CN106267321A - A kind of surgical operation suturing new material and preparation method thereof - Google Patents
A kind of surgical operation suturing new material and preparation method thereof Download PDFInfo
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- CN106267321A CN106267321A CN201610915672.4A CN201610915672A CN106267321A CN 106267321 A CN106267321 A CN 106267321A CN 201610915672 A CN201610915672 A CN 201610915672A CN 106267321 A CN106267321 A CN 106267321A
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- parts
- surgical operation
- new material
- operation suturing
- ossein
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
- A61L17/12—Homopolymers or copolymers of glycolic acid or lactic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/005—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/08—At least partially resorbable materials of animal origin, e.g. catgut, collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
- A61L17/105—Polyesters not covered by A61L17/12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/14—Post-treatment to improve physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Abstract
The invention discloses a kind of surgical operation suturing new material and preparation method thereof, described surgical operation suturing new material, in parts by weight, raw material is: polyglycolic acid 15 23 parts, ossein 58 parts, polylactic acid 11 14 parts, tryptophan 0.5 0.9 parts, Herba Duchesneae Indicae extract 0.4 0.8 parts, Radix Notoginseng powder 24 parts, nisin 0.01 0.05 parts.The stitching new material that the present invention prepares is nontoxic without accumulation, easily machine-shaping, and intensity is high, easily tie a knot, and has the premium properties such as good flexibility and resistant to the sterilising sterilizing, and the healing of wound can be promoted, can be degraded by absorption completely for 15 25 days in biological tissue.
Description
Technical field
The present invention relates to a kind of medical material field, specifically a kind of surgical operation suturing new material and preparation side thereof
Method.
Background technology
Suture is common bio-compatible textile, is widely used in all kinds of surgical operation, in order to sew up wound
Mouthful, connection tissue and ligation blood vessel.As far back as B.C. 3500, ancient Egyptian sewed up a wound with cotton fiber, Iuba Equi the most, in
In the history records in state ancient times, also early the record of stitching thread made by useful flaxen fiber.Along with high polymer and the development of fiber, medical sutures
The kind of line also gets more and more.
Stitching thread kind is a lot, including absorbability and nonabsorbable stitching thread.Many common natural and weavings of synthesis
Be used successfully as medical not absorbable suture line with fiber, the not absorbable suture line kind the most developed have cotton, silkworm silk,
Fiber crops, polyamide, polyester, polypropylene and metal suture line.Absorbable suture have casing, ossein, chitin, PGA,
Acetic acid, hydroxy-, bimol. cyclic ester and the copolymer of lactide, poly-to dioxane ethyl ketone stitching thread.
Suture must have a following performance requirement:
(1) intensity of line is higher, is not affected by body fluid and deforms, and before wound healing, mechanical property does not has big change
Change；(2) pliability of fiber is good, colludes with intensity height, easy by tissue during stitching, easy to operate during ligation, makes knots
After hold knot property good；(3) biocompatibility is good, and tissue reaction is little, does not affect the growth of tissue；(4) for absorbability
Stitching thread, should be absorbed after tissue repair completely, does not leave foreign body in human body；(5) stable and reliable product quality, it is possible to long
Phase preserves, and easily sterilizes and invariance；(6) there is no toxicity, anaphylaxis, electrolyte, septic, carcinogenecity and capillarity.
Visible, the prescription of suture is the highest, but current most of suture exists that biocompatibility is low, suture is at tissue
Interior tensile strength is little and hinders the phenomenons such as normal wound healing, is badly in need of researching and developing a kind of novel surgical operation suturing green wood
Material.
Summary of the invention
It is an object of the invention to provide a kind of surgical operation suturing new material and preparation method thereof, to solve the above-mentioned back of the body
The problem proposed in scape technology.
For achieving the above object, the present invention provides following technical scheme:
A kind of surgical operation suturing new material, in parts by weight, raw material is: polyglycolic acid 15-23 part, ossein 5-
8 parts, polylactic acid 11-14 part, tryptophan 0.5-0.9 part, Herba Duchesneae Indicae extract 0.4-0.8 part, Radix Notoginseng powder 2-4 part, nisin 0.01-
0.05 part.
As the further scheme of the present invention: in parts by weight, raw material is: polyglycolic acid 18-21 part, ossein 6-7
Part, polylactic acid 12-13 part, tryptophan 0.6-0.8 part, Herba Duchesneae Indicae extract 0.5-0.7 part, Radix Notoginseng powder 2-4 part, nisin 0.02-
0.04 part.
As the further scheme of the present invention: in parts by weight, raw material is: polyglycolic acid 20 parts, ossein 7 parts, poly-
Lactic acid 13 parts, tryptophan 0.7 part, Herba Duchesneae Indicae extract 0.6 part, Radix Notoginseng powder 3 parts, nisin 0.03 part.
The preparation method of a kind of surgical operation suturing new material, concretely comprises the following steps:
(1) first, polyglycolic acid, polylactic acid and tryptophan are mixed, puts into subsequently in reactor, 2MPa pressure and nitrogen
Reacting under gas shielded, reaction passes through melt spinning after terminating, and obtains spinning mixture after cooling；
(2) then, spinning mixture is mixed with ossein, Herba Duchesneae Indicae extract, Radix Notoginseng powder, nisin, control moisture and contain
Amount, at 45%-50%, is then used by sonic oscillation and processes, and the power that sonic oscillation processes is 120W, and the time is 13 minutes, is placed in
Oven drying at low temperature at a temperature of 4 DEG C, obtains surgical operation suturing new material.
As the further scheme of the present invention: step (2) controls moisture 48%.
Compared with prior art, the invention has the beneficial effects as follows:
Stitching new material that the present invention prepares is nontoxic without accumulation, and easy machine-shaping is, and intensity is high, easily tie a knot, tool
There is a premium properties such as good flexibility and resistant to the sterilising sterilizing, and the healing of wound can be promoted, can in biological tissue 15-25 days
Degraded by absorption completely.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described,
Obviously, described embodiment is only a part of embodiment of the present invention rather than whole embodiments.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under not making creative work premise, all
Belong to the scope of protection of the invention.
Embodiment 1
A kind of surgical operation suturing new material, in parts by weight, raw material is: polyglycolic acid 15 parts, ossein 5 parts,
Polylactic acid 11 parts, tryptophan 0.5 part, Herba Duchesneae Indicae extract 0.4 part, Radix Notoginseng powder 2 parts, nisin 0.01 part.
The preparation method of a kind of surgical operation suturing new material, concretely comprises the following steps:
(1) first, polyglycolic acid, polylactic acid and tryptophan are mixed, puts into subsequently in reactor, 2MPa pressure and nitrogen
Reacting under gas shielded, reaction passes through melt spinning after terminating, and obtains spinning mixture after cooling；
(2) then, spinning mixture is mixed with ossein, Herba Duchesneae Indicae extract, Radix Notoginseng powder, nisin, control moisture and contain
Amount, 45%, is then used by sonic oscillation and processes, and the power that sonic oscillation processes is 120W, and the time is 13 minutes, is placed in 4 DEG C of temperature
The lower oven drying at low temperature of degree, obtains surgical operation suturing new material.
Embodiment 2
A kind of surgical operation suturing new material, in parts by weight, raw material is: polyglycolic acid 18 parts, ossein 6 parts,
Polylactic acid 12 parts, tryptophan 0.6 part, Herba Duchesneae Indicae extract 0.5 part, Radix Notoginseng powder 2 parts, nisin 0.02 part.
The preparation method of a kind of surgical operation suturing new material, concretely comprises the following steps:
(1) first, polyglycolic acid, polylactic acid and tryptophan are mixed, puts into subsequently in reactor, 2MPa pressure and nitrogen
Reacting under gas shielded, reaction passes through melt spinning after terminating, and obtains spinning mixture after cooling；
(2) then, spinning mixture is mixed with ossein, Herba Duchesneae Indicae extract, Radix Notoginseng powder, nisin, control moisture and contain
Amount, 45%, is then used by sonic oscillation and processes, and the power that sonic oscillation processes is 120W, and the time is 13 minutes, is placed in 4 DEG C of temperature
The lower oven drying at low temperature of degree, obtains surgical operation suturing new material.
Embodiment 3
A kind of surgical operation suturing new material, in parts by weight, raw material is: polyglycolic acid 20 parts, ossein 7 parts,
Polylactic acid 13 parts, tryptophan 0.7 part, Herba Duchesneae Indicae extract 0.6 part, Radix Notoginseng powder 3 parts, nisin 0.03 part.
The preparation method of a kind of surgical operation suturing new material, concretely comprises the following steps:
(1) first, polyglycolic acid, polylactic acid and tryptophan are mixed, puts into subsequently in reactor, 2MPa pressure and nitrogen
Reacting under gas shielded, reaction passes through melt spinning after terminating, and obtains spinning mixture after cooling；
(2) then, spinning mixture is mixed with ossein, Herba Duchesneae Indicae extract, Radix Notoginseng powder, nisin, control moisture and contain
Amount, 48%, is then used by sonic oscillation and processes, and the power that sonic oscillation processes is 120W, and the time is 13 minutes, is placed in 4 DEG C of temperature
The lower oven drying at low temperature of degree, obtains surgical operation suturing new material.
Embodiment 4
A kind of surgical operation suturing new material, in parts by weight, raw material is: polyglycolic acid 21 parts, ossein 7 parts,
Polylactic acid 13 parts, tryptophan 0.8 part, Herba Duchesneae Indicae extract 0.7 part, Radix Notoginseng powder 4 parts, nisin 0.04 part.
The preparation method of a kind of surgical operation suturing new material, concretely comprises the following steps:
(1) first, polyglycolic acid, polylactic acid and tryptophan are mixed, puts into subsequently in reactor, 2MPa pressure and nitrogen
Reacting under gas shielded, reaction passes through melt spinning after terminating, and obtains spinning mixture after cooling；
(2) then, spinning mixture is mixed with ossein, Herba Duchesneae Indicae extract, Radix Notoginseng powder, nisin, control moisture and contain
Amount, 50%, is then used by sonic oscillation and processes, and the power that sonic oscillation processes is 120W, and the time is 13 minutes, is placed in 4 DEG C of temperature
The lower oven drying at low temperature of degree, obtains surgical operation suturing new material.
Embodiment 5
A kind of surgical operation suturing new material, in parts by weight, raw material is: polyglycolic acid 23 parts, ossein 8 parts,
Polylactic acid 14 parts, tryptophan 0.9 part, Herba Duchesneae Indicae extract 0.8 part, Radix Notoginseng powder 4 parts, nisin 0.05 part.
The preparation method of a kind of surgical operation suturing new material, concretely comprises the following steps:
(1) first, polyglycolic acid, polylactic acid and tryptophan are mixed, puts into subsequently in reactor, 2MPa pressure and nitrogen
Reacting under gas shielded, reaction passes through melt spinning after terminating, and obtains spinning mixture after cooling；
(2) then, spinning mixture is mixed with ossein, Herba Duchesneae Indicae extract, Radix Notoginseng powder, nisin, control moisture and contain
Amount, 50%, is then used by sonic oscillation and processes, and the power that sonic oscillation processes is 120W, and the time is 13 minutes, is placed in 4 DEG C of temperature
The lower oven drying at low temperature of degree, obtains surgical operation suturing new material.
After tested, the surgical operation stitching new material that prepared by embodiment of the present invention 1-5 all meets YY1116-2010 can
Absorbable surgical suture standard；Wherein the surgical operation of specification 4-0 is with sewing up new material tensile strength meansigma methods more than 9.3N, list
Individual value is more than 8.7N, and the surgical operation of specification 4-0 is more than 5.6N with sewing up new material bonding strength meansigma methods, and single value is more than
5.2N；Wherein chemical property testing result shows, the biological property that surgical operation sews up new material is excellent, and Intradermal test is stingless
Swashing property, no cytotoxicity, without sensitivity response, without pyrogen reaction, NIP reacts, and Salmonella reversion test is negative, average degradation cycle
At 20 days, the average healing cycle of wound was 4 days (as a example by mice cesarean).
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of the spirit or essential attributes of the present invention, it is possible to realize the present invention in other specific forms.Therefore, no matter
From the point of view of which point, all should regard embodiment as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit requires rather than described above limits, it is intended that all by fall in the implication of equivalency and scope of claim
Change is included in the present invention.
Although moreover, it will be appreciated that this specification is been described by according to embodiment, but the most each embodiment only wraps
Containing an independent technical scheme, this narrating mode of description is only that for clarity sake those skilled in the art should
Description can also be formed those skilled in the art through appropriately combined as an entirety, the technical scheme in each embodiment
May be appreciated other embodiments.
Claims (5)
1. a surgical operation suturing new material, it is characterised in that in parts by weight, raw material is: polyglycolic acid 15-23
Part, ossein 5-8 part, polylactic acid 11-14 part, tryptophan 0.5-0.9 part, Herba Duchesneae Indicae extract 0.4-0.8 part, Radix Notoginseng powder 2-4 part,
Nisin 0.01-0.05 part.
Surgical operation suturing new material the most according to claim 1, it is characterised in that in parts by weight, raw material is: poly-
Hydroxyacetic acid 18-21 part, ossein 6-7 part, polylactic acid 12-13 part, tryptophan 0.6-0.8 part, Herba Duchesneae Indicae extract 0.5-0.7
Part, Radix Notoginseng powder 2-4 part, nisin 0.02-0.04 part.
Surgical operation suturing new material the most according to claim 1 and 2, it is characterised in that in parts by weight, raw material
For: polyglycolic acid 20 parts, ossein 7 parts, polylactic acid 13 parts, tryptophan 0.7 part, Herba Duchesneae Indicae extract 0.6 part, Radix Notoginseng powder 3 parts,
Nisin 0.03 part.
4. the preparation method of the surgical operation suturing new material as described in claim 1-3 is arbitrary, it is characterised in that tool
Body step is:
(1) first, polyglycolic acid, polylactic acid and tryptophan being mixed, put into subsequently in reactor, 2MPa pressure and nitrogen are protected
Protecting down and react, reaction passes through melt spinning after terminating, and obtains spinning mixture after cooling；
(2) then, spinning mixture is mixed with ossein, Herba Duchesneae Indicae extract, Radix Notoginseng powder, nisin, control moisture and exist
45%-50%, is then used by sonic oscillation and processes, and the power that sonic oscillation processes is 120W, and the time is 13 minutes, is placed in 4 DEG C
At a temperature of oven drying at low temperature, obtain surgical operation suturing new material.
The preparation method of surgical operation suturing new material the most according to claim 4, it is characterised in that in step (2)
Control moisture 48%.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610915672.4A CN106267321A (en) | 2016-10-20 | 2016-10-20 | A kind of surgical operation suturing new material and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610915672.4A CN106267321A (en) | 2016-10-20 | 2016-10-20 | A kind of surgical operation suturing new material and preparation method thereof |
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| Publication Number | Publication Date |
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| CN106267321A true CN106267321A (en) | 2017-01-04 |
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Family Applications (1)
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| CN201610915672.4A Pending CN106267321A (en) | 2016-10-20 | 2016-10-20 | A kind of surgical operation suturing new material and preparation method thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110251639A1 (en) * | 2010-04-08 | 2011-10-13 | Tyco Healthcare Group Lp | Coated Looped Suture |
| CN104474586A (en) * | 2014-11-25 | 2015-04-01 | 苏州市贝克生物科技有限公司 | Polyglycolic acid medical absorbable suture and preparation method thereof |
| CN105056294A (en) * | 2015-08-11 | 2015-11-18 | 安徽省康宁医疗用品有限公司 | Slow-release, antibacterial and absorbable medical suture and preparation method thereof |
| CN105251043A (en) * | 2015-10-28 | 2016-01-20 | 钊桂英 | Medical polylactic acid (PLA) suture line and manufacturing method |
-
2016
- 2016-10-20 CN CN201610915672.4A patent/CN106267321A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110251639A1 (en) * | 2010-04-08 | 2011-10-13 | Tyco Healthcare Group Lp | Coated Looped Suture |
| CN104474586A (en) * | 2014-11-25 | 2015-04-01 | 苏州市贝克生物科技有限公司 | Polyglycolic acid medical absorbable suture and preparation method thereof |
| CN105056294A (en) * | 2015-08-11 | 2015-11-18 | 安徽省康宁医疗用品有限公司 | Slow-release, antibacterial and absorbable medical suture and preparation method thereof |
| CN105251043A (en) * | 2015-10-28 | 2016-01-20 | 钊桂英 | Medical polylactic acid (PLA) suture line and manufacturing method |
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