minutes, is placed in
Low temperature drying at a temperature of 4 DEG C obtains surgical operation suturing new material.
As a further solution of the present invention: control moisture content is 48% in step (2).
Compared with prior art, the beneficial effects of the present invention are:
The nontoxic no accumulation of suture new material produced by the present invention, easy processing molding, and intensity are high, easily knot, tool
There are the excellent performances such as good flexibility and resistant to the sterilising sterilizing, and can promote the healing of wound, it can be 15-25 days in biological tissue
It is absorbed degradation completely.
Specific embodiment
Below in conjunction with the embodiment of the present invention, technical scheme in the embodiment of the invention is clearly and completely described,
Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based in the present invention
Embodiment, every other embodiment obtained by those of ordinary skill in the art without making creative efforts, all
Belong to the scope of protection of the invention.
Embodiment 1
A kind of surgical operation suturing new material, in parts by weight, raw material are as follows: 15 parts of hydroxy methyl acetate, ossein 5
Part, 11 parts of polyamide, 0.5 part of indoles, 0.4 part of Herba Duchesneae Indicae extract, 2 parts of Radix Notoginseng powder, 0.01 part of nisin.
A kind of preparation method of surgical operation suturing new material, specific steps are as follows:
(1) it firstly, hydroxy methyl acetate, polyamide and indoles are mixed, then puts into reaction kettle, 2MPa pressure and nitrogen
It is reacted under gas shielded, after reaction by melt spinning, obtains spinning mixture after cooling;
(2) then, spinning mixture is mixed with ossein, Herba Duchesneae Indicae extract, Radix Notoginseng powder, nisin, control moisture contains
Amount is then handled using sonic oscillation 45%, and the power of sonic oscillation processing is 120W, and the time is 13 minutes, is placed in 4 DEG C of temperature
Lower low temperature drying is spent, surgical operation suturing new material is obtained.
Embodiment 2
A kind of surgical operation suturing new material, in parts by weight, raw material are as follows: 18 parts of hydroxy methyl acetate, ossein 6
Part, 12 parts of polyamide, 0.6 part of indoles, 0.5 part of Herba Duchesneae Indicae extract, 2 parts of Radix Notoginseng powder, 0.02 part of nisin.
A kind of preparation method of surgical operation suturing new material, specific steps are as follows:
(1) it firstly, hydroxy methyl acetate, polyamide and indoles are mixed, then puts into reaction kettle, 2MPa pressure and nitrogen
It is reacted under gas shielded, after reaction by melt spinning, obtains spinning mixture after cooling;
(2) then, spinning mixture is mixed with ossein, Herba Duchesneae Indicae extract, Radix Notoginseng powder, nisin, control moisture contains
Amount is then handled using sonic oscillation 45%, and the power of sonic oscillation processing is 120W, and the time is 13 minutes, is placed in 4 DEG C of temperature
Lower low temperature drying is spent, surgical operation suturing new material is obtained.
Embodiment 3
A kind of surgical operation suturing new material, in parts by weight, raw material are as follows: 20 parts of hydroxy methyl acetate, ossein 7
Part, 13 parts of polyamide, 0.7 part of indoles, 0.6 part of Herba Duchesneae Indicae extract, 3 parts of Radix Notoginseng powder, 0.03 part of nisin.
A kind of preparation method of surgical operation suturing new material, specific steps are as follows:
(1) it firstly, hydroxy methyl acetate, polyamide and indoles are mixed, then puts into reaction kettle, 2MPa pressure and nitrogen
It is reacted under gas shielded, after reaction by melt spinning, obtains spinning mixture after cooling;
(2) then, spinning mixture is mixed with ossein, Herba Duchesneae Indicae extract, Radix Notoginseng powder, nisin, control moisture contains
Amount is then handled using sonic oscillation 48%, and the power of sonic oscillation processing is 120W, and the time is 13 minutes, is placed in 4 DEG C of temperature
Lower low temperature drying is spent, surgical operation suturing new material is obtained.
Embodiment 4
A kind of surgical operation suturing new material, in parts by weight, raw material are as follows: 21 parts of hydroxy methyl acetate, ossein 7
Part, 13 parts of polyamide, 0.8 part of indoles, 0.7 part of Herba Duchesneae Indicae extract, 4 parts of Radix Notoginseng powder, 0.04 part of nisin.
A kind of preparation method of surgical operation suturing new material, specific steps are as follows:
(1) it firstly, hydroxy methyl acetate, polyamide and indoles are mixed, then puts into reaction kettle, 2MPa pressure and nitrogen
It is reacted under gas shielded, after reaction by melt spinning, obtains spinning mixture after cooling;
(2) then, spinning mixture is mixed with ossein, Herba Duchesneae Indicae extract, Radix Notoginseng powder, nisin, control moisture contains
Amount is then handled using sonic oscillation 50%, and the power of sonic oscillation processing is 120W, and the time is 13 minutes, is placed in 4 DEG C of temperature
Lower low temperature drying is spent, surgical operation suturing new material is obtained.
Embodiment 5
A kind of surgical operation suturing new material, in parts by weight, raw material are as follows: 23 parts of hydroxy methyl acetate, ossein 8
Part, 14 parts of polyamide, 0.9 part of indoles, 0.8 part of Herba Duchesneae Indicae extract, 4 parts of Radix Notoginseng powder, 0.05 part of nisin.
A kind of preparation method of surgical operation suturing new material, specific steps are as follows:
(1) it firstly, hydroxy methyl acetate, polyamide and indoles are mixed, then puts into reaction kettle, 2MPa pressure and nitrogen
It is reacted under gas shielded, after reaction by melt spinning, obtains spinning mixture after cooling;
(2) then, spinning mixture is mixed with ossein, Herba Duchesneae Indicae extract, Radix Notoginseng powder, nisin, control moisture contains
Amount is then handled using sonic oscillation 50%, and the power of sonic oscillation processing is 120W, and the time is 13 minutes, is placed in 4 DEG C of temperature
Lower low temperature drying is spent, surgical operation suturing new material is obtained.
After tested, the surgical operation suture new material that prepared by 1-5 of the embodiment of the present invention all meets YY1116-2010 can
Absorbable surgical suture standard;Wherein the surgical operation of specification 4-0 is greater than 9.3N with suture new material tensile strength average value, single
A value is greater than 8.7N, and the surgical operation of specification 4-0 is greater than 5.6N with suture new material bonding strength average value, and single value is greater than
5.2N;Wherein chemical property testing result shows that the biological property of surgical operation suture new material is excellent, and intradermal test is stingless
Swash property, no cytotoxicity, no sensitivity response, no pyrogen reaction, no inflammation reaction, Salmonella reversion test is negative, average degradation cycle
At 20 days, the average healing cycle of wound was 4 days (by taking mouse caesarean birth as an example).
It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie
In the case where without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power
Benefit requires rather than above description limits, it is intended that all by what is fallen within the meaning and scope of the equivalent elements of the claims
Variation is included within the present invention.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
The other embodiments being understood that.
Claims (5)
1. a kind of surgical operation suturing new material, which is characterized in that in parts by weight, raw material are as follows: hydroxy methyl acetate 15-23
Part, 5-8 parts of ossein, 11-14 parts of polyamide, 0.5-0.9 parts of indoles, 0.4-0.8 parts of Herba Duchesneae Indicae extract, 2-4 parts of Radix Notoginseng powder, Buddhist nun
Raw 0.01-0.05 parts of element.
2. surgical operation suturing new material according to claim 1, which is characterized in that in parts by weight, raw material are as follows: hydroxyl
18-21 parts of acetic acid methyl ester, 6-7 parts of ossein, 12-13 parts of polyamide, 0.6-0.8 parts of indoles, Herba Duchesneae Indicae extract 0.5-0.7
Part, 2-4 parts of Radix Notoginseng powder, 0.02-0.04 parts of nisin.
3. surgical operation suturing new material according to claim 1 or 2, which is characterized in that in parts by weight, raw material
Are as follows: 20 parts of hydroxy methyl acetate, 7 parts of ossein, 13 parts of polyamide, 0.7 part of indoles, 0.6 part of Herba Duchesneae Indicae extract, 3 parts of Radix Notoginseng powder,
0.03 part of nisin.
4. a kind of preparation method of surgical operation suturing new material a method according to any one of claims 1-3, which is characterized in that tool
Body step are as follows:
(1) it firstly, hydroxy methyl acetate, polyamide and indoles are mixed, then puts into reaction kettle, 2MPa pressure and nitrogen are protected
It is reacted under shield, after reaction by melt spinning, obtains spinning mixture after cooling;
(2) then, spinning mixture is mixed with ossein, Herba Duchesneae Indicae extract, Radix Notoginseng powder, nisin, control moisture content exists
45%-50% is then handled using sonic oscillation, and the power of sonic oscillation processing is 120W, and the time is 13 minutes, is placed in 4 DEG C
At a temperature of low temperature drying, obtain surgical operation suturing new material.
5. the preparation method of surgical operation suturing new material according to claim 4, which is characterized in that in step (2)
Moisture content is controlled 48%.
Priority Applications (1)
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CN201710636857.6A CN109276751A (en) | 2017-07-20 | 2017-07-20 | A kind of surgical operation suturing new material |
Applications Claiming Priority (1)
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CN201710636857.6A CN109276751A (en) | 2017-07-20 | 2017-07-20 | A kind of surgical operation suturing new material |
Publications (1)
Publication Number | Publication Date |
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CN109276751A true CN109276751A (en) | 2019-01-29 |
Family
ID=65185140
Family Applications (1)
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CN201710636857.6A Pending CN109276751A (en) | 2017-07-20 | 2017-07-20 | A kind of surgical operation suturing new material |
Country Status (1)
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CN (1) | CN109276751A (en) |
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2017
- 2017-07-20 CN CN201710636857.6A patent/CN109276751A/en active Pending
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Application publication date: 20190129 |